LeishMANIAdb
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Nucleoside 2-deoxyribosyltransferase

Quick info Annotations Function or PPIs Localization Phosphorylation Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Nucleoside 2-deoxyribosyltransferase
Gene product:
Nucleoside 2-deoxyribosyltransferase - putative
Species:
Leishmania infantum
UniProt:
E9AH20_LEIIN
TriTrypDb:
LINF_230026500
Length:
155

Annotations

Annotations by Jardim et al.

Intracellular signaling, Nucleoside 2-deoxyribosyltransferase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) yes yes: 2
Forrest at al. (procyclic) yes yes: 2
Silverman et al. no yes: 2
Pissara et al. yes yes: 6
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 5
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Phosphorylation

Amastigote: 71

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

E9AH20
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AH20

PDB structure(s): 6qai_A , 6qai_B

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 1
GO:0006725 cellular aromatic compound metabolic process 3 1
GO:0006753 nucleoside phosphate metabolic process 4 1
GO:0006793 phosphorus metabolic process 3 1
GO:0006796 phosphate-containing compound metabolic process 4 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0009056 catabolic process 2 1
GO:0009123 nucleoside monophosphate metabolic process 5 1
GO:0009125 nucleoside monophosphate catabolic process 6 1
GO:0009159 deoxyribonucleoside monophosphate catabolic process 7 1
GO:0009162 deoxyribonucleoside monophosphate metabolic process 6 1
GO:0009987 cellular process 1 1
GO:0019439 aromatic compound catabolic process 4 1
GO:0019637 organophosphate metabolic process 3 1
GO:0034641 cellular nitrogen compound metabolic process 3 1
GO:0034655 nucleobase-containing compound catabolic process 4 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0044248 cellular catabolic process 3 1
GO:0044270 cellular nitrogen compound catabolic process 4 1
GO:0044281 small molecule metabolic process 2 1
GO:0046434 organophosphate catabolic process 4 1
GO:0046483 heterocycle metabolic process 3 1
GO:0046700 heterocycle catabolic process 4 1
GO:0055086 nucleobase-containing small molecule metabolic process 3 1
GO:0071704 organic substance metabolic process 2 1
GO:1901292 nucleoside phosphate catabolic process 5 1
GO:1901360 organic cyclic compound metabolic process 3 1
GO:1901361 organic cyclic compound catabolic process 4 1
GO:1901575 organic substance catabolic process 3 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 6
GO:0016787 hydrolase activity 2 1
GO:0016798 hydrolase activity, acting on glycosyl bonds 3 1
GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 4 1
GO:0070694 deoxyribonucleoside 5'-monophosphate N-glycosidase activity 5 1
GO:0016740 transferase activity 2 5
GO:0016757 glycosyltransferase activity 3 1
GO:0016763 pentosyltransferase activity 4 1
GO:0050144 nucleoside deoxyribosyltransferase activity 5 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 113 117 PF00656 0.395
CLV_PCSK_SKI1_1 94 98 PF00082 0.230
DOC_CKS1_1 1 6 PF01111 0.370
DOC_CYCLIN_RxL_1 91 101 PF00134 0.486
DOC_MAPK_DCC_7 32 42 PF00069 0.517
DOC_MAPK_gen_1 32 39 PF00069 0.486
DOC_MAPK_MEF2A_6 34 42 PF00069 0.520
DOC_PP4_FxxP_1 123 126 PF00568 0.444
DOC_USP7_MATH_1 72 76 PF00917 0.430
DOC_WW_Pin1_4 68 73 PF00397 0.419
LIG_BIR_II_1 1 5 PF00653 0.443
LIG_BIR_III_1 1 5 PF00653 0.450
LIG_BIR_III_3 1 5 PF00653 0.450
LIG_Clathr_ClatBox_1 39 43 PF01394 0.423
LIG_FHA_1 4 10 PF00498 0.275
LIG_FHA_1 45 51 PF00498 0.503
LIG_FHA_2 80 86 PF00498 0.419
LIG_LIR_Apic_2 121 126 PF02991 0.444
LIG_LIR_Gen_1 135 146 PF02991 0.383
LIG_LIR_Gen_1 21 31 PF02991 0.488
LIG_LIR_Nem_3 135 141 PF02991 0.349
LIG_LIR_Nem_3 142 148 PF02991 0.318
LIG_LIR_Nem_3 21 27 PF02991 0.488
LIG_NRBOX 91 97 PF00104 0.419
LIG_Pex14_2 123 127 PF04695 0.444
LIG_Pex14_2 141 145 PF04695 0.323
LIG_SH2_CRK 24 28 PF00017 0.465
LIG_SH2_GRB2like 23 26 PF00017 0.470
LIG_SH2_STAP1 88 92 PF00017 0.465
LIG_SH2_STAT5 8 11 PF00017 0.419
LIG_SH3_3 11 17 PF00018 0.470
LIG_SH3_3 35 41 PF00018 0.419
LIG_WRC_WIRS_1 138 143 PF05994 0.339
LIG_WRC_WIRS_1 96 101 PF05994 0.486
MOD_CDC14_SPxK_1 71 74 PF00782 0.419
MOD_CDK_SPxK_1 68 74 PF00069 0.419
MOD_CK1_1 100 106 PF00069 0.506
MOD_CK2_1 79 85 PF00069 0.439
MOD_GSK3_1 44 51 PF00069 0.419
MOD_GSK3_1 68 75 PF00069 0.459
MOD_NEK2_1 95 100 PF00069 0.513
MOD_NEK2_2 48 53 PF00069 0.419
MOD_Plk_2-3 116 122 PF00069 0.514
MOD_Plk_4 3 9 PF00069 0.524
MOD_ProDKin_1 68 74 PF00069 0.419
TRG_DiLeu_BaLyEn_6 35 40 PF01217 0.449
TRG_ENDOCYTIC_2 24 27 PF00928 0.419
TRG_Pf-PMV_PEXEL_1 28 33 PF00026 0.317

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HZ26 Leptomonas seymouri 75% 100%
A0A1X0NWK1 Trypanosomatidae 66% 99%
A0A3R7L3D6 Trypanosoma rangeli 73% 100%
A0A3R7MAG4 Trypanosoma rangeli 68% 79%
A0A3S7WY56 Leishmania donovani 99% 100%
A0A422N0V5 Trypanosoma rangeli 69% 100%
A4HD42 Leishmania braziliensis 82% 100%
C9ZNS0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 69% 100%
E9AWJ0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
Q4QAY0 Leishmania major 96% 100%
Q9Y7P9 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 38% 73%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS