LeishMANIAdb
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Dynein intermediate-chain-like protein

Quick info Annotations Function or PPIs Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Dynein intermediate-chain-like protein
Gene product:
Dynein intermediate chain 1 - axonemal
Species:
Leishmania infantum
UniProt:
E9AH39_LEIIN
TriTrypDb:
LINF_240007500
Length:
686

Annotations

Annotations by Jardim et al.

Structural Proteins, Dynein intermediate-chain-like

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005856 cytoskeleton 5 1
GO:0005858 axonemal dynein complex 4 1
GO:0005875 microtubule associated complex 2 1
GO:0005930 axoneme 2 1
GO:0030286 dynein complex 3 1
GO:0032991 protein-containing complex 1 1
GO:0036157 outer dynein arm 5 1
GO:0043226 organelle 2 1
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1
GO:1902494 catalytic complex 2 1

Phosphorylation

Promastigote: 30

Expansion

Sequence features

E9AH39
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AH39

Function

Biological processes
Term Name Level Count
GO:0003341 cilium movement 4 1
GO:0007017 microtubule-based process 2 1
GO:0007018 microtubule-based movement 3 1
GO:0009987 cellular process 1 1
GO:0016043 cellular component organization 3 1
GO:0022607 cellular component assembly 4 1
GO:0033058 directional locomotion 2 1
GO:0036158 outer dynein arm assembly 7 1
GO:0040011 locomotion 1 1
GO:0043056 forward locomotion 3 1
GO:0043933 protein-containing complex organization 4 1
GO:0060294 cilium movement involved in cell motility 5 1
GO:0065003 protein-containing complex assembly 5 1
GO:0070286 axonemal dynein complex assembly 6 1
GO:0071840 cellular component organization or biogenesis 2 1
Molecular functions
Term Name Level Count
GO:0003774 cytoskeletal motor activity 1 1
GO:0005488 binding 1 1
GO:0005515 protein binding 2 1
GO:0045503 dynein light chain binding 3 1
GO:0045504 dynein heavy chain binding 3 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 230 234 PF00656 0.527
CLV_C14_Caspase3-7 564 568 PF00656 0.360
CLV_NRD_NRD_1 118 120 PF00675 0.425
CLV_NRD_NRD_1 206 208 PF00675 0.588
CLV_NRD_NRD_1 26 28 PF00675 0.573
CLV_NRD_NRD_1 301 303 PF00675 0.491
CLV_NRD_NRD_1 645 647 PF00675 0.469
CLV_PCSK_FUR_1 116 120 PF00082 0.426
CLV_PCSK_KEX2_1 118 120 PF00082 0.425
CLV_PCSK_KEX2_1 206 208 PF00082 0.573
CLV_PCSK_KEX2_1 454 456 PF00082 0.430
CLV_PCSK_PC1ET2_1 454 456 PF00082 0.430
CLV_PCSK_SKI1_1 143 147 PF00082 0.564
CLV_PCSK_SKI1_1 252 256 PF00082 0.414
CLV_PCSK_SKI1_1 295 299 PF00082 0.339
CLV_PCSK_SKI1_1 304 308 PF00082 0.287
CLV_PCSK_SKI1_1 455 459 PF00082 0.486
CLV_PCSK_SKI1_1 460 464 PF00082 0.487
CLV_PCSK_SKI1_1 57 61 PF00082 0.456
CLV_PCSK_SKI1_1 611 615 PF00082 0.364
CLV_PCSK_SKI1_1 681 685 PF00082 0.424
DEG_APCC_DBOX_1 251 259 PF00400 0.402
DEG_Nend_UBRbox_3 1 3 PF02207 0.556
DEG_SCF_FBW7_1 430 437 PF00400 0.294
DEG_SPOP_SBC_1 576 580 PF00917 0.289
DOC_MAPK_DCC_7 554 562 PF00069 0.400
DOC_MAPK_gen_1 116 125 PF00069 0.574
DOC_MAPK_gen_1 302 311 PF00069 0.323
DOC_MAPK_gen_1 611 620 PF00069 0.312
DOC_MAPK_gen_1 679 686 PF00069 0.440
DOC_MAPK_HePTP_8 551 563 PF00069 0.465
DOC_MAPK_MEF2A_6 554 563 PF00069 0.331
DOC_MAPK_MEF2A_6 633 641 PF00069 0.289
DOC_MAPK_MEF2A_6 669 678 PF00069 0.328
DOC_PP4_FxxP_1 328 331 PF00568 0.499
DOC_USP7_MATH_1 16 20 PF00917 0.613
DOC_USP7_MATH_1 174 178 PF00917 0.456
DOC_USP7_MATH_1 212 216 PF00917 0.566
DOC_USP7_MATH_1 227 231 PF00917 0.621
DOC_USP7_MATH_1 346 350 PF00917 0.551
DOC_USP7_MATH_1 576 580 PF00917 0.289
DOC_USP7_MATH_1 7 11 PF00917 0.679
DOC_USP7_UBL2_3 300 304 PF12436 0.487
DOC_USP7_UBL2_3 550 554 PF12436 0.423
DOC_WW_Pin1_4 103 108 PF00397 0.568
DOC_WW_Pin1_4 245 250 PF00397 0.497
DOC_WW_Pin1_4 3 8 PF00397 0.682
DOC_WW_Pin1_4 430 435 PF00397 0.308
DOC_WW_Pin1_4 487 492 PF00397 0.485
DOC_WW_Pin1_4 530 535 PF00397 0.516
DOC_WW_Pin1_4 553 558 PF00397 0.500
DOC_WW_Pin1_4 639 644 PF00397 0.303
LIG_14-3-3_CanoR_1 154 160 PF00244 0.460
LIG_14-3-3_CanoR_1 166 172 PF00244 0.526
LIG_14-3-3_CanoR_1 314 321 PF00244 0.346
LIG_14-3-3_CanoR_1 89 95 PF00244 0.481
LIG_Actin_WH2_2 632 648 PF00022 0.405
LIG_APCC_ABBA_1 69 74 PF00400 0.442
LIG_BIR_III_4 567 571 PF00653 0.365
LIG_BRCT_BRCA1_1 174 178 PF00533 0.429
LIG_BRCT_BRCA1_1 247 251 PF00533 0.509
LIG_BRCT_BRCA1_1 315 319 PF00533 0.411
LIG_BRCT_BRCA1_1 324 328 PF00533 0.312
LIG_BRCT_BRCA1_1 578 582 PF00533 0.273
LIG_BRCT_BRCA1_1 91 95 PF00533 0.561
LIG_BRCT_BRCA1_2 324 330 PF00533 0.418
LIG_Clathr_ClatBox_1 560 564 PF01394 0.310
LIG_Clathr_ClatBox_1 94 98 PF01394 0.494
LIG_deltaCOP1_diTrp_1 422 429 PF00928 0.307
LIG_deltaCOP1_diTrp_1 546 552 PF00928 0.412
LIG_FHA_1 140 146 PF00498 0.463
LIG_FHA_1 431 437 PF00498 0.412
LIG_FHA_1 546 552 PF00498 0.420
LIG_FHA_1 599 605 PF00498 0.423
LIG_FHA_1 614 620 PF00498 0.337
LIG_FHA_1 636 642 PF00498 0.430
LIG_FHA_1 662 668 PF00498 0.372
LIG_FHA_1 86 92 PF00498 0.544
LIG_FHA_2 129 135 PF00498 0.593
LIG_FHA_2 212 218 PF00498 0.489
LIG_FHA_2 456 462 PF00498 0.484
LIG_FHA_2 675 681 PF00498 0.356
LIG_Integrin_isoDGR_2 312 314 PF01839 0.378
LIG_LIR_Apic_2 325 331 PF02991 0.481
LIG_LIR_Gen_1 325 331 PF02991 0.413
LIG_LIR_Gen_1 422 430 PF02991 0.449
LIG_LIR_Gen_1 579 587 PF02991 0.426
LIG_LIR_LC3C_4 558 562 PF02991 0.343
LIG_LIR_Nem_3 175 181 PF02991 0.558
LIG_LIR_Nem_3 183 188 PF02991 0.391
LIG_LIR_Nem_3 325 329 PF02991 0.407
LIG_LIR_Nem_3 435 441 PF02991 0.351
LIG_LIR_Nem_3 529 535 PF02991 0.445
LIG_LIR_Nem_3 571 577 PF02991 0.287
LIG_LIR_Nem_3 579 585 PF02991 0.301
LIG_PDZ_Class_2 681 686 PF00595 0.523
LIG_REV1ctd_RIR_1 294 304 PF16727 0.358
LIG_SH2_CRK 326 330 PF00017 0.420
LIG_SH2_STAP1 315 319 PF00017 0.433
LIG_SH2_STAP1 528 532 PF00017 0.412
LIG_SH2_STAP1 577 581 PF00017 0.282
LIG_SH2_STAT5 528 531 PF00017 0.419
LIG_SH3_1 531 537 PF00018 0.421
LIG_SH3_3 351 357 PF00018 0.393
LIG_SH3_3 531 537 PF00018 0.437
LIG_SH3_3 645 651 PF00018 0.431
LIG_SUMO_SIM_par_1 558 564 PF11976 0.384
LIG_SUMO_SIM_par_1 663 668 PF11976 0.409
LIG_SUMO_SIM_par_1 672 677 PF11976 0.349
LIG_TYR_ITAM 312 329 PF00017 0.352
MOD_CDK_SPK_2 3 8 PF00069 0.675
MOD_CDK_SPxxK_3 245 252 PF00069 0.399
MOD_CDK_SPxxK_3 639 646 PF00069 0.308
MOD_CK1_1 398 404 PF00069 0.460
MOD_CK1_1 437 443 PF00069 0.296
MOD_CK2_1 212 218 PF00069 0.581
MOD_CK2_1 429 435 PF00069 0.418
MOD_CK2_1 450 456 PF00069 0.487
MOD_GlcNHglycan 174 177 PF01048 0.529
MOD_GlcNHglycan 18 21 PF01048 0.644
MOD_GlcNHglycan 252 255 PF01048 0.505
MOD_GlcNHglycan 30 33 PF01048 0.524
MOD_GlcNHglycan 348 351 PF01048 0.535
MOD_GlcNHglycan 402 405 PF01048 0.436
MOD_GlcNHglycan 543 546 PF01048 0.225
MOD_GSK3_1 149 156 PF00069 0.539
MOD_GSK3_1 3 10 PF00069 0.652
MOD_GSK3_1 394 401 PF00069 0.428
MOD_GSK3_1 430 437 PF00069 0.472
MOD_GSK3_1 464 471 PF00069 0.498
MOD_GSK3_1 483 490 PF00069 0.407
MOD_GSK3_1 526 533 PF00069 0.482
MOD_GSK3_1 541 548 PF00069 0.363
MOD_GSK3_1 635 642 PF00069 0.381
MOD_GSK3_1 85 92 PF00069 0.404
MOD_LATS_1 373 379 PF00433 0.509
MOD_N-GLC_1 149 154 PF02516 0.500
MOD_N-GLC_1 598 603 PF02516 0.490
MOD_N-GLC_2 265 267 PF02516 0.365
MOD_NEK2_1 394 399 PF00069 0.521
MOD_NEK2_1 506 511 PF00069 0.332
MOD_NEK2_2 227 232 PF00069 0.568
MOD_NEK2_2 332 337 PF00069 0.423
MOD_NEK2_2 357 362 PF00069 0.309
MOD_NEK2_2 434 439 PF00069 0.269
MOD_NEK2_2 545 550 PF00069 0.430
MOD_NEK2_2 577 582 PF00069 0.279
MOD_PIKK_1 153 159 PF00454 0.496
MOD_PIKK_1 497 503 PF00454 0.311
MOD_PKA_1 27 33 PF00069 0.575
MOD_PKA_1 646 652 PF00069 0.459
MOD_PKA_2 153 159 PF00069 0.523
MOD_PKA_2 212 218 PF00069 0.611
MOD_PKA_2 313 319 PF00069 0.426
MOD_PKA_2 394 400 PF00069 0.551
MOD_PKA_2 43 49 PF00069 0.590
MOD_PKA_2 632 638 PF00069 0.302
MOD_PKA_2 7 13 PF00069 0.647
MOD_Plk_1 164 170 PF00069 0.567
MOD_Plk_1 227 233 PF00069 0.642
MOD_Plk_1 357 363 PF00069 0.265
MOD_Plk_1 375 381 PF00069 0.432
MOD_Plk_1 434 440 PF00069 0.418
MOD_Plk_1 545 551 PF00069 0.423
MOD_Plk_1 674 680 PF00069 0.339
MOD_Plk_4 286 292 PF00069 0.464
MOD_Plk_4 375 381 PF00069 0.472
MOD_Plk_4 434 440 PF00069 0.463
MOD_Plk_4 577 583 PF00069 0.304
MOD_Plk_4 605 611 PF00069 0.349
MOD_Plk_4 632 638 PF00069 0.301
MOD_Plk_4 90 96 PF00069 0.530
MOD_ProDKin_1 103 109 PF00069 0.563
MOD_ProDKin_1 245 251 PF00069 0.493
MOD_ProDKin_1 3 9 PF00069 0.683
MOD_ProDKin_1 430 436 PF00069 0.303
MOD_ProDKin_1 487 493 PF00069 0.488
MOD_ProDKin_1 530 536 PF00069 0.516
MOD_ProDKin_1 553 559 PF00069 0.495
MOD_ProDKin_1 639 645 PF00069 0.303
TRG_DiLeu_BaEn_1 286 291 PF01217 0.373
TRG_DiLeu_BaEn_1 502 507 PF01217 0.444
TRG_ENDOCYTIC_2 315 318 PF00928 0.307
TRG_ENDOCYTIC_2 326 329 PF00928 0.418
TRG_ENDOCYTIC_2 82 85 PF00928 0.390
TRG_ER_diArg_1 116 119 PF00400 0.429
TRG_LysEnd_GGAAcLL_1 680 686 PF00790 0.485
TRG_NES_CRM1_1 668 680 PF08389 0.479
TRG_NLS_MonoExtN_4 300 306 PF00514 0.420
TRG_Pf-PMV_PEXEL_1 118 122 PF00026 0.572
TRG_Pf-PMV_PEXEL_1 143 148 PF00026 0.617

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I862 Leptomonas seymouri 81% 100%
A0A0S4INJ7 Bodo saltans 57% 100%
A0A1X0NJ43 Trypanosomatidae 60% 100%
A0A3Q8ICR4 Leishmania donovani 100% 100%
A0A422P471 Trypanosoma rangeli 62% 100%
A4HD84 Leishmania braziliensis 89% 100%
A4HK88 Leishmania braziliensis 26% 100%
C9ZJC3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 26% 79%
D0A6Z5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 60% 100%
E9AWL7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
E9PYY5 Mus musculus 26% 85%
F1QHZ6 Danio rerio 28% 88%
Q16959 Heliocidaris crassispina 40% 98%
Q32KS2 Bos taurus 36% 98%
Q39578 Chlamydomonas reinhardtii 39% 100%
Q4QAV3 Leishmania major 97% 100%
Q4V8G4 Rattus norvegicus 25% 85%
Q5U4F6 Mus musculus 25% 100%
Q5VTH9 Homo sapiens 25% 81%
Q5XIL8 Rattus norvegicus 37% 97%
Q6GPB9 Xenopus laevis 28% 92%
Q8C0M8 Mus musculus 38% 98%
Q9UI46 Homo sapiens 38% 98%
V5BJK6 Trypanosoma cruzi 30% 83%
V5DSN6 Trypanosoma cruzi 60% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS