Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

E9AH62_LEIIN

TriTrypDb:

LINF_240021000

Length:

953

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AH62

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AH62

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	306	310	PF00656	0.739
CLV_NRD_NRD_1	131	133	PF00675	0.817
CLV_NRD_NRD_1	201	203	PF00675	0.683
CLV_NRD_NRD_1	412	414	PF00675	0.729
CLV_NRD_NRD_1	562	564	PF00675	0.727
CLV_NRD_NRD_1	639	641	PF00675	0.773
CLV_NRD_NRD_1	719	721	PF00675	0.621
CLV_NRD_NRD_1	73	75	PF00675	0.603
CLV_NRD_NRD_1	764	766	PF00675	0.830
CLV_NRD_NRD_1	786	788	PF00675	0.656
CLV_NRD_NRD_1	876	878	PF00675	0.725
CLV_NRD_NRD_1	96	98	PF00675	0.566
CLV_PCSK_FUR_1	410	414	PF00082	0.556
CLV_PCSK_KEX2_1	131	133	PF00082	0.817
CLV_PCSK_KEX2_1	201	203	PF00082	0.683
CLV_PCSK_KEX2_1	412	414	PF00082	0.563
CLV_PCSK_KEX2_1	561	563	PF00082	0.734
CLV_PCSK_KEX2_1	639	641	PF00082	0.773
CLV_PCSK_KEX2_1	719	721	PF00082	0.621
CLV_PCSK_KEX2_1	73	75	PF00082	0.603
CLV_PCSK_KEX2_1	764	766	PF00082	0.816
CLV_PCSK_KEX2_1	786	788	PF00082	0.656
CLV_PCSK_KEX2_1	876	878	PF00082	0.715
CLV_PCSK_KEX2_1	95	97	PF00082	0.567
CLV_PCSK_SKI1_1	160	164	PF00082	0.727
CLV_PCSK_SKI1_1	185	189	PF00082	0.734
CLV_PCSK_SKI1_1	573	577	PF00082	0.562
CLV_PCSK_SKI1_1	621	625	PF00082	0.671
CLV_PCSK_SKI1_1	63	67	PF00082	0.615
CLV_PCSK_SKI1_1	687	691	PF00082	0.608
CLV_PCSK_SKI1_1	935	939	PF00082	0.617
CLV_Separin_Metazoa	603	607	PF03568	0.597
DEG_APCC_DBOX_1	184	192	PF00400	0.639
DEG_APCC_DBOX_1	526	534	PF00400	0.638
DEG_APCC_DBOX_1	934	942	PF00400	0.750
DEG_Nend_Nbox_1	1	3	PF02207	0.634
DEG_SCF_FBW7_1	288	294	PF00400	0.834
DOC_ANK_TNKS_1	111	118	PF00023	0.681
DOC_CDC14_PxL_1	468	476	PF14671	0.773
DOC_CKS1_1	288	293	PF01111	0.761
DOC_CYCLIN_RxL_1	182	190	PF00134	0.746
DOC_CYCLIN_yCln2_LP_2	469	475	PF00134	0.597
DOC_MAPK_gen_1	606	613	PF00069	0.591
DOC_MAPK_gen_1	639	646	PF00069	0.669
DOC_MAPK_gen_1	726	734	PF00069	0.660
DOC_MAPK_MEF2A_6	639	646	PF00069	0.761
DOC_MAPK_MEF2A_6	728	736	PF00069	0.683
DOC_PP2B_LxvP_1	380	383	PF13499	0.696
DOC_PP2B_LxvP_1	469	472	PF13499	0.667
DOC_PP2B_LxvP_1	681	684	PF13499	0.635
DOC_PP4_MxPP_1	462	465	PF00568	0.655
DOC_USP7_MATH_1	121	125	PF00917	0.732
DOC_USP7_MATH_1	221	225	PF00917	0.790
DOC_USP7_MATH_1	227	231	PF00917	0.746
DOC_USP7_MATH_1	291	295	PF00917	0.737
DOC_USP7_MATH_1	346	350	PF00917	0.757
DOC_USP7_MATH_1	475	479	PF00917	0.676
DOC_USP7_MATH_1	482	486	PF00917	0.703
DOC_USP7_MATH_1	654	658	PF00917	0.720
DOC_USP7_MATH_1	850	854	PF00917	0.787
DOC_USP7_MATH_1	857	861	PF00917	0.732
DOC_USP7_MATH_2	432	438	PF00917	0.811
DOC_WW_Pin1_4	208	213	PF00397	0.740
DOC_WW_Pin1_4	214	219	PF00397	0.745
DOC_WW_Pin1_4	228	233	PF00397	0.515
DOC_WW_Pin1_4	287	292	PF00397	0.744
DOC_WW_Pin1_4	335	340	PF00397	0.839
DOC_WW_Pin1_4	357	362	PF00397	0.750
DOC_WW_Pin1_4	453	458	PF00397	0.774
DOC_WW_Pin1_4	666	671	PF00397	0.816
DOC_WW_Pin1_4	765	770	PF00397	0.818
DOC_WW_Pin1_4	899	904	PF00397	0.653
LIG_14-3-3_CanoR_1	109	115	PF00244	0.663
LIG_14-3-3_CanoR_1	283	289	PF00244	0.808
LIG_14-3-3_CanoR_1	311	320	PF00244	0.656
LIG_14-3-3_CanoR_1	568	576	PF00244	0.614
LIG_14-3-3_CanoR_1	621	628	PF00244	0.693
LIG_14-3-3_CanoR_1	639	645	PF00244	0.495
LIG_14-3-3_CanoR_1	73	78	PF00244	0.621
LIG_14-3-3_CanoR_1	758	766	PF00244	0.612
LIG_14-3-3_CanoR_1	786	792	PF00244	0.636
LIG_14-3-3_CanoR_1	884	888	PF00244	0.639
LIG_BRCT_BRCA1_1	632	636	PF00533	0.734
LIG_CaM_IQ_9	88	104	PF13499	0.649
LIG_CtBP_PxDLS_1	869	873	PF00389	0.609
LIG_FHA_1	223	229	PF00498	0.775
LIG_FHA_1	60	66	PF00498	0.607
LIG_FHA_1	622	628	PF00498	0.683
LIG_FHA_1	675	681	PF00498	0.674
LIG_FHA_1	86	92	PF00498	0.706
LIG_FHA_1	909	915	PF00498	0.682
LIG_FHA_1	921	927	PF00498	0.581
LIG_FHA_2	156	162	PF00498	0.722
LIG_FHA_2	263	269	PF00498	0.659
LIG_FHA_2	346	352	PF00498	0.833
LIG_FHA_2	794	800	PF00498	0.680
LIG_LIR_Apic_2	449	455	PF02991	0.793
LIG_LIR_Gen_1	155	163	PF02991	0.637
LIG_LIR_Gen_1	377	387	PF02991	0.688
LIG_LIR_Gen_1	543	554	PF02991	0.662
LIG_LIR_Gen_1	599	609	PF02991	0.606
LIG_LIR_Gen_1	730	738	PF02991	0.704
LIG_LIR_Gen_1	842	851	PF02991	0.691
LIG_LIR_LC3C_4	643	646	PF02991	0.590
LIG_LIR_Nem_3	155	159	PF02991	0.634
LIG_LIR_Nem_3	377	382	PF02991	0.706
LIG_LIR_Nem_3	543	549	PF02991	0.586
LIG_LIR_Nem_3	599	604	PF02991	0.607
LIG_LIR_Nem_3	688	693	PF02991	0.483
LIG_LIR_Nem_3	730	734	PF02991	0.702
LIG_LIR_Nem_3	842	846	PF02991	0.657
LIG_NRBOX	183	189	PF00104	0.745
LIG_NRBOX	254	260	PF00104	0.651
LIG_Pex14_1	794	798	PF04695	0.576
LIG_RPA_C_Fungi	715	727	PF08784	0.604
LIG_SH2_PTP2	452	455	PF00017	0.791
LIG_SH2_PTP2	843	846	PF00017	0.658
LIG_SH2_STAP1	609	613	PF00017	0.583
LIG_SH2_STAT3	2	5	PF00017	0.714
LIG_SH2_STAT3	261	264	PF00017	0.774
LIG_SH2_STAT5	2	5	PF00017	0.714
LIG_SH2_STAT5	391	394	PF00017	0.739
LIG_SH2_STAT5	406	409	PF00017	0.734
LIG_SH2_STAT5	425	428	PF00017	0.531
LIG_SH2_STAT5	452	455	PF00017	0.791
LIG_SH2_STAT5	468	471	PF00017	0.500
LIG_SH2_STAT5	691	694	PF00017	0.552
LIG_SH2_STAT5	695	698	PF00017	0.542
LIG_SH2_STAT5	731	734	PF00017	0.704
LIG_SH2_STAT5	802	805	PF00017	0.694
LIG_SH2_STAT5	843	846	PF00017	0.608
LIG_SH3_3	170	176	PF00018	0.670
LIG_SH3_3	550	556	PF00018	0.726
LIG_SH3_3	74	80	PF00018	0.619
LIG_SH3_3	763	769	PF00018	0.607
LIG_SH3_3	844	850	PF00018	0.629
LIG_Sin3_3	894	901	PF02671	0.744
LIG_SUMO_SIM_anti_2	842	848	PF11976	0.673
LIG_SUMO_SIM_par_1	732	737	PF11976	0.682
LIG_SUMO_SIM_par_1	842	848	PF11976	0.634
LIG_SUMO_SIM_par_1	868	874	PF11976	0.640
LIG_TRAF2_1	372	375	PF00917	0.779
LIG_TRAF2_1	521	524	PF00917	0.772
LIG_TRAF2_1	778	781	PF00917	0.691
MOD_CDK_SPK_2	228	233	PF00069	0.729
MOD_CDK_SPxxK_3	335	342	PF00069	0.621
MOD_CK1_1	122	128	PF00069	0.722
MOD_CK1_1	217	223	PF00069	0.833
MOD_CK1_1	243	249	PF00069	0.729
MOD_CK1_1	284	290	PF00069	0.842
MOD_CK1_1	315	321	PF00069	0.634
MOD_CK1_1	345	351	PF00069	0.759
MOD_CK1_1	360	366	PF00069	0.764
MOD_CK1_1	478	484	PF00069	0.737
MOD_CK1_1	485	491	PF00069	0.641
MOD_CK1_1	630	636	PF00069	0.714
MOD_CK1_1	823	829	PF00069	0.630
MOD_CK1_1	899	905	PF00069	0.649
MOD_CK2_1	155	161	PF00069	0.721
MOD_CK2_1	262	268	PF00069	0.577
MOD_CK2_1	346	352	PF00069	0.718
MOD_CK2_1	481	487	PF00069	0.758
MOD_CK2_1	518	524	PF00069	0.745
MOD_CK2_1	793	799	PF00069	0.691
MOD_Cter_Amidation	717	720	PF01082	0.617
MOD_DYRK1A_RPxSP_1	765	769	PF00069	0.743
MOD_GlcNHglycan	112	115	PF01048	0.614
MOD_GlcNHglycan	124	127	PF01048	0.725
MOD_GlcNHglycan	136	139	PF01048	0.701
MOD_GlcNHglycan	179	182	PF01048	0.745
MOD_GlcNHglycan	196	199	PF01048	0.483
MOD_GlcNHglycan	242	245	PF01048	0.832
MOD_GlcNHglycan	283	286	PF01048	0.791
MOD_GlcNHglycan	293	296	PF01048	0.711
MOD_GlcNHglycan	344	347	PF01048	0.795
MOD_GlcNHglycan	348	351	PF01048	0.758
MOD_GlcNHglycan	366	369	PF01048	0.735
MOD_GlcNHglycan	436	439	PF01048	0.734
MOD_GlcNHglycan	480	483	PF01048	0.710
MOD_GlcNHglycan	484	487	PF01048	0.684
MOD_GlcNHglycan	49	52	PF01048	0.608
MOD_GlcNHglycan	520	523	PF01048	0.751
MOD_GlcNHglycan	538	541	PF01048	0.599
MOD_GlcNHglycan	570	573	PF01048	0.649
MOD_GlcNHglycan	583	586	PF01048	0.791
MOD_GlcNHglycan	656	659	PF01048	0.713
MOD_GlcNHglycan	68	71	PF01048	0.571
MOD_GlcNHglycan	769	772	PF01048	0.759
MOD_GlcNHglycan	817	820	PF01048	0.688
MOD_GlcNHglycan	853	856	PF01048	0.734
MOD_GlcNHglycan	859	862	PF01048	0.695
MOD_GlcNHglycan	899	902	PF01048	0.662
MOD_GlcNHglycan	918	921	PF01048	0.412
MOD_GlcNHglycan	941	944	PF01048	0.747
MOD_GSK3_1	217	224	PF00069	0.700
MOD_GSK3_1	287	294	PF00069	0.780
MOD_GSK3_1	342	349	PF00069	0.795
MOD_GSK3_1	359	366	PF00069	0.696
MOD_GSK3_1	478	485	PF00069	0.695
MOD_GSK3_1	564	571	PF00069	0.605
MOD_GSK3_1	820	827	PF00069	0.635
MOD_GSK3_1	916	923	PF00069	0.639
MOD_NEK2_1	1	6	PF00069	0.499
MOD_NEK2_1	136	141	PF00069	0.820
MOD_NEK2_1	152	157	PF00069	0.485
MOD_NEK2_1	240	245	PF00069	0.631
MOD_NEK2_1	66	71	PF00069	0.614
MOD_NEK2_1	676	681	PF00069	0.648
MOD_NEK2_1	72	77	PF00069	0.620
MOD_NEK2_1	896	901	PF00069	0.666
MOD_NEK2_1	927	932	PF00069	0.720
MOD_NEK2_1	939	944	PF00069	0.575
MOD_NEK2_2	793	798	PF00069	0.604
MOD_PIKK_1	1	7	PF00454	0.500
MOD_PIKK_1	360	366	PF00454	0.634
MOD_PIKK_1	596	602	PF00454	0.726
MOD_PKA_1	73	79	PF00069	0.723
MOD_PKA_2	152	158	PF00069	0.672
MOD_PKA_2	262	268	PF00069	0.761
MOD_PKA_2	404	410	PF00069	0.752
MOD_PKA_2	659	665	PF00069	0.733
MOD_PKA_2	72	78	PF00069	0.619
MOD_PKA_2	757	763	PF00069	0.823
MOD_PKA_2	883	889	PF00069	0.638
MOD_PKB_1	561	569	PF00069	0.639
MOD_PKB_1	765	773	PF00069	0.693
MOD_Plk_1	267	273	PF00069	0.612
MOD_Plk_1	374	380	PF00069	0.697
MOD_Plk_1	525	531	PF00069	0.627
MOD_Plk_1	549	555	PF00069	0.717
MOD_Plk_1	630	636	PF00069	0.735
MOD_Plk_2-3	324	330	PF00069	0.690
MOD_Plk_4	36	42	PF00069	0.557
MOD_Plk_4	374	380	PF00069	0.814
MOD_Plk_4	485	491	PF00069	0.776
MOD_Plk_4	549	555	PF00069	0.717
MOD_Plk_4	630	636	PF00069	0.735
MOD_Plk_4	640	646	PF00069	0.600
MOD_Plk_4	676	682	PF00069	0.669
MOD_Plk_4	73	79	PF00069	0.723
MOD_Plk_4	793	799	PF00069	0.606
MOD_Plk_4	820	826	PF00069	0.687
MOD_Plk_4	883	889	PF00069	0.573
MOD_ProDKin_1	208	214	PF00069	0.745
MOD_ProDKin_1	219	225	PF00069	0.737
MOD_ProDKin_1	228	234	PF00069	0.513
MOD_ProDKin_1	287	293	PF00069	0.743
MOD_ProDKin_1	335	341	PF00069	0.842
MOD_ProDKin_1	357	363	PF00069	0.749
MOD_ProDKin_1	453	459	PF00069	0.770
MOD_ProDKin_1	666	672	PF00069	0.812
MOD_ProDKin_1	765	771	PF00069	0.816
MOD_ProDKin_1	899	905	PF00069	0.649
MOD_SUMO_rev_2	161	170	PF00179	0.608
TRG_DiLeu_BaEn_1	893	898	PF01217	0.733
TRG_DiLeu_BaEn_4	525	531	PF01217	0.651
TRG_DiLeu_BaLyEn_6	77	82	PF01217	0.706
TRG_ENDOCYTIC_2	731	734	PF00928	0.704
TRG_ENDOCYTIC_2	833	836	PF00928	0.661
TRG_ENDOCYTIC_2	843	846	PF00928	0.531
TRG_ER_diArg_1	130	132	PF00400	0.816
TRG_ER_diArg_1	201	203	PF00400	0.683
TRG_ER_diArg_1	561	563	PF00400	0.734
TRG_ER_diArg_1	605	608	PF00400	0.604
TRG_ER_diArg_1	639	641	PF00400	0.773
TRG_ER_diArg_1	72	74	PF00400	0.602
TRG_ER_diArg_1	763	765	PF00400	0.826
TRG_ER_diArg_1	876	878	PF00400	0.613
TRG_ER_diArg_1	95	97	PF00400	0.570
TRG_NES_CRM1_1	316	329	PF08389	0.735
TRG_Pf-PMV_PEXEL_1	185	190	PF00026	0.743
TRG_Pf-PMV_PEXEL_1	63	68	PF00026	0.613

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I728	Leptomonas seymouri	39%	100%
A0A3S7WYF6	Leishmania donovani	100%	100%
A4HDI6	Leishmania braziliensis	74%	100%
E9AX00	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QAH6	Leishmania major	90%	100%