Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

UBA/TS-N domain containing protein - putative

Species:

Leishmania infantum

UniProt:

E9AH65_LEIIN

TriTrypDb:

LINF_240021300

Length:

396

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

E9AH65

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AH65

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	191	193	PF00675	0.734
CLV_NRD_NRD_1	321	323	PF00675	0.465
CLV_NRD_NRD_1	347	349	PF00675	0.545
CLV_NRD_NRD_1	85	87	PF00675	0.351
CLV_PCSK_FUR_1	319	323	PF00082	0.510
CLV_PCSK_KEX2_1	191	193	PF00082	0.734
CLV_PCSK_KEX2_1	321	323	PF00082	0.467
CLV_PCSK_KEX2_1	346	348	PF00082	0.568
CLV_PCSK_KEX2_1	51	53	PF00082	0.629
CLV_PCSK_KEX2_1	85	87	PF00082	0.348
CLV_PCSK_PC1ET2_1	51	53	PF00082	0.667
CLV_PCSK_PC7_1	317	323	PF00082	0.532
CLV_PCSK_PC7_1	81	87	PF00082	0.335
CLV_PCSK_SKI1_1	167	171	PF00082	0.341
CLV_PCSK_SKI1_1	176	180	PF00082	0.297
CLV_PCSK_SKI1_1	237	241	PF00082	0.367
CLV_PCSK_SKI1_1	244	248	PF00082	0.356
CLV_PCSK_SKI1_1	51	55	PF00082	0.699
DEG_APCC_DBOX_1	203	211	PF00400	0.368
DEG_APCC_DBOX_1	236	244	PF00400	0.566
DEG_APCC_DBOX_1	51	59	PF00400	0.433
DEG_Nend_Nbox_1	1	3	PF02207	0.495
DOC_CYCLIN_RxL_1	48	57	PF00134	0.558
DOC_MAPK_gen_1	241	251	PF00069	0.610
DOC_MAPK_HePTP_8	230	242	PF00069	0.597
DOC_MAPK_MEF2A_6	233	242	PF00069	0.558
DOC_PP2B_LxvP_1	40	43	PF13499	0.402
DOC_PP4_FxxP_1	242	245	PF00568	0.586
DOC_USP7_MATH_1	148	152	PF00917	0.658
DOC_USP7_MATH_1	215	219	PF00917	0.434
DOC_WW_Pin1_4	177	182	PF00397	0.575
DOC_WW_Pin1_4	346	351	PF00397	0.762
LIG_14-3-3_CanoR_1	125	134	PF00244	0.313
LIG_14-3-3_CanoR_1	150	154	PF00244	0.716
LIG_14-3-3_CanoR_1	225	231	PF00244	0.588
LIG_14-3-3_CanoR_1	244	253	PF00244	0.477
LIG_Actin_WH2_2	132	147	PF00022	0.428
LIG_eIF4E_1	234	240	PF01652	0.631
LIG_FHA_1	10	16	PF00498	0.364
LIG_FHA_1	104	110	PF00498	0.286
LIG_FHA_1	139	145	PF00498	0.355
LIG_FHA_1	158	164	PF00498	0.668
LIG_FHA_1	230	236	PF00498	0.590
LIG_FHA_1	245	251	PF00498	0.619
LIG_FHA_1	96	102	PF00498	0.356
LIG_FHA_2	304	310	PF00498	0.728
LIG_GBD_Chelix_1	136	144	PF00786	0.424
LIG_GBD_Chelix_1	209	217	PF00786	0.363
LIG_IRF3_LxIS_1	11	16	PF10401	0.447
LIG_IRF3_LxIS_1	158	165	PF10401	0.667
LIG_IRF3_LxIS_1	59	66	PF10401	0.447
LIG_LIR_Gen_1	203	214	PF02991	0.407
LIG_LIR_Gen_1	69	78	PF02991	0.441
LIG_LIR_Gen_1	89	100	PF02991	0.482
LIG_LIR_Nem_3	203	209	PF02991	0.370
LIG_LIR_Nem_3	229	234	PF02991	0.608
LIG_LIR_Nem_3	69	74	PF02991	0.441
LIG_LIR_Nem_3	89	95	PF02991	0.482
LIG_Pex14_1	227	231	PF04695	0.556
LIG_Pex14_2	251	255	PF04695	0.713
LIG_PTB_Apo_2	29	36	PF02174	0.709
LIG_SH2_STAT5	143	146	PF00017	0.569
LIG_SH2_STAT5	234	237	PF00017	0.621
LIG_SH2_STAT5	27	30	PF00017	0.667
LIG_SH2_STAT5	300	303	PF00017	0.640
LIG_SH3_3	175	181	PF00018	0.415
LIG_SH3_3	56	62	PF00018	0.362
LIG_SUMO_SIM_anti_2	9	17	PF11976	0.447
LIG_SUMO_SIM_par_1	11	17	PF11976	0.447
LIG_TRAF2_1	310	313	PF00917	0.719
LIG_TRAF2_1	349	352	PF00917	0.728
LIG_UBA3_1	171	176	PF00899	0.415
MOD_CK1_1	149	155	PF00069	0.710
MOD_CK1_1	16	22	PF00069	0.353
MOD_CK1_1	180	186	PF00069	0.490
MOD_CK1_1	218	224	PF00069	0.575
MOD_CK2_1	307	313	PF00069	0.748
MOD_CK2_1	346	352	PF00069	0.767
MOD_CK2_1	368	374	PF00069	0.658
MOD_GlcNHglycan	113	116	PF01048	0.599
MOD_GlcNHglycan	127	130	PF01048	0.270
MOD_GlcNHglycan	98	101	PF01048	0.356
MOD_GSK3_1	109	116	PF00069	0.413
MOD_GSK3_1	125	132	PF00069	0.218
MOD_GSK3_1	303	310	PF00069	0.733
MOD_GSK3_1	9	16	PF00069	0.357
MOD_N-GLC_1	271	276	PF02516	0.573
MOD_NEK2_1	13	18	PF00069	0.392
MOD_NEK2_1	379	384	PF00069	0.679
MOD_NEK2_1	54	59	PF00069	0.445
MOD_NEK2_1	63	68	PF00069	0.360
MOD_NEK2_1	95	100	PF00069	0.329
MOD_NEK2_2	138	143	PF00069	0.480
MOD_NEK2_2	226	231	PF00069	0.619
MOD_PIKK_1	180	186	PF00454	0.460
MOD_PK_1	117	123	PF00069	0.507
MOD_PKA_2	149	155	PF00069	0.710
MOD_PKA_2	368	374	PF00069	0.692
MOD_Plk_4	129	135	PF00069	0.296
MOD_Plk_4	167	173	PF00069	0.414
MOD_Plk_4	18	24	PF00069	0.347
MOD_Plk_4	226	232	PF00069	0.604
MOD_Plk_4	88	94	PF00069	0.526
MOD_Plk_4	9	15	PF00069	0.394
MOD_ProDKin_1	177	183	PF00069	0.582
MOD_ProDKin_1	346	352	PF00069	0.759
TRG_DiLeu_BaLyEn_6	235	240	PF01217	0.594
TRG_DiLeu_BaLyEn_6	49	54	PF01217	0.665
TRG_ENDOCYTIC_2	30	33	PF00928	0.714
TRG_ENDOCYTIC_2	92	95	PF00928	0.480
TRG_ER_diArg_1	190	192	PF00400	0.519
TRG_ER_diArg_1	314	317	PF00400	0.705
TRG_ER_diArg_1	318	321	PF00400	0.681
TRG_ER_diArg_1	346	348	PF00400	0.759
TRG_ER_diArg_1	85	87	PF00400	0.548
TRG_Pf-PMV_PEXEL_1	244	248	PF00026	0.449
TRG_Pf-PMV_PEXEL_1	52	56	PF00026	0.663

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM84	Leptomonas seymouri	63%	100%
A0A1X0NVU5	Trypanosomatidae	35%	100%
A0A3S7WYG8	Leishmania donovani	100%	100%
A0A422N8E9	Trypanosoma rangeli	32%	100%
A4HDL8	Leishmania braziliensis	84%	100%
C9ZWE6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AX03	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4QAH3	Leishmania major	97%	100%
V5AVK1	Trypanosoma cruzi	35%	100%