Oxidoreductase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

oxidoreductase-like protein

Species:

Leishmania infantum

UniProt:

E9AH12_LEIIN

TriTrypDb:

LINF_230011200

Length:

431

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AH12

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AH12

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	16
GO:0005488	binding	1	16
GO:0036094	small molecule binding	2	16
GO:0097159	organic cyclic compound binding	2	16
GO:1901265	nucleoside phosphate binding	3	16
GO:1901363	heterocyclic compound binding	2	16

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	123	125	PF00675	0.283
CLV_NRD_NRD_1	219	221	PF00675	0.363
CLV_NRD_NRD_1	412	414	PF00675	0.404
CLV_PCSK_KEX2_1	219	221	PF00082	0.363
CLV_PCSK_SKI1_1	102	106	PF00082	0.411
CLV_PCSK_SKI1_1	189	193	PF00082	0.292
CLV_PCSK_SKI1_1	219	223	PF00082	0.470
CLV_PCSK_SKI1_1	22	26	PF00082	0.407
CLV_PCSK_SKI1_1	259	263	PF00082	0.325
CLV_PCSK_SKI1_1	347	351	PF00082	0.471
DEG_APCC_DBOX_1	258	266	PF00400	0.338
DEG_Nend_UBRbox_4	1	3	PF02207	0.395
DOC_MAPK_gen_1	22	32	PF00069	0.409
DOC_MAPK_MEF2A_6	25	32	PF00069	0.412
DOC_PP1_RVXF_1	69	75	PF00149	0.360
DOC_PP4_FxxP_1	267	270	PF00568	0.382
DOC_PP4_FxxP_1	353	356	PF00568	0.432
DOC_USP7_MATH_1	285	289	PF00917	0.461
DOC_USP7_MATH_1	300	304	PF00917	0.362
DOC_USP7_MATH_1	356	360	PF00917	0.596
DOC_USP7_MATH_1	412	416	PF00917	0.490
DOC_USP7_UBL2_3	105	109	PF12436	0.195
DOC_WW_Pin1_4	172	177	PF00397	0.396
DOC_WW_Pin1_4	227	232	PF00397	0.470
DOC_WW_Pin1_4	24	29	PF00397	0.408
DOC_WW_Pin1_4	333	338	PF00397	0.393
DOC_WW_Pin1_4	58	63	PF00397	0.518
LIG_14-3-3_CanoR_1	219	224	PF00244	0.438
LIG_14-3-3_CanoR_1	233	242	PF00244	0.214
LIG_14-3-3_CanoR_1	413	417	PF00244	0.433
LIG_APCC_ABBAyCdc20_2	189	195	PF00400	0.254
LIG_Clathr_ClatBox_1	191	195	PF01394	0.300
LIG_deltaCOP1_diTrp_1	252	261	PF00928	0.302
LIG_deltaCOP1_diTrp_1	410	416	PF00928	0.475
LIG_FHA_1	113	119	PF00498	0.334
LIG_FHA_1	333	339	PF00498	0.389
LIG_FHA_1	416	422	PF00498	0.363
LIG_FHA_1	67	73	PF00498	0.436
LIG_FHA_2	128	134	PF00498	0.308
LIG_FHA_2	149	155	PF00498	0.338
LIG_GBD_Chelix_1	273	281	PF00786	0.369
LIG_LIR_Apic_2	266	270	PF02991	0.427
LIG_LIR_Apic_2	352	356	PF02991	0.364
LIG_LIR_Gen_1	130	135	PF02991	0.315
LIG_LIR_Gen_1	141	149	PF02991	0.274
LIG_LIR_Gen_1	260	269	PF02991	0.370
LIG_LIR_Gen_1	27	37	PF02991	0.570
LIG_LIR_Gen_1	302	313	PF02991	0.383
LIG_LIR_Nem_3	130	134	PF02991	0.315
LIG_LIR_Nem_3	141	147	PF02991	0.274
LIG_LIR_Nem_3	252	258	PF02991	0.311
LIG_LIR_Nem_3	27	32	PF02991	0.572
LIG_LIR_Nem_3	302	308	PF02991	0.373
LIG_LIR_Nem_3	383	389	PF02991	0.377
LIG_MYND_1	242	246	PF01753	0.406
LIG_Pex14_2	223	227	PF04695	0.314
LIG_Pex14_2	308	312	PF04695	0.366
LIG_SH2_CRK	144	148	PF00017	0.386
LIG_SH2_SRC	131	134	PF00017	0.268
LIG_SH2_STAP1	131	135	PF00017	0.300
LIG_SH2_STAP1	305	309	PF00017	0.471
LIG_SH2_STAT5	204	207	PF00017	0.447
LIG_SH2_STAT5	307	310	PF00017	0.397
LIG_SH3_3	368	374	PF00018	0.524
LIG_SUMO_SIM_anti_2	137	144	PF11976	0.348
LIG_SUMO_SIM_par_1	29	36	PF11976	0.410
LIG_SUMO_SIM_par_1	8	14	PF11976	0.609
LIG_TYR_ITIM	142	147	PF00017	0.300
LIG_WRC_WIRS_1	224	229	PF05994	0.330
LIG_WRC_WIRS_1	258	263	PF05994	0.406
LIG_WRC_WIRS_1	286	291	PF05994	0.517
LIG_WRC_WIRS_1	309	314	PF05994	0.348
MOD_CDC14_SPxK_1	230	233	PF00782	0.373
MOD_CDK_SPxK_1	227	233	PF00069	0.361
MOD_CK1_1	311	317	PF00069	0.323
MOD_CK1_1	336	342	PF00069	0.456
MOD_CK1_1	36	42	PF00069	0.530
MOD_CK1_1	415	421	PF00069	0.449
MOD_CK1_1	66	72	PF00069	0.495
MOD_CK2_1	127	133	PF00069	0.336
MOD_CK2_1	148	154	PF00069	0.399
MOD_CK2_1	178	184	PF00069	0.364
MOD_GlcNHglycan	186	189	PF01048	0.374
MOD_GlcNHglycan	322	325	PF01048	0.402
MOD_GlcNHglycan	353	356	PF01048	0.563
MOD_GlcNHglycan	396	400	PF01048	0.528
MOD_GlcNHglycan	427	430	PF01048	0.412
MOD_GSK3_1	114	121	PF00069	0.120
MOD_GSK3_1	143	150	PF00069	0.352
MOD_GSK3_1	20	27	PF00069	0.404
MOD_GSK3_1	219	226	PF00069	0.378
MOD_GSK3_1	265	272	PF00069	0.287
MOD_GSK3_1	308	315	PF00069	0.351
MOD_GSK3_1	316	323	PF00069	0.311
MOD_GSK3_1	332	339	PF00069	0.317
MOD_GSK3_1	356	363	PF00069	0.496
MOD_GSK3_1	54	61	PF00069	0.427
MOD_GSK3_1	94	101	PF00069	0.310
MOD_NEK2_1	194	199	PF00069	0.306
MOD_NEK2_1	223	228	PF00069	0.363
MOD_NEK2_1	308	313	PF00069	0.346
MOD_NEK2_1	316	321	PF00069	0.395
MOD_NEK2_1	33	38	PF00069	0.406
MOD_NEK2_1	380	385	PF00069	0.366
MOD_NEK2_1	425	430	PF00069	0.397
MOD_NEK2_1	75	80	PF00069	0.348
MOD_NEK2_1	94	99	PF00069	0.358
MOD_NEK2_2	100	105	PF00069	0.203
MOD_NEK2_2	114	119	PF00069	0.168
MOD_NEK2_2	285	290	PF00069	0.460
MOD_NEK2_2	300	305	PF00069	0.453
MOD_PIKK_1	380	386	PF00454	0.481
MOD_PKA_1	219	225	PF00069	0.436
MOD_PKA_2	219	225	PF00069	0.436
MOD_PKA_2	412	418	PF00069	0.416
MOD_Plk_1	20	26	PF00069	0.404
MOD_Plk_1	265	271	PF00069	0.405
MOD_Plk_1	291	297	PF00069	0.413
MOD_Plk_1	300	306	PF00069	0.413
MOD_Plk_1	360	366	PF00069	0.540
MOD_Plk_4	178	184	PF00069	0.300
MOD_Plk_4	194	200	PF00069	0.316
MOD_Plk_4	219	225	PF00069	0.428
MOD_Plk_4	300	306	PF00069	0.383
MOD_Plk_4	308	314	PF00069	0.340
MOD_Plk_4	316	322	PF00069	0.342
MOD_Plk_4	33	39	PF00069	0.406
MOD_Plk_4	412	418	PF00069	0.420
MOD_Plk_4	94	100	PF00069	0.307
MOD_ProDKin_1	172	178	PF00069	0.396
MOD_ProDKin_1	227	233	PF00069	0.474
MOD_ProDKin_1	24	30	PF00069	0.410
MOD_ProDKin_1	333	339	PF00069	0.393
MOD_ProDKin_1	58	64	PF00069	0.516
MOD_SUMO_for_1	289	292	PF00179	0.483
MOD_SUMO_rev_2	117	127	PF00179	0.404
TRG_DiLeu_BaEn_1	397	402	PF01217	0.402
TRG_DiLeu_LyEn_5	397	402	PF01217	0.402
TRG_ENDOCYTIC_2	131	134	PF00928	0.313
TRG_ENDOCYTIC_2	144	147	PF00928	0.231
TRG_ENDOCYTIC_2	305	308	PF00928	0.422
TRG_ENDOCYTIC_2	309	312	PF00928	0.359
TRG_ER_diArg_1	218	220	PF00400	0.367
TRG_Pf-PMV_PEXEL_1	276	280	PF00026	0.522
TRG_Pf-PMV_PEXEL_1	400	404	PF00026	0.524

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P740	Leptomonas seymouri	29%	94%
A0A0N1I5Z7	Leptomonas seymouri	69%	100%
A0A0N1I7E8	Leptomonas seymouri	38%	100%
A0A0S4IRH3	Bodo saltans	38%	100%
A0A0S4JVB2	Bodo saltans	22%	100%
A0A1X0NWZ0	Trypanosomatidae	26%	89%
A0A1X0NX10	Trypanosomatidae	43%	100%
A0A1X0NX22	Trypanosomatidae	41%	93%
A0A1X0NXP4	Trypanosomatidae	50%	100%
A0A3Q8IM07	Leishmania donovani	100%	100%
A0A3S7WXP2	Leishmania donovani	31%	100%
A0A3S7WXT7	Leishmania donovani	38%	100%
A4HCS3	Leishmania braziliensis	30%	100%
A4I097	Leishmania infantum	31%	100%
A4I0B8	Leishmania infantum	39%	100%
E9AW61	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9AW62	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
E9AW82	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
Q4QBB6	Leishmania major	95%	100%
Q4QBB7	Leishmania major	31%	100%
Q9SZ83	Arabidopsis thaliana	32%	100%
Q9U0V7	Leishmania major	39%	100%
V5BB31	Trypanosoma cruzi	25%	99%
V5BH08	Trypanosoma cruzi	41%	100%