Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

E9AH18_LEIIN

TriTrypDb:

LINF_230026300

Length:

339

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AH18

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AH18

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	318	320	PF00675	0.414
CLV_NRD_NRD_1	74	76	PF00675	0.463
CLV_PCSK_KEX2_1	263	265	PF00082	0.494
CLV_PCSK_KEX2_1	76	78	PF00082	0.469
CLV_PCSK_PC1ET2_1	263	265	PF00082	0.541
CLV_PCSK_PC1ET2_1	76	78	PF00082	0.565
CLV_PCSK_SKI1_1	167	171	PF00082	0.560
CLV_PCSK_SKI1_1	252	256	PF00082	0.433
CLV_PCSK_SKI1_1	275	279	PF00082	0.482
CLV_PCSK_SKI1_1	77	81	PF00082	0.449
CLV_Separin_Metazoa	272	276	PF03568	0.516
DEG_Nend_Nbox_1	1	3	PF02207	0.577
DEG_SCF_FBW7_1	85	92	PF00400	0.598
DOC_CKS1_1	86	91	PF01111	0.614
DOC_CYCLIN_RxL_1	164	174	PF00134	0.525
DOC_CYCLIN_yCln2_LP_2	273	279	PF00134	0.585
DOC_MAPK_gen_1	263	273	PF00069	0.520
DOC_MAPK_RevD_3	61	77	PF00069	0.486
DOC_PP2B_LxvP_1	51	54	PF13499	0.506
DOC_PP4_FxxP_1	307	310	PF00568	0.536
DOC_PP4_MxPP_1	82	85	PF00568	0.378
DOC_USP7_MATH_1	26	30	PF00917	0.551
DOC_USP7_MATH_1	315	319	PF00917	0.587
DOC_USP7_MATH_1	334	338	PF00917	0.497
DOC_USP7_MATH_1	54	58	PF00917	0.511
DOC_USP7_MATH_1	67	71	PF00917	0.508
DOC_WW_Pin1_4	120	125	PF00397	0.607
DOC_WW_Pin1_4	284	289	PF00397	0.633
DOC_WW_Pin1_4	85	90	PF00397	0.571
LIG_14-3-3_CanoR_1	106	111	PF00244	0.525
LIG_14-3-3_CanoR_1	191	196	PF00244	0.457
LIG_14-3-3_CanoR_1	209	219	PF00244	0.522
LIG_14-3-3_CanoR_1	247	251	PF00244	0.505
LIG_14-3-3_CanoR_1	266	272	PF00244	0.259
LIG_Actin_WH2_2	218	236	PF00022	0.292
LIG_APCC_ABBA_1	301	306	PF00400	0.506
LIG_BRCT_BRCA1_1	110	114	PF00533	0.492
LIG_BRCT_BRCA1_1	256	260	PF00533	0.503
LIG_EH_1	155	159	PF12763	0.447
LIG_FHA_1	222	228	PF00498	0.499
LIG_FHA_1	330	336	PF00498	0.580
LIG_FHA_1	53	59	PF00498	0.504
LIG_FHA_2	139	145	PF00498	0.597
LIG_FHA_2	191	197	PF00498	0.476
LIG_LIR_Apic_2	29	35	PF02991	0.498
LIG_LIR_Apic_2	306	310	PF02991	0.539
LIG_LIR_Gen_1	193	203	PF02991	0.447
LIG_LIR_Nem_3	193	198	PF02991	0.434
LIG_LIR_Nem_3	255	261	PF02991	0.480
LIG_MAD2	78	86	PF02301	0.377
LIG_Pex14_2	114	118	PF04695	0.489
LIG_SH2_SRC	175	178	PF00017	0.515
LIG_SH2_STAT3	235	238	PF00017	0.502
LIG_SH2_STAT3	323	326	PF00017	0.517
LIG_SH2_STAT3	47	50	PF00017	0.486
LIG_SH2_STAT5	192	195	PF00017	0.374
LIG_SH2_STAT5	235	238	PF00017	0.521
LIG_SH2_STAT5	258	261	PF00017	0.512
LIG_SH3_3	42	48	PF00018	0.559
LIG_SH3_3	83	89	PF00018	0.577
LIG_WRC_WIRS_1	192	197	PF05994	0.514
MOD_CK1_1	123	129	PF00069	0.573
MOD_CK1_1	178	184	PF00069	0.423
MOD_CK2_1	106	112	PF00069	0.450
MOD_CK2_1	138	144	PF00069	0.600
MOD_CK2_1	91	97	PF00069	0.467
MOD_GlcNHglycan	212	215	PF01048	0.503
MOD_GlcNHglycan	63	66	PF01048	0.488
MOD_GlcNHglycan	97	101	PF01048	0.538
MOD_GSK3_1	118	125	PF00069	0.459
MOD_GSK3_1	171	178	PF00069	0.490
MOD_GSK3_1	246	253	PF00069	0.463
MOD_GSK3_1	67	74	PF00069	0.503
MOD_GSK3_1	85	92	PF00069	0.532
MOD_NEK2_1	190	195	PF00069	0.401
MOD_NEK2_1	233	238	PF00069	0.414
MOD_NEK2_1	250	255	PF00069	0.422
MOD_NEK2_1	322	327	PF00069	0.438
MOD_NEK2_1	96	101	PF00069	0.497
MOD_NEK2_2	2	7	PF00069	0.468
MOD_NEK2_2	221	226	PF00069	0.373
MOD_OFUCOSY	87	93	PF10250	0.484
MOD_PIKK_1	228	234	PF00454	0.427
MOD_PIKK_1	322	328	PF00454	0.414
MOD_PKA_2	190	196	PF00069	0.462
MOD_PKA_2	210	216	PF00069	0.532
MOD_PKA_2	233	239	PF00069	0.500
MOD_PKA_2	246	252	PF00069	0.523
MOD_PKA_2	315	321	PF00069	0.589
MOD_PKB_1	104	112	PF00069	0.520
MOD_Plk_1	144	150	PF00069	0.545
MOD_Plk_4	144	150	PF00069	0.552
MOD_Plk_4	246	252	PF00069	0.468
MOD_Plk_4	54	60	PF00069	0.536
MOD_Plk_4	91	97	PF00069	0.561
MOD_ProDKin_1	120	126	PF00069	0.609
MOD_ProDKin_1	284	290	PF00069	0.624
MOD_ProDKin_1	85	91	PF00069	0.571
TRG_DiLeu_BaEn_1	13	18	PF01217	0.487
TRG_DiLeu_BaLyEn_6	273	278	PF01217	0.598
TRG_DiLeu_BaLyEn_6	292	297	PF01217	0.546
TRG_ENDOCYTIC_2	192	195	PF00928	0.364
TRG_ER_diArg_1	208	211	PF00400	0.524
TRG_NES_CRM1_1	291	306	PF08389	0.476
TRG_NLS_MonoCore_2	74	79	PF00514	0.367
TRG_NLS_MonoExtN_4	72	79	PF00514	0.370

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC82	Leptomonas seymouri	52%	100%
A0A1X0NWL6	Trypanosomatidae	28%	100%
A0A3S7WY36	Leishmania donovani	98%	100%
A0A422NJF2	Trypanosoma rangeli	29%	99%
A4HD40	Leishmania braziliensis	76%	100%
C9ZNR9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9AWI8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QAY2	Leishmania major	93%	100%
V5BFT2	Trypanosoma cruzi	28%	95%