Metallo-peptidase, Clan MA(E), Family M3,putative, partial

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein (non-ATG)

Species:

Leishmania infantum

UniProt:

E9AH08_LEIIN

TriTrypDb:

LINF_270033860

Length:

204

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 2
NetGPI	no	yes: 0, no: 2

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AH08

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AH08

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	3
GO:0006807	nitrogen compound metabolic process	2	3
GO:0008152	metabolic process	1	3
GO:0019538	protein metabolic process	3	3
GO:0043170	macromolecule metabolic process	3	3
GO:0044238	primary metabolic process	2	3
GO:0071704	organic substance metabolic process	2	3
GO:1901564	organonitrogen compound metabolic process	3	3

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0004175	endopeptidase activity	4	3
GO:0004222	metalloendopeptidase activity	5	3
GO:0005488	binding	1	3
GO:0008233	peptidase activity	3	3
GO:0008237	metallopeptidase activity	4	3
GO:0016787	hydrolase activity	2	3
GO:0043167	ion binding	2	3
GO:0043169	cation binding	3	3
GO:0046872	metal ion binding	4	3
GO:0140096	catalytic activity, acting on a protein	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	187	189	PF00675	0.575
CLV_PCSK_SKI1_1	17	21	PF00082	0.504
CLV_PCSK_SKI1_1	193	197	PF00082	0.575
DEG_Nend_Nbox_1	1	3	PF02207	0.575
DOC_USP7_MATH_1	102	106	PF00917	0.312
DOC_USP7_UBL2_3	189	193	PF12436	0.575
LIG_BRCT_BRCA1_1	118	122	PF00533	0.575
LIG_FHA_1	68	74	PF00498	0.575
LIG_FHA_1	88	94	PF00498	0.224
LIG_LIR_Gen_1	146	152	PF02991	0.470
LIG_LIR_Gen_1	18	26	PF02991	0.575
LIG_LIR_Gen_1	80	91	PF02991	0.312
LIG_LIR_Nem_3	132	137	PF02991	0.517
LIG_LIR_Nem_3	146	151	PF02991	0.312
LIG_LIR_Nem_3	18	22	PF02991	0.575
LIG_LIR_Nem_3	28	33	PF02991	0.575
LIG_LIR_Nem_3	80	86	PF02991	0.312
LIG_MLH1_MIPbox_1	118	122	PF16413	0.575
LIG_Pex14_2	122	126	PF04695	0.312
LIG_PTB_Apo_2	1	8	PF02174	0.575
LIG_PTB_Phospho_1	1	7	PF10480	0.575
LIG_SH2_CRK	33	37	PF00017	0.575
LIG_SH2_CRK	7	11	PF00017	0.575
LIG_SH2_SRC	40	43	PF00017	0.312
LIG_SH2_STAP1	130	134	PF00017	0.575
LIG_SH2_STAP1	182	186	PF00017	0.575
LIG_SH2_STAP1	33	37	PF00017	0.575
LIG_SH2_STAP1	40	44	PF00017	0.575
LIG_SH2_STAT3	135	138	PF00017	0.312
LIG_SH2_STAT5	121	124	PF00017	0.399
LIG_SH2_STAT5	135	138	PF00017	0.399
LIG_SH2_STAT5	78	81	PF00017	0.575
LIG_SH3_3	89	95	PF00018	0.312
LIG_SUMO_SIM_anti_2	70	75	PF11976	0.312
LIG_TYR_ITIM	5	10	PF00017	0.575
LIG_UBA3_1	1	6	PF00899	0.312
LIG_WRC_WIRS_1	103	108	PF05994	0.312
LIG_WRC_WIRS_1	123	128	PF05994	0.312
LIG_WW_1	114	117	PF00397	0.575
LIG_WW_3	113	117	PF00397	0.575
MOD_CK1_1	8	14	PF00069	0.575
MOD_Cter_Amidation	186	189	PF01082	0.575
MOD_GlcNHglycan	10	13	PF01048	0.529
MOD_GlcNHglycan	118	121	PF01048	0.575
MOD_GlcNHglycan	126	129	PF01048	0.434
MOD_GSK3_1	168	175	PF00069	0.575
MOD_GSK3_1	6	13	PF00069	0.437
MOD_NEK2_1	122	127	PF00069	0.312
MOD_NEK2_1	5	10	PF00069	0.552
MOD_PIKK_1	21	27	PF00454	0.575
MOD_Plk_1	87	93	PF00069	0.312
TRG_DiLeu_BaEn_4	88	94	PF01217	0.312
TRG_ENDOCYTIC_2	182	185	PF00928	0.575
TRG_ENDOCYTIC_2	33	36	PF00928	0.575
TRG_ENDOCYTIC_2	7	10	PF00928	0.575
TRG_ENDOCYTIC_2	78	81	PF00928	0.575
TRG_Pf-PMV_PEXEL_1	141	146	PF00026	0.529

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4H3G0	Leishmania braziliensis	85%	96%