DUF3592 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

E9AH21_LEIIN

TriTrypDb:

LINF_240005700

Length:

228

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0005739	mitochondrion	5	1
GO:0020023	kinetoplast	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

E9AH21

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AH21

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	17	19	PF00675	0.462
CLV_NRD_NRD_1	188	190	PF00675	0.428
CLV_NRD_NRD_1	73	75	PF00675	0.514
CLV_PCSK_KEX2_1	97	99	PF00082	0.548
CLV_PCSK_PC1ET2_1	97	99	PF00082	0.548
CLV_PCSK_SKI1_1	14	18	PF00082	0.373
DEG_Nend_Nbox_1	1	3	PF02207	0.651
DOC_CDC14_PxL_1	128	136	PF14671	0.282
DOC_CYCLIN_RxL_1	11	20	PF00134	0.629
DOC_MAPK_gen_1	196	202	PF00069	0.705
DOC_PP1_RVXF_1	12	18	PF00149	0.523
DOC_PP1_RVXF_1	197	203	PF00149	0.678
DOC_WW_Pin1_4	105	110	PF00397	0.271
LIG_14-3-3_CanoR_1	139	143	PF00244	0.296
LIG_14-3-3_CanoR_1	62	71	PF00244	0.344
LIG_Actin_WH2_2	174	191	PF00022	0.536
LIG_APCC_ABBAyCdc20_2	139	145	PF00400	0.296
LIG_FHA_2	119	125	PF00498	0.272
LIG_LIR_Nem_3	163	169	PF02991	0.379
LIG_Pex14_2	162	166	PF04695	0.315
LIG_Pex14_2	169	173	PF04695	0.261
LIG_SH2_CRK	119	123	PF00017	0.340
LIG_SH2_CRK	13	17	PF00017	0.616
LIG_SH2_CRK	51	55	PF00017	0.273
LIG_SH2_CRK	78	82	PF00017	0.269
LIG_SH2_GRB2like	44	47	PF00017	0.323
LIG_SH2_NCK_1	119	123	PF00017	0.340
LIG_SH2_PTP2	80	83	PF00017	0.269
LIG_SH2_SRC	205	208	PF00017	0.728
LIG_SH2_SRC	80	83	PF00017	0.340
LIG_SH2_STAP1	86	90	PF00017	0.282
LIG_SH2_STAT5	127	130	PF00017	0.282
LIG_SH2_STAT5	44	47	PF00017	0.340
LIG_SH2_STAT5	80	83	PF00017	0.270
LIG_SH2_STAT5	99	102	PF00017	0.359
LIG_SH3_1	205	211	PF00018	0.706
LIG_SH3_2	211	216	PF14604	0.740
LIG_SH3_3	205	211	PF00018	0.654
LIG_SH3_3	212	218	PF00018	0.674
LIG_SH3_3	29	35	PF00018	0.447
LIG_TYR_ITIM	76	81	PF00017	0.282
LIG_UBA3_1	70	75	PF00899	0.296
MOD_CDC14_SPxK_1	108	111	PF00782	0.271
MOD_CDK_SPxK_1	105	111	PF00069	0.271
MOD_CK1_1	102	108	PF00069	0.238
MOD_CK2_1	118	124	PF00069	0.277
MOD_Cter_Amidation	95	98	PF01082	0.491
MOD_GlcNHglycan	152	155	PF01048	0.482
MOD_GlcNHglycan	54	57	PF01048	0.501
MOD_GlcNHglycan	8	11	PF01048	0.374
MOD_GSK3_1	158	165	PF00069	0.274
MOD_GSK3_1	98	105	PF00069	0.278
MOD_NEK2_1	162	167	PF00069	0.282
MOD_PIKK_1	63	69	PF00454	0.362
MOD_PKA_1	5	11	PF00069	0.674
MOD_PKA_2	102	108	PF00069	0.282
MOD_PKA_2	138	144	PF00069	0.296
MOD_Plk_1	162	168	PF00069	0.276
MOD_Plk_2-3	120	126	PF00069	0.313
MOD_Plk_2-3	158	164	PF00069	0.281
MOD_Plk_4	138	144	PF00069	0.282
MOD_ProDKin_1	105	111	PF00069	0.271
MOD_SUMO_for_1	88	91	PF00179	0.334
MOD_SUMO_rev_2	141	149	PF00179	0.362
TRG_DiLeu_BaLyEn_6	171	176	PF01217	0.378
TRG_ENDOCYTIC_2	119	122	PF00928	0.340
TRG_ENDOCYTIC_2	13	16	PF00928	0.564
TRG_ENDOCYTIC_2	51	54	PF00928	0.248
TRG_ENDOCYTIC_2	78	81	PF00928	0.282
TRG_ER_diArg_1	198	201	PF00400	0.646
TRG_NLS_MonoExtN_4	194	200	PF00514	0.684

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P429	Leptomonas seymouri	84%	100%
A0A0S4J094	Bodo saltans	68%	100%
A0A1X0NJD4	Trypanosomatidae	76%	100%
A0A3R7KS59	Trypanosoma rangeli	72%	100%
A0A3S7WXZ8	Leishmania donovani	99%	100%
A4HD67	Leishmania braziliensis	90%	100%
D0A6Y0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	74%	100%
E9AWJ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4QAX1	Leishmania major	94%	100%