Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

E9AH15_LEIIN

TriTrypDb:

LINF_230026000

Length:

651

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AH15

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AH15

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	353	357	PF00656	0.579
CLV_C14_Caspase3-7	421	425	PF00656	0.493
CLV_NRD_NRD_1	17	19	PF00675	0.628
CLV_NRD_NRD_1	193	195	PF00675	0.487
CLV_NRD_NRD_1	319	321	PF00675	0.436
CLV_PCSK_KEX2_1	17	19	PF00082	0.628
CLV_PCSK_KEX2_1	193	195	PF00082	0.487
CLV_PCSK_KEX2_1	319	321	PF00082	0.442
CLV_PCSK_KEX2_1	369	371	PF00082	0.509
CLV_PCSK_PC1ET2_1	369	371	PF00082	0.509
CLV_PCSK_SKI1_1	102	106	PF00082	0.626
CLV_PCSK_SKI1_1	131	135	PF00082	0.571
CLV_PCSK_SKI1_1	181	185	PF00082	0.463
CLV_PCSK_SKI1_1	355	359	PF00082	0.514
CLV_PCSK_SKI1_1	496	500	PF00082	0.563
CLV_PCSK_SKI1_1	567	571	PF00082	0.469
DEG_APCC_DBOX_1	180	188	PF00400	0.476
DEG_APCC_DBOX_1	307	315	PF00400	0.372
DEG_APCC_DBOX_1	32	40	PF00400	0.468
DEG_Nend_UBRbox_2	1	3	PF02207	0.621
DOC_CDC14_PxL_1	613	621	PF14671	0.376
DOC_CKS1_1	499	504	PF01111	0.484
DOC_CYCLIN_RxL_1	573	585	PF00134	0.460
DOC_CYCLIN_RxL_1	628	636	PF00134	0.449
DOC_CYCLIN_yCln2_LP_2	489	495	PF00134	0.377
DOC_MAPK_DCC_7	640	649	PF00069	0.358
DOC_MAPK_MEF2A_6	308	315	PF00069	0.439
DOC_MAPK_MEF2A_6	40	47	PF00069	0.484
DOC_MAPK_NFAT4_5	308	316	PF00069	0.435
DOC_PP2B_LxvP_1	302	305	PF13499	0.418
DOC_PP2B_LxvP_1	9	12	PF13499	0.618
DOC_PP4_FxxP_1	286	289	PF00568	0.463
DOC_PP4_FxxP_1	499	502	PF00568	0.540
DOC_USP7_MATH_1	112	116	PF00917	0.605
DOC_USP7_MATH_1	12	16	PF00917	0.693
DOC_USP7_MATH_1	243	247	PF00917	0.496
DOC_USP7_MATH_1	348	352	PF00917	0.621
DOC_USP7_MATH_1	529	533	PF00917	0.521
DOC_USP7_MATH_1	541	545	PF00917	0.518
DOC_WW_Pin1_4	204	209	PF00397	0.389
DOC_WW_Pin1_4	341	346	PF00397	0.548
DOC_WW_Pin1_4	408	413	PF00397	0.488
DOC_WW_Pin1_4	498	503	PF00397	0.505
DOC_WW_Pin1_4	504	509	PF00397	0.459
LIG_14-3-3_CanoR_1	111	117	PF00244	0.634
LIG_14-3-3_CanoR_1	181	190	PF00244	0.301
LIG_14-3-3_CanoR_1	308	314	PF00244	0.519
LIG_14-3-3_CanoR_1	33	43	PF00244	0.536
LIG_14-3-3_CanoR_1	391	396	PF00244	0.460
LIG_14-3-3_CanoR_1	51	56	PF00244	0.505
LIG_14-3-3_CanoR_1	567	572	PF00244	0.460
LIG_14-3-3_CanoR_1	578	583	PF00244	0.289
LIG_Actin_WH2_2	309	327	PF00022	0.379
LIG_Actin_WH2_2	482	498	PF00022	0.452
LIG_APCC_ABBA_1	43	48	PF00400	0.483
LIG_APCC_ABBA_1	580	585	PF00400	0.439
LIG_APCC_ABBA_1	610	615	PF00400	0.454
LIG_BIR_III_2	538	542	PF00653	0.386
LIG_eIF4E_1	359	365	PF01652	0.503
LIG_eIF4E_1	613	619	PF01652	0.411
LIG_FHA_1	156	162	PF00498	0.591
LIG_FHA_1	319	325	PF00498	0.444
LIG_FHA_1	449	455	PF00498	0.429
LIG_FHA_1	65	71	PF00498	0.467
LIG_FHA_2	405	411	PF00498	0.543
LIG_GBD_Chelix_1	95	103	PF00786	0.516
LIG_LIR_Gen_1	142	148	PF02991	0.450
LIG_LIR_Gen_1	356	366	PF02991	0.507
LIG_LIR_Gen_1	531	542	PF02991	0.424
LIG_LIR_Gen_1	590	598	PF02991	0.339
LIG_LIR_Nem_3	142	147	PF02991	0.410
LIG_LIR_Nem_3	327	332	PF02991	0.492
LIG_LIR_Nem_3	356	362	PF02991	0.474
LIG_LIR_Nem_3	590	594	PF02991	0.361
LIG_LIR_Nem_3	627	633	PF02991	0.356
LIG_NRBOX	451	457	PF00104	0.457
LIG_Pex14_1	512	516	PF04695	0.441
LIG_SH2_CRK	359	363	PF00017	0.496
LIG_SH2_GRB2like	326	329	PF00017	0.445
LIG_SH2_SRC	422	425	PF00017	0.471
LIG_SH2_SRC	613	616	PF00017	0.427
LIG_SH2_STAP1	256	260	PF00017	0.463
LIG_SH2_STAP1	326	330	PF00017	0.499
LIG_SH2_STAP1	419	423	PF00017	0.460
LIG_SH2_STAP1	516	520	PF00017	0.349
LIG_SH2_STAT5	214	217	PF00017	0.368
LIG_SH2_STAT5	266	269	PF00017	0.343
LIG_SH2_STAT5	326	329	PF00017	0.591
LIG_SH2_STAT5	399	402	PF00017	0.508
LIG_SH2_STAT5	422	425	PF00017	0.347
LIG_SH2_STAT5	607	610	PF00017	0.445
LIG_SH3_1	406	412	PF00018	0.517
LIG_SH3_3	199	205	PF00018	0.381
LIG_SH3_3	406	412	PF00018	0.517
LIG_SH3_3	640	646	PF00018	0.338
LIG_Sin3_3	300	307	PF02671	0.470
LIG_Sin3_3	434	441	PF02671	0.411
LIG_SUMO_SIM_anti_2	451	456	PF11976	0.403
LIG_SUMO_SIM_anti_2	78	84	PF11976	0.502
LIG_SUMO_SIM_par_1	214	221	PF11976	0.379
LIG_TRAF2_1	11	14	PF00917	0.672
LIG_TRAF2_1	137	140	PF00917	0.451
LIG_TRFH_1	171	175	PF08558	0.500
LIG_WRC_WIRS_1	390	395	PF05994	0.490
MOD_CK1_1	115	121	PF00069	0.569
MOD_CK1_1	155	161	PF00069	0.579
MOD_CK1_1	162	168	PF00069	0.441
MOD_CK1_1	176	182	PF00069	0.439
MOD_CK1_1	221	227	PF00069	0.383
MOD_CK1_1	235	241	PF00069	0.366
MOD_CK1_1	411	417	PF00069	0.484
MOD_CK1_1	466	472	PF00069	0.496
MOD_CK1_1	624	630	PF00069	0.413
MOD_CK2_1	134	140	PF00069	0.473
MOD_CK2_1	142	148	PF00069	0.420
MOD_CK2_1	182	188	PF00069	0.297
MOD_CK2_1	203	209	PF00069	0.503
MOD_CK2_1	221	227	PF00069	0.272
MOD_CK2_1	290	296	PF00069	0.574
MOD_CK2_1	404	410	PF00069	0.509
MOD_CK2_1	482	488	PF00069	0.487
MOD_CK2_1	589	595	PF00069	0.538
MOD_CK2_1	7	13	PF00069	0.681
MOD_Cter_Amidation	15	18	PF01082	0.742
MOD_GlcNHglycan	114	117	PF01048	0.546
MOD_GlcNHglycan	13	17	PF01048	0.674
MOD_GlcNHglycan	136	139	PF01048	0.527
MOD_GlcNHglycan	144	147	PF01048	0.426
MOD_GlcNHglycan	154	157	PF01048	0.382
MOD_GlcNHglycan	184	187	PF01048	0.284
MOD_GlcNHglycan	220	223	PF01048	0.427
MOD_GlcNHglycan	239	242	PF01048	0.244
MOD_GlcNHglycan	352	355	PF01048	0.630
MOD_GlcNHglycan	475	478	PF01048	0.431
MOD_GlcNHglycan	562	565	PF01048	0.455
MOD_GlcNHglycan	567	570	PF01048	0.493
MOD_GlcNHglycan	591	594	PF01048	0.426
MOD_GlcNHglycan	595	599	PF01048	0.480
MOD_GlcNHglycan	9	12	PF01048	0.693
MOD_GSK3_1	102	109	PF00069	0.539
MOD_GSK3_1	115	122	PF00069	0.587
MOD_GSK3_1	155	162	PF00069	0.576
MOD_GSK3_1	217	224	PF00069	0.466
MOD_GSK3_1	228	235	PF00069	0.422
MOD_GSK3_1	385	392	PF00069	0.420
MOD_GSK3_1	404	411	PF00069	0.290
MOD_GSK3_1	446	453	PF00069	0.391
MOD_GSK3_1	498	505	PF00069	0.585
MOD_GSK3_1	90	97	PF00069	0.524
MOD_LATS_1	100	106	PF00433	0.445
MOD_N-GLC_1	309	314	PF02516	0.381
MOD_N-GLC_2	577	579	PF02516	0.345
MOD_NEK2_1	318	323	PF00069	0.429
MOD_NEK2_1	324	329	PF00069	0.447
MOD_NEK2_1	364	369	PF00069	0.452
MOD_NEK2_1	385	390	PF00069	0.401
MOD_NEK2_1	46	51	PF00069	0.531
MOD_NEK2_1	572	577	PF00069	0.500
MOD_NEK2_1	589	594	PF00069	0.286
MOD_NEK2_1	94	99	PF00069	0.472
MOD_NEK2_2	232	237	PF00069	0.402
MOD_PIKK_1	411	417	PF00454	0.545
MOD_PK_1	51	57	PF00069	0.511
MOD_PKA_2	142	148	PF00069	0.423
MOD_PKA_2	2	8	PF00069	0.788
MOD_PKA_2	318	324	PF00069	0.453
MOD_Plk_1	309	315	PF00069	0.383
MOD_Plk_1	404	410	PF00069	0.565
MOD_Plk_1	624	630	PF00069	0.473
MOD_Plk_4	243	249	PF00069	0.461
MOD_Plk_4	309	315	PF00069	0.399
MOD_Plk_4	450	456	PF00069	0.496
MOD_Plk_4	51	57	PF00069	0.509
MOD_Plk_4	529	535	PF00069	0.522
MOD_Plk_4	541	547	PF00069	0.413
MOD_Plk_4	567	573	PF00069	0.459
MOD_Plk_4	578	584	PF00069	0.484
MOD_Plk_4	90	96	PF00069	0.487
MOD_ProDKin_1	204	210	PF00069	0.384
MOD_ProDKin_1	341	347	PF00069	0.559
MOD_ProDKin_1	408	414	PF00069	0.481
MOD_ProDKin_1	498	504	PF00069	0.502
TRG_DiLeu_BaEn_1	615	620	PF01217	0.444
TRG_DiLeu_BaLyEn_6	286	291	PF01217	0.479
TRG_DiLeu_BaLyEn_6	614	619	PF01217	0.447
TRG_DiLeu_BaLyEn_6	643	648	PF01217	0.456
TRG_DiLeu_BaLyEn_6	99	104	PF01217	0.524
TRG_ENDOCYTIC_2	326	329	PF00928	0.506
TRG_ENDOCYTIC_2	359	362	PF00928	0.505
TRG_ENDOCYTIC_2	607	610	PF00928	0.355
TRG_ENDOCYTIC_2	613	616	PF00928	0.333
TRG_ER_diArg_1	193	195	PF00400	0.487
TRG_ER_diArg_1	318	320	PF00400	0.449
TRG_ER_diArg_1	456	459	PF00400	0.466
TRG_NES_CRM1_1	35	48	PF08389	0.481
TRG_Pf-PMV_PEXEL_1	102	106	PF00026	0.503
TRG_Pf-PMV_PEXEL_1	194	199	PF00026	0.479
TRG_Pf-PMV_PEXEL_1	237	242	PF00026	0.434
TRG_Pf-PMV_PEXEL_1	631	636	PF00026	0.440

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKS3	Leptomonas seymouri	53%	78%
A0A1X0NXC2	Trypanosomatidae	27%	83%
A0A3Q8IBR0	Leishmania donovani	100%	100%
A0A3R7RJS0	Trypanosoma rangeli	29%	82%
A4HD37	Leishmania braziliensis	86%	100%
C9ZNR6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	80%
E9AWI5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QAY5	Leishmania major	94%	100%
V5BFS5	Trypanosoma cruzi	26%	82%