WD repeat protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

WD repeat protein

Gene product:

WD repeat protein

Species:

Leishmania infantum

UniProt:

E9AH35_LEIIN

TriTrypDb:

LINF_240007100

Length:

467

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AH35

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AH35

Function

Biological processes
Term	Name	Level	Count
GO:0006325	chromatin organization	4	1
GO:0006338	chromatin remodeling	5	1
GO:0006355	regulation of DNA-templated transcription	6	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0009987	cellular process	1	1
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0016043	cellular component organization	3	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0080090	regulation of primary metabolic process	4	1
GO:1903506	regulation of nucleic acid-templated transcription	7	1
GO:2001141	regulation of RNA biosynthetic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0042393	histone binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	143	145	PF00675	0.400
CLV_NRD_NRD_1	233	235	PF00675	0.544
CLV_NRD_NRD_1	45	47	PF00675	0.265
CLV_PCSK_KEX2_1	143	145	PF00082	0.400
CLV_PCSK_KEX2_1	216	218	PF00082	0.446
CLV_PCSK_KEX2_1	233	235	PF00082	0.522
CLV_PCSK_PC1ET2_1	216	218	PF00082	0.481
CLV_PCSK_SKI1_1	143	147	PF00082	0.375
CLV_PCSK_SKI1_1	399	403	PF00082	0.373
CLV_PCSK_SKI1_1	420	424	PF00082	0.366
CLV_PCSK_SKI1_1	461	465	PF00082	0.386
DEG_SPOP_SBC_1	165	169	PF00917	0.474
DEG_SPOP_SBC_1	318	322	PF00917	0.478
DOC_ANK_TNKS_1	232	239	PF00023	0.613
DOC_CYCLIN_RxL_1	396	404	PF00134	0.375
DOC_CYCLIN_yClb5_NLxxxL_5	50	56	PF00134	0.532
DOC_MAPK_DCC_7	155	164	PF00069	0.410
DOC_MAPK_gen_1	216	225	PF00069	0.558
DOC_MAPK_MEF2A_6	216	225	PF00069	0.507
DOC_USP7_MATH_1	165	169	PF00917	0.389
DOC_USP7_MATH_1	265	269	PF00917	0.374
DOC_USP7_MATH_1	318	322	PF00917	0.472
DOC_USP7_MATH_1	344	348	PF00917	0.437
DOC_USP7_MATH_1	363	367	PF00917	0.426
DOC_USP7_MATH_2	199	205	PF00917	0.593
DOC_USP7_UBL2_3	420	424	PF12436	0.490
DOC_WW_Pin1_4	309	314	PF00397	0.536
DOC_WW_Pin1_4	348	353	PF00397	0.340
DOC_WW_Pin1_4	62	67	PF00397	0.454
LIG_14-3-3_CanoR_1	302	310	PF00244	0.397
LIG_14-3-3_CanoR_1	331	341	PF00244	0.519
LIG_14-3-3_CanoR_1	373	381	PF00244	0.410
LIG_14-3-3_CanoR_1	41	46	PF00244	0.449
LIG_14-3-3_CanoR_1	418	423	PF00244	0.419
LIG_Actin_WH2_2	357	375	PF00022	0.474
LIG_BIR_III_4	362	366	PF00653	0.449
LIG_BRCT_BRCA1_1	365	369	PF00533	0.396
LIG_Clathr_ClatBox_1	56	60	PF01394	0.479
LIG_deltaCOP1_diTrp_1	434	439	PF00928	0.344
LIG_deltaCOP1_diTrp_1	60	70	PF00928	0.504
LIG_FHA_1	108	114	PF00498	0.549
LIG_FHA_1	122	128	PF00498	0.416
LIG_FHA_1	267	273	PF00498	0.415
LIG_FHA_1	320	326	PF00498	0.398
LIG_FHA_1	333	339	PF00498	0.384
LIG_FHA_1	427	433	PF00498	0.367
LIG_FHA_1	80	86	PF00498	0.454
LIG_FHA_1	9	15	PF00498	0.719
LIG_FHA_2	205	211	PF00498	0.484
LIG_FHA_2	224	230	PF00498	0.525
LIG_FHA_2	256	262	PF00498	0.465
LIG_FHA_2	309	315	PF00498	0.523
LIG_LIR_Apic_2	309	313	PF02991	0.406
LIG_LIR_Apic_2	60	66	PF02991	0.454
LIG_LIR_Gen_1	177	186	PF02991	0.459
LIG_LIR_Gen_1	95	106	PF02991	0.454
LIG_LIR_Nem_3	177	181	PF02991	0.409
LIG_LIR_Nem_3	289	294	PF02991	0.472
LIG_LIR_Nem_3	366	372	PF02991	0.349
LIG_LIR_Nem_3	95	101	PF02991	0.478
LIG_LYPXL_SIV_4	72	80	PF13949	0.432
LIG_PDZ_Class_2	462	467	PF00595	0.481
LIG_REV1ctd_RIR_1	367	377	PF16727	0.524
LIG_SH2_CRK	156	160	PF00017	0.413
LIG_SH2_GRB2like	326	329	PF00017	0.509
LIG_SH2_NCK_1	120	124	PF00017	0.568
LIG_SH2_NCK_1	156	160	PF00017	0.452
LIG_SH2_PTP2	98	101	PF00017	0.515
LIG_SH2_SRC	156	159	PF00017	0.488
LIG_SH2_STAT5	174	177	PF00017	0.355
LIG_SH2_STAT5	326	329	PF00017	0.509
LIG_SH2_STAT5	73	76	PF00017	0.513
LIG_SH2_STAT5	98	101	PF00017	0.454
LIG_SH3_1	155	161	PF00018	0.500
LIG_SH3_2	187	192	PF14604	0.521
LIG_SH3_3	11	17	PF00018	0.725
LIG_SH3_3	155	161	PF00018	0.500
LIG_SH3_3	184	190	PF00018	0.519
LIG_SH3_3	193	199	PF00018	0.487
LIG_SUMO_SIM_par_1	160	169	PF11976	0.369
LIG_TRAF2_1	206	209	PF00917	0.496
LIG_TRAF2_1	29	32	PF00917	0.615
LIG_TRAF2_1	35	38	PF00917	0.438
LIG_TRAF2_1	438	441	PF00917	0.501
LIG_UBA3_1	368	377	PF00899	0.432
MOD_CK1_1	121	127	PF00069	0.582
MOD_CK1_1	166	172	PF00069	0.395
MOD_CK1_1	204	210	PF00069	0.543
MOD_CK1_1	22	28	PF00069	0.635
MOD_CK1_1	266	272	PF00069	0.400
MOD_CK1_1	309	315	PF00069	0.452
MOD_CK1_1	449	455	PF00069	0.408
MOD_CK1_1	78	84	PF00069	0.559
MOD_CK2_1	204	210	PF00069	0.490
MOD_CK2_1	255	261	PF00069	0.531
MOD_CK2_1	32	38	PF00069	0.559
MOD_CK2_1	435	441	PF00069	0.435
MOD_GlcNHglycan	102	105	PF01048	0.265
MOD_GlcNHglycan	265	268	PF01048	0.361
MOD_GlcNHglycan	3	6	PF01048	0.709
MOD_GlcNHglycan	403	406	PF01048	0.329
MOD_GlcNHglycan	77	80	PF01048	0.328
MOD_GlcNHglycan	86	89	PF01048	0.319
MOD_GSK3_1	19	26	PF00069	0.644
MOD_GSK3_1	200	207	PF00069	0.515
MOD_GSK3_1	278	285	PF00069	0.494
MOD_GSK3_1	308	315	PF00069	0.437
MOD_GSK3_1	32	39	PF00069	0.482
MOD_GSK3_1	333	340	PF00069	0.488
MOD_GSK3_1	344	351	PF00069	0.267
MOD_GSK3_1	414	421	PF00069	0.415
MOD_GSK3_1	75	82	PF00069	0.554
MOD_GSK3_1	84	91	PF00069	0.507
MOD_N-GLC_1	278	283	PF02516	0.452
MOD_N-GLC_1	306	311	PF02516	0.520
MOD_N-GLC_1	414	419	PF02516	0.382
MOD_NEK2_1	1	6	PF00069	0.571
MOD_NEK2_1	102	107	PF00069	0.389
MOD_NEK2_1	163	168	PF00069	0.397
MOD_NEK2_1	176	181	PF00069	0.332
MOD_NEK2_1	254	259	PF00069	0.462
MOD_NEK2_1	308	313	PF00069	0.483
MOD_NEK2_1	372	377	PF00069	0.478
MOD_NEK2_1	401	406	PF00069	0.324
MOD_NEK2_1	435	440	PF00069	0.440
MOD_NEK2_1	86	91	PF00069	0.470
MOD_NEK2_2	36	41	PF00069	0.584
MOD_PIKK_1	107	113	PF00454	0.585
MOD_PIKK_1	19	25	PF00454	0.667
MOD_PIKK_1	301	307	PF00454	0.435
MOD_PKA_2	23	29	PF00069	0.598
MOD_PKA_2	232	238	PF00069	0.613
MOD_PKA_2	301	307	PF00069	0.378
MOD_PKA_2	372	378	PF00069	0.421
MOD_Plk_1	176	182	PF00069	0.410
MOD_Plk_1	306	312	PF00069	0.405
MOD_Plk_1	31	37	PF00069	0.645
MOD_Plk_1	387	393	PF00069	0.437
MOD_Plk_1	94	100	PF00069	0.505
MOD_Plk_2-3	32	38	PF00069	0.633
MOD_Plk_2-3	337	343	PF00069	0.467
MOD_Plk_4	312	318	PF00069	0.385
MOD_Plk_4	363	369	PF00069	0.342
MOD_Plk_4	418	424	PF00069	0.504
MOD_Plk_4	81	87	PF00069	0.461
MOD_Plk_4	94	100	PF00069	0.437
MOD_ProDKin_1	309	315	PF00069	0.529
MOD_ProDKin_1	348	354	PF00069	0.342
MOD_ProDKin_1	62	68	PF00069	0.454
TRG_DiLeu_BaLyEn_6	158	163	PF01217	0.421
TRG_ENDOCYTIC_2	156	159	PF00928	0.410
TRG_ENDOCYTIC_2	53	56	PF00928	0.454
TRG_ENDOCYTIC_2	98	101	PF00928	0.454
TRG_ER_diArg_1	143	145	PF00400	0.400
TRG_ER_diArg_1	458	461	PF00400	0.338
TRG_NES_CRM1_1	362	374	PF08389	0.499
TRG_Pf-PMV_PEXEL_1	144	148	PF00026	0.391
TRG_Pf-PMV_PEXEL_1	50	54	PF00026	0.265

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILV6	Leptomonas seymouri	79%	100%
A0A0S4J9M2	Bodo saltans	49%	94%
A0A1X0NIM0	Trypanosomatidae	57%	100%
A0A3Q8IMH5	Leishmania donovani	100%	79%
A0A3R7LDW9	Trypanosoma rangeli	59%	100%
A4HD80	Leishmania braziliensis	90%	100%
D0A6Z2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
E9AWL3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
O22466	Solanum lycopersicum	24%	100%
O22467	Arabidopsis thaliana	24%	100%
O22468	Arabidopsis thaliana	24%	100%
O22469	Arabidopsis thaliana	22%	100%
O22607	Arabidopsis thaliana	23%	92%
O93377	Xenopus laevis	25%	100%
O94244	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	100%
P0CS36	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	24%	100%
P0CS37	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	24%	100%
P13712	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	100%
P90916	Caenorhabditis elegans	25%	100%
P90917	Caenorhabditis elegans	25%	100%
Q09028	Homo sapiens	25%	100%
Q10G81	Oryza sativa subsp. japonica	24%	100%
Q16576	Homo sapiens	24%	100%
Q24572	Drosophila melanogaster	25%	100%
Q2UA71	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	23%	100%
Q3MHL3	Bos taurus	25%	100%
Q3SWX8	Bos taurus	24%	100%
Q4I7L0	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	23%	100%
Q4P553	Ustilago maydis (strain 521 / FGSC 9021)	26%	100%
Q4QAV7	Leishmania major	98%	100%
Q4R304	Macaca fascicularis	24%	100%
Q4WEI5	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	24%	100%
Q54SD4	Dictyostelium discoideum	23%	100%
Q5M7K4	Xenopus tropicalis	25%	100%
Q5R654	Pongo abelii	24%	100%
Q5RF92	Pongo abelii	25%	100%
Q60972	Mus musculus	25%	100%
Q60973	Mus musculus	24%	100%
Q61Y48	Caenorhabditis briggsae	25%	100%
Q6C7Q4	Yarrowia lipolytica (strain CLIB 122 / E 150)	22%	100%
Q6INH0	Xenopus laevis	25%	100%
Q6P315	Xenopus tropicalis	24%	100%
Q6P3H7	Danio rerio	25%	100%
Q71UF4	Rattus norvegicus	24%	100%
Q7S7N3	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	22%	100%
Q7ZTY4	Danio rerio	25%	100%
Q8AVH1	Xenopus laevis	25%	100%
Q8SRK1	Encephalitozoon cuniculi (strain GB-M1)	25%	100%
Q9I8G9	Gallus gallus	24%	100%
Q9W7I5	Gallus gallus	25%	100%
Q9Y825	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	100%
V5BAV4	Trypanosoma cruzi	60%	89%