SET domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TPR repeat - putative

Species:

Leishmania infantum

UniProt:

E9AH51_LEIIN

TriTrypDb:

LINF_240008800

Length:

662

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005576	extracellular region	2	3
GO:0110165	cellular anatomical entity	1	3

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Expansion

Sequence features

E9AH51

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AH51

Function

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Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	1
GO:0009892	negative regulation of metabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010468	regulation of gene expression	5	1
GO:0010605	negative regulation of macromolecule metabolic process	5	1
GO:0010629	negative regulation of gene expression	6	1
GO:0019222	regulation of metabolic process	3	1
GO:0040029	epigenetic regulation of gene expression	6	1
GO:0045814	negative regulation of gene expression, epigenetic	7	1
GO:0048519	negative regulation of biological process	3	1

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0005102	signaling receptor binding	3	3
GO:0005179	hormone activity	5	3
GO:0005184	neuropeptide hormone activity	6	3
GO:0005488	binding	1	4
GO:0005515	protein binding	2	4
GO:0008168	methyltransferase activity	4	1
GO:0008170	N-methyltransferase activity	5	1
GO:0008276	protein methyltransferase activity	3	1
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	555	559	PF00656	0.487
CLV_C14_Caspase3-7	587	591	PF00656	0.439
CLV_NRD_NRD_1	114	116	PF00675	0.392
CLV_NRD_NRD_1	141	143	PF00675	0.517
CLV_NRD_NRD_1	186	188	PF00675	0.423
CLV_NRD_NRD_1	359	361	PF00675	0.341
CLV_NRD_NRD_1	65	67	PF00675	0.445
CLV_PCSK_KEX2_1	113	115	PF00082	0.382
CLV_PCSK_KEX2_1	141	143	PF00082	0.495
CLV_PCSK_KEX2_1	186	188	PF00082	0.420

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9W0	Leptomonas seymouri	66%	100%
A0A0S4J867	Bodo saltans	31%	100%
A0A1X0NIX9	Trypanosomatidae	37%	98%
A0A3S5H7C8	Leishmania donovani	100%	100%
A0A422P403	Trypanosoma rangeli	39%	100%
A4HD96	Leishmania braziliensis	85%	100%
D0A710	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9AWN0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QAU1	Leishmania major	93%	100%
V5BRA0	Trypanosoma cruzi	39%	100%

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