Putative ATPase domain protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATPase domain protein - putative

Species:

Leishmania infantum

UniProt:

E9AH29_LEIIN

TriTrypDb:

LINF_240006500

Length:

535

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AH29

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AH29

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0016462	pyrophosphatase activity	5	11
GO:0016787	hydrolase activity	2	11
GO:0016817	hydrolase activity, acting on acid anhydrides	3	11
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	11
GO:0016887	ATP hydrolysis activity	7	11
GO:0017076	purine nucleotide binding	4	11
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	177	179	PF00675	0.465
CLV_NRD_NRD_1	242	244	PF00675	0.735
CLV_NRD_NRD_1	345	347	PF00675	0.291
CLV_NRD_NRD_1	390	392	PF00675	0.349
CLV_NRD_NRD_1	463	465	PF00675	0.512
CLV_NRD_NRD_1	486	488	PF00675	0.470
CLV_NRD_NRD_1	527	529	PF00675	0.422
CLV_PCSK_KEX2_1	177	179	PF00082	0.465
CLV_PCSK_KEX2_1	242	244	PF00082	0.740
CLV_PCSK_KEX2_1	345	347	PF00082	0.326
CLV_PCSK_KEX2_1	390	392	PF00082	0.271
CLV_PCSK_KEX2_1	463	465	PF00082	0.512
CLV_PCSK_KEX2_1	527	529	PF00082	0.515
CLV_PCSK_PC7_1	341	347	PF00082	0.378
CLV_PCSK_SKI1_1	169	173	PF00082	0.615
CLV_PCSK_SKI1_1	177	181	PF00082	0.563
CLV_PCSK_SKI1_1	205	209	PF00082	0.456
CLV_PCSK_SKI1_1	236	240	PF00082	0.489
CLV_PCSK_SKI1_1	390	394	PF00082	0.271
CLV_PCSK_SKI1_1	487	491	PF00082	0.404
DEG_APCC_DBOX_1	176	184	PF00400	0.545
DEG_APCC_DBOX_1	389	397	PF00400	0.349
DEG_SPOP_SBC_1	135	139	PF00917	0.503
DEG_SPOP_SBC_1	85	89	PF00917	0.593
DOC_CDC14_PxL_1	434	442	PF14671	0.314
DOC_CYCLIN_yCln2_LP_2	100	106	PF00134	0.358
DOC_CYCLIN_yCln2_LP_2	124	127	PF00134	0.305
DOC_CYCLIN_yCln2_LP_2	62	68	PF00134	0.525
DOC_MAPK_gen_1	189	196	PF00069	0.489
DOC_MAPK_gen_1	262	271	PF00069	0.491
DOC_MAPK_gen_1	348	357	PF00069	0.314
DOC_MAPK_gen_1	427	437	PF00069	0.289
DOC_MAPK_gen_1	463	470	PF00069	0.415
DOC_MAPK_MEF2A_6	348	356	PF00069	0.271
DOC_PP2B_LxvP_1	124	127	PF13499	0.305
DOC_PP2B_LxvP_1	507	510	PF13499	0.391
DOC_PP2B_LxvP_1	62	65	PF13499	0.538
DOC_USP7_MATH_1	201	205	PF00917	0.576
DOC_USP7_MATH_1	245	249	PF00917	0.602
DOC_USP7_MATH_1	273	277	PF00917	0.553
DOC_USP7_MATH_1	32	36	PF00917	0.470
DOC_USP7_MATH_1	37	41	PF00917	0.469
DOC_USP7_MATH_1	478	482	PF00917	0.352
DOC_USP7_MATH_1	85	89	PF00917	0.509
DOC_USP7_UBL2_3	30	34	PF12436	0.453
DOC_WW_Pin1_4	197	202	PF00397	0.464
DOC_WW_Pin1_4	241	246	PF00397	0.621
DOC_WW_Pin1_4	274	279	PF00397	0.510
DOC_WW_Pin1_4	348	353	PF00397	0.363
DOC_WW_Pin1_4	66	71	PF00397	0.450
LIG_14-3-3_CanoR_1	178	184	PF00244	0.545
LIG_14-3-3_CanoR_1	262	272	PF00244	0.443
LIG_14-3-3_CanoR_1	309	316	PF00244	0.341
LIG_Actin_WH2_2	326	343	PF00022	0.271
LIG_Actin_WH2_2	482	498	PF00022	0.409
LIG_Actin_WH2_2	512	529	PF00022	0.484
LIG_BRCT_BRCA1_1	316	320	PF00533	0.414
LIG_deltaCOP1_diTrp_1	446	453	PF00928	0.371
LIG_EH1_1	262	270	PF00400	0.488
LIG_FHA_1	290	296	PF00498	0.370
LIG_FHA_1	349	355	PF00498	0.363
LIG_FHA_1	409	415	PF00498	0.324
LIG_FHA_2	309	315	PF00498	0.270
LIG_FHA_2	509	515	PF00498	0.402
LIG_LIR_Apic_2	433	439	PF02991	0.314
LIG_LIR_Gen_1	21	27	PF02991	0.377
LIG_LIR_Gen_1	450	459	PF02991	0.395
LIG_LIR_Gen_1	78	85	PF02991	0.482
LIG_LIR_Nem_3	21	26	PF02991	0.391
LIG_LIR_Nem_3	314	318	PF02991	0.338
LIG_LIR_Nem_3	326	332	PF02991	0.286
LIG_LIR_Nem_3	450	456	PF02991	0.385
LIG_LIR_Nem_3	78	84	PF02991	0.504
LIG_MYND_1	163	167	PF01753	0.424
LIG_MYND_1	99	103	PF01753	0.358
LIG_NRBOX	113	119	PF00104	0.537
LIG_NRBOX	392	398	PF00104	0.271
LIG_PCNA_yPIPBox_3	427	435	PF02747	0.335
LIG_PCNA_yPIPBox_3	483	496	PF02747	0.474
LIG_Pex14_1	448	452	PF04695	0.371
LIG_Pex14_1	77	81	PF04695	0.402
LIG_Pex14_2	452	456	PF04695	0.362
LIG_REV1ctd_RIR_1	450	459	PF16727	0.413
LIG_SH2_CRK	81	85	PF00017	0.433
LIG_SH2_NCK_1	81	85	PF00017	0.410
LIG_SH2_PTP2	436	439	PF00017	0.289
LIG_SH2_SRC	436	439	PF00017	0.314
LIG_SH2_STAP1	81	85	PF00017	0.410
LIG_SH2_STAT5	332	335	PF00017	0.296
LIG_SH2_STAT5	436	439	PF00017	0.289
LIG_SH2_STAT5	484	487	PF00017	0.393
LIG_SH3_3	180	186	PF00018	0.615
LIG_SH3_3	313	319	PF00018	0.428
LIG_SH3_3	432	438	PF00018	0.349
LIG_SH3_3	526	532	PF00018	0.475
LIG_SUMO_SIM_anti_2	110	116	PF11976	0.381
LIG_SUMO_SIM_anti_2	358	364	PF11976	0.284
LIG_SUMO_SIM_par_1	353	359	PF11976	0.289
LIG_SUMO_SIM_par_1	465	472	PF11976	0.361
LIG_TYR_ITIM	79	84	PF00017	0.425
LIG_UBA3_1	22	30	PF00899	0.402
LIG_WRC_WIRS_1	38	43	PF05994	0.439
MOD_CK1_1	146	152	PF00069	0.512
MOD_CK1_1	197	203	PF00069	0.640
MOD_CK1_1	287	293	PF00069	0.489
MOD_CK1_1	379	385	PF00069	0.350
MOD_CK1_1	40	46	PF00069	0.491
MOD_CK1_1	503	509	PF00069	0.540
MOD_CK1_1	87	93	PF00069	0.550
MOD_CK2_1	187	193	PF00069	0.678
MOD_CK2_1	508	514	PF00069	0.532
MOD_GlcNHglycan	145	148	PF01048	0.385
MOD_GlcNHglycan	196	199	PF01048	0.591
MOD_GlcNHglycan	299	302	PF01048	0.303
MOD_GlcNHglycan	378	381	PF01048	0.306
MOD_GlcNHglycan	405	409	PF01048	0.379
MOD_GlcNHglycan	42	45	PF01048	0.484
MOD_GlcNHglycan	502	505	PF01048	0.545
MOD_GSK3_1	197	204	PF00069	0.454
MOD_GSK3_1	217	224	PF00069	0.516
MOD_GSK3_1	241	248	PF00069	0.668
MOD_GSK3_1	263	270	PF00069	0.508
MOD_GSK3_1	284	291	PF00069	0.499
MOD_GSK3_1	323	330	PF00069	0.398
MOD_GSK3_1	33	40	PF00069	0.527
MOD_GSK3_1	375	382	PF00069	0.332
MOD_GSK3_1	404	411	PF00069	0.370
MOD_GSK3_1	80	87	PF00069	0.483
MOD_LATS_1	241	247	PF00433	0.688
MOD_N-GLC_2	211	213	PF02516	0.598
MOD_NEK2_1	117	122	PF00069	0.426
MOD_NEK2_1	136	141	PF00069	0.232
MOD_NEK2_1	179	184	PF00069	0.560
MOD_NEK2_1	187	192	PF00069	0.644
MOD_NEK2_1	194	199	PF00069	0.549
MOD_NEK2_1	284	289	PF00069	0.525
MOD_NEK2_1	327	332	PF00069	0.388
MOD_NEK2_1	386	391	PF00069	0.297
MOD_NEK2_1	469	474	PF00069	0.430
MOD_NEK2_1	519	524	PF00069	0.392
MOD_NEK2_2	18	23	PF00069	0.426
MOD_PIKK_1	146	152	PF00454	0.429
MOD_PIKK_1	245	251	PF00454	0.663
MOD_PIKK_1	381	387	PF00454	0.270
MOD_PIKK_1	438	444	PF00454	0.372
MOD_PK_1	102	108	PF00069	0.485
MOD_PKA_2	263	269	PF00069	0.339
MOD_PKA_2	308	314	PF00069	0.412
MOD_PKB_1	262	270	PF00069	0.488
MOD_Plk_1	18	24	PF00069	0.396
MOD_Plk_1	323	329	PF00069	0.335
MOD_Plk_1	72	78	PF00069	0.429
MOD_Plk_4	18	24	PF00069	0.418
MOD_Plk_4	264	270	PF00069	0.364
MOD_Plk_4	323	329	PF00069	0.371
MOD_Plk_4	430	436	PF00069	0.289
MOD_Plk_4	521	527	PF00069	0.377
MOD_ProDKin_1	197	203	PF00069	0.449
MOD_ProDKin_1	241	247	PF00069	0.618
MOD_ProDKin_1	274	280	PF00069	0.523
MOD_ProDKin_1	348	354	PF00069	0.363
MOD_ProDKin_1	66	72	PF00069	0.441
TRG_DiLeu_BaEn_2	18	24	PF01217	0.352
TRG_DiLeu_BaEn_2	233	239	PF01217	0.665
TRG_DiLeu_BaLyEn_6	175	180	PF01217	0.523
TRG_DiLeu_BaLyEn_6	96	101	PF01217	0.415
TRG_ENDOCYTIC_2	81	84	PF00928	0.429
TRG_ER_diArg_1	177	179	PF00400	0.465
TRG_ER_diArg_1	261	264	PF00400	0.493
TRG_ER_diArg_1	344	346	PF00400	0.353
TRG_ER_diArg_1	390	392	PF00400	0.349
TRG_ER_diArg_1	526	528	PF00400	0.412
TRG_NES_CRM1_1	206	217	PF08389	0.448
TRG_Pf-PMV_PEXEL_1	15	19	PF00026	0.470
TRG_Pf-PMV_PEXEL_1	169	173	PF00026	0.599
TRG_Pf-PMV_PEXEL_1	229	233	PF00026	0.590
TRG_Pf-PMV_PEXEL_1	331	335	PF00026	0.271

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTJ8	Leptomonas seymouri	63%	100%
A0A1X0NKH8	Trypanosomatidae	37%	100%
A0A3Q8IG04	Leishmania donovani	99%	100%
A0A3R7MBQ6	Trypanosoma rangeli	37%	100%
A4HD75	Leishmania braziliensis	84%	100%
D0A6Y7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	99%
E9AWK7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QAW3	Leishmania major	93%	100%
V5BRB9	Trypanosoma cruzi	37%	100%