Putative CMP-sialic acid transporter

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

UDP-galactose transporter - putative

Species:

Leishmania infantum

UniProt:

E9AH47_LEIIN

TriTrypDb:

LINF_240008400

Length:

540

Annotations

LeishMANIAdb annotations

Homologous to animal UDP-N-acetylglucosamine, UDP-galactose and CMP-sialic acid transporters. Only expanded in the Leptomonas lineage. Localization: Golgi (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 2, no: 14
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0000139	Golgi membrane	5	17
GO:0016020	membrane	2	17
GO:0031090	organelle membrane	3	17
GO:0098588	bounding membrane of organelle	4	17
GO:0110165	cellular anatomical entity	1	17

Expansion

Sequence features

E9AH47

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AH47

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006811	monoatomic ion transport	4	1
GO:0006820	monoatomic anion transport	5	1
GO:0009987	cellular process	1	1
GO:0015711	organic anion transport	5	1
GO:0015780	nucleotide-sugar transmembrane transport	3	1
GO:0015931	nucleobase-containing compound transport	5	1
GO:0034220	monoatomic ion transmembrane transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0055085	transmembrane transport	2	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0072334	UDP-galactose transmembrane transport	5	1
GO:0090481	pyrimidine nucleotide-sugar transmembrane transport	4	1
GO:0098656	monoatomic anion transmembrane transport	4	1
GO:1901264	carbohydrate derivative transport	5	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	17
GO:0005338	nucleotide-sugar transmembrane transporter activity	4	17
GO:0015165	pyrimidine nucleotide-sugar transmembrane transporter activity	5	17
GO:0015932	nucleobase-containing compound transmembrane transporter activity	3	17
GO:0022857	transmembrane transporter activity	2	17
GO:1901505	carbohydrate derivative transmembrane transporter activity	3	17
GO:0005459	UDP-galactose transmembrane transporter activity	6	1
GO:0015136	sialic acid transmembrane transporter activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	219	223	PF00656	0.603
CLV_C14_Caspase3-7	236	240	PF00656	0.627
CLV_NRD_NRD_1	100	102	PF00675	0.504
CLV_NRD_NRD_1	254	256	PF00675	0.313
CLV_NRD_NRD_1	35	37	PF00675	0.388
CLV_PCSK_FUR_1	16	20	PF00082	0.412
CLV_PCSK_KEX2_1	100	102	PF00082	0.476
CLV_PCSK_KEX2_1	18	20	PF00082	0.402
CLV_PCSK_KEX2_1	256	258	PF00082	0.297
CLV_PCSK_KEX2_1	37	39	PF00082	0.366
CLV_PCSK_KEX2_1	414	416	PF00082	0.361
CLV_PCSK_PC1ET2_1	18	20	PF00082	0.411
CLV_PCSK_PC1ET2_1	256	258	PF00082	0.327
CLV_PCSK_PC1ET2_1	37	39	PF00082	0.366
CLV_PCSK_PC1ET2_1	414	416	PF00082	0.361
CLV_PCSK_SKI1_1	101	105	PF00082	0.394
CLV_PCSK_SKI1_1	150	154	PF00082	0.620
CLV_PCSK_SKI1_1	167	171	PF00082	0.234
CLV_PCSK_SKI1_1	250	254	PF00082	0.321
CLV_PCSK_SKI1_1	315	319	PF00082	0.372
CLV_PCSK_SKI1_1	324	328	PF00082	0.320
DOC_CKS1_1	193	198	PF01111	0.586
DOC_CKS1_1	514	519	PF01111	0.287
DOC_MAPK_gen_1	100	106	PF00069	0.577
DOC_MAPK_gen_1	255	263	PF00069	0.569
DOC_MAPK_gen_1	265	272	PF00069	0.557
DOC_MAPK_gen_1	275	284	PF00069	0.529
DOC_MAPK_MEF2A_6	315	323	PF00069	0.335
DOC_MAPK_MEF2A_6	335	344	PF00069	0.332
DOC_PP1_RVXF_1	148	155	PF00149	0.383
DOC_PP1_RVXF_1	248	254	PF00149	0.462
DOC_PP1_RVXF_1	313	319	PF00149	0.393
DOC_PP1_RVXF_1	465	472	PF00149	0.262
DOC_PP4_FxxP_1	514	517	PF00568	0.335
DOC_PP4_FxxP_1	93	96	PF00568	0.625
DOC_USP7_MATH_1	202	206	PF00917	0.592
DOC_USP7_MATH_1	221	225	PF00917	0.773
DOC_USP7_MATH_1	368	372	PF00917	0.386
DOC_USP7_MATH_1	60	64	PF00917	0.593
DOC_WW_Pin1_4	192	197	PF00397	0.719
DOC_WW_Pin1_4	213	218	PF00397	0.768
DOC_WW_Pin1_4	28	33	PF00397	0.576
DOC_WW_Pin1_4	329	334	PF00397	0.561
DOC_WW_Pin1_4	38	43	PF00397	0.581
DOC_WW_Pin1_4	49	54	PF00397	0.587
DOC_WW_Pin1_4	513	518	PF00397	0.428
DOC_WW_Pin1_4	92	97	PF00397	0.627
LIG_14-3-3_CanoR_1	150	155	PF00244	0.465
LIG_14-3-3_CanoR_1	187	193	PF00244	0.569
LIG_14-3-3_CanoR_1	424	431	PF00244	0.527
LIG_14-3-3_CanoR_1	5	12	PF00244	0.620
LIG_AP2alpha_1	461	465	PF02296	0.361
LIG_BH_BH3_1	223	239	PF00452	0.565
LIG_BIR_III_4	26	30	PF00653	0.596
LIG_BRCT_BRCA1_1	403	407	PF00533	0.440
LIG_BRCT_BRCA1_1	458	462	PF00533	0.361
LIG_BRCT_BRCA1_1	497	501	PF00533	0.438
LIG_CaMK_CASK_1	95	101	PF00069	0.546
LIG_EH1_1	288	296	PF00400	0.440
LIG_eIF4E_1	276	282	PF01652	0.561
LIG_eIF4E_1	289	295	PF01652	0.440
LIG_eIF4E_1	312	318	PF01652	0.424
LIG_EVH1_2	44	48	PF00568	0.581
LIG_FHA_1	160	166	PF00498	0.325
LIG_FHA_1	195	201	PF00498	0.720
LIG_FHA_1	244	250	PF00498	0.408
LIG_FHA_1	464	470	PF00498	0.307
LIG_FHA_1	506	512	PF00498	0.366
LIG_FHA_1	519	525	PF00498	0.248
LIG_FHA_2	354	360	PF00498	0.307
LIG_FHA_2	458	464	PF00498	0.359
LIG_GBD_Chelix_1	287	295	PF00786	0.337
LIG_HCF-1_HBM_1	273	276	PF13415	0.525
LIG_LIR_Gen_1	171	182	PF02991	0.401
LIG_LIR_Gen_1	306	316	PF02991	0.314
LIG_LIR_Gen_1	404	412	PF02991	0.389
LIG_LIR_Gen_1	463	473	PF02991	0.337
LIG_LIR_Gen_1	498	509	PF02991	0.381
LIG_LIR_Gen_1	526	535	PF02991	0.349
LIG_LIR_Nem_3	171	177	PF02991	0.332
LIG_LIR_Nem_3	306	311	PF02991	0.306
LIG_LIR_Nem_3	401	406	PF02991	0.392
LIG_LIR_Nem_3	432	438	PF02991	0.345
LIG_LIR_Nem_3	459	465	PF02991	0.283
LIG_LIR_Nem_3	498	504	PF02991	0.394
LIG_LIR_Nem_3	526	530	PF02991	0.327
LIG_MLH1_MIPbox_1	458	462	PF16413	0.361
LIG_Pex14_1	98	102	PF04695	0.725
LIG_Pex14_2	258	262	PF04695	0.501
LIG_Pex14_2	399	403	PF04695	0.424
LIG_Pex14_2	436	440	PF04695	0.440
LIG_Pex14_2	457	461	PF04695	0.328
LIG_Pex14_2	497	501	PF04695	0.438
LIG_PTB_Apo_2	115	122	PF02174	0.433
LIG_PTB_Phospho_1	115	121	PF10480	0.413
LIG_SH2_STAP1	298	302	PF00017	0.452
LIG_SH2_STAT3	127	130	PF00017	0.380
LIG_SH2_STAT3	289	292	PF00017	0.315
LIG_SH2_STAT5	102	105	PF00017	0.587
LIG_SH2_STAT5	121	124	PF00017	0.355
LIG_SH2_STAT5	435	438	PF00017	0.361
LIG_SH2_STAT5	489	492	PF00017	0.561
LIG_SH2_STAT5	536	539	PF00017	0.408
LIG_SH3_2	32	37	PF14604	0.587
LIG_SH3_3	29	35	PF00018	0.586
LIG_SH3_3	39	45	PF00018	0.577
LIG_SH3_3	50	56	PF00018	0.592
LIG_Sin3_3	108	115	PF02671	0.363
LIG_SUMO_SIM_anti_2	278	285	PF11976	0.527
LIG_SUMO_SIM_par_1	121	126	PF11976	0.426
LIG_SUMO_SIM_par_1	293	299	PF11976	0.337
LIG_TRAF2_1	144	147	PF00917	0.439
LIG_TRFH_1	329	333	PF08558	0.525
LIG_TYR_ITIM	433	438	PF00017	0.389
LIG_UBA3_1	294	301	PF00899	0.337
LIG_Vh1_VBS_1	220	238	PF01044	0.593
LIG_WRC_WIRS_1	494	499	PF05994	0.501
LIG_WRC_WIRS_1	524	529	PF05994	0.339
MOD_CDC14_SPxK_1	332	335	PF00782	0.525
MOD_CDK_SPxK_1	329	335	PF00069	0.525
MOD_CK1_1	189	195	PF00069	0.637
MOD_CK1_1	205	211	PF00069	0.739
MOD_CK1_1	384	390	PF00069	0.361
MOD_CK1_1	401	407	PF00069	0.200
MOD_CK1_1	49	55	PF00069	0.629
MOD_CK1_1	496	502	PF00069	0.399
MOD_CK1_1	63	69	PF00069	0.580
MOD_CK1_1	75	81	PF00069	0.577
MOD_CK1_1	8	14	PF00069	0.621
MOD_CK2_1	368	374	PF00069	0.404
MOD_GlcNHglycan	188	191	PF01048	0.438
MOD_GlcNHglycan	203	207	PF01048	0.582
MOD_GlcNHglycan	400	403	PF01048	0.356
MOD_GlcNHglycan	421	424	PF01048	0.333
MOD_GlcNHglycan	505	508	PF01048	0.270
MOD_GSK3_1	150	157	PF00069	0.375
MOD_GSK3_1	221	228	PF00069	0.701
MOD_GSK3_1	239	246	PF00069	0.465
MOD_GSK3_1	376	383	PF00069	0.322
MOD_GSK3_1	384	391	PF00069	0.273
MOD_GSK3_1	419	426	PF00069	0.482
MOD_GSK3_1	44	51	PF00069	0.647
MOD_GSK3_1	503	510	PF00069	0.298
MOD_GSK3_1	73	80	PF00069	0.799
MOD_GSK3_1	8	15	PF00069	0.620
MOD_N-GLC_1	518	523	PF02516	0.525
MOD_NEK2_1	12	17	PF00069	0.603
MOD_NEK2_1	154	159	PF00069	0.347
MOD_NEK2_1	168	173	PF00069	0.285
MOD_NEK2_1	243	248	PF00069	0.466
MOD_NEK2_1	296	301	PF00069	0.398
MOD_NEK2_1	344	349	PF00069	0.425
MOD_NEK2_1	360	365	PF00069	0.262
MOD_NEK2_1	388	393	PF00069	0.319
MOD_NEK2_1	419	424	PF00069	0.504
MOD_NEK2_1	457	462	PF00069	0.355
MOD_NEK2_1	48	53	PF00069	0.637
MOD_NEK2_1	505	510	PF00069	0.321
MOD_NEK2_1	518	523	PF00069	0.257
MOD_NEK2_1	528	533	PF00069	0.326
MOD_NEK2_2	221	226	PF00069	0.645
MOD_NEK2_2	507	512	PF00069	0.433
MOD_PIKK_1	125	131	PF00454	0.319
MOD_PKA_2	186	192	PF00069	0.607
MOD_PKA_2	423	429	PF00069	0.565
MOD_PKA_2	73	79	PF00069	0.790
MOD_Plk_1	243	249	PF00069	0.463
MOD_Plk_1	63	69	PF00069	0.588
MOD_Plk_2-3	239	245	PF00069	0.516
MOD_Plk_4	168	174	PF00069	0.344
MOD_Plk_4	276	282	PF00069	0.570
MOD_Plk_4	303	309	PF00069	0.277
MOD_Plk_4	457	463	PF00069	0.311
MOD_Plk_4	507	513	PF00069	0.318
MOD_Plk_4	518	524	PF00069	0.271
MOD_ProDKin_1	192	198	PF00069	0.722
MOD_ProDKin_1	213	219	PF00069	0.767
MOD_ProDKin_1	28	34	PF00069	0.576
MOD_ProDKin_1	329	335	PF00069	0.561
MOD_ProDKin_1	38	44	PF00069	0.579
MOD_ProDKin_1	49	55	PF00069	0.587
MOD_ProDKin_1	513	519	PF00069	0.428
MOD_ProDKin_1	92	98	PF00069	0.624
TRG_ENDOCYTIC_2	121	124	PF00928	0.413
TRG_ENDOCYTIC_2	435	438	PF00928	0.349
TRG_ER_diArg_1	247	250	PF00400	0.510
TRG_ER_diArg_1	255	258	PF00400	0.510
TRG_ER_diArg_1	35	38	PF00400	0.585
TRG_ER_diArg_1	99	101	PF00400	0.683
TRG_NES_CRM1_1	292	304	PF08389	0.328
TRG_NES_CRM1_1	476	491	PF08389	0.337
TRG_NLS_Bipartite_1	18	40	PF00514	0.596
TRG_NLS_MonoExtN_4	35	40	PF00514	0.595
TRG_Pf-PMV_PEXEL_1	229	233	PF00026	0.365

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7L9	Leptomonas seymouri	51%	100%
A0A0N1HVQ8	Leptomonas seymouri	28%	100%
A0A1X0NTD6	Trypanosomatidae	29%	100%
A0A3Q8IES0	Leishmania donovani	100%	100%
A0A3S7WVZ3	Leishmania donovani	98%	100%
A0A3S7WY47	Leishmania donovani	79%	97%
A0A422P321	Trypanosoma rangeli	29%	100%
A4HD92	Leishmania braziliensis	72%	100%
A4HDA0	Leishmania braziliensis	71%	100%
A4I0N2	Leishmania infantum	79%	98%
D0AAP4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AWM5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%
E9AWM6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QAU5	Leishmania major	90%	100%
V5BLB8	Trypanosoma cruzi	29%	100%