SET domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TPR repeat - putative

Species:

Leishmania infantum

UniProt:

E9AH51_LEIIN

TriTrypDb:

LINF_240008800

Length:

662

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005576	extracellular region	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

E9AH51

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AH51

Function

Biological processes
Term	Name	Level	Count
GO:0009892	negative regulation of metabolic process	4	1
GO:0010468	regulation of gene expression	5	1
GO:0010605	negative regulation of macromolecule metabolic process	5	1
GO:0010629	negative regulation of gene expression	6	1
GO:0019222	regulation of metabolic process	3	1
GO:0040029	epigenetic regulation of gene expression	6	1
GO:0045814	negative regulation of gene expression, epigenetic	7	1
GO:0048519	negative regulation of biological process	3	1
GO:0050789	regulation of biological process	2	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0006457	protein folding	2	1
GO:0009987	cellular process	1	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0008168	methyltransferase activity	4	1
GO:0008170	N-methyltransferase activity	5	1
GO:0008276	protein methyltransferase activity	3	1
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	1
GO:0016278	lysine N-methyltransferase activity	6	1
GO:0016279	protein-lysine N-methyltransferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016741	transferase activity, transferring one-carbon groups	3	1
GO:0018024	obsolete histone lysine N-methyltransferase activity	5	1
GO:0042054	histone methyltransferase activity	4	1
GO:0042799	histone H4K20 methyltransferase activity	6	1
GO:0140096	catalytic activity, acting on a protein	2	1
GO:0005102	signaling receptor binding	3	3
GO:0005179	hormone activity	5	3
GO:0005184	neuropeptide hormone activity	6	3
GO:0005488	binding	1	4
GO:0005515	protein binding	2	4
GO:0030545	signaling receptor regulator activity	2	3
GO:0030546	signaling receptor activator activity	3	3
GO:0048018	receptor ligand activity	4	3
GO:0098772	molecular function regulator activity	1	3
GO:0140677	molecular function activator activity	2	3
GO:0030544	Hsp70 protein binding	4	1
GO:0031072	heat shock protein binding	3	1
GO:0051879	Hsp90 protein binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	555	559	PF00656	0.487
CLV_C14_Caspase3-7	587	591	PF00656	0.439
CLV_NRD_NRD_1	114	116	PF00675	0.392
CLV_NRD_NRD_1	141	143	PF00675	0.517
CLV_NRD_NRD_1	186	188	PF00675	0.423
CLV_NRD_NRD_1	359	361	PF00675	0.341
CLV_NRD_NRD_1	65	67	PF00675	0.445
CLV_PCSK_KEX2_1	113	115	PF00082	0.382
CLV_PCSK_KEX2_1	141	143	PF00082	0.495
CLV_PCSK_KEX2_1	186	188	PF00082	0.420
CLV_PCSK_KEX2_1	239	241	PF00082	0.509
CLV_PCSK_KEX2_1	358	360	PF00082	0.320
CLV_PCSK_KEX2_1	65	67	PF00082	0.445
CLV_PCSK_PC1ET2_1	239	241	PF00082	0.511
CLV_PCSK_PC1ET2_1	358	360	PF00082	0.333
CLV_PCSK_SKI1_1	131	135	PF00082	0.378
CLV_PCSK_SKI1_1	141	145	PF00082	0.445
CLV_PCSK_SKI1_1	246	250	PF00082	0.370
CLV_PCSK_SKI1_1	284	288	PF00082	0.481
CLV_PCSK_SKI1_1	360	364	PF00082	0.468
CLV_PCSK_SKI1_1	432	436	PF00082	0.508
CLV_PCSK_SKI1_1	479	483	PF00082	0.325
CLV_PCSK_SKI1_1	514	518	PF00082	0.487
CLV_PCSK_SKI1_1	594	598	PF00082	0.374
CLV_PCSK_SKI1_1	656	660	PF00082	0.439
CLV_Separin_Metazoa	361	365	PF03568	0.493
DEG_Nend_UBRbox_2	1	3	PF02207	0.554
DEG_SCF_FBW7_1	601	608	PF00400	0.479
DEG_SPOP_SBC_1	553	557	PF00917	0.425
DOC_CKS1_1	449	454	PF01111	0.329
DOC_CKS1_1	602	607	PF01111	0.490
DOC_CYCLIN_RxL_1	125	137	PF00134	0.464
DOC_CYCLIN_RxL_1	357	365	PF00134	0.433
DOC_CYCLIN_yCln2_LP_2	575	581	PF00134	0.352
DOC_MAPK_gen_1	65	71	PF00069	0.419
DOC_MAPK_MEF2A_6	167	174	PF00069	0.401
DOC_PP1_RVXF_1	190	197	PF00149	0.469
DOC_PP1_RVXF_1	201	207	PF00149	0.369
DOC_PP2B_LxvP_1	575	578	PF13499	0.459
DOC_USP7_MATH_1	235	239	PF00917	0.530
DOC_USP7_MATH_1	309	313	PF00917	0.336
DOC_USP7_MATH_1	605	609	PF00917	0.439
DOC_USP7_UBL2_3	656	660	PF12436	0.440
DOC_WW_Pin1_4	166	171	PF00397	0.454
DOC_WW_Pin1_4	448	453	PF00397	0.334
DOC_WW_Pin1_4	601	606	PF00397	0.482
LIG_14-3-3_CanoR_1	141	149	PF00244	0.385
LIG_14-3-3_CanoR_1	495	503	PF00244	0.529
LIG_14-3-3_CanoR_1	504	510	PF00244	0.485
LIG_14-3-3_CanoR_1	641	645	PF00244	0.549
LIG_APCC_ABBA_1	469	474	PF00400	0.365
LIG_APCC_ABBAyCdc20_2	192	198	PF00400	0.459
LIG_APCC_ABBAyCdc20_2	468	474	PF00400	0.476
LIG_BRCT_BRCA1_1	299	303	PF00533	0.374
LIG_BRCT_BRCA1_1	364	368	PF00533	0.364
LIG_CSL_BTD_1	426	429	PF09270	0.493
LIG_deltaCOP1_diTrp_1	474	482	PF00928	0.443
LIG_FHA_1	217	223	PF00498	0.419
LIG_FHA_1	303	309	PF00498	0.448
LIG_FHA_1	464	470	PF00498	0.501
LIG_FHA_1	488	494	PF00498	0.332
LIG_FHA_1	522	528	PF00498	0.460
LIG_FHA_2	142	148	PF00498	0.463
LIG_FHA_2	211	217	PF00498	0.599
LIG_FHA_2	449	455	PF00498	0.472
LIG_FHA_2	459	465	PF00498	0.460
LIG_FHA_2	553	559	PF00498	0.478
LIG_FHA_2	57	63	PF00498	0.614
LIG_FHA_2	94	100	PF00498	0.386
LIG_HCF-1_HBM_1	198	201	PF13415	0.493
LIG_LIR_Apic_2	126	132	PF02991	0.466
LIG_LIR_Apic_2	446	452	PF02991	0.337
LIG_LIR_Apic_2	524	528	PF02991	0.434
LIG_LIR_Gen_1	198	206	PF02991	0.457
LIG_LIR_Gen_1	238	248	PF02991	0.334
LIG_LIR_Gen_1	76	85	PF02991	0.447
LIG_LIR_Nem_3	198	204	PF02991	0.471
LIG_LIR_Nem_3	238	244	PF02991	0.355
LIG_LIR_Nem_3	273	278	PF02991	0.526
LIG_LIR_Nem_3	280	286	PF02991	0.382
LIG_LIR_Nem_3	47	51	PF02991	0.484
LIG_LIR_Nem_3	76	82	PF02991	0.438
LIG_MLH1_MIPbox_1	299	303	PF16413	0.374
LIG_MYND_1	607	611	PF01753	0.314
LIG_NRBOX	571	577	PF00104	0.448
LIG_NRBOX	66	72	PF00104	0.489
LIG_Pex14_1	633	637	PF04695	0.366
LIG_Pex14_2	244	248	PF04695	0.370
LIG_Pex14_2	298	302	PF04695	0.420
LIG_Pex14_2	85	89	PF04695	0.461
LIG_PTB_Apo_2	340	347	PF02174	0.356
LIG_PTB_Phospho_1	340	346	PF10480	0.357
LIG_REV1ctd_RIR_1	300	308	PF16727	0.318
LIG_SH2_CRK	201	205	PF00017	0.515
LIG_SH2_CRK	478	482	PF00017	0.341
LIG_SH2_GRB2like	72	75	PF00017	0.352
LIG_SH2_NCK_1	201	205	PF00017	0.515
LIG_SH2_NCK_1	321	325	PF00017	0.524
LIG_SH2_STAT5	129	132	PF00017	0.431
LIG_SH2_STAT5	201	204	PF00017	0.533
LIG_SH2_STAT5	225	228	PF00017	0.415
LIG_SH2_STAT5	346	349	PF00017	0.364
LIG_SH2_STAT5	450	453	PF00017	0.528
LIG_SH2_STAT5	483	486	PF00017	0.339
LIG_SH2_STAT5	526	529	PF00017	0.467
LIG_SH2_STAT5	624	627	PF00017	0.392
LIG_SH2_STAT5	79	82	PF00017	0.439
LIG_SH3_3	423	429	PF00018	0.535
LIG_SH3_3	575	581	PF00018	0.336
LIG_SUMO_SIM_anti_2	171	176	PF11976	0.479
LIG_SUMO_SIM_anti_2	568	574	PF11976	0.424
LIG_SUMO_SIM_par_1	329	334	PF11976	0.452
LIG_SUMO_SIM_par_1	545	551	PF11976	0.451
LIG_SUMO_SIM_par_1	568	574	PF11976	0.449
LIG_TRAF2_1	323	326	PF00917	0.516
LIG_TRAF2_1	60	63	PF00917	0.553
LIG_WRC_WIRS_1	440	445	PF05994	0.426
LIG_WRPW_2	103	106	PF00400	0.489
MOD_CK1_1	209	215	PF00069	0.569
MOD_CK1_1	379	385	PF00069	0.399
MOD_CK1_1	445	451	PF00069	0.461
MOD_CK1_1	54	60	PF00069	0.663
MOD_CK1_1	556	562	PF00069	0.529
MOD_CK1_1	73	79	PF00069	0.232
MOD_CK2_1	141	147	PF00069	0.522
MOD_CK2_1	319	325	PF00069	0.481
MOD_CK2_1	448	454	PF00069	0.482
MOD_CK2_1	458	464	PF00069	0.453
MOD_CK2_1	56	62	PF00069	0.637
MOD_CMANNOS	103	106	PF00535	0.489
MOD_CMANNOS	366	369	PF00535	0.357
MOD_Cter_Amidation	356	359	PF01082	0.319
MOD_GlcNHglycan	17	20	PF01048	0.505
MOD_GlcNHglycan	299	302	PF01048	0.388
MOD_GlcNHglycan	389	393	PF01048	0.481
MOD_GlcNHglycan	398	401	PF01048	0.457
MOD_GlcNHglycan	421	424	PF01048	0.525
MOD_GlcNHglycan	496	499	PF01048	0.447
MOD_GlcNHglycan	53	56	PF01048	0.719
MOD_GlcNHglycan	558	561	PF01048	0.526
MOD_GSK3_1	206	213	PF00069	0.544
MOD_GSK3_1	266	273	PF00069	0.476
MOD_GSK3_1	320	327	PF00069	0.441
MOD_GSK3_1	439	446	PF00069	0.508
MOD_GSK3_1	494	501	PF00069	0.496
MOD_GSK3_1	53	60	PF00069	0.667
MOD_GSK3_1	552	559	PF00069	0.526
MOD_GSK3_1	601	608	PF00069	0.516
MOD_GSK3_1	635	642	PF00069	0.485
MOD_N-GLC_1	309	314	PF02516	0.339
MOD_N-GLC_1	73	78	PF02516	0.339
MOD_NEK2_1	123	128	PF00069	0.463
MOD_NEK2_1	286	291	PF00069	0.418
MOD_NEK2_1	302	307	PF00069	0.276
MOD_NEK2_1	319	324	PF00069	0.412
MOD_NEK2_1	362	367	PF00069	0.459
MOD_NEK2_1	396	401	PF00069	0.460
MOD_NEK2_1	439	444	PF00069	0.435
MOD_NEK2_1	565	570	PF00069	0.430
MOD_NEK2_1	70	75	PF00069	0.400
MOD_NEK2_2	309	314	PF00069	0.420
MOD_OFUCOSY	306	313	PF10250	0.325
MOD_PIKK_1	210	216	PF00454	0.536
MOD_PIKK_1	376	382	PF00454	0.472
MOD_PIKK_1	458	464	PF00454	0.491
MOD_PIKK_1	503	509	PF00454	0.514
MOD_PK_1	320	326	PF00069	0.514
MOD_PKA_1	141	147	PF00069	0.533
MOD_PKA_2	141	147	PF00069	0.468
MOD_PKA_2	263	269	PF00069	0.544
MOD_PKA_2	376	382	PF00069	0.434
MOD_PKA_2	494	500	PF00069	0.510
MOD_PKA_2	503	509	PF00069	0.502
MOD_PKA_2	640	646	PF00069	0.547
MOD_PKA_2	85	91	PF00069	0.406
MOD_Plk_1	324	330	PF00069	0.455
MOD_Plk_2-3	584	590	PF00069	0.473
MOD_Plk_4	218	224	PF00069	0.491
MOD_Plk_4	445	451	PF00069	0.476
MOD_Plk_4	521	527	PF00069	0.454
MOD_Plk_4	565	571	PF00069	0.494
MOD_Plk_4	620	626	PF00069	0.415
MOD_ProDKin_1	166	172	PF00069	0.447
MOD_ProDKin_1	448	454	PF00069	0.333
MOD_ProDKin_1	601	607	PF00069	0.479
MOD_SUMO_for_1	8	11	PF00179	0.453
MOD_SUMO_rev_2	193	202	PF00179	0.485
MOD_SUMO_rev_2	506	516	PF00179	0.474
TRG_DiLeu_BaEn_1	430	435	PF01217	0.347
TRG_DiLeu_BaEn_3	325	331	PF01217	0.473
TRG_DiLeu_BaEn_4	62	68	PF01217	0.507
TRG_DiLeu_BaLyEn_6	129	134	PF01217	0.354
TRG_DiLeu_BaLyEn_6	407	412	PF01217	0.454
TRG_DiLeu_BaLyEn_6	613	618	PF01217	0.363
TRG_ENDOCYTIC_2	201	204	PF00928	0.505
TRG_ENDOCYTIC_2	321	324	PF00928	0.506
TRG_ENDOCYTIC_2	478	481	PF00928	0.311
TRG_ENDOCYTIC_2	72	75	PF00928	0.334
TRG_ENDOCYTIC_2	79	82	PF00928	0.363
TRG_ER_diArg_1	113	115	PF00400	0.407
TRG_ER_diArg_1	141	143	PF00400	0.504
TRG_ER_diArg_1	229	232	PF00400	0.507
TRG_ER_diArg_1	271	274	PF00400	0.498
TRG_ER_diArg_1	468	471	PF00400	0.466
TRG_ER_diArg_1	65	67	PF00400	0.445
TRG_ER_FFAT_2	445	454	PF00635	0.416
TRG_NES_CRM1_1	454	467	PF08389	0.416
TRG_Pf-PMV_PEXEL_1	432	436	PF00026	0.502

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9W0	Leptomonas seymouri	66%	100%
A0A0S4J867	Bodo saltans	31%	100%
A0A1X0NIX9	Trypanosomatidae	37%	98%
A0A3S5H7C8	Leishmania donovani	100%	100%
A0A422P403	Trypanosoma rangeli	39%	100%
A4HD96	Leishmania braziliensis	85%	100%
D0A710	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9AWN0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QAU1	Leishmania major	93%	100%
V5BRA0	Trypanosoma cruzi	39%	100%