LeishMANIAdb
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Crinkler (CRN) family protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Crinkler (CRN) family protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
E9AH52_LEIIN
TriTrypDb:
LINF_240008900
Length:
756

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AH52
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AH52

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 484 488 PF00656 0.444
CLV_C14_Caspase3-7 79 83 PF00656 0.492
CLV_NRD_NRD_1 132 134 PF00675 0.782
CLV_NRD_NRD_1 207 209 PF00675 0.719
CLV_NRD_NRD_1 365 367 PF00675 0.452
CLV_NRD_NRD_1 396 398 PF00675 0.561
CLV_NRD_NRD_1 700 702 PF00675 0.604
CLV_NRD_NRD_1 97 99 PF00675 0.650
CLV_PCSK_KEX2_1 132 134 PF00082 0.745
CLV_PCSK_KEX2_1 207 209 PF00082 0.719
CLV_PCSK_KEX2_1 97 99 PF00082 0.650
CLV_PCSK_SKI1_1 265 269 PF00082 0.686
CLV_PCSK_SKI1_1 453 457 PF00082 0.442
CLV_PCSK_SKI1_1 493 497 PF00082 0.587
CLV_PCSK_SKI1_1 659 663 PF00082 0.656
DEG_APCC_DBOX_1 427 435 PF00400 0.479
DEG_SPOP_SBC_1 172 176 PF00917 0.838
DEG_SPOP_SBC_1 300 304 PF00917 0.779
DEG_SPOP_SBC_1 99 103 PF00917 0.714
DOC_CYCLIN_RxL_1 428 439 PF00134 0.490
DOC_CYCLIN_yClb3_PxF_3 517 523 PF00134 0.603
DOC_CYCLIN_yCln2_LP_2 275 281 PF00134 0.631
DOC_CYCLIN_yCln2_LP_2 734 740 PF00134 0.641
DOC_MAPK_gen_1 674 682 PF00069 0.513
DOC_MAPK_gen_1 698 706 PF00069 0.606
DOC_MAPK_MEF2A_6 565 573 PF00069 0.441
DOC_MAPK_MEF2A_6 676 684 PF00069 0.523
DOC_PP1_RVXF_1 430 437 PF00149 0.499
DOC_PP1_RVXF_1 451 457 PF00149 0.461
DOC_PP2B_LxvP_1 275 278 PF13499 0.738
DOC_PP2B_LxvP_1 704 707 PF13499 0.618
DOC_PP2B_LxvP_1 734 737 PF13499 0.573
DOC_PP4_FxxP_1 297 300 PF00568 0.620
DOC_USP7_MATH_1 108 112 PF00917 0.677
DOC_USP7_MATH_1 125 129 PF00917 0.863
DOC_USP7_MATH_1 173 177 PF00917 0.795
DOC_USP7_MATH_1 183 187 PF00917 0.683
DOC_USP7_MATH_1 202 206 PF00917 0.661
DOC_USP7_MATH_1 237 241 PF00917 0.696
DOC_USP7_MATH_1 246 250 PF00917 0.723
DOC_USP7_MATH_1 257 261 PF00917 0.808
DOC_USP7_MATH_1 279 283 PF00917 0.798
DOC_USP7_MATH_1 333 337 PF00917 0.655
DOC_USP7_MATH_1 632 636 PF00917 0.580
DOC_USP7_MATH_1 99 103 PF00917 0.711
DOC_USP7_MATH_2 577 583 PF00917 0.539
DOC_WW_Pin1_4 113 118 PF00397 0.726
DOC_WW_Pin1_4 132 137 PF00397 0.759
DOC_WW_Pin1_4 219 224 PF00397 0.767
DOC_WW_Pin1_4 258 263 PF00397 0.784
DOC_WW_Pin1_4 320 325 PF00397 0.559
DOC_WW_Pin1_4 375 380 PF00397 0.566
DOC_WW_Pin1_4 555 560 PF00397 0.505
DOC_WW_Pin1_4 635 640 PF00397 0.545
DOC_WW_Pin1_4 9 14 PF00397 0.471
LIG_14-3-3_CanoR_1 265 271 PF00244 0.688
LIG_14-3-3_CanoR_1 280 286 PF00244 0.719
LIG_14-3-3_CanoR_1 29 33 PF00244 0.506
LIG_14-3-3_CanoR_1 373 379 PF00244 0.569
LIG_14-3-3_CanoR_1 416 426 PF00244 0.576
LIG_14-3-3_CanoR_1 701 705 PF00244 0.618
LIG_14-3-3_CanoR_1 97 107 PF00244 0.721
LIG_Actin_WH2_2 39 55 PF00022 0.648
LIG_Actin_WH2_2 482 499 PF00022 0.460
LIG_Actin_WH2_2 569 587 PF00022 0.543
LIG_APCC_ABBAyCdc20_2 313 319 PF00400 0.617
LIG_BIR_II_1 1 5 PF00653 0.694
LIG_BIR_III_3 1 5 PF00653 0.694
LIG_BRCT_BRCA1_1 247 251 PF00533 0.622
LIG_BRCT_BRCA1_1 293 297 PF00533 0.701
LIG_BRCT_BRCA1_1 388 392 PF00533 0.522
LIG_BRCT_BRCA1_1 582 586 PF00533 0.456
LIG_Clathr_ClatBox_1 447 451 PF01394 0.533
LIG_CSL_BTD_1 199 202 PF09270 0.753
LIG_FHA_1 272 278 PF00498 0.818
LIG_FHA_1 286 292 PF00498 0.594
LIG_FHA_1 313 319 PF00498 0.611
LIG_FHA_1 45 51 PF00498 0.528
LIG_FHA_1 556 562 PF00498 0.514
LIG_FHA_1 625 631 PF00498 0.445
LIG_FHA_1 646 652 PF00498 0.526
LIG_FHA_1 701 707 PF00498 0.720
LIG_FHA_1 83 89 PF00498 0.488
LIG_FHA_2 36 42 PF00498 0.513
LIG_FHA_2 376 382 PF00498 0.494
LIG_LIR_Apic_2 294 300 PF02991 0.619
LIG_LIR_Gen_1 264 275 PF02991 0.668
LIG_LIR_Gen_1 359 370 PF02991 0.459
LIG_LIR_Gen_1 389 400 PF02991 0.539
LIG_LIR_Gen_1 540 549 PF02991 0.566
LIG_LIR_Nem_3 216 221 PF02991 0.613
LIG_LIR_Nem_3 248 254 PF02991 0.619
LIG_LIR_Nem_3 264 270 PF02991 0.668
LIG_LIR_Nem_3 359 365 PF02991 0.433
LIG_LIR_Nem_3 389 395 PF02991 0.526
LIG_LIR_Nem_3 451 455 PF02991 0.477
LIG_LIR_Nem_3 540 544 PF02991 0.487
LIG_LIR_Nem_3 570 576 PF02991 0.434
LIG_LIR_Nem_3 583 589 PF02991 0.454
LIG_LIR_Nem_3 665 670 PF02991 0.466
LIG_LIR_Nem_3 708 714 PF02991 0.695
LIG_LYPXL_S_1 548 552 PF13949 0.558
LIG_LYPXL_yS_3 549 552 PF13949 0.562
LIG_NRBOX 359 365 PF00104 0.571
LIG_NRBOX 742 748 PF00104 0.530
LIG_PCNA_yPIPBox_3 479 493 PF02747 0.525
LIG_Pex14_2 452 456 PF04695 0.462
LIG_Pex14_2 586 590 PF04695 0.428
LIG_SH2_CRK 371 375 PF00017 0.513
LIG_SH2_CRK 443 447 PF00017 0.469
LIG_SH2_CRK 478 482 PF00017 0.448
LIG_SH2_CRK 574 578 PF00017 0.431
LIG_SH2_CRK 63 67 PF00017 0.524
LIG_SH2_GRB2like 17 20 PF00017 0.503
LIG_SH2_NCK_1 574 578 PF00017 0.431
LIG_SH2_SRC 17 20 PF00017 0.503
LIG_SH2_SRC 574 577 PF00017 0.431
LIG_SH2_SRC 643 646 PF00017 0.624
LIG_SH2_STAP1 603 607 PF00017 0.586
LIG_SH2_STAP1 678 682 PF00017 0.325
LIG_SH2_STAP1 730 734 PF00017 0.555
LIG_SH2_STAT3 714 717 PF00017 0.583
LIG_SH2_STAT5 17 20 PF00017 0.503
LIG_SH2_STAT5 362 365 PF00017 0.407
LIG_SH2_STAT5 430 433 PF00017 0.579
LIG_SH2_STAT5 45 48 PF00017 0.615
LIG_SH2_STAT5 643 646 PF00017 0.624
LIG_SH2_STAT5 689 692 PF00017 0.519
LIG_SH3_1 321 327 PF00018 0.661
LIG_SH3_3 114 120 PF00018 0.728
LIG_SH3_3 198 204 PF00018 0.758
LIG_SH3_3 231 237 PF00018 0.642
LIG_SH3_3 256 262 PF00018 0.733
LIG_SH3_3 321 327 PF00018 0.531
LIG_SH3_3 408 414 PF00018 0.437
LIG_SH3_3 435 441 PF00018 0.635
LIG_SH3_3 48 54 PF00018 0.572
LIG_SH3_3 512 518 PF00018 0.537
LIG_SH3_3 604 610 PF00018 0.556
LIG_SH3_4 512 519 PF00018 0.688
LIG_SUMO_SIM_par_1 445 451 PF11976 0.432
LIG_SUMO_SIM_par_1 702 709 PF11976 0.626
LIG_SUMO_SIM_par_1 84 89 PF11976 0.482
LIG_TRAF2_1 261 264 PF00917 0.615
LIG_TYR_ITIM 360 365 PF00017 0.432
LIG_UBA3_1 391 398 PF00899 0.652
LIG_WRC_WIRS_1 523 528 PF05994 0.542
LIG_WW_3 325 329 PF00397 0.538
LIG_WW_3 413 417 PF00397 0.537
LIG_WW_3 466 470 PF00397 0.664
MOD_CDK_SPK_2 219 224 PF00069 0.619
MOD_CDK_SPxK_1 113 119 PF00069 0.651
MOD_CDK_SPxxK_3 136 143 PF00069 0.755
MOD_CDK_SPxxK_3 258 265 PF00069 0.600
MOD_CK1_1 307 313 PF00069 0.626
MOD_CK1_1 35 41 PF00069 0.506
MOD_CK1_1 352 358 PF00069 0.503
MOD_CK1_1 417 423 PF00069 0.523
MOD_CK1_1 635 641 PF00069 0.548
MOD_CK1_1 691 697 PF00069 0.636
MOD_CK1_1 705 711 PF00069 0.488
MOD_CK2_1 207 213 PF00069 0.817
MOD_CK2_1 257 263 PF00069 0.707
MOD_CK2_1 35 41 PF00069 0.528
MOD_CK2_1 355 361 PF00069 0.482
MOD_Cter_Amidation 130 133 PF01082 0.784
MOD_Cter_Amidation 395 398 PF01082 0.548
MOD_GlcNHglycan 110 113 PF01048 0.565
MOD_GlcNHglycan 127 130 PF01048 0.853
MOD_GlcNHglycan 136 139 PF01048 0.720
MOD_GlcNHglycan 185 188 PF01048 0.767
MOD_GlcNHglycan 248 251 PF01048 0.781
MOD_GlcNHglycan 255 258 PF01048 0.817
MOD_GlcNHglycan 291 294 PF01048 0.766
MOD_GlcNHglycan 306 309 PF01048 0.728
MOD_GlcNHglycan 341 344 PF01048 0.588
MOD_GlcNHglycan 351 354 PF01048 0.497
MOD_GlcNHglycan 411 414 PF01048 0.445
MOD_GlcNHglycan 416 419 PF01048 0.463
MOD_GlcNHglycan 586 589 PF01048 0.446
MOD_GlcNHglycan 69 72 PF01048 0.556
MOD_GlcNHglycan 693 696 PF01048 0.546
MOD_GlcNHglycan 711 714 PF01048 0.491
MOD_GlcNHglycan 720 724 PF01048 0.577
MOD_GSK3_1 132 139 PF00069 0.709
MOD_GSK3_1 173 180 PF00069 0.843
MOD_GSK3_1 237 244 PF00069 0.761
MOD_GSK3_1 253 260 PF00069 0.751
MOD_GSK3_1 28 35 PF00069 0.504
MOD_GSK3_1 285 292 PF00069 0.763
MOD_GSK3_1 299 306 PF00069 0.717
MOD_GSK3_1 333 340 PF00069 0.647
MOD_GSK3_1 352 359 PF00069 0.398
MOD_GSK3_1 414 421 PF00069 0.570
MOD_GSK3_1 5 12 PF00069 0.552
MOD_GSK3_1 580 587 PF00069 0.452
MOD_GSK3_1 645 652 PF00069 0.581
MOD_GSK3_1 702 709 PF00069 0.619
MOD_GSK3_1 82 89 PF00069 0.496
MOD_N-GLC_1 521 526 PF02516 0.513
MOD_N-GLC_1 662 667 PF02516 0.586
MOD_NEK2_1 266 271 PF00069 0.821
MOD_NEK2_1 291 296 PF00069 0.695
MOD_NEK2_1 337 342 PF00069 0.709
MOD_NEK2_1 354 359 PF00069 0.374
MOD_NEK2_1 374 379 PF00069 0.561
MOD_NEK2_1 391 396 PF00069 0.418
MOD_NEK2_1 442 447 PF00069 0.509
MOD_NEK2_1 580 585 PF00069 0.450
MOD_NEK2_1 662 667 PF00069 0.514
MOD_NEK2_1 700 705 PF00069 0.713
MOD_NEK2_2 312 317 PF00069 0.624
MOD_PIKK_1 207 213 PF00454 0.693
MOD_PIKK_1 237 243 PF00454 0.748
MOD_PIKK_1 462 468 PF00454 0.481
MOD_PIKK_1 524 530 PF00454 0.486
MOD_PK_1 217 223 PF00069 0.725
MOD_PK_1 230 236 PF00069 0.642
MOD_PK_1 702 708 PF00069 0.644
MOD_PKA_1 207 213 PF00069 0.642
MOD_PKA_1 97 103 PF00069 0.660
MOD_PKA_2 192 198 PF00069 0.730
MOD_PKA_2 207 213 PF00069 0.693
MOD_PKA_2 279 285 PF00069 0.732
MOD_PKA_2 28 34 PF00069 0.499
MOD_PKA_2 312 318 PF00069 0.618
MOD_PKA_2 327 333 PF00069 0.395
MOD_PKA_2 605 611 PF00069 0.557
MOD_PKA_2 700 706 PF00069 0.713
MOD_PKA_2 97 103 PF00069 0.660
MOD_PKB_1 215 223 PF00069 0.725
MOD_PKB_1 228 236 PF00069 0.756
MOD_Plk_1 521 527 PF00069 0.494
MOD_Plk_1 662 668 PF00069 0.397
MOD_Plk_1 676 682 PF00069 0.318
MOD_Plk_4 312 318 PF00069 0.618
MOD_Plk_4 421 427 PF00069 0.567
MOD_Plk_4 442 448 PF00069 0.446
MOD_Plk_4 638 644 PF00069 0.586
MOD_Plk_4 688 694 PF00069 0.574
MOD_Plk_4 82 88 PF00069 0.585
MOD_ProDKin_1 113 119 PF00069 0.739
MOD_ProDKin_1 132 138 PF00069 0.758
MOD_ProDKin_1 219 225 PF00069 0.768
MOD_ProDKin_1 258 264 PF00069 0.787
MOD_ProDKin_1 320 326 PF00069 0.550
MOD_ProDKin_1 375 381 PF00069 0.567
MOD_ProDKin_1 555 561 PF00069 0.507
MOD_ProDKin_1 635 641 PF00069 0.548
MOD_ProDKin_1 9 15 PF00069 0.461
TRG_DiLeu_BaEn_1 498 503 PF01217 0.578
TRG_DiLeu_BaEn_1 742 747 PF01217 0.550
TRG_DiLeu_BaLyEn_6 10 15 PF01217 0.529
TRG_DiLeu_BaLyEn_6 450 455 PF01217 0.447
TRG_DiLeu_BaLyEn_6 466 471 PF01217 0.398
TRG_DiLeu_BaLyEn_6 613 618 PF01217 0.577
TRG_ENDOCYTIC_2 362 365 PF00928 0.459
TRG_ENDOCYTIC_2 371 374 PF00928 0.524
TRG_ENDOCYTIC_2 443 446 PF00928 0.495
TRG_ENDOCYTIC_2 478 481 PF00928 0.452
TRG_ENDOCYTIC_2 549 552 PF00928 0.562
TRG_ENDOCYTIC_2 63 66 PF00928 0.534
TRG_ENDOCYTIC_2 689 692 PF00928 0.541
TRG_ER_diArg_1 206 208 PF00400 0.721
TRG_ER_diArg_1 227 230 PF00400 0.752
TRG_ER_diArg_1 671 674 PF00400 0.521
TRG_ER_diArg_1 97 99 PF00400 0.650
TRG_Pf-PMV_PEXEL_1 432 437 PF00026 0.513
TRG_Pf-PMV_PEXEL_1 469 473 PF00026 0.602

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I868 Leptomonas seymouri 53% 96%
A0A3S7WY82 Leishmania donovani 99% 100%
A4HD97 Leishmania braziliensis 77% 100%
E9AWN1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 99%
Q4QAU0 Leishmania major 92% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS