Transcription elongation factor-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

transcription elongation factor-like protein

Species:

Leishmania infantum

UniProt:

E9AH31_LEIIN

TriTrypDb:

LINF_240006700

Length:

235

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AH31

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AH31

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	10
GO:0006351	DNA-templated transcription	7	10
GO:0006725	cellular aromatic compound metabolic process	3	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0009058	biosynthetic process	2	10
GO:0009059	macromolecule biosynthetic process	4	10
GO:0009987	cellular process	1	10
GO:0016070	RNA metabolic process	5	10
GO:0018130	heterocycle biosynthetic process	4	10
GO:0019438	aromatic compound biosynthetic process	4	10
GO:0032774	RNA biosynthetic process	5	10
GO:0034641	cellular nitrogen compound metabolic process	3	10
GO:0034654	nucleobase-containing compound biosynthetic process	4	10
GO:0043170	macromolecule metabolic process	3	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0044249	cellular biosynthetic process	3	10
GO:0044271	cellular nitrogen compound biosynthetic process	4	10
GO:0046483	heterocycle metabolic process	3	10
GO:0071704	organic substance metabolic process	2	10
GO:0090304	nucleic acid metabolic process	4	10
GO:0097659	nucleic acid-templated transcription	6	10
GO:1901360	organic cyclic compound metabolic process	3	10
GO:1901362	organic cyclic compound biosynthetic process	4	10
GO:1901576	organic substance biosynthetic process	3	10

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0003746	translation elongation factor activity	4	10
GO:0005488	binding	1	10
GO:0008135	translation factor activity, RNA binding	3	10
GO:0045182	translation regulator activity	1	10
GO:0090079	translation regulator activity, nucleic acid binding	2	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10
GO:0008270	zinc ion binding	6	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1
GO:0046914	transition metal ion binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	42	44	PF00675	0.564
CLV_NRD_NRD_1	70	72	PF00675	0.665
CLV_PCSK_KEX2_1	42	44	PF00082	0.589
CLV_PCSK_PC7_1	38	44	PF00082	0.564
CLV_PCSK_SKI1_1	120	124	PF00082	0.500
CLV_PCSK_SKI1_1	162	166	PF00082	0.526
CLV_PCSK_SKI1_1	83	87	PF00082	0.536
DOC_MAPK_gen_1	142	151	PF00069	0.347
DOC_MAPK_gen_1	225	233	PF00069	0.461
DOC_MAPK_gen_1	71	78	PF00069	0.569
DOC_PP4_FxxP_1	192	195	PF00568	0.372
DOC_USP7_UBL2_3	58	62	PF12436	0.507
DOC_WW_Pin1_4	217	222	PF00397	0.441
LIG_14-3-3_CanoR_1	120	129	PF00244	0.505
LIG_14-3-3_CanoR_1	183	189	PF00244	0.489
LIG_14-3-3_CanoR_1	207	214	PF00244	0.557
LIG_14-3-3_CanoR_1	228	234	PF00244	0.425
LIG_14-3-3_CanoR_1	38	46	PF00244	0.609
LIG_14-3-3_CanoR_1	53	59	PF00244	0.721
LIG_Actin_WH2_2	119	137	PF00022	0.463
LIG_BIR_II_1	1	5	PF00653	0.574
LIG_BRCT_BRCA1_1	229	233	PF00533	0.346
LIG_Clathr_ClatBox_1	148	152	PF01394	0.480
LIG_CtBP_PxDLS_1	145	149	PF00389	0.392
LIG_FHA_1	121	127	PF00498	0.462
LIG_FHA_1	207	213	PF00498	0.508
LIG_FHA_1	218	224	PF00498	0.363
LIG_FHA_2	191	197	PF00498	0.573
LIG_GBD_Chelix_1	19	27	PF00786	0.385
LIG_LIR_Apic_2	189	195	PF02991	0.316
LIG_LIR_Gen_1	201	211	PF02991	0.546
LIG_LIR_Nem_3	201	206	PF02991	0.503
LIG_PCNA_yPIPBox_3	183	192	PF02747	0.404
LIG_PTB_Apo_2	202	209	PF02174	0.414
LIG_SH2_GRB2like	203	206	PF00017	0.386
LIG_SH2_STAT5	180	183	PF00017	0.510
LIG_SUMO_SIM_anti_2	152	158	PF11976	0.488
LIG_SUMO_SIM_par_1	146	153	PF11976	0.495
LIG_SUMO_SIM_par_1	26	33	PF11976	0.593
MOD_CK1_1	137	143	PF00069	0.581
MOD_CK1_1	37	43	PF00069	0.663
MOD_CK1_1	4	10	PF00069	0.546
MOD_CK1_1	49	55	PF00069	0.609
MOD_CK1_1	60	66	PF00069	0.687
MOD_CK2_1	10	16	PF00069	0.632
MOD_CK2_1	190	196	PF00069	0.582
MOD_GlcNHglycan	139	142	PF01048	0.615
MOD_GlcNHglycan	55	58	PF01048	0.726
MOD_GlcNHglycan	65	68	PF01048	0.606
MOD_GlcNHglycan	88	91	PF01048	0.498
MOD_GlcNHglycan	9	12	PF01048	0.585
MOD_GlcNHglycan	94	97	PF01048	0.465
MOD_GSK3_1	1	8	PF00069	0.606
MOD_GSK3_1	186	193	PF00069	0.467
MOD_GSK3_1	30	37	PF00069	0.676
MOD_GSK3_1	45	52	PF00069	0.724
MOD_GSK3_1	53	60	PF00069	0.519
MOD_N-GLC_1	184	189	PF02516	0.403
MOD_NEK2_1	134	139	PF00069	0.534
MOD_NEK2_1	186	191	PF00069	0.418
MOD_NEK2_1	30	35	PF00069	0.472
MOD_NEK2_1	86	91	PF00069	0.536
MOD_NEK2_2	229	234	PF00069	0.370
MOD_PIKK_1	30	36	PF00454	0.530
MOD_PIKK_1	84	90	PF00454	0.439
MOD_PKA_2	134	140	PF00069	0.498
MOD_PKA_2	206	212	PF00069	0.501
MOD_PKA_2	227	233	PF00069	0.514
MOD_PKA_2	37	43	PF00069	0.546
MOD_PKA_2	52	58	PF00069	0.722
MOD_PKA_2	63	69	PF00069	0.712
MOD_Plk_1	152	158	PF00069	0.531
MOD_Plk_1	184	190	PF00069	0.444
MOD_Plk_4	134	140	PF00069	0.584
MOD_Plk_4	152	158	PF00069	0.495
MOD_Plk_4	219	225	PF00069	0.396
MOD_ProDKin_1	217	223	PF00069	0.435
TRG_DiLeu_BaEn_4	146	152	PF01217	0.406
TRG_ENDOCYTIC_2	203	206	PF00928	0.549
TRG_ER_diArg_1	109	112	PF00400	0.460
TRG_ER_diArg_1	142	145	PF00400	0.566
TRG_ER_diArg_1	42	44	PF00400	0.609
TRG_NES_CRM1_1	146	159	PF08389	0.407

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7Y9	Leptomonas seymouri	54%	100%
A0A1X0NIZ8	Trypanosomatidae	28%	97%
A0A1X0NJC1	Trypanosomatidae	36%	100%
A0A3R7MWP5	Trypanosoma rangeli	33%	100%
A0A3S7WY11	Leishmania donovani	100%	100%
E9AWK9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QAW1	Leishmania major	88%	100%
V5BVZ7	Trypanosoma cruzi	31%	92%