LeishMANIAdb
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Glycosomal membrane like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Glycosomal membrane like protein
Gene product:
glycosomal membrane like protein
Species:
Leishmania infantum
UniProt:
E9AH26_LEIIN
TriTrypDb:
LINF_240006200
Length:
220

Annotations

Annotations by Jardim et al.

Glycosome membrane, Peroxin 11 Glycosomal membrane like

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 12
NetGPI no yes: 0, no: 12
Cellular components
Term Name Level Count
GO:0016020 membrane 2 2
GO:0110165 cellular anatomical entity 1 2

Expansion

Sequence features

E9AH26
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AH26

Function

Biological processes
Term Name Level Count
GO:0006996 organelle organization 4 11
GO:0009987 cellular process 1 11
GO:0016043 cellular component organization 3 11
GO:0016559 peroxisome fission 6 11
GO:0048285 organelle fission 5 11
GO:0071840 cellular component organization or biogenesis 2 11
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 93 97 PF00656 0.388
CLV_PCSK_KEX2_1 146 148 PF00082 0.363
CLV_PCSK_KEX2_1 72 74 PF00082 0.338
CLV_PCSK_PC1ET2_1 146 148 PF00082 0.397
CLV_PCSK_PC1ET2_1 72 74 PF00082 0.337
CLV_PCSK_SKI1_1 120 124 PF00082 0.574
CLV_PCSK_SKI1_1 19 23 PF00082 0.292
CLV_PCSK_SKI1_1 78 82 PF00082 0.280
CLV_PCSK_SKI1_1 85 89 PF00082 0.308
DEG_APCC_DBOX_1 77 85 PF00400 0.520
DOC_CYCLIN_RxL_1 82 89 PF00134 0.388
DOC_MAPK_gen_1 146 154 PF00069 0.551
DOC_PP1_RVXF_1 53 60 PF00149 0.479
DOC_PP1_RVXF_1 76 83 PF00149 0.490
DOC_PP4_FxxP_1 104 107 PF00568 0.221
DOC_USP7_MATH_1 13 17 PF00917 0.545
DOC_USP7_MATH_1 198 202 PF00917 0.581
DOC_USP7_MATH_1 45 49 PF00917 0.492
DOC_WW_Pin1_4 106 111 PF00397 0.320
LIG_14-3-3_CanoR_1 55 60 PF00244 0.453
LIG_BIR_II_1 1 5 PF00653 0.560
LIG_FHA_1 168 174 PF00498 0.633
LIG_GBD_Chelix_1 3 11 PF00786 0.238
LIG_Integrin_RGD_1 147 149 PF01839 0.316
LIG_LIR_Gen_1 134 144 PF02991 0.235
LIG_LIR_Gen_1 89 100 PF02991 0.367
LIG_LIR_Nem_3 134 139 PF02991 0.313
LIG_LIR_Nem_3 89 95 PF02991 0.378
LIG_Pex14_2 100 104 PF04695 0.320
LIG_Pex14_2 88 92 PF04695 0.409
LIG_PTB_Apo_2 34 41 PF02174 0.422
LIG_PTB_Apo_2 94 101 PF02174 0.335
LIG_Rb_pABgroove_1 82 90 PF01858 0.388
LIG_REV1ctd_RIR_1 25 33 PF16727 0.488
LIG_SH2_CRK 136 140 PF00017 0.354
LIG_SH2_CRK 35 39 PF00017 0.461
LIG_SH2_STAP1 127 131 PF00017 0.428
LIG_SH2_STAT5 117 120 PF00017 0.300
LIG_SH3_2 142 147 PF14604 0.602
LIG_SH3_3 104 110 PF00018 0.311
LIG_SH3_3 136 142 PF00018 0.429
LIG_SUMO_SIM_par_1 131 137 PF11976 0.288
LIG_UBA3_1 56 65 PF00899 0.475
MOD_CK1_1 113 119 PF00069 0.312
MOD_CK1_1 58 64 PF00069 0.465
MOD_GlcNHglycan 162 165 PF01048 0.337
MOD_GlcNHglycan 184 187 PF01048 0.304
MOD_GlcNHglycan 200 203 PF01048 0.345
MOD_GSK3_1 106 113 PF00069 0.241
MOD_GSK3_1 198 205 PF00069 0.579
MOD_N-GLC_2 157 159 PF02516 0.299
MOD_N-GLC_2 167 169 PF02516 0.330
MOD_NEK2_1 152 157 PF00069 0.558
MOD_NEK2_1 40 45 PF00069 0.423
MOD_PIKK_1 110 116 PF00454 0.284
MOD_Plk_4 113 119 PF00069 0.317
MOD_Plk_4 55 61 PF00069 0.460
MOD_Plk_4 6 12 PF00069 0.520
MOD_ProDKin_1 106 112 PF00069 0.320
TRG_ENDOCYTIC_2 136 139 PF00928 0.371
TRG_Pf-PMV_PEXEL_1 85 89 PF00026 0.305

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IIQ6 Leptomonas seymouri 74% 100%
A0A1X0NJI5 Trypanosomatidae 33% 100%
A0A1X0NR15 Trypanosomatidae 31% 100%
A0A3Q8IB71 Leishmania donovani 100% 100%
A0A422P470 Trypanosoma rangeli 31% 100%
A4HD72 Leishmania braziliensis 86% 100%
A4HGT0 Leishmania braziliensis 25% 100%
D0A924 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 31% 100%
E9AWK4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
Q4QAW6 Leishmania major 95% 100%
V5BEE7 Trypanosoma cruzi 29% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS