Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

E9AH27_LEIIN

TriTrypDb:

LINF_240006300

Length:

289

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AH27

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AH27

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	41	45	PF00656	0.586
CLV_NRD_NRD_1	168	170	PF00675	0.477
CLV_NRD_NRD_1	33	35	PF00675	0.648
CLV_NRD_NRD_1	80	82	PF00675	0.484
CLV_PCSK_KEX2_1	256	258	PF00082	0.726
CLV_PCSK_KEX2_1	278	280	PF00082	0.677
CLV_PCSK_KEX2_1	33	35	PF00082	0.617
CLV_PCSK_KEX2_1	60	62	PF00082	0.690
CLV_PCSK_PC1ET2_1	256	258	PF00082	0.726
CLV_PCSK_PC1ET2_1	278	280	PF00082	0.677
CLV_PCSK_PC1ET2_1	60	62	PF00082	0.690
CLV_PCSK_SKI1_1	128	132	PF00082	0.623
CLV_PCSK_SKI1_1	169	173	PF00082	0.476
CLV_PCSK_SKI1_1	38	42	PF00082	0.575
CLV_PCSK_SKI1_1	64	68	PF00082	0.688
DEG_SPOP_SBC_1	28	32	PF00917	0.371
DOC_MAPK_gen_1	33	42	PF00069	0.715
DOC_PP4_FxxP_1	245	248	PF00568	0.551
DOC_USP7_MATH_1	121	125	PF00917	0.627
DOC_USP7_MATH_1	146	150	PF00917	0.474
DOC_USP7_MATH_1	154	158	PF00917	0.521
DOC_USP7_MATH_1	240	244	PF00917	0.608
LIG_14-3-3_CanoR_1	239	249	PF00244	0.705
LIG_14-3-3_CanoR_1	257	262	PF00244	0.534
LIG_14-3-3_CanoR_1	92	99	PF00244	0.598
LIG_AP2alpha_2	120	122	PF02296	0.630
LIG_BIR_II_1	1	5	PF00653	0.500
LIG_BRCT_BRCA1_1	107	111	PF00533	0.554
LIG_FHA_2	179	185	PF00498	0.476
LIG_FHA_2	39	45	PF00498	0.591
LIG_LIR_Apic_2	117	121	PF02991	0.564
LIG_LIR_Apic_2	243	248	PF02991	0.545
LIG_Pex14_1	118	122	PF04695	0.560
LIG_SH2_NCK_1	142	146	PF00017	0.412
LIG_SH2_SRC	142	145	PF00017	0.407
LIG_SH2_STAP1	142	146	PF00017	0.430
LIG_SH2_STAT5	103	106	PF00017	0.534
LIG_SH2_STAT5	231	234	PF00017	0.663
LIG_SH2_STAT5	78	81	PF00017	0.494
LIG_SH3_3	227	233	PF00018	0.531
LIG_SH3_3	48	54	PF00018	0.625
LIG_SUMO_SIM_par_1	38	45	PF11976	0.505
MOD_CK1_1	11	17	PF00069	0.565
MOD_CK1_1	124	130	PF00069	0.492
MOD_CK1_1	49	55	PF00069	0.672
MOD_CK2_1	146	152	PF00069	0.508
MOD_CK2_1	178	184	PF00069	0.487
MOD_GlcNHglycan	131	134	PF01048	0.592
MOD_GlcNHglycan	148	151	PF01048	0.632
MOD_GlcNHglycan	216	219	PF01048	0.683
MOD_GlcNHglycan	48	51	PF01048	0.630
MOD_GlcNHglycan	99	102	PF01048	0.558
MOD_GSK3_1	122	129	PF00069	0.591
MOD_GSK3_1	154	161	PF00069	0.513
MOD_GSK3_1	214	221	PF00069	0.594
MOD_GSK3_1	248	255	PF00069	0.606
MOD_GSK3_1	256	263	PF00069	0.635
MOD_GSK3_1	281	288	PF00069	0.643
MOD_GSK3_1	29	36	PF00069	0.493
MOD_GSK3_1	38	45	PF00069	0.451
MOD_GSK3_1	7	14	PF00069	0.546
MOD_GSK3_1	72	79	PF00069	0.486
MOD_GSK3_1	88	95	PF00069	0.439
MOD_N-GLC_1	263	268	PF02516	0.642
MOD_N-GLC_1	97	102	PF02516	0.524
MOD_NEK2_1	122	127	PF00069	0.587
MOD_NEK2_1	76	81	PF00069	0.651
MOD_NEK2_1	8	13	PF00069	0.569
MOD_NEK2_1	88	93	PF00069	0.443
MOD_NEK2_1	99	104	PF00069	0.486
MOD_PKA_1	256	262	PF00069	0.622
MOD_PKA_1	33	39	PF00069	0.596
MOD_PKA_2	122	128	PF00069	0.536
MOD_PKA_2	256	262	PF00069	0.747
MOD_PKA_2	33	39	PF00069	0.577
MOD_Plk_1	158	164	PF00069	0.538
MOD_Plk_1	55	61	PF00069	0.604
MOD_Plk_1	72	78	PF00069	0.420
MOD_Plk_4	281	287	PF00069	0.692
MOD_Plk_4	99	105	PF00069	0.516
MOD_SUMO_for_1	277	280	PF00179	0.592
TRG_DiLeu_BaEn_1	187	192	PF01217	0.509
TRG_ER_diArg_1	33	35	PF00400	0.628
TRG_Pf-PMV_PEXEL_1	92	96	PF00026	0.629

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PA94	Leptomonas seymouri	59%	100%
A0A0S4J4T0	Bodo saltans	31%	97%
A0A1X0NIP3	Trypanosomatidae	41%	100%
A0A3S7WY29	Leishmania donovani	100%	100%
A0A422P481	Trypanosoma rangeli	42%	100%
A4HD73	Leishmania braziliensis	81%	100%
D0A6Y5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9AWK5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QAW5	Leishmania major	93%	100%
V5DSP6	Trypanosoma cruzi	41%	100%