Small hydrophilic endoplasmic reticulum-associated protein (Sherp)

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

small hydrophilic endoplasmic reticulum-associated protein (sherp)

Species:

Leishmania infantum

UniProt:

E9AH13_LEIIN

TriTrypDb:

LINF_230018650

Length:

Annotations

Annotations by Jardim et al.

ER/Golgi Proteins, Small hydrophilic endoplasmic reticulum-associated (Sherp) SHERP

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AH13

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AH13

PDB structure(s): 2x43_S

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	15	19	PF00656	0.606
CLV_C14_Caspase3-7	26	30	PF00656	0.481
CLV_C14_Caspase3-7	37	41	PF00656	0.504
DEG_Nend_UBRbox_3	1	3	PF02207	0.528
DOC_USP7_MATH_1	14	18	PF00917	0.564
DOC_USP7_MATH_1	41	45	PF00917	0.501
LIG_BIR_III_4	40	44	PF00653	0.465
MOD_CK2_1	41	47	PF00069	0.501
MOD_GlcNHglycan	53	56	PF01048	0.731
MOD_GSK3_1	41	48	PF00069	0.504

Homologs


Protein	Taxonomy	Sequence identity	Coverage
E9AWB6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q9XTN3	Leishmania major	79%	100%