Nucleoside 2-deoxyribosyltransferase

Quick info Annotations Localization Phosphorylation Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nucleoside 2-deoxyribosyltransferase - putative

Species:

Leishmania infantum

UniProt:

E9AH20_LEIIN

TriTrypDb:

LINF_230026500

Length:

155

Annotations

Annotations by Jardim et al.

Intracellular signaling, Nucleoside 2-deoxyribosyltransferase

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	yes	yes: 2
Forrest at al. (procyclic)	yes	yes: 2
Silverman et al.	no	yes: 2
Pissara et al.	yes	yes: 6

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 5

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Phosphorylation

Amastigote: 71

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

E9AH20

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AH20

PDB structure(s): 6qai_A , 6qai_B

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006753	nucleoside phosphate metabolic process	4	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009123	nucleoside monophosphate metabolic process	5	1
GO:0009125	nucleoside monophosphate catabolic process	6	1
GO:0009159	deoxyribonucleoside monophosphate catabolic process	7	1
GO:0009162	deoxyribonucleoside monophosphate metabolic process	6	1
GO:0009987	cellular process	1	1
GO:0019439	aromatic compound catabolic process	4	1
GO:0019637	organophosphate metabolic process	3	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034655	nucleobase-containing compound catabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044270	cellular nitrogen compound catabolic process	4	1
GO:0044281	small molecule metabolic process	2	1
GO:0046434	organophosphate catabolic process	4	1
GO:0046483	heterocycle metabolic process	3	1
GO:0046700	heterocycle catabolic process	4	1
GO:0055086	nucleobase-containing small molecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901292	nucleoside phosphate catabolic process	5	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901361	organic cyclic compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0016787	hydrolase activity	2	1
GO:0016798	hydrolase activity, acting on glycosyl bonds	3	1
GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds	4	1
GO:0070694	deoxyribonucleoside 5'-monophosphate N-glycosidase activity	5	1
GO:0016740	transferase activity	2	5
GO:0016757	glycosyltransferase activity	3	1
GO:0016763	pentosyltransferase activity	4	1
GO:0050144	nucleoside deoxyribosyltransferase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	113	117	PF00656	0.395
CLV_PCSK_SKI1_1	94	98	PF00082	0.230
DOC_CKS1_1	1	6	PF01111	0.370
DOC_CYCLIN_RxL_1	91	101	PF00134	0.486
DOC_MAPK_DCC_7	32	42	PF00069	0.517
DOC_MAPK_gen_1	32	39	PF00069	0.486
DOC_MAPK_MEF2A_6	34	42	PF00069	0.520
DOC_PP4_FxxP_1	123	126	PF00568	0.444
DOC_USP7_MATH_1	72	76	PF00917	0.430
DOC_WW_Pin1_4	68	73	PF00397	0.419
LIG_BIR_II_1	1	5	PF00653	0.443
LIG_BIR_III_1	1	5	PF00653	0.450
LIG_BIR_III_3	1	5	PF00653	0.450
LIG_Clathr_ClatBox_1	39	43	PF01394	0.423
LIG_FHA_1	4	10	PF00498	0.275
LIG_FHA_1	45	51	PF00498	0.503
LIG_FHA_2	80	86	PF00498	0.419
LIG_LIR_Apic_2	121	126	PF02991	0.444
LIG_LIR_Gen_1	135	146	PF02991	0.383
LIG_LIR_Gen_1	21	31	PF02991	0.488
LIG_LIR_Nem_3	135	141	PF02991	0.349
LIG_LIR_Nem_3	142	148	PF02991	0.318
LIG_LIR_Nem_3	21	27	PF02991	0.488
LIG_NRBOX	91	97	PF00104	0.419
LIG_Pex14_2	123	127	PF04695	0.444
LIG_Pex14_2	141	145	PF04695	0.323
LIG_SH2_CRK	24	28	PF00017	0.465
LIG_SH2_GRB2like	23	26	PF00017	0.470
LIG_SH2_STAP1	88	92	PF00017	0.465
LIG_SH2_STAT5	8	11	PF00017	0.419
LIG_SH3_3	11	17	PF00018	0.470
LIG_SH3_3	35	41	PF00018	0.419
LIG_WRC_WIRS_1	138	143	PF05994	0.339
LIG_WRC_WIRS_1	96	101	PF05994	0.486
MOD_CDC14_SPxK_1	71	74	PF00782	0.419
MOD_CDK_SPxK_1	68	74	PF00069	0.419
MOD_CK1_1	100	106	PF00069	0.506
MOD_CK2_1	79	85	PF00069	0.439
MOD_GSK3_1	44	51	PF00069	0.419
MOD_GSK3_1	68	75	PF00069	0.459
MOD_NEK2_1	95	100	PF00069	0.513
MOD_NEK2_2	48	53	PF00069	0.419
MOD_Plk_2-3	116	122	PF00069	0.514
MOD_Plk_4	3	9	PF00069	0.524
MOD_ProDKin_1	68	74	PF00069	0.419
TRG_DiLeu_BaLyEn_6	35	40	PF01217	0.449
TRG_ENDOCYTIC_2	24	27	PF00928	0.419
TRG_Pf-PMV_PEXEL_1	28	33	PF00026	0.317

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZ26	Leptomonas seymouri	75%	100%
A0A1X0NWK1	Trypanosomatidae	66%	99%
A0A3R7L3D6	Trypanosoma rangeli	73%	100%
A0A3R7MAG4	Trypanosoma rangeli	68%	79%
A0A3S7WY56	Leishmania donovani	99%	100%
A0A422N0V5	Trypanosoma rangeli	69%	100%
A4HD42	Leishmania braziliensis	82%	100%
C9ZNS0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	100%
E9AWJ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4QAY0	Leishmania major	96%	100%
Q9Y7P9	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	38%	73%