Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

E9AH60_LEIIN

TriTrypDb:

LINF_240020100

Length:

812

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AH60

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AH60

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	217	221	PF00656	0.656
CLV_C14_Caspase3-7	223	227	PF00656	0.571
CLV_NRD_NRD_1	119	121	PF00675	0.662
CLV_NRD_NRD_1	169	171	PF00675	0.611
CLV_NRD_NRD_1	184	186	PF00675	0.714
CLV_NRD_NRD_1	32	34	PF00675	0.744
CLV_NRD_NRD_1	375	377	PF00675	0.639
CLV_NRD_NRD_1	423	425	PF00675	0.538
CLV_NRD_NRD_1	43	45	PF00675	0.563
CLV_NRD_NRD_1	448	450	PF00675	0.576
CLV_NRD_NRD_1	462	464	PF00675	0.348
CLV_NRD_NRD_1	505	507	PF00675	0.672
CLV_NRD_NRD_1	555	557	PF00675	0.432
CLV_NRD_NRD_1	668	670	PF00675	0.585
CLV_NRD_NRD_1	796	798	PF00675	0.616
CLV_PCSK_KEX2_1	118	120	PF00082	0.654
CLV_PCSK_KEX2_1	169	171	PF00082	0.605
CLV_PCSK_KEX2_1	184	186	PF00082	0.709
CLV_PCSK_KEX2_1	270	272	PF00082	0.393
CLV_PCSK_KEX2_1	32	34	PF00082	0.745
CLV_PCSK_KEX2_1	410	412	PF00082	0.515
CLV_PCSK_KEX2_1	422	424	PF00082	0.455
CLV_PCSK_KEX2_1	43	45	PF00082	0.561
CLV_PCSK_KEX2_1	448	450	PF00082	0.576
CLV_PCSK_KEX2_1	462	464	PF00082	0.331
CLV_PCSK_KEX2_1	505	507	PF00082	0.636
CLV_PCSK_KEX2_1	541	543	PF00082	0.507
CLV_PCSK_KEX2_1	554	556	PF00082	0.397
CLV_PCSK_KEX2_1	668	670	PF00082	0.585
CLV_PCSK_KEX2_1	796	798	PF00082	0.616
CLV_PCSK_PC1ET2_1	270	272	PF00082	0.393
CLV_PCSK_PC1ET2_1	410	412	PF00082	0.515
CLV_PCSK_PC1ET2_1	541	543	PF00082	0.472
CLV_PCSK_PC7_1	550	556	PF00082	0.436
CLV_PCSK_PC7_1	792	798	PF00082	0.602
CLV_PCSK_SKI1_1	277	281	PF00082	0.606
CLV_PCSK_SKI1_1	313	317	PF00082	0.452
CLV_PCSK_SKI1_1	355	359	PF00082	0.508
CLV_PCSK_SKI1_1	463	467	PF00082	0.428
CLV_PCSK_SKI1_1	506	510	PF00082	0.636
CLV_PCSK_SKI1_1	586	590	PF00082	0.595
CLV_PCSK_SKI1_1	701	705	PF00082	0.425
CLV_PCSK_SKI1_1	75	79	PF00082	0.570
CLV_PCSK_SKI1_1	785	789	PF00082	0.510
DEG_APCC_DBOX_1	101	109	PF00400	0.624
DEG_APCC_DBOX_1	261	269	PF00400	0.499
DEG_APCC_DBOX_1	423	431	PF00400	0.446
DEG_APCC_DBOX_1	741	749	PF00400	0.445
DEG_COP1_1	208	216	PF00400	0.571
DEG_Nend_UBRbox_3	1	3	PF02207	0.560
DEG_SPOP_SBC_1	13	17	PF00917	0.503
DEG_SPOP_SBC_1	481	485	PF00917	0.516
DEG_SPOP_SBC_1	640	644	PF00917	0.488
DOC_AGCK_PIF_1	301	306	PF00069	0.476
DOC_CKS1_1	194	199	PF01111	0.685
DOC_CKS1_1	688	693	PF01111	0.506
DOC_CYCLIN_yCln2_LP_2	280	286	PF00134	0.548
DOC_CYCLIN_yCln2_LP_2	320	326	PF00134	0.395
DOC_CYCLIN_yCln2_LP_2	692	698	PF00134	0.415
DOC_MAPK_DCC_7	554	562	PF00069	0.444
DOC_MAPK_DCC_7	577	585	PF00069	0.535
DOC_MAPK_gen_1	344	353	PF00069	0.387
DOC_MAPK_gen_1	4	13	PF00069	0.535
DOC_MAPK_gen_1	422	430	PF00069	0.497
DOC_MAPK_gen_1	554	562	PF00069	0.444
DOC_MAPK_HePTP_8	552	564	PF00069	0.437
DOC_MAPK_MEF2A_6	4	13	PF00069	0.510
DOC_MAPK_MEF2A_6	423	432	PF00069	0.434
DOC_MAPK_MEF2A_6	554	562	PF00069	0.444
DOC_MAPK_MEF2A_6	577	585	PF00069	0.535
DOC_PP2B_LxvP_1	28	31	PF13499	0.620
DOC_PP2B_LxvP_1	320	323	PF13499	0.431
DOC_SPAK_OSR1_1	336	340	PF12202	0.445
DOC_USP7_MATH_1	133	137	PF00917	0.667
DOC_USP7_MATH_1	14	18	PF00917	0.583
DOC_USP7_MATH_1	151	155	PF00917	0.598
DOC_USP7_MATH_1	19	23	PF00917	0.557
DOC_USP7_MATH_1	207	211	PF00917	0.579
DOC_USP7_MATH_1	361	365	PF00917	0.650
DOC_USP7_MATH_1	566	570	PF00917	0.329
DOC_USP7_MATH_1	610	614	PF00917	0.651
DOC_USP7_MATH_1	616	620	PF00917	0.613
DOC_USP7_MATH_1	639	643	PF00917	0.495
DOC_USP7_MATH_1	657	661	PF00917	0.506
DOC_WW_Pin1_4	100	105	PF00397	0.564
DOC_WW_Pin1_4	131	136	PF00397	0.640
DOC_WW_Pin1_4	179	184	PF00397	0.657
DOC_WW_Pin1_4	193	198	PF00397	0.688
DOC_WW_Pin1_4	433	438	PF00397	0.411
DOC_WW_Pin1_4	612	617	PF00397	0.662
DOC_WW_Pin1_4	620	625	PF00397	0.555
DOC_WW_Pin1_4	642	647	PF00397	0.604
DOC_WW_Pin1_4	687	692	PF00397	0.557
DOC_WW_Pin1_4	69	74	PF00397	0.634
LIG_14-3-3_CanoR_1	102	110	PF00244	0.570
LIG_14-3-3_CanoR_1	120	126	PF00244	0.544
LIG_14-3-3_CanoR_1	328	332	PF00244	0.422
LIG_14-3-3_CanoR_1	490	498	PF00244	0.619
LIG_14-3-3_CanoR_1	738	746	PF00244	0.550
LIG_Actin_WH2_2	704	720	PF00022	0.390
LIG_BIR_III_2	204	208	PF00653	0.696
LIG_BRCT_BRCA1_1	333	337	PF00533	0.440
LIG_BRCT_BRCA1_1	644	648	PF00533	0.618
LIG_CtBP_PxDLS_1	624	628	PF00389	0.475
LIG_FHA_1	54	60	PF00498	0.622
LIG_FHA_1	590	596	PF00498	0.650
LIG_FHA_1	718	724	PF00498	0.480
LIG_FHA_1	734	740	PF00498	0.500
LIG_FHA_1	78	84	PF00498	0.562
LIG_FHA_2	143	149	PF00498	0.560
LIG_FHA_2	194	200	PF00498	0.685
LIG_FHA_2	213	219	PF00498	0.503
LIG_FHA_2	261	267	PF00498	0.450
LIG_FHA_2	360	366	PF00498	0.639
LIG_FHA_2	386	392	PF00498	0.633
LIG_FHA_2	445	451	PF00498	0.558
LIG_FHA_2	483	489	PF00498	0.635
LIG_FHA_2	647	653	PF00498	0.700
LIG_FHA_2	728	734	PF00498	0.686
LIG_FHA_2	76	82	PF00498	0.563
LIG_Integrin_isoDGR_2	420	422	PF01839	0.514
LIG_IRF3_LxIS_1	557	563	PF10401	0.418
LIG_LIR_Gen_1	546	552	PF02991	0.420
LIG_LIR_Gen_1	704	715	PF02991	0.445
LIG_LIR_LC3C_4	468	472	PF02991	0.345
LIG_LIR_Nem_3	296	301	PF02991	0.375
LIG_LIR_Nem_3	310	315	PF02991	0.396
LIG_LIR_Nem_3	546	551	PF02991	0.426
LIG_LIR_Nem_3	704	710	PF02991	0.448
LIG_MYND_1	69	73	PF01753	0.611
LIG_Pex14_1	333	337	PF04695	0.440
LIG_Pex14_2	297	301	PF04695	0.354
LIG_Pex14_2	783	787	PF04695	0.543
LIG_SH2_CRK	312	316	PF00017	0.378
LIG_SH2_CRK	475	479	PF00017	0.405
LIG_SH2_CRK	712	716	PF00017	0.381
LIG_SH2_STAP1	304	308	PF00017	0.483
LIG_SH2_STAT3	304	307	PF00017	0.412
LIG_SH2_STAT5	162	165	PF00017	0.684
LIG_SH2_STAT5	526	529	PF00017	0.454
LIG_SH2_STAT5	763	766	PF00017	0.432
LIG_SH3_1	475	481	PF00018	0.424
LIG_SH3_2	180	185	PF14604	0.667
LIG_SH3_3	129	135	PF00018	0.740
LIG_SH3_3	177	183	PF00018	0.670
LIG_SH3_3	28	34	PF00018	0.625
LIG_SH3_3	282	288	PF00018	0.571
LIG_SH3_3	434	440	PF00018	0.429
LIG_SH3_3	474	480	PF00018	0.417
LIG_SH3_3	670	676	PF00018	0.646
LIG_SH3_3	685	691	PF00018	0.469
LIG_SUMO_SIM_anti_2	468	474	PF11976	0.425
LIG_SUMO_SIM_par_1	558	563	PF11976	0.387
LIG_SUMO_SIM_par_1	623	628	PF11976	0.512
LIG_TYR_ITIM	710	715	PF00017	0.377
MOD_CDC14_SPxK_1	182	185	PF00782	0.583
MOD_CDK_SPK_2	179	184	PF00069	0.582
MOD_CDK_SPxK_1	179	185	PF00069	0.583
MOD_CDK_SPxK_1	69	75	PF00069	0.573
MOD_CDK_SPxxK_3	687	694	PF00069	0.544
MOD_CK1_1	103	109	PF00069	0.509
MOD_CK1_1	136	142	PF00069	0.674
MOD_CK1_1	154	160	PF00069	0.682
MOD_CK1_1	239	245	PF00069	0.533
MOD_CK1_1	394	400	PF00069	0.609
MOD_CK1_1	483	489	PF00069	0.616
MOD_CK1_1	53	59	PF00069	0.554
MOD_CK1_1	534	540	PF00069	0.418
MOD_CK1_1	642	648	PF00069	0.627
MOD_CK1_1	727	733	PF00069	0.641
MOD_CK2_1	142	148	PF00069	0.579
MOD_CK2_1	205	211	PF00069	0.693
MOD_CK2_1	260	266	PF00069	0.455
MOD_CK2_1	359	365	PF00069	0.592
MOD_CK2_1	444	450	PF00069	0.498
MOD_CK2_1	620	626	PF00069	0.541
MOD_CK2_1	727	733	PF00069	0.690
MOD_Cter_Amidation	41	44	PF01082	0.529
MOD_Cter_Amidation	420	423	PF01082	0.527
MOD_DYRK1A_RPxSP_1	179	183	PF00069	0.579
MOD_GlcNHglycan	157	160	PF01048	0.719
MOD_GlcNHglycan	176	179	PF01048	0.656
MOD_GlcNHglycan	189	192	PF01048	0.502
MOD_GlcNHglycan	21	24	PF01048	0.587
MOD_GlcNHglycan	231	234	PF01048	0.632
MOD_GlcNHglycan	333	336	PF01048	0.446
MOD_GlcNHglycan	397	400	PF01048	0.740
MOD_GlcNHglycan	467	470	PF01048	0.558
MOD_GlcNHglycan	612	615	PF01048	0.726
MOD_GlcNHglycan	616	619	PF01048	0.652
MOD_GlcNHglycan	626	630	PF01048	0.417
MOD_GlcNHglycan	655	658	PF01048	0.760
MOD_GlcNHglycan	696	699	PF01048	0.412
MOD_GlcNHglycan	725	729	PF01048	0.615
MOD_GlcNHglycan	803	806	PF01048	0.573
MOD_GlcNHglycan	94	98	PF01048	0.609
MOD_GSK3_1	133	140	PF00069	0.607
MOD_GSK3_1	150	157	PF00069	0.716
MOD_GSK3_1	327	334	PF00069	0.431
MOD_GSK3_1	391	398	PF00069	0.595
MOD_GSK3_1	480	487	PF00069	0.618
MOD_GSK3_1	509	516	PF00069	0.604
MOD_GSK3_1	562	569	PF00069	0.371
MOD_GSK3_1	610	617	PF00069	0.655
MOD_GSK3_1	642	649	PF00069	0.605
MOD_GSK3_1	653	660	PF00069	0.655
MOD_GSK3_1	717	724	PF00069	0.525
MOD_GSK3_1	733	740	PF00069	0.496
MOD_LATS_1	587	593	PF00433	0.639
MOD_N-GLC_1	137	142	PF02516	0.573
MOD_NEK2_1	108	113	PF00069	0.569
MOD_NEK2_1	12	17	PF00069	0.507
MOD_NEK2_1	142	147	PF00069	0.787
MOD_NEK2_1	229	234	PF00069	0.630
MOD_NEK2_1	428	433	PF00069	0.559
MOD_NEK2_1	444	449	PF00069	0.419
MOD_NEK2_1	496	501	PF00069	0.616
MOD_NEK2_1	532	537	PF00069	0.398
MOD_NEK2_1	560	565	PF00069	0.405
MOD_NEK2_1	627	632	PF00069	0.415
MOD_NEK2_1	717	722	PF00069	0.418
MOD_NEK2_1	737	742	PF00069	0.593
MOD_PIKK_1	163	169	PF00454	0.761
MOD_PIKK_1	205	211	PF00454	0.781
MOD_PIKK_1	260	266	PF00454	0.528
MOD_PIKK_1	717	723	PF00454	0.444
MOD_PKA_2	142	148	PF00069	0.690
MOD_PKA_2	160	166	PF00069	0.662
MOD_PKA_2	187	193	PF00069	0.570
MOD_PKA_2	327	333	PF00069	0.409
MOD_PKA_2	385	391	PF00069	0.534
MOD_PKA_2	489	495	PF00069	0.593
MOD_PKA_2	67	73	PF00069	0.740
MOD_PKA_2	717	723	PF00069	0.431
MOD_PKA_2	737	743	PF00069	0.582
MOD_PKB_1	147	155	PF00069	0.640
MOD_Plk_1	137	143	PF00069	0.609
MOD_Plk_1	391	397	PF00069	0.537
MOD_Plk_1	732	738	PF00069	0.606
MOD_Plk_1	779	785	PF00069	0.485
MOD_Plk_2-3	220	226	PF00069	0.655
MOD_Plk_4	428	434	PF00069	0.507
MOD_Plk_4	522	528	PF00069	0.481
MOD_ProDKin_1	100	106	PF00069	0.563
MOD_ProDKin_1	131	137	PF00069	0.642
MOD_ProDKin_1	179	185	PF00069	0.658
MOD_ProDKin_1	193	199	PF00069	0.689
MOD_ProDKin_1	433	439	PF00069	0.415
MOD_ProDKin_1	612	618	PF00069	0.662
MOD_ProDKin_1	620	626	PF00069	0.548
MOD_ProDKin_1	642	648	PF00069	0.617
MOD_ProDKin_1	687	693	PF00069	0.543
MOD_ProDKin_1	69	75	PF00069	0.636
MOD_SUMO_rev_2	241	249	PF00179	0.519
TRG_DiLeu_BaEn_4	759	765	PF01217	0.476
TRG_DiLeu_BaLyEn_6	449	454	PF01217	0.496
TRG_DiLeu_BaLyEn_6	547	552	PF01217	0.448
TRG_ENDOCYTIC_2	312	315	PF00928	0.414
TRG_ENDOCYTIC_2	712	715	PF00928	0.381
TRG_ER_diArg_1	118	120	PF00400	0.660
TRG_ER_diArg_1	169	172	PF00400	0.610
TRG_ER_diArg_1	183	185	PF00400	0.697
TRG_ER_diArg_1	31	33	PF00400	0.745
TRG_ER_diArg_1	422	424	PF00400	0.497
TRG_ER_diArg_1	461	463	PF00400	0.386
TRG_ER_diArg_1	554	556	PF00400	0.403
TRG_ER_diArg_1	667	669	PF00400	0.593
TRG_ER_diArg_1	796	799	PF00400	0.540
TRG_Pf-PMV_PEXEL_1	277	281	PF00026	0.562
TRG_Pf-PMV_PEXEL_1	37	41	PF00026	0.609
TRG_Pf-PMV_PEXEL_1	796	801	PF00026	0.599

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM86	Leptomonas seymouri	43%	100%
A0A3Q8IBE1	Leishmania donovani	99%	100%
A4HDJ4	Leishmania braziliensis	69%	100%
E9AWZ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4QAI5	Leishmania major	88%	100%