HpcH_HpaI domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

HpcH/HpaI aldolase/citrate lyase family - putative

Species:

Leishmania infantum

UniProt:

E9AH59_LEIIN

TriTrypDb:

LINF_240019900

Length:

537

Annotations

Annotations by Jardim et al.

Mitochondrial protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AH59

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AH59

Function

Biological processes
Term	Name	Level	Count
GO:0019222	regulation of metabolic process	3	1
GO:0030656	regulation of vitamin metabolic process	5	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0062012	regulation of small molecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0106064	regulation of cobalamin metabolic process	6	1
GO:1901401	regulation of tetrapyrrole metabolic process	5	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0016829	lyase activity	2	3
GO:0016830	carbon-carbon lyase activity	3	1
GO:0016833	oxo-acid-lyase activity	4	1
GO:0047777	(S)-citramalyl-CoA lyase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	236	240	PF00656	0.575
CLV_C14_Caspase3-7	456	460	PF00656	0.338
CLV_NRD_NRD_1	146	148	PF00675	0.703
CLV_NRD_NRD_1	198	200	PF00675	0.310
CLV_NRD_NRD_1	2	4	PF00675	0.688
CLV_NRD_NRD_1	402	404	PF00675	0.432
CLV_NRD_NRD_1	47	49	PF00675	0.656
CLV_NRD_NRD_1	487	489	PF00675	0.643
CLV_PCSK_FUR_1	144	148	PF00082	0.655
CLV_PCSK_KEX2_1	146	148	PF00082	0.695
CLV_PCSK_KEX2_1	197	199	PF00082	0.341
CLV_PCSK_KEX2_1	2	4	PF00082	0.710
CLV_PCSK_KEX2_1	402	404	PF00082	0.432
CLV_PCSK_KEX2_1	47	49	PF00082	0.656
CLV_PCSK_PC1ET2_1	197	199	PF00082	0.341
CLV_PCSK_SKI1_1	160	164	PF00082	0.263
CLV_PCSK_SKI1_1	472	476	PF00082	0.395
DEG_Nend_UBRbox_1	1	4	PF02207	0.760
DOC_CDC14_PxL_1	173	181	PF14671	0.545
DOC_CKS1_1	25	30	PF01111	0.634
DOC_CKS1_1	338	343	PF01111	0.597
DOC_CYCLIN_yCln2_LP_2	418	424	PF00134	0.305
DOC_MAPK_DCC_7	416	424	PF00069	0.255
DOC_MAPK_gen_1	469	477	PF00069	0.366
DOC_PP1_RVXF_1	158	165	PF00149	0.418
DOC_PP2B_LxvP_1	163	166	PF13499	0.477
DOC_PP2B_LxvP_1	334	337	PF13499	0.511
DOC_PP4_FxxP_1	302	305	PF00568	0.340
DOC_PP4_FxxP_1	392	395	PF00568	0.509
DOC_USP7_MATH_1	227	231	PF00917	0.592
DOC_USP7_MATH_1	46	50	PF00917	0.722
DOC_USP7_MATH_1	70	74	PF00917	0.664
DOC_USP7_UBL2_3	485	489	PF12436	0.585
DOC_WW_Pin1_4	145	150	PF00397	0.725
DOC_WW_Pin1_4	24	29	PF00397	0.708
DOC_WW_Pin1_4	247	252	PF00397	0.354
DOC_WW_Pin1_4	301	306	PF00397	0.330
DOC_WW_Pin1_4	337	342	PF00397	0.542
DOC_WW_Pin1_4	42	47	PF00397	0.757
DOC_WW_Pin1_4	429	434	PF00397	0.374
DOC_WW_Pin1_4	526	531	PF00397	0.748
DOC_WW_Pin1_4	53	58	PF00397	0.667
DOC_WW_Pin1_4	61	66	PF00397	0.606
LIG_14-3-3_CanoR_1	402	406	PF00244	0.418
LIG_14-3-3_CanoR_1	47	57	PF00244	0.714
LIG_14-3-3_CterR_2	534	537	PF00244	0.749
LIG_APCC_ABBA_1	89	94	PF00400	0.496
LIG_BIR_III_2	239	243	PF00653	0.499
LIG_BRCT_BRCA1_1	160	164	PF00533	0.543
LIG_BRCT_BRCA1_1	57	61	PF00533	0.721
LIG_CaM_IQ_9	208	224	PF13499	0.543
LIG_Clathr_ClatBox_1	410	414	PF01394	0.372
LIG_FHA_1	25	31	PF00498	0.748
LIG_FHA_1	255	261	PF00498	0.474
LIG_FHA_1	282	288	PF00498	0.385
LIG_FHA_1	371	377	PF00498	0.475
LIG_FHA_1	494	500	PF00498	0.678
LIG_FHA_2	430	436	PF00498	0.387
LIG_FHA_2	454	460	PF00498	0.394
LIG_LIR_Apic_2	290	294	PF02991	0.398
LIG_LIR_Apic_2	389	395	PF02991	0.489
LIG_LIR_Nem_3	239	244	PF02991	0.536
LIG_LIR_Nem_3	88	92	PF02991	0.516
LIG_LYPXL_yS_3	241	244	PF13949	0.502
LIG_MYND_1	155	159	PF01753	0.538
LIG_NRBOX	263	269	PF00104	0.417
LIG_SH2_NCK_1	253	257	PF00017	0.494
LIG_SH2_NCK_1	431	435	PF00017	0.421
LIG_SH2_PTP2	291	294	PF00017	0.449
LIG_SH2_SRC	253	256	PF00017	0.498
LIG_SH2_SRC	291	294	PF00017	0.414
LIG_SH2_SRC	320	323	PF00017	0.405
LIG_SH2_STAT5	291	294	PF00017	0.424
LIG_SH2_STAT5	431	434	PF00017	0.427
LIG_SH2_STAT5	86	89	PF00017	0.524
LIG_SH3_3	174	180	PF00018	0.510
LIG_SH3_3	6	12	PF00018	0.626
LIG_SUMO_SIM_anti_2	303	310	PF11976	0.403
LIG_SUMO_SIM_par_1	184	191	PF11976	0.485
LIG_TRAF2_1	101	104	PF00917	0.602
LIG_TRAF2_1	404	407	PF00917	0.421
LIG_TRAF2_1	433	436	PF00917	0.255
LIG_UBA3_1	410	416	PF00899	0.372
MOD_CDK_SPK_2	42	47	PF00069	0.606
MOD_CDK_SPK_2	61	66	PF00069	0.667
MOD_CDK_SPxK_1	42	48	PF00069	0.609
MOD_CDK_SPxK_1	526	532	PF00069	0.751
MOD_CK1_1	304	310	PF00069	0.463
MOD_CK1_1	360	366	PF00069	0.412
MOD_CK1_1	49	55	PF00069	0.720
MOD_CK1_1	56	62	PF00069	0.712
MOD_CK2_1	349	355	PF00069	0.489
MOD_CK2_1	401	407	PF00069	0.421
MOD_CK2_1	429	435	PF00069	0.329
MOD_CK2_1	458	464	PF00069	0.388
MOD_Cter_Amidation	144	147	PF01082	0.755
MOD_GlcNHglycan	122	125	PF01048	0.749
MOD_GlcNHglycan	229	232	PF01048	0.580
MOD_GlcNHglycan	329	333	PF01048	0.546
MOD_GlcNHglycan	450	453	PF01048	0.485
MOD_GlcNHglycan	479	482	PF01048	0.544
MOD_GlcNHglycan	58	61	PF01048	0.755
MOD_GlcNHglycan	68	71	PF01048	0.638
MOD_GlcNHglycan	72	75	PF01048	0.545
MOD_GSK3_1	114	121	PF00069	0.544
MOD_GSK3_1	145	152	PF00069	0.733
MOD_GSK3_1	277	284	PF00069	0.462
MOD_GSK3_1	340	347	PF00069	0.523
MOD_GSK3_1	36	43	PF00069	0.660
MOD_GSK3_1	454	461	PF00069	0.338
MOD_GSK3_1	46	53	PF00069	0.735
MOD_GSK3_1	483	490	PF00069	0.663
MOD_GSK3_1	55	62	PF00069	0.639
MOD_GSK3_1	66	73	PF00069	0.608
MOD_N-GLC_1	70	75	PF02516	0.601
MOD_NEK2_1	188	193	PF00069	0.313
MOD_NEK2_1	35	40	PF00069	0.762
MOD_NEK2_1	369	374	PF00069	0.464
MOD_NEK2_1	401	406	PF00069	0.428
MOD_NEK2_1	483	488	PF00069	0.559
MOD_NEK2_1	50	55	PF00069	0.662
MOD_NEK2_2	278	283	PF00069	0.386
MOD_NEK2_2	357	362	PF00069	0.540
MOD_PIKK_1	138	144	PF00454	0.588
MOD_PIKK_1	214	220	PF00454	0.599
MOD_PKA_2	35	41	PF00069	0.732
MOD_PKA_2	401	407	PF00069	0.421
MOD_PKA_2	46	52	PF00069	0.653
MOD_PKA_2	487	493	PF00069	0.692
MOD_PKA_2	509	515	PF00069	0.621
MOD_Plk_1	188	194	PF00069	0.418
MOD_Plk_1	453	459	PF00069	0.393
MOD_Plk_1	483	489	PF00069	0.620
MOD_Plk_2-3	349	355	PF00069	0.519
MOD_Plk_2-3	454	460	PF00069	0.372
MOD_Plk_4	26	32	PF00069	0.655
MOD_Plk_4	304	310	PF00069	0.378
MOD_Plk_4	414	420	PF00069	0.418
MOD_ProDKin_1	145	151	PF00069	0.714
MOD_ProDKin_1	24	30	PF00069	0.709
MOD_ProDKin_1	247	253	PF00069	0.362
MOD_ProDKin_1	301	307	PF00069	0.328
MOD_ProDKin_1	337	343	PF00069	0.545
MOD_ProDKin_1	42	48	PF00069	0.760
MOD_ProDKin_1	429	435	PF00069	0.374
MOD_ProDKin_1	526	532	PF00069	0.751
MOD_ProDKin_1	53	59	PF00069	0.666
MOD_ProDKin_1	61	67	PF00069	0.607
TRG_DiLeu_BaLyEn_6	146	151	PF01217	0.702
TRG_DiLeu_BaLyEn_6	240	245	PF01217	0.504
TRG_DiLeu_BaLyEn_6	309	314	PF01217	0.471
TRG_DiLeu_BaLyEn_6	406	411	PF01217	0.372
TRG_ENDOCYTIC_2	241	244	PF00928	0.502
TRG_ENDOCYTIC_2	295	298	PF00928	0.371
TRG_ENDOCYTIC_2	322	325	PF00928	0.321
TRG_ENDOCYTIC_2	327	330	PF00928	0.355
TRG_ENDOCYTIC_2	86	89	PF00928	0.505
TRG_ER_diArg_1	1	3	PF00400	0.698
TRG_ER_diArg_1	144	147	PF00400	0.702
TRG_ER_diArg_1	198	201	PF00400	0.372
TRG_ER_diArg_1	401	403	PF00400	0.432
TRG_ER_diArg_1	46	48	PF00400	0.656
TRG_NLS_MonoExtC_3	196	201	PF00514	0.372
TRG_Pf-PMV_PEXEL_1	403	407	PF00026	0.384
TRG_Pf-PMV_PEXEL_1	409	414	PF00026	0.342
TRG_Pf-PMV_PEXEL_1	83	88	PF00026	0.534

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHZ0	Leptomonas seymouri	57%	100%
A0A1X0NVS5	Trypanosomatidae	31%	100%
A0A3S7WYJ5	Leishmania donovani	100%	100%
A4HDJ6	Leishmania braziliensis	74%	99%
C9ZWG8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AWY9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	99%
Q4QAI7	Leishmania major	89%	100%
V5DBJ5	Trypanosoma cruzi	35%	100%