LeishMANIAdb
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RNA binding protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
RNA binding protein
Gene product:
RNA recognition motif. (a.k.a. RRM - RBD - or RNP domain)/RNA recognition motif (a.k.a. RRM - RBD - or RNP domain) - putative
Species:
Leishmania infantum
UniProt:
E9AH64_LEIIN
TriTrypDb:
LINF_240021200
Length:
693

Annotations

Annotations by Jardim et al.

Nucleic acid binding, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0005654 nucleoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

E9AH64
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AH64

Function

Biological processes
Term Name Level Count
GO:0010468 regulation of gene expression 5 1
GO:0019222 regulation of metabolic process 3 1
GO:0050789 regulation of biological process 2 1
GO:0060255 regulation of macromolecule metabolic process 4 1
GO:0065007 biological regulation 1 1
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 7
GO:0003723 RNA binding 4 7
GO:0005488 binding 1 7
GO:0097159 organic cyclic compound binding 2 7
GO:1901363 heterocyclic compound binding 2 7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 199 203 PF00656 0.727
CLV_NRD_NRD_1 421 423 PF00675 0.578
CLV_NRD_NRD_1 428 430 PF00675 0.588
CLV_PCSK_KEX2_1 421 423 PF00082 0.586
CLV_PCSK_KEX2_1 428 430 PF00082 0.656
CLV_PCSK_SKI1_1 244 248 PF00082 0.346
CLV_PCSK_SKI1_1 260 264 PF00082 0.346
CLV_PCSK_SKI1_1 431 435 PF00082 0.697
DEG_Nend_UBRbox_3 1 3 PF02207 0.766
DEG_SCF_FBW7_1 163 168 PF00400 0.807
DEG_SCF_FBW7_1 493 500 PF00400 0.695
DEG_SCF_FBW7_1 650 656 PF00400 0.567
DEG_SPOP_SBC_1 442 446 PF00917 0.748
DOC_CDC14_PxL_1 619 627 PF14671 0.739
DOC_CKS1_1 111 116 PF01111 0.705
DOC_CKS1_1 180 185 PF01111 0.783
DOC_CKS1_1 595 600 PF01111 0.806
DOC_CKS1_1 650 655 PF01111 0.569
DOC_MAPK_FxFP_2 151 154 PF00069 0.776
DOC_MAPK_FxFP_2 28 31 PF00069 0.693
DOC_MAPK_gen_1 242 249 PF00069 0.620
DOC_MAPK_gen_1 269 278 PF00069 0.576
DOC_PP1_RVXF_1 269 276 PF00149 0.619
DOC_PP2B_LxvP_1 163 166 PF13499 0.636
DOC_PP2B_LxvP_1 499 502 PF13499 0.799
DOC_PP4_FxxP_1 151 154 PF00568 0.776
DOC_PP4_FxxP_1 28 31 PF00568 0.693
DOC_PP4_FxxP_1 457 460 PF00568 0.706
DOC_PP4_FxxP_1 620 623 PF00568 0.816
DOC_PP4_MxPP_1 471 474 PF00568 0.718
DOC_USP7_MATH_1 123 127 PF00917 0.700
DOC_USP7_MATH_1 187 191 PF00917 0.801
DOC_USP7_MATH_1 211 215 PF00917 0.758
DOC_USP7_MATH_1 217 221 PF00917 0.645
DOC_USP7_MATH_1 29 33 PF00917 0.771
DOC_USP7_MATH_1 452 456 PF00917 0.714
DOC_USP7_MATH_1 458 462 PF00917 0.620
DOC_USP7_MATH_1 549 553 PF00917 0.738
DOC_USP7_MATH_1 630 634 PF00917 0.718
DOC_USP7_MATH_1 653 657 PF00917 0.594
DOC_USP7_MATH_1 668 672 PF00917 0.709
DOC_USP7_MATH_1 77 81 PF00917 0.777
DOC_USP7_MATH_1 92 96 PF00917 0.617
DOC_USP7_UBL2_3 400 404 PF12436 0.573
DOC_WW_Pin1_4 110 115 PF00397 0.581
DOC_WW_Pin1_4 161 166 PF00397 0.809
DOC_WW_Pin1_4 179 184 PF00397 0.785
DOC_WW_Pin1_4 3 8 PF00397 0.772
DOC_WW_Pin1_4 398 403 PF00397 0.563
DOC_WW_Pin1_4 493 498 PF00397 0.775
DOC_WW_Pin1_4 564 569 PF00397 0.717
DOC_WW_Pin1_4 594 599 PF00397 0.813
DOC_WW_Pin1_4 649 654 PF00397 0.574
DOC_WW_Pin1_4 98 103 PF00397 0.721
LIG_14-3-3_CanoR_1 125 129 PF00244 0.692
LIG_14-3-3_CanoR_1 332 336 PF00244 0.546
LIG_14-3-3_CanoR_1 364 373 PF00244 0.551
LIG_14-3-3_CanoR_1 85 89 PF00244 0.748
LIG_Actin_WH2_2 502 520 PF00022 0.726
LIG_BIR_III_4 519 523 PF00653 0.673
LIG_BRCT_BRCA1_1 229 233 PF00533 0.509
LIG_BRCT_BRCA1_1 23 27 PF00533 0.639
LIG_BRCT_BRCA1_1 551 555 PF00533 0.768
LIG_EVH1_1 620 624 PF00568 0.702
LIG_EVH1_2 483 487 PF00568 0.759
LIG_FHA_1 147 153 PF00498 0.772
LIG_FHA_1 300 306 PF00498 0.694
LIG_FHA_1 437 443 PF00498 0.759
LIG_FHA_1 46 52 PF00498 0.720
LIG_FHA_1 494 500 PF00498 0.697
LIG_FHA_1 588 594 PF00498 0.711
LIG_FHA_2 332 338 PF00498 0.546
LIG_FHA_2 366 372 PF00498 0.715
LIG_FHA_2 432 438 PF00498 0.707
LIG_FHA_2 71 77 PF00498 0.730
LIG_IBAR_NPY_1 679 681 PF08397 0.720
LIG_LIR_Apic_2 148 154 PF02991 0.775
LIG_LIR_Apic_2 455 460 PF02991 0.708
LIG_LIR_Gen_1 333 342 PF02991 0.555
LIG_LIR_Gen_1 486 493 PF02991 0.689
LIG_LIR_Nem_3 150 156 PF02991 0.779
LIG_LIR_Nem_3 24 30 PF02991 0.780
LIG_LIR_Nem_3 333 339 PF02991 0.555
LIG_LIR_Nem_3 486 490 PF02991 0.731
LIG_LYPXL_S_1 152 156 PF13949 0.703
LIG_MLH1_MIPbox_1 551 555 PF16413 0.768
LIG_MYND_1 106 110 PF01753 0.623
LIG_MYND_1 623 627 PF01753 0.801
LIG_PTB_Apo_2 520 527 PF02174 0.700
LIG_PTB_Apo_2 676 683 PF02174 0.722
LIG_PTB_Phospho_1 520 526 PF10480 0.696
LIG_SH2_CRK 542 546 PF00017 0.793
LIG_SH2_NCK_1 131 135 PF00017 0.672
LIG_SH2_NCK_1 526 530 PF00017 0.711
LIG_SH2_NCK_1 542 546 PF00017 0.691
LIG_SH2_SRC 312 315 PF00017 0.574
LIG_SH2_SRC 526 529 PF00017 0.637
LIG_SH2_STAT3 338 341 PF00017 0.546
LIG_SH2_STAT5 312 315 PF00017 0.612
LIG_SH2_STAT5 338 341 PF00017 0.546
LIG_SH2_STAT5 594 597 PF00017 0.740
LIG_SH2_STAT5 681 684 PF00017 0.808
LIG_SH3_3 177 183 PF00018 0.686
LIG_SH3_3 311 317 PF00018 0.626
LIG_SH3_3 471 477 PF00018 0.655
LIG_SH3_3 485 491 PF00018 0.741
LIG_SH3_3 525 531 PF00018 0.801
LIG_SH3_3 556 562 PF00018 0.735
LIG_SH3_3 599 605 PF00018 0.665
LIG_SH3_3 618 624 PF00018 0.679
LIG_SUMO_SIM_par_1 237 243 PF11976 0.518
LIG_SUMO_SIM_par_1 245 251 PF11976 0.486
LIG_SUMO_SIM_par_1 261 267 PF11976 0.443
LIG_SUMO_SIM_par_1 326 331 PF11976 0.546
LIG_UBA3_1 246 252 PF00899 0.375
MOD_CDK_SPxK_1 398 404 PF00069 0.571
MOD_CK1_1 101 107 PF00069 0.679
MOD_CK1_1 121 127 PF00069 0.567
MOD_CK1_1 130 136 PF00069 0.680
MOD_CK1_1 146 152 PF00069 0.770
MOD_CK1_1 161 167 PF00069 0.564
MOD_CK1_1 191 197 PF00069 0.786
MOD_CK1_1 209 215 PF00069 0.579
MOD_CK1_1 331 337 PF00069 0.411
MOD_CK1_1 349 355 PF00069 0.411
MOD_CK1_1 362 368 PF00069 0.590
MOD_CK1_1 443 449 PF00069 0.722
MOD_CK1_1 489 495 PF00069 0.790
MOD_CK1_1 596 602 PF00069 0.591
MOD_CK1_1 70 76 PF00069 0.716
MOD_CK2_1 331 337 PF00069 0.389
MOD_CK2_1 364 370 PF00069 0.640
MOD_CK2_1 382 388 PF00069 0.447
MOD_CK2_1 431 437 PF00069 0.683
MOD_CK2_1 52 58 PF00069 0.683
MOD_CK2_1 70 76 PF00069 0.709
MOD_GlcNHglycan 126 129 PF01048 0.747
MOD_GlcNHglycan 132 135 PF01048 0.655
MOD_GlcNHglycan 145 148 PF01048 0.673
MOD_GlcNHglycan 167 170 PF01048 0.603
MOD_GlcNHglycan 213 216 PF01048 0.735
MOD_GlcNHglycan 219 222 PF01048 0.767
MOD_GlcNHglycan 257 260 PF01048 0.369
MOD_GlcNHglycan 31 34 PF01048 0.700
MOD_GlcNHglycan 361 364 PF01048 0.416
MOD_GlcNHglycan 37 40 PF01048 0.801
MOD_GlcNHglycan 519 523 PF01048 0.599
MOD_GlcNHglycan 555 558 PF01048 0.755
MOD_GlcNHglycan 598 601 PF01048 0.625
MOD_GlcNHglycan 639 642 PF01048 0.616
MOD_GlcNHglycan 653 656 PF01048 0.563
MOD_GlcNHglycan 69 72 PF01048 0.796
MOD_GlcNHglycan 94 97 PF01048 0.782
MOD_GSK3_1 1 8 PF00069 0.803
MOD_GSK3_1 123 130 PF00069 0.703
MOD_GSK3_1 143 150 PF00069 0.441
MOD_GSK3_1 161 168 PF00069 0.805
MOD_GSK3_1 187 194 PF00069 0.776
MOD_GSK3_1 202 209 PF00069 0.635
MOD_GSK3_1 211 218 PF00069 0.812
MOD_GSK3_1 326 333 PF00069 0.492
MOD_GSK3_1 362 369 PF00069 0.715
MOD_GSK3_1 394 401 PF00069 0.555
MOD_GSK3_1 436 443 PF00069 0.726
MOD_GSK3_1 446 453 PF00069 0.707
MOD_GSK3_1 489 496 PF00069 0.731
MOD_GSK3_1 52 59 PF00069 0.680
MOD_GSK3_1 549 556 PF00069 0.768
MOD_GSK3_1 560 567 PF00069 0.651
MOD_GSK3_1 589 596 PF00069 0.753
MOD_GSK3_1 649 656 PF00069 0.591
MOD_GSK3_1 668 675 PF00069 0.706
MOD_GSK3_1 97 104 PF00069 0.717
MOD_N-GLC_1 121 126 PF02516 0.795
MOD_N-GLC_1 188 193 PF02516 0.739
MOD_N-GLC_1 202 207 PF02516 0.650
MOD_N-GLC_1 291 296 PF02516 0.411
MOD_N-GLC_1 318 323 PF02516 0.514
MOD_N-GLC_1 564 569 PF02516 0.718
MOD_NEK2_1 188 193 PF00069 0.729
MOD_NEK2_1 291 296 PF00069 0.387
MOD_NEK2_1 328 333 PF00069 0.411
MOD_NEK2_1 593 598 PF00069 0.696
MOD_NEK2_1 86 91 PF00069 0.748
MOD_NEK2_2 416 421 PF00069 0.683
MOD_PIKK_1 1 7 PF00454 0.812
MOD_PIKK_1 101 107 PF00454 0.696
MOD_PIKK_1 206 212 PF00454 0.778
MOD_PIKK_1 52 58 PF00454 0.785
MOD_PIKK_1 587 593 PF00454 0.623
MOD_PIKK_1 608 614 PF00454 0.706
MOD_PIKK_1 630 636 PF00454 0.797
MOD_PIKK_1 672 678 PF00454 0.726
MOD_PKA_2 124 130 PF00069 0.707
MOD_PKA_2 331 337 PF00069 0.411
MOD_PKA_2 424 430 PF00069 0.637
MOD_PKA_2 84 90 PF00069 0.690
MOD_PKB_1 429 437 PF00069 0.673
MOD_Plk_1 147 153 PF00069 0.674
MOD_Plk_1 158 164 PF00069 0.693
MOD_Plk_1 188 194 PF00069 0.800
MOD_Plk_1 318 324 PF00069 0.514
MOD_Plk_1 346 352 PF00069 0.411
MOD_Plk_1 416 422 PF00069 0.687
MOD_Plk_4 147 153 PF00069 0.751
MOD_Plk_4 318 324 PF00069 0.514
MOD_Plk_4 331 337 PF00069 0.411
MOD_Plk_4 483 489 PF00069 0.808
MOD_Plk_4 500 506 PF00069 0.606
MOD_Plk_4 549 555 PF00069 0.765
MOD_Plk_4 56 62 PF00069 0.672
MOD_Plk_4 589 595 PF00069 0.713
MOD_Plk_4 653 659 PF00069 0.594
MOD_Plk_4 668 674 PF00069 0.707
MOD_ProDKin_1 110 116 PF00069 0.580
MOD_ProDKin_1 161 167 PF00069 0.812
MOD_ProDKin_1 179 185 PF00069 0.785
MOD_ProDKin_1 3 9 PF00069 0.774
MOD_ProDKin_1 398 404 PF00069 0.571
MOD_ProDKin_1 493 499 PF00069 0.777
MOD_ProDKin_1 564 570 PF00069 0.720
MOD_ProDKin_1 594 600 PF00069 0.810
MOD_ProDKin_1 649 655 PF00069 0.570
MOD_ProDKin_1 98 104 PF00069 0.721
MOD_SUMO_rev_2 370 377 PF00179 0.615
TRG_DiLeu_BaLyEn_6 407 412 PF01217 0.488
TRG_ENDOCYTIC_2 153 156 PF00928 0.705
TRG_ENDOCYTIC_2 681 684 PF00928 0.706
TRG_ER_diArg_1 420 422 PF00400 0.649
TRG_ER_diArg_1 428 431 PF00400 0.630
TRG_Pf-PMV_PEXEL_1 244 248 PF00026 0.513

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I1V6 Leptomonas seymouri 44% 91%
A0A3S7WYI1 Leishmania donovani 99% 100%
A4HDU7 Leishmania braziliensis 69% 98%
E9AX02 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
Q4QAH4 Leishmania major 92% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS