LeishMANIAdb
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Ankyrin/TPR repeat protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Ankyrin/TPR repeat protein
Gene product:
ankyrin/TPR repeat protein
Species:
Leishmania infantum
UniProt:
E9AH25_LEIIN
TriTrypDb:
LINF_240006100
Length:
394

Annotations

Annotations by Jardim et al.

Structural Proteins, Ankyrin/TPR repeat

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) yes yes: 3
Silverman et al. no yes: 0
Pissara et al. no yes: 8
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 7
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AH25
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AH25

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 220 224 PF00656 0.269
CLV_C14_Caspase3-7 73 77 PF00656 0.483
CLV_NRD_NRD_1 349 351 PF00675 0.392
CLV_PCSK_KEX2_1 272 274 PF00082 0.457
CLV_PCSK_PC1ET2_1 272 274 PF00082 0.477
CLV_PCSK_SKI1_1 28 32 PF00082 0.514
CLV_PCSK_SKI1_1 295 299 PF00082 0.402
CLV_PCSK_SKI1_1 346 350 PF00082 0.399
CLV_PCSK_SKI1_1 351 355 PF00082 0.365
CLV_PCSK_SKI1_1 390 394 PF00082 0.492
CLV_PCSK_SKI1_1 61 65 PF00082 0.359
CLV_Separin_Metazoa 58 62 PF03568 0.269
DEG_Nend_UBRbox_2 1 3 PF02207 0.595
DOC_CYCLIN_RxL_1 58 65 PF00134 0.359
DOC_MAPK_gen_1 188 195 PF00069 0.378
DOC_MAPK_gen_1 295 304 PF00069 0.393
DOC_MAPK_gen_1 350 358 PF00069 0.500
DOC_MAPK_MEF2A_6 298 306 PF00069 0.391
DOC_PP4_FxxP_1 166 169 PF00568 0.390
DOC_USP7_MATH_1 150 154 PF00917 0.372
DOC_USP7_MATH_1 17 21 PF00917 0.537
DOC_USP7_MATH_1 235 239 PF00917 0.429
DOC_USP7_MATH_1 24 28 PF00917 0.544
DOC_USP7_UBL2_3 261 265 PF12436 0.482
DOC_USP7_UBL2_3 390 394 PF12436 0.532
DOC_WW_Pin1_4 210 215 PF00397 0.338
DOC_WW_Pin1_4 243 248 PF00397 0.338
DOC_WW_Pin1_4 76 81 PF00397 0.338
LIG_14-3-3_CanoR_1 350 358 PF00244 0.454
LIG_APCC_ABBA_1 302 307 PF00400 0.401
LIG_CtBP_PxDLS_1 247 251 PF00389 0.450
LIG_deltaCOP1_diTrp_1 341 348 PF00928 0.363
LIG_FHA_1 299 305 PF00498 0.385
LIG_FHA_1 307 313 PF00498 0.394
LIG_FHA_1 77 83 PF00498 0.301
LIG_FHA_2 244 250 PF00498 0.462
LIG_FHA_2 375 381 PF00498 0.503
LIG_LIR_Apic_2 165 169 PF02991 0.415
LIG_LIR_Gen_1 179 190 PF02991 0.382
LIG_LIR_Nem_3 179 185 PF02991 0.364
LIG_LIR_Nem_3 386 392 PF02991 0.539
LIG_Pex14_1 344 348 PF04695 0.390
LIG_Pex14_2 182 186 PF04695 0.378
LIG_Pex14_2 322 326 PF04695 0.506
LIG_PTB_Apo_2 320 327 PF02174 0.414
LIG_SH2_CRK 45 49 PF00017 0.469
LIG_SH2_GRB2like 314 317 PF00017 0.391
LIG_SH2_GRB2like 321 324 PF00017 0.362
LIG_SH2_STAP1 116 120 PF00017 0.450
LIG_SH2_STAP1 164 168 PF00017 0.406
LIG_SH2_STAP1 300 304 PF00017 0.385
LIG_SH2_STAP1 314 318 PF00017 0.361
LIG_SH2_STAP1 361 365 PF00017 0.509
LIG_SH2_STAT3 321 324 PF00017 0.393
LIG_SH2_STAT5 122 125 PF00017 0.339
LIG_SH2_STAT5 300 303 PF00017 0.389
LIG_SH2_STAT5 321 324 PF00017 0.400
LIG_SH2_STAT5 327 330 PF00017 0.383
LIG_SH3_3 339 345 PF00018 0.454
LIG_UBA3_1 128 135 PF00899 0.450
LIG_UBA3_1 181 189 PF00899 0.404
MOD_CK1_1 109 115 PF00069 0.424
MOD_CK1_1 20 26 PF00069 0.489
MOD_GlcNHglycan 108 111 PF01048 0.431
MOD_GlcNHglycan 152 155 PF01048 0.380
MOD_GlcNHglycan 236 240 PF01048 0.372
MOD_GSK3_1 104 111 PF00069 0.443
MOD_GSK3_1 138 145 PF00069 0.530
MOD_GSK3_1 176 183 PF00069 0.372
MOD_GSK3_1 20 27 PF00069 0.494
MOD_GSK3_1 359 366 PF00069 0.532
MOD_N-GLC_1 254 259 PF02516 0.562
MOD_NEK2_1 229 234 PF00069 0.360
MOD_NEK2_2 133 138 PF00069 0.447
MOD_NEK2_2 300 305 PF00069 0.449
MOD_OFUCOSY 226 233 PF10250 0.437
MOD_PIKK_1 366 372 PF00454 0.520
MOD_PKA_1 359 365 PF00069 0.529
MOD_PKA_2 20 26 PF00069 0.450
MOD_Plk_1 24 30 PF00069 0.494
MOD_Plk_4 133 139 PF00069 0.500
MOD_Plk_4 142 148 PF00069 0.392
MOD_Plk_4 158 164 PF00069 0.450
MOD_ProDKin_1 210 216 PF00069 0.338
MOD_ProDKin_1 243 249 PF00069 0.338
MOD_ProDKin_1 76 82 PF00069 0.338
MOD_SUMO_for_1 384 387 PF00179 0.540
MOD_SUMO_rev_2 238 247 PF00179 0.488
TRG_DiLeu_BaEn_1 142 147 PF01217 0.450
TRG_DiLeu_BaEn_1 225 230 PF01217 0.338
TRG_DiLeu_BaEn_1 32 37 PF01217 0.443
TRG_DiLeu_BaEn_1 58 63 PF01217 0.405
TRG_DiLeu_BaEn_2 190 196 PF01217 0.354
TRG_DiLeu_BaLyEn_6 124 129 PF01217 0.392
TRG_DiLeu_LyEn_5 225 230 PF01217 0.450
TRG_DiLeu_LyEn_5 58 63 PF01217 0.405
TRG_ENDOCYTIC_2 45 48 PF00928 0.470
TRG_Pf-PMV_PEXEL_1 127 131 PF00026 0.335
TRG_Pf-PMV_PEXEL_1 28 32 PF00026 0.544
TRG_Pf-PMV_PEXEL_1 61 65 PF00026 0.359

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I340 Leptomonas seymouri 84% 100%
A0A0S4ILI7 Bodo saltans 23% 100%
A0A0S4J2H9 Bodo saltans 28% 69%
A0A0S4J875 Bodo saltans 23% 89%
A0A0S4JCJ8 Bodo saltans 26% 87%
A0A1X0NIN0 Trypanosomatidae 65% 100%
A0A3Q8ICQ2 Leishmania donovani 99% 100%
A0A3R7N419 Trypanosoma rangeli 62% 100%
A4HD71 Leishmania braziliensis 87% 100%
A6NHY2 Homo sapiens 23% 75%
C7B178 Petunia hybrida 30% 74%
C9ZRD5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 27% 95%
D0A6Y4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 61% 100%
E5RJM6 Homo sapiens 29% 99%
E9AWK3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
Q08DV6 Bos taurus 30% 75%
Q14DN9 Mus musculus 22% 76%
Q15653 Homo sapiens 26% 100%
Q337A0 Oryza sativa subsp. japonica 31% 76%
Q3V096 Mus musculus 24% 75%
Q495B1 Homo sapiens 27% 75%
Q4FE45 Arabidopsis thaliana 27% 77%
Q4QAW7 Leishmania major 96% 100%
Q5UPG5 Acanthamoeba polyphaga mimivirus 26% 94%
Q60778 Mus musculus 25% 100%
Q6KAE5 Oryza sativa subsp. japonica 30% 79%
Q6NLQ8 Arabidopsis thaliana 28% 78%
Q7EZ44 Oryza sativa subsp. japonica 31% 80%
Q8HXA6 Bos taurus 27% 67%
Q8N9B4 Homo sapiens 25% 100%
Q8Q0U0 Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) 28% 100%
Q9GKW8 Macaca fascicularis 25% 84%
Q9J516 Fowlpox virus (strain NVSL) 23% 91%
Q9J5G9 Fowlpox virus (strain NVSL) 27% 95%
Q9J5H7 Fowlpox virus (strain NVSL) 26% 66%
Q9J5I7 Fowlpox virus (strain NVSL) 25% 90%
Q9JIA3 Rattus norvegicus 26% 100%
Q9SAR5 Arabidopsis thaliana 27% 100%
Q9WV72 Mus musculus 29% 75%
Q9Y575 Homo sapiens 29% 76%
V5BW01 Trypanosoma cruzi 63% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS