LeishMANIAdb
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Intraflagellar transport protein-like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Intraflagellar transport protein-like protein
Gene product:
intraflagellar transport protein-like protein
Species:
Leishmania infantum
UniProt:
E9AH05_LEIIN
TriTrypDb:
LINF_220019800
Length:
536

Annotations

Annotations by Jardim et al.

Flagella, Intraflagellar transport -like

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) yes yes: 3
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 8
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005929 cilium 4 11
GO:0030992 intraciliary transport particle B 2 11
GO:0031514 motile cilium 5 9
GO:0032991 protein-containing complex 1 11
GO:0042995 cell projection 2 11
GO:0043226 organelle 2 11
GO:0043227 membrane-bounded organelle 3 11
GO:0110165 cellular anatomical entity 1 11
GO:0120025 plasma membrane bounded cell projection 3 11
GO:0005737 cytoplasm 2 1
GO:0005813 centrosome 3 1
GO:0005815 microtubule organizing center 2 1
GO:0030990 intraciliary transport particle 2 1
GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) 4 1
GO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain 3 1
GO:0045263 proton-transporting ATP synthase complex, coupling factor F(o) 4 1
GO:0098796 membrane protein complex 2 1
GO:0098798 mitochondrial protein-containing complex 2 1
GO:0098800 inner mitochondrial membrane protein complex 3 1

Expansion

Sequence features

E9AH05
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AH05

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 11
GO:0006996 organelle organization 4 10
GO:0007017 microtubule-based process 2 11
GO:0007018 microtubule-based movement 3 11
GO:0009987 cellular process 1 11
GO:0010970 transport along microtubule 4 11
GO:0016043 cellular component organization 3 10
GO:0022607 cellular component assembly 4 10
GO:0030030 cell projection organization 4 10
GO:0030031 cell projection assembly 5 10
GO:0030705 cytoskeleton-dependent intracellular transport 4 11
GO:0031503 protein-containing complex localization 2 11
GO:0042073 intraciliary transport 3 11
GO:0044782 cilium organization 5 10
GO:0046907 intracellular transport 3 11
GO:0051179 localization 1 11
GO:0051234 establishment of localization 2 11
GO:0051641 cellular localization 2 11
GO:0051649 establishment of localization in cell 3 11
GO:0060271 cilium assembly 6 10
GO:0070925 organelle assembly 5 10
GO:0071840 cellular component organization or biogenesis 2 10
GO:0099111 microtubule-based transport 4 11
GO:0120031 plasma membrane bounded cell projection assembly 6 10
GO:0120036 plasma membrane bounded cell projection organization 5 10
GO:0035735 intraciliary transport involved in cilium assembly 4 1
GO:0006139 nucleobase-containing compound metabolic process 3 1
GO:0006163 purine nucleotide metabolic process 5 1
GO:0006164 purine nucleotide biosynthetic process 6 1
GO:0006725 cellular aromatic compound metabolic process 3 1
GO:0006753 nucleoside phosphate metabolic process 4 1
GO:0006754 ATP biosynthetic process 8 1
GO:0006793 phosphorus metabolic process 3 1
GO:0006796 phosphate-containing compound metabolic process 4 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0009058 biosynthetic process 2 1
GO:0009117 nucleotide metabolic process 5 1
GO:0009141 nucleoside triphosphate metabolic process 5 1
GO:0009142 nucleoside triphosphate biosynthetic process 6 1
GO:0009144 purine nucleoside triphosphate metabolic process 6 1
GO:0009145 purine nucleoside triphosphate biosynthetic process 7 1
GO:0009150 purine ribonucleotide metabolic process 6 1
GO:0009152 purine ribonucleotide biosynthetic process 7 1
GO:0009165 nucleotide biosynthetic process 6 1
GO:0009199 ribonucleoside triphosphate metabolic process 6 1
GO:0009201 ribonucleoside triphosphate biosynthetic process 7 1
GO:0009205 purine ribonucleoside triphosphate metabolic process 7 1
GO:0009206 purine ribonucleoside triphosphate biosynthetic process 8 1
GO:0009259 ribonucleotide metabolic process 5 1
GO:0009260 ribonucleotide biosynthetic process 6 1
GO:0015986 proton motive force-driven ATP synthesis 9 1
GO:0018130 heterocycle biosynthetic process 4 1
GO:0019438 aromatic compound biosynthetic process 4 1
GO:0019637 organophosphate metabolic process 3 1
GO:0019693 ribose phosphate metabolic process 4 1
GO:0034641 cellular nitrogen compound metabolic process 3 1
GO:0034654 nucleobase-containing compound biosynthetic process 4 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0044249 cellular biosynthetic process 3 1
GO:0044271 cellular nitrogen compound biosynthetic process 4 1
GO:0044281 small molecule metabolic process 2 1
GO:0046034 ATP metabolic process 7 1
GO:0046390 ribose phosphate biosynthetic process 5 1
GO:0046483 heterocycle metabolic process 3 1
GO:0055086 nucleobase-containing small molecule metabolic process 3 1
GO:0071704 organic substance metabolic process 2 1
GO:0072521 purine-containing compound metabolic process 4 1
GO:0072522 purine-containing compound biosynthetic process 5 1
GO:0090407 organophosphate biosynthetic process 4 1
GO:1901135 carbohydrate derivative metabolic process 3 1
GO:1901137 carbohydrate derivative biosynthetic process 4 1
GO:1901293 nucleoside phosphate biosynthetic process 5 1
GO:1901360 organic cyclic compound metabolic process 3 1
GO:1901362 organic cyclic compound biosynthetic process 4 1
GO:1901564 organonitrogen compound metabolic process 3 1
GO:1901566 organonitrogen compound biosynthetic process 4 1
GO:1901576 organic substance biosynthetic process 3 1
Molecular functions
Term Name Level Count
GO:0005488 binding 1 11
GO:0005515 protein binding 2 11
GO:0008092 cytoskeletal protein binding 3 11
GO:0015631 tubulin binding 4 11
GO:0048487 beta-tubulin binding 5 11
GO:0005215 transporter activity 1 1
GO:0008324 monoatomic cation transmembrane transporter activity 4 1
GO:0015075 monoatomic ion transmembrane transporter activity 3 1
GO:0015078 proton transmembrane transporter activity 5 1
GO:0015318 inorganic molecular entity transmembrane transporter activity 3 1
GO:0022857 transmembrane transporter activity 2 1
GO:0022890 inorganic cation transmembrane transporter activity 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 348 352 PF00656 0.572
CLV_C14_Caspase3-7 410 414 PF00656 0.463
CLV_NRD_NRD_1 110 112 PF00675 0.403
CLV_NRD_NRD_1 144 146 PF00675 0.418
CLV_NRD_NRD_1 208 210 PF00675 0.465
CLV_NRD_NRD_1 211 213 PF00675 0.461
CLV_NRD_NRD_1 373 375 PF00675 0.483
CLV_NRD_NRD_1 422 424 PF00675 0.426
CLV_NRD_NRD_1 453 455 PF00675 0.432
CLV_PCSK_FUR_1 209 213 PF00082 0.549
CLV_PCSK_KEX2_1 110 112 PF00082 0.419
CLV_PCSK_KEX2_1 144 146 PF00082 0.418
CLV_PCSK_KEX2_1 198 200 PF00082 0.431
CLV_PCSK_KEX2_1 210 212 PF00082 0.412
CLV_PCSK_KEX2_1 353 355 PF00082 0.530
CLV_PCSK_PC1ET2_1 198 200 PF00082 0.429
CLV_PCSK_PC1ET2_1 210 212 PF00082 0.401
CLV_PCSK_PC1ET2_1 353 355 PF00082 0.563
CLV_PCSK_SKI1_1 144 148 PF00082 0.537
CLV_PCSK_SKI1_1 205 209 PF00082 0.426
CLV_PCSK_SKI1_1 369 373 PF00082 0.474
CLV_PCSK_SKI1_1 386 390 PF00082 0.459
CLV_PCSK_SKI1_1 423 427 PF00082 0.433
CLV_Separin_Metazoa 202 206 PF03568 0.439
DEG_APCC_DBOX_1 303 311 PF00400 0.547
DEG_Nend_UBRbox_1 1 4 PF02207 0.577
DOC_CYCLIN_RxL_1 364 373 PF00134 0.484
DOC_MAPK_gen_1 110 119 PF00069 0.398
DOC_MAPK_gen_1 237 245 PF00069 0.401
DOC_MAPK_gen_1 435 444 PF00069 0.512
DOC_MAPK_MEF2A_6 112 121 PF00069 0.415
DOC_MAPK_MEF2A_6 506 515 PF00069 0.447
DOC_PP1_SILK_1 205 210 PF00149 0.494
DOC_USP7_MATH_1 238 242 PF00917 0.481
DOC_USP7_MATH_1 262 266 PF00917 0.557
DOC_USP7_MATH_1 393 397 PF00917 0.447
DOC_USP7_MATH_1 4 8 PF00917 0.567
LIG_14-3-3_CanoR_1 261 271 PF00244 0.480
LIG_14-3-3_CanoR_1 323 330 PF00244 0.494
LIG_14-3-3_CanoR_1 423 433 PF00244 0.586
LIG_14-3-3_CanoR_1 52 57 PF00244 0.559
LIG_EH1_1 163 171 PF00400 0.472
LIG_FHA_1 338 344 PF00498 0.609
LIG_FHA_1 345 351 PF00498 0.521
LIG_FHA_1 420 426 PF00498 0.490
LIG_FHA_1 479 485 PF00498 0.522
LIG_FHA_1 493 499 PF00498 0.391
LIG_FHA_1 524 530 PF00498 0.683
LIG_FHA_2 237 243 PF00498 0.465
LIG_FHA_2 254 260 PF00498 0.575
LIG_FHA_2 292 298 PF00498 0.545
LIG_FHA_2 340 346 PF00498 0.725
LIG_FHA_2 498 504 PF00498 0.492
LIG_FHA_2 64 70 PF00498 0.466
LIG_FHA_2 75 81 PF00498 0.336
LIG_FHA_2 99 105 PF00498 0.403
LIG_LIR_Gen_1 115 126 PF02991 0.483
LIG_LIR_Gen_1 407 417 PF02991 0.578
LIG_LIR_Gen_1 462 471 PF02991 0.550
LIG_LIR_Gen_1 485 494 PF02991 0.413
LIG_LIR_Nem_3 115 121 PF02991 0.487
LIG_LIR_Nem_3 152 156 PF02991 0.398
LIG_LIR_Nem_3 23 28 PF02991 0.423
LIG_LIR_Nem_3 407 412 PF02991 0.594
LIG_LIR_Nem_3 462 467 PF02991 0.511
LIG_LIR_Nem_3 485 490 PF02991 0.401
LIG_Pex14_1 478 482 PF04695 0.526
LIG_SH2_CRK 156 160 PF00017 0.516
LIG_SH2_CRK 433 437 PF00017 0.480
LIG_SH2_PTP2 25 28 PF00017 0.413
LIG_SH2_PTP2 487 490 PF00017 0.487
LIG_SH2_STAT5 25 28 PF00017 0.413
LIG_SH2_STAT5 433 436 PF00017 0.498
LIG_SH2_STAT5 487 490 PF00017 0.465
LIG_SH2_STAT5 497 500 PF00017 0.385
LIG_SUMO_SIM_anti_2 241 247 PF11976 0.404
LIG_TRAF2_1 134 137 PF00917 0.428
LIG_TRAF2_1 182 185 PF00917 0.408
LIG_TRAF2_1 256 259 PF00917 0.557
LIG_TRAF2_1 266 269 PF00917 0.472
LIG_TRAF2_1 281 284 PF00917 0.357
LIG_TRAF2_1 468 471 PF00917 0.477
LIG_UBA3_1 203 210 PF00899 0.497
LIG_UBA3_1 232 237 PF00899 0.541
LIG_Vh1_VBS_1 117 135 PF01044 0.481
LIG_WRC_WIRS_1 292 297 PF05994 0.429
MOD_CK1_1 219 225 PF00069 0.445
MOD_CK1_1 322 328 PF00069 0.544
MOD_CK1_1 480 486 PF00069 0.439
MOD_CK1_1 55 61 PF00069 0.516
MOD_CK2_1 131 137 PF00069 0.484
MOD_CK2_1 221 227 PF00069 0.426
MOD_CK2_1 238 244 PF00069 0.400
MOD_CK2_1 253 259 PF00069 0.387
MOD_CK2_1 262 268 PF00069 0.435
MOD_CK2_1 465 471 PF00069 0.448
MOD_CK2_1 497 503 PF00069 0.522
MOD_CK2_1 98 104 PF00069 0.460
MOD_GlcNHglycan 11 14 PF01048 0.595
MOD_GlcNHglycan 264 267 PF01048 0.467
MOD_GlcNHglycan 274 277 PF01048 0.403
MOD_GlcNHglycan 35 39 PF01048 0.532
MOD_GlcNHglycan 395 398 PF01048 0.503
MOD_GlcNHglycan 426 429 PF01048 0.407
MOD_GlcNHglycan 530 533 PF01048 0.593
MOD_GlcNHglycan 6 9 PF01048 0.634
MOD_GSK3_1 121 128 PF00069 0.501
MOD_GSK3_1 253 260 PF00069 0.516
MOD_GSK3_1 333 340 PF00069 0.795
MOD_GSK3_1 4 11 PF00069 0.668
MOD_GSK3_1 51 58 PF00069 0.495
MOD_GSK3_1 528 535 PF00069 0.615
MOD_N-GLC_1 272 277 PF02516 0.524
MOD_N-GLC_1 337 342 PF02516 0.600
MOD_N-GLC_1 52 57 PF02516 0.433
MOD_N-GLC_1 86 91 PF02516 0.547
MOD_NEK2_1 236 241 PF00069 0.519
MOD_NEK2_1 257 262 PF00069 0.428
MOD_NEK2_1 477 482 PF00069 0.395
MOD_NEK2_1 530 535 PF00069 0.589
MOD_NEK2_1 74 79 PF00069 0.398
MOD_NEK2_2 221 226 PF00069 0.560
MOD_PIKK_1 216 222 PF00454 0.534
MOD_PIKK_1 310 316 PF00454 0.468
MOD_PIKK_1 322 328 PF00454 0.441
MOD_PIKK_1 345 351 PF00454 0.619
MOD_PIKK_1 466 472 PF00454 0.485
MOD_PIKK_1 492 498 PF00454 0.569
MOD_PIKK_1 55 61 PF00454 0.492
MOD_PK_1 52 58 PF00069 0.448
MOD_PKA_1 211 217 PF00069 0.442
MOD_PKA_2 211 217 PF00069 0.449
MOD_PKA_2 253 259 PF00069 0.554
MOD_PKA_2 262 268 PF00069 0.557
MOD_PKA_2 322 328 PF00069 0.455
MOD_PKA_2 51 57 PF00069 0.582
MOD_PKB_1 209 217 PF00069 0.445
MOD_PKB_1 435 443 PF00069 0.533
MOD_Plk_1 20 26 PF00069 0.449
MOD_Plk_1 52 58 PF00069 0.433
MOD_Plk_1 86 92 PF00069 0.585
MOD_Plk_1 98 104 PF00069 0.447
MOD_Plk_2-3 291 297 PF00069 0.429
MOD_Plk_2-3 407 413 PF00069 0.600
MOD_Plk_4 291 297 PF00069 0.429
MOD_Plk_4 52 58 PF00069 0.427
MOD_SUMO_for_1 182 185 PF00179 0.431
MOD_SUMO_for_1 225 228 PF00179 0.504
MOD_SUMO_for_1 388 391 PF00179 0.496
MOD_SUMO_for_1 96 99 PF00179 0.547
MOD_SUMO_rev_2 123 128 PF00179 0.522
MOD_SUMO_rev_2 194 200 PF00179 0.455
MOD_SUMO_rev_2 265 274 PF00179 0.458
MOD_SUMO_rev_2 355 363 PF00179 0.579
MOD_SUMO_rev_2 368 376 PF00179 0.390
MOD_SUMO_rev_2 379 388 PF00179 0.440
MOD_SUMO_rev_2 396 404 PF00179 0.435
TRG_AP2beta_CARGO_1 407 416 PF09066 0.581
TRG_DiLeu_BaEn_1 228 233 PF01217 0.415
TRG_DiLeu_BaEn_1 45 50 PF01217 0.414
TRG_DiLeu_BaEn_1 510 515 PF01217 0.410
TRG_DiLeu_BaEn_2 290 296 PF01217 0.431
TRG_DiLeu_BaEn_4 137 143 PF01217 0.393
TRG_DiLeu_BaEn_4 98 104 PF01217 0.511
TRG_ENDOCYTIC_2 156 159 PF00928 0.524
TRG_ENDOCYTIC_2 25 28 PF00928 0.413
TRG_ENDOCYTIC_2 433 436 PF00928 0.480
TRG_ENDOCYTIC_2 487 490 PF00928 0.538
TRG_ER_diArg_1 144 146 PF00400 0.418
TRG_ER_diArg_1 208 211 PF00400 0.444
TRG_ER_diArg_1 473 476 PF00400 0.527
TRG_ER_diArg_1 488 491 PF00400 0.542
TRG_NES_CRM1_1 319 333 PF08389 0.554
TRG_NES_CRM1_1 503 516 PF08389 0.491
TRG_Pf-PMV_PEXEL_1 145 149 PF00026 0.438
TRG_Pf-PMV_PEXEL_1 315 319 PF00026 0.578
TRG_Pf-PMV_PEXEL_1 369 373 PF00026 0.480
TRG_Pf-PMV_PEXEL_1 475 479 PF00026 0.523

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P3E7 Leptomonas seymouri 79% 90%
A0A1X0NTR4 Trypanosomatidae 58% 89%
A0A3R7KQW5 Trypanosoma rangeli 58% 90%
A0A3S7WX98 Leishmania donovani 100% 90%
A4HCH3 Leishmania braziliensis 92% 100%
C9ZSP9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 57% 90%
E9AVW9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 97% 100%
Q4QBL0 Leishmania major 98% 100%
Q6RCE1 Chlamydomonas reinhardtii 23% 84%
Q8BKE9 Mus musculus 25% 89%
Q96LB3 Homo sapiens 25% 89%
V5B464 Trypanosoma cruzi 58% 90%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS