LeishMANIAdb
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Leucine-rich repeat domain, L domain-like

Quick info Annotations Function or PPIs Localization Phosphorylation Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Leucine-rich repeat domain, L domain-like
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
E9AH63_LEIIN
TriTrypDb:
LINF_240021100
Length:
600

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) yes yes: 2
Forrest at al. (procyclic) yes yes: 2
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005929 cilium 4 12
GO:0042995 cell projection 2 12
GO:0043226 organelle 2 12
GO:0043227 membrane-bounded organelle 3 12
GO:0110165 cellular anatomical entity 1 12
GO:0120025 plasma membrane bounded cell projection 3 12

Phosphorylation

Promastigote: 482

Expansion

Sequence features

E9AH63
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AH63

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 112 116 PF00656 0.441
CLV_C14_Caspase3-7 311 315 PF00656 0.587
CLV_NRD_NRD_1 219 221 PF00675 0.517
CLV_NRD_NRD_1 486 488 PF00675 0.636
CLV_NRD_NRD_1 80 82 PF00675 0.439
CLV_PCSK_FUR_1 484 488 PF00082 0.593
CLV_PCSK_KEX2_1 221 223 PF00082 0.495
CLV_PCSK_KEX2_1 486 488 PF00082 0.627
CLV_PCSK_PC1ET2_1 221 223 PF00082 0.500
CLV_PCSK_SKI1_1 178 182 PF00082 0.448
CLV_PCSK_SKI1_1 213 217 PF00082 0.544
CLV_PCSK_SKI1_1 266 270 PF00082 0.414
CLV_PCSK_SKI1_1 375 379 PF00082 0.549
CLV_PCSK_SKI1_1 524 528 PF00082 0.617
CLV_PCSK_SKI1_1 59 63 PF00082 0.547
CLV_Separin_Metazoa 405 409 PF03568 0.657
DEG_COP1_1 396 406 PF00400 0.671
DEG_COP1_1 492 501 PF00400 0.403
DOC_CKS1_1 307 312 PF01111 0.498
DOC_CYCLIN_RxL_1 173 185 PF00134 0.538
DOC_CYCLIN_RxL_1 56 64 PF00134 0.573
DOC_CYCLIN_yClb5_NLxxxL_5 158 167 PF00134 0.589
DOC_CYCLIN_yCln2_LP_2 199 205 PF00134 0.469
DOC_CYCLIN_yCln2_LP_2 366 372 PF00134 0.534
DOC_MAPK_gen_1 220 229 PF00069 0.462
DOC_MAPK_gen_1 375 383 PF00069 0.642
DOC_MAPK_gen_1 569 576 PF00069 0.531
DOC_MAPK_MEF2A_6 252 261 PF00069 0.481
DOC_PP2B_LxvP_1 366 369 PF13499 0.496
DOC_PP2B_PxIxI_1 71 77 PF00149 0.541
DOC_PP4_FxxP_1 450 453 PF00568 0.566
DOC_PP4_FxxP_1 590 593 PF00568 0.683
DOC_USP7_MATH_1 19 23 PF00917 0.520
DOC_USP7_MATH_1 376 380 PF00917 0.487
DOC_USP7_MATH_1 388 392 PF00917 0.592
DOC_USP7_MATH_1 430 434 PF00917 0.658
DOC_USP7_UBL2_3 217 221 PF12436 0.563
DOC_USP7_UBL2_3 466 470 PF12436 0.541
DOC_USP7_UBL2_3 489 493 PF12436 0.674
DOC_WW_Pin1_4 15 20 PF00397 0.485
DOC_WW_Pin1_4 306 311 PF00397 0.565
DOC_WW_Pin1_4 426 431 PF00397 0.745
DOC_WW_Pin1_4 479 484 PF00397 0.574
LIG_14-3-3_CanoR_1 220 229 PF00244 0.518
LIG_14-3-3_CanoR_1 375 381 PF00244 0.482
LIG_14-3-3_CanoR_1 412 417 PF00244 0.690
LIG_14-3-3_CanoR_1 554 559 PF00244 0.511
LIG_14-3-3_CanoR_1 81 86 PF00244 0.489
LIG_Actin_WH2_2 94 111 PF00022 0.535
LIG_APCC_ABBA_1 591 596 PF00400 0.682
LIG_BIR_III_4 185 189 PF00653 0.572
LIG_BRCT_BRCA1_1 390 394 PF00533 0.631
LIG_BRCT_BRCA1_1 410 414 PF00533 0.375
LIG_BRCT_BRCA1_1 419 423 PF00533 0.618
LIG_BRCT_BRCA1_1 502 506 PF00533 0.504
LIG_BRCT_BRCA1_1 90 94 PF00533 0.538
LIG_eIF4E_1 522 528 PF01652 0.617
LIG_FHA_1 187 193 PF00498 0.549
LIG_FHA_1 224 230 PF00498 0.468
LIG_FHA_1 369 375 PF00498 0.565
LIG_FHA_1 447 453 PF00498 0.583
LIG_FHA_1 52 58 PF00498 0.598
LIG_FHA_1 531 537 PF00498 0.493
LIG_FHA_2 240 246 PF00498 0.480
LIG_FHA_2 251 257 PF00498 0.596
LIG_FHA_2 307 313 PF00498 0.569
LIG_FHA_2 394 400 PF00498 0.659
LIG_FHA_2 427 433 PF00498 0.730
LIG_FHA_2 483 489 PF00498 0.581
LIG_FHA_2 533 539 PF00498 0.447
LIG_LIR_Apic_2 120 125 PF02991 0.558
LIG_LIR_Apic_2 449 453 PF02991 0.452
LIG_LIR_Apic_2 589 593 PF02991 0.666
LIG_LIR_Gen_1 189 199 PF02991 0.451
LIG_LIR_Gen_1 231 240 PF02991 0.425
LIG_LIR_Gen_1 255 263 PF02991 0.439
LIG_LIR_Gen_1 37 47 PF02991 0.590
LIG_LIR_Gen_1 592 600 PF02991 0.760
LIG_LIR_Nem_3 189 194 PF02991 0.467
LIG_LIR_Nem_3 21 26 PF02991 0.548
LIG_LIR_Nem_3 231 235 PF02991 0.427
LIG_LIR_Nem_3 255 261 PF02991 0.349
LIG_LIR_Nem_3 37 42 PF02991 0.490
LIG_LIR_Nem_3 391 395 PF02991 0.586
LIG_LIR_Nem_3 592 597 PF02991 0.758
LIG_LYPXL_yS_3 203 206 PF13949 0.520
LIG_PCNA_yPIPBox_3 132 143 PF02747 0.545
LIG_PCNA_yPIPBox_3 157 167 PF02747 0.540
LIG_PCNA_yPIPBox_3 549 562 PF02747 0.435
LIG_Pex14_1 49 53 PF04695 0.603
LIG_Pex14_2 590 594 PF04695 0.684
LIG_PTB_Apo_2 197 204 PF02174 0.449
LIG_PTB_Phospho_1 197 203 PF10480 0.521
LIG_REV1ctd_RIR_1 461 470 PF16727 0.486
LIG_SH2_CRK 122 126 PF00017 0.557
LIG_SH2_CRK 23 27 PF00017 0.493
LIG_SH2_CRK 39 43 PF00017 0.505
LIG_SH2_GRB2like 237 240 PF00017 0.424
LIG_SH2_GRB2like 249 252 PF00017 0.571
LIG_SH2_PTP2 258 261 PF00017 0.478
LIG_SH2_STAP1 170 174 PF00017 0.482
LIG_SH2_STAP1 522 526 PF00017 0.599
LIG_SH2_STAP1 53 57 PF00017 0.598
LIG_SH2_STAT5 174 177 PF00017 0.448
LIG_SH2_STAT5 258 261 PF00017 0.527
LIG_SH2_STAT5 306 309 PF00017 0.592
LIG_SH2_STAT5 395 398 PF00017 0.548
LIG_SH2_STAT5 402 405 PF00017 0.471
LIG_SH2_STAT5 53 56 PF00017 0.607
LIG_SH3_3 285 291 PF00018 0.646
LIG_SH3_3 379 385 PF00018 0.549
LIG_SH3_3 40 46 PF00018 0.600
LIG_SH3_3 477 483 PF00018 0.625
LIG_SUMO_SIM_par_1 117 123 PF11976 0.461
LIG_SUMO_SIM_par_1 223 231 PF11976 0.492
LIG_SUMO_SIM_par_1 530 538 PF11976 0.489
LIG_SUMO_SIM_par_1 553 560 PF11976 0.594
LIG_SUMO_SIM_par_1 72 79 PF11976 0.367
LIG_TRAF2_1 535 538 PF00917 0.444
LIG_TRAF2_2 291 296 PF00917 0.660
LIG_UBA3_1 555 562 PF00899 0.541
LIG_WRC_WIRS_1 229 234 PF05994 0.446
LIG_WRC_WIRS_1 498 503 PF05994 0.600
LIG_WRC_WIRS_1 573 578 PF05994 0.516
MOD_CDK_SPK_2 15 20 PF00069 0.485
MOD_CDK_SPK_2 479 484 PF00069 0.576
MOD_CDK_SPxxK_3 479 486 PF00069 0.650
MOD_CK1_1 104 110 PF00069 0.252
MOD_CK1_1 223 229 PF00069 0.497
MOD_CK1_1 250 256 PF00069 0.539
MOD_CK1_1 393 399 PF00069 0.545
MOD_CK1_1 417 423 PF00069 0.552
MOD_CK1_1 433 439 PF00069 0.691
MOD_CK1_1 482 488 PF00069 0.553
MOD_CK1_1 572 578 PF00069 0.552
MOD_CK1_1 84 90 PF00069 0.575
MOD_CK2_1 111 117 PF00069 0.554
MOD_CK2_1 239 245 PF00069 0.482
MOD_CK2_1 250 256 PF00069 0.596
MOD_CK2_1 505 511 PF00069 0.452
MOD_CK2_1 532 538 PF00069 0.455
MOD_CK2_1 586 592 PF00069 0.701
MOD_GlcNHglycan 122 125 PF01048 0.447
MOD_GlcNHglycan 327 330 PF01048 0.660
MOD_GlcNHglycan 339 342 PF01048 0.808
MOD_GlcNHglycan 423 426 PF01048 0.632
MOD_GlcNHglycan 432 435 PF01048 0.700
MOD_GlcNHglycan 502 505 PF01048 0.504
MOD_GSK3_1 107 114 PF00069 0.457
MOD_GSK3_1 142 149 PF00069 0.490
MOD_GSK3_1 15 22 PF00069 0.564
MOD_GSK3_1 349 356 PF00069 0.768
MOD_GSK3_1 408 415 PF00069 0.563
MOD_GSK3_1 417 424 PF00069 0.565
MOD_GSK3_1 426 433 PF00069 0.665
MOD_GSK3_1 448 455 PF00069 0.517
MOD_GSK3_1 470 477 PF00069 0.629
MOD_GSK3_1 57 64 PF00069 0.572
MOD_GSK3_1 72 79 PF00069 0.569
MOD_GSK3_1 84 91 PF00069 0.558
MOD_LATS_1 468 474 PF00433 0.611
MOD_N-GLC_1 132 137 PF02516 0.597
MOD_N-GLC_1 250 255 PF02516 0.552
MOD_N-GLC_1 337 342 PF02516 0.818
MOD_N-GLC_1 408 413 PF02516 0.722
MOD_NEK2_1 414 419 PF00069 0.620
MOD_NEK2_1 57 62 PF00069 0.532
MOD_NEK2_2 390 395 PF00069 0.533
MOD_PK_1 412 418 PF00069 0.590
MOD_PK_1 474 480 PF00069 0.663
MOD_PKA_1 220 226 PF00069 0.494
MOD_PKA_1 474 480 PF00069 0.629
MOD_PKA_1 81 87 PF00069 0.492
MOD_PKA_2 19 25 PF00069 0.546
MOD_PKA_2 417 423 PF00069 0.674
MOD_Plk_1 223 229 PF00069 0.587
MOD_Plk_1 250 256 PF00069 0.599
MOD_Plk_1 569 575 PF00069 0.652
MOD_Plk_1 7 13 PF00069 0.535
MOD_Plk_2-3 505 511 PF00069 0.528
MOD_Plk_2-3 586 592 PF00069 0.718
MOD_Plk_4 117 123 PF00069 0.490
MOD_Plk_4 193 199 PF00069 0.560
MOD_Plk_4 228 234 PF00069 0.446
MOD_Plk_4 376 382 PF00069 0.596
MOD_Plk_4 390 396 PF00069 0.621
MOD_Plk_4 452 458 PF00069 0.480
MOD_Plk_4 474 480 PF00069 0.719
MOD_Plk_4 497 503 PF00069 0.587
MOD_Plk_4 569 575 PF00069 0.661
MOD_Plk_4 57 63 PF00069 0.566
MOD_ProDKin_1 15 21 PF00069 0.486
MOD_ProDKin_1 306 312 PF00069 0.564
MOD_ProDKin_1 426 432 PF00069 0.751
MOD_ProDKin_1 479 485 PF00069 0.569
MOD_SUMO_rev_2 462 471 PF00179 0.509
MOD_SUMO_rev_2 557 564 PF00179 0.546
TRG_DiLeu_BaEn_2 255 261 PF01217 0.460
TRG_DiLeu_BaEn_2 585 591 PF01217 0.659
TRG_DiLeu_BaLyEn_6 551 556 PF01217 0.433
TRG_DiLeu_BaLyEn_6 69 74 PF01217 0.485
TRG_ENDOCYTIC_2 174 177 PF00928 0.471
TRG_ENDOCYTIC_2 203 206 PF00928 0.520
TRG_ENDOCYTIC_2 23 26 PF00928 0.478
TRG_ENDOCYTIC_2 258 261 PF00928 0.409
TRG_ENDOCYTIC_2 39 42 PF00928 0.490
TRG_ER_diArg_1 219 222 PF00400 0.517
TRG_ER_diArg_1 301 304 PF00400 0.459
TRG_ER_diArg_1 483 486 PF00400 0.705
TRG_Pf-PMV_PEXEL_1 516 520 PF00026 0.464

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PCU8 Leptomonas seymouri 64% 100%
A0A0S4JJW4 Bodo saltans 30% 100%
A0A1X0NW77 Trypanosomatidae 40% 89%
A0A3S7WYG2 Leishmania donovani 100% 100%
A0A422N8J0 Trypanosoma rangeli 42% 97%
A4HDI5 Leishmania braziliensis 80% 100%
C9ZWF1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 40% 99%
E9AX01 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
Q4QAH5 Leishmania major 95% 100%
V5BK17 Trypanosoma cruzi 41% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS