Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

E9AH50_LEIIN

TriTrypDb:

LINF_240008700

Length:

625

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

E9AH50

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AH50

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	101	105	PF00656	0.528
CLV_C14_Caspase3-7	113	117	PF00656	0.469
CLV_C14_Caspase3-7	118	122	PF00656	0.426
CLV_C14_Caspase3-7	335	339	PF00656	0.546
CLV_MEL_PAP_1	569	575	PF00089	0.670
CLV_NRD_NRD_1	296	298	PF00675	0.675
CLV_NRD_NRD_1	481	483	PF00675	0.657
CLV_NRD_NRD_1	582	584	PF00675	0.605
CLV_PCSK_KEX2_1	296	298	PF00082	0.675
CLV_PCSK_KEX2_1	399	401	PF00082	0.646
CLV_PCSK_KEX2_1	582	584	PF00082	0.605
CLV_PCSK_PC1ET2_1	399	401	PF00082	0.636
CLV_PCSK_SKI1_1	155	159	PF00082	0.592
CLV_PCSK_SKI1_1	497	501	PF00082	0.712
CLV_PCSK_SKI1_1	565	569	PF00082	0.634
DEG_APCC_DBOX_1	198	206	PF00400	0.436
DEG_APCC_DBOX_1	460	468	PF00400	0.445
DEG_Nend_UBRbox_2	1	3	PF02207	0.648
DEG_SPOP_SBC_1	422	426	PF00917	0.435
DOC_ANK_TNKS_1	315	322	PF00023	0.561
DOC_CDC14_PxL_1	159	167	PF14671	0.515
DOC_CKS1_1	134	139	PF01111	0.544
DOC_CKS1_1	69	74	PF01111	0.533
DOC_CYCLIN_yCln2_LP_2	444	450	PF00134	0.443
DOC_MAPK_gen_1	565	575	PF00069	0.427
DOC_MAPK_JIP1_4	284	290	PF00069	0.591
DOC_MAPK_MEF2A_6	6	14	PF00069	0.545
DOC_PP1_RVXF_1	434	441	PF00149	0.537
DOC_PP1_RVXF_1	570	576	PF00149	0.496
DOC_PP1_RVXF_1	613	619	PF00149	0.429
DOC_PP2B_LxvP_1	500	503	PF13499	0.433
DOC_PP2B_LxvP_1	532	535	PF13499	0.580
DOC_PP4_FxxP_1	495	498	PF00568	0.552
DOC_PP4_FxxP_1	530	533	PF00568	0.447
DOC_USP7_MATH_1	106	110	PF00917	0.532
DOC_USP7_MATH_1	141	145	PF00917	0.397
DOC_USP7_MATH_1	172	176	PF00917	0.421
DOC_USP7_MATH_1	232	236	PF00917	0.502
DOC_USP7_MATH_1	237	241	PF00917	0.498
DOC_USP7_MATH_1	276	280	PF00917	0.433
DOC_USP7_MATH_1	421	425	PF00917	0.460
DOC_USP7_MATH_1	524	528	PF00917	0.549
DOC_USP7_MATH_1	561	565	PF00917	0.420
DOC_USP7_MATH_1	593	597	PF00917	0.467
DOC_WW_Pin1_4	133	138	PF00397	0.443
DOC_WW_Pin1_4	251	256	PF00397	0.554
DOC_WW_Pin1_4	68	73	PF00397	0.462
LIG_14-3-3_CanoR_1	107	112	PF00244	0.537
LIG_14-3-3_CanoR_1	231	237	PF00244	0.592
LIG_14-3-3_CanoR_1	284	289	PF00244	0.485
LIG_14-3-3_CanoR_1	303	311	PF00244	0.516
LIG_14-3-3_CanoR_1	329	333	PF00244	0.604
LIG_14-3-3_CanoR_1	423	432	PF00244	0.497
LIG_14-3-3_CanoR_1	572	576	PF00244	0.402
LIG_14-3-3_CanoR_1	6	10	PF00244	0.489
LIG_14-3-3_CanoR_1	615	619	PF00244	0.424
LIG_Actin_WH2_2	467	484	PF00022	0.488
LIG_BIR_III_2	121	125	PF00653	0.525
LIG_BRCT_BRCA1_1	526	530	PF00533	0.539
LIG_deltaCOP1_diTrp_1	437	443	PF00928	0.458
LIG_FHA_1	14	20	PF00498	0.363
LIG_FHA_1	204	210	PF00498	0.490
LIG_FHA_1	228	234	PF00498	0.579
LIG_FHA_1	36	42	PF00498	0.526
LIG_FHA_1	47	53	PF00498	0.444
LIG_FHA_1	550	556	PF00498	0.450
LIG_FHA_1	69	75	PF00498	0.470
LIG_FHA_2	116	122	PF00498	0.550
LIG_FHA_2	32	38	PF00498	0.528
LIG_FHA_2	333	339	PF00498	0.572
LIG_LIR_Apic_2	131	137	PF02991	0.434
LIG_LIR_Apic_2	198	203	PF02991	0.466
LIG_LIR_Apic_2	362	368	PF02991	0.471
LIG_LIR_Apic_2	527	533	PF02991	0.538
LIG_LIR_Gen_1	574	581	PF02991	0.404
LIG_LIR_Gen_1	599	608	PF02991	0.499
LIG_LIR_Gen_1	617	624	PF02991	0.332
LIG_LIR_Nem_3	547	551	PF02991	0.448
LIG_LIR_Nem_3	574	579	PF02991	0.405
LIG_LIR_Nem_3	599	604	PF02991	0.512
LIG_LIR_Nem_3	617	621	PF02991	0.327
LIG_MYND_1	510	514	PF01753	0.588
LIG_NBox_RRM_1	119	129	PF00076	0.559
LIG_NRBOX	265	271	PF00104	0.466
LIG_PCNA_TLS_4	582	589	PF02747	0.398
LIG_PCNA_yPIPBox_3	139	149	PF02747	0.453
LIG_Pex14_1	584	588	PF04695	0.394
LIG_SH2_CRK	156	160	PF00017	0.399
LIG_SH2_CRK	88	92	PF00017	0.416
LIG_SH2_GRB2like	578	581	PF00017	0.405
LIG_SH2_SRC	597	600	PF00017	0.412
LIG_SH2_STAP1	146	150	PF00017	0.371
LIG_SH2_STAP1	273	277	PF00017	0.514
LIG_SH2_STAP1	62	66	PF00017	0.555
LIG_SH2_STAP1	77	81	PF00017	0.395
LIG_SH2_STAT5	22	25	PF00017	0.343
LIG_SH2_STAT5	551	554	PF00017	0.458
LIG_SH2_STAT5	578	581	PF00017	0.415
LIG_SH2_STAT5	88	91	PF00017	0.488
LIG_SH3_3	322	328	PF00018	0.571
LIG_SH3_3	381	387	PF00018	0.553
LIG_SH3_3	495	501	PF00018	0.558
LIG_SH3_3	504	510	PF00018	0.557
LIG_SH3_3	528	534	PF00018	0.487
LIG_SH3_3	66	72	PF00018	0.458
LIG_SUMO_SIM_anti_2	16	22	PF11976	0.337
LIG_SUMO_SIM_anti_2	413	418	PF11976	0.527
LIG_SUMO_SIM_anti_2	5	11	PF11976	0.484
LIG_SUMO_SIM_par_1	388	394	PF11976	0.463
LIG_SUMO_SIM_par_1	410	415	PF11976	0.492
LIG_TRFH_1	530	534	PF08558	0.450
LIG_UBA3_1	464	468	PF00899	0.446
LIG_WW_1	533	536	PF00397	0.508
MOD_CK1_1	110	116	PF00069	0.564
MOD_CK1_1	239	245	PF00069	0.580
MOD_CK1_1	261	267	PF00069	0.512
MOD_CK1_1	271	277	PF00069	0.445
MOD_CK1_1	304	310	PF00069	0.600
MOD_CK1_1	424	430	PF00069	0.457
MOD_CK1_1	5	11	PF00069	0.483
MOD_CK2_1	167	173	PF00069	0.414
MOD_CK2_1	192	198	PF00069	0.463
MOD_CMANNOS	440	443	PF00535	0.646
MOD_CMANNOS	584	587	PF00535	0.598
MOD_GlcNHglycan	109	112	PF01048	0.769
MOD_GlcNHglycan	159	162	PF01048	0.710
MOD_GlcNHglycan	167	170	PF01048	0.591
MOD_GlcNHglycan	270	273	PF01048	0.784
MOD_GlcNHglycan	278	281	PF01048	0.636
MOD_GlcNHglycan	306	309	PF01048	0.774
MOD_GlcNHglycan	361	364	PF01048	0.716
MOD_GlcNHglycan	428	431	PF01048	0.752
MOD_GlcNHglycan	514	517	PF01048	0.814
MOD_GSK3_1	106	113	PF00069	0.537
MOD_GSK3_1	129	136	PF00069	0.543
MOD_GSK3_1	232	239	PF00069	0.583
MOD_GSK3_1	258	265	PF00069	0.510
MOD_GSK3_1	271	278	PF00069	0.436
MOD_GSK3_1	302	309	PF00069	0.568
MOD_GSK3_1	31	38	PF00069	0.479
MOD_GSK3_1	328	335	PF00069	0.522
MOD_GSK3_1	421	428	PF00069	0.467
MOD_GSK3_1	602	609	PF00069	0.401
MOD_LATS_1	282	288	PF00433	0.566
MOD_N-GLC_1	10	15	PF02516	0.480
MOD_N-GLC_1	375	380	PF02516	0.669
MOD_N-GLC_1	549	554	PF02516	0.636
MOD_N-GLC_1	86	91	PF02516	0.701
MOD_NEK2_1	10	15	PF00069	0.348
MOD_NEK2_1	165	170	PF00069	0.522
MOD_NEK2_1	211	216	PF00069	0.484
MOD_NEK2_1	262	267	PF00069	0.479
MOD_NEK2_1	275	280	PF00069	0.478
MOD_NEK2_1	31	36	PF00069	0.423
MOD_NEK2_1	488	493	PF00069	0.541
MOD_NEK2_1	588	593	PF00069	0.404
MOD_NEK2_2	141	146	PF00069	0.450
MOD_NEK2_2	328	333	PF00069	0.508
MOD_NEK2_2	571	576	PF00069	0.496
MOD_PIKK_1	243	249	PF00454	0.572
MOD_PIKK_1	264	270	PF00454	0.528
MOD_PIKK_1	474	480	PF00454	0.553
MOD_PIKK_1	98	104	PF00454	0.551
MOD_PKA_2	106	112	PF00069	0.534
MOD_PKA_2	211	217	PF00069	0.384
MOD_PKA_2	243	249	PF00069	0.540
MOD_PKA_2	302	308	PF00069	0.633
MOD_PKA_2	328	334	PF00069	0.574
MOD_PKA_2	422	428	PF00069	0.489
MOD_PKA_2	5	11	PF00069	0.520
MOD_PKA_2	571	577	PF00069	0.401
MOD_PKA_2	614	620	PF00069	0.428
MOD_Plk_1	10	16	PF00069	0.500
MOD_Plk_1	115	121	PF00069	0.577
MOD_Plk_1	130	136	PF00069	0.377
MOD_Plk_1	172	178	PF00069	0.398
MOD_Plk_1	412	418	PF00069	0.497
MOD_Plk_1	561	567	PF00069	0.416
MOD_Plk_4	130	136	PF00069	0.425
MOD_Plk_4	141	147	PF00069	0.404
MOD_Plk_4	192	198	PF00069	0.400
MOD_Plk_4	284	290	PF00069	0.566
MOD_Plk_4	328	334	PF00069	0.501
MOD_Plk_4	412	418	PF00069	0.416
MOD_Plk_4	448	454	PF00069	0.455
MOD_Plk_4	5	11	PF00069	0.515
MOD_Plk_4	571	577	PF00069	0.499
MOD_ProDKin_1	133	139	PF00069	0.442
MOD_ProDKin_1	251	257	PF00069	0.551
MOD_ProDKin_1	68	74	PF00069	0.462
MOD_SUMO_for_1	346	349	PF00179	0.502
MOD_SUMO_for_1	544	547	PF00179	0.564
MOD_SUMO_rev_2	340	348	PF00179	0.492
TRG_DiLeu_BaLyEn_6	146	151	PF01217	0.369
TRG_DiLeu_BaLyEn_6	179	184	PF01217	0.431
TRG_DiLeu_BaLyEn_6	495	500	PF01217	0.507
TRG_ENDOCYTIC_2	156	159	PF00928	0.393
TRG_ENDOCYTIC_2	218	221	PF00928	0.389
TRG_ENDOCYTIC_2	536	539	PF00928	0.512
TRG_ENDOCYTIC_2	55	58	PF00928	0.451
TRG_ER_diArg_1	295	297	PF00400	0.478
TRG_ER_diArg_1	526	529	PF00400	0.563
TRG_ER_diArg_1	581	583	PF00400	0.415

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7L4	Leptomonas seymouri	46%	97%
A0A3Q8IMJ3	Leishmania donovani	99%	100%
A4HD95	Leishmania braziliensis	77%	95%
E9AWM9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QAU2	Leishmania major	94%	100%