Intraflagellar transport protein-like protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

intraflagellar transport protein-like protein

Species:

Leishmania infantum

UniProt:

E9AH05_LEIIN

TriTrypDb:

LINF_220019800

Length:

536

Annotations

Annotations by Jardim et al.

Flagella, Intraflagellar transport -like

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	yes	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Show entries

Cellular components
Term	Name	Level	Count
GO:0000276	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)	4	1
GO:0005737	cytoplasm	2	1
GO:0005813	centrosome	3	1
GO:0005815	microtubule organizing center	2	1
GO:0005929	cilium	4	11
GO:0030990	intraciliary transport particle	2	1
GO:0030992	intraciliary transport particle B	2	11
GO:0031514	motile cilium	5	9
GO:0032991	protein-containing complex	1	11
GO:0033177	proton-transporting two-sector ATPase complex, proton-transporting domain	3	1

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Expansion

Sequence features

E9AH05

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AH05

Function

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Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006163	purine nucleotide metabolic process	5	1
GO:0006164	purine nucleotide biosynthetic process	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006753	nucleoside phosphate metabolic process	4	1
GO:0006754	ATP biosynthetic process	8	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006810	transport	3	11

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Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	1
GO:0005488	binding	1	11
GO:0005515	protein binding	2	11
GO:0008092	cytoskeletal protein binding	3	11
GO:0008324	monoatomic cation transmembrane transporter activity	4	1
GO:0015075	monoatomic ion transmembrane transporter activity	3	1
GO:0015078	proton transmembrane transporter activity	5	1
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	1
GO:0015631	tubulin binding	4	11
GO:0022857	transmembrane transporter activity	2	1

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Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	348	352	PF00656	0.572
CLV_C14_Caspase3-7	410	414	PF00656	0.463
CLV_NRD_NRD_1	110	112	PF00675	0.403
CLV_NRD_NRD_1	144	146	PF00675	0.418
CLV_NRD_NRD_1	208	210	PF00675	0.465
CLV_NRD_NRD_1	211	213	PF00675	0.461
CLV_NRD_NRD_1	373	375	PF00675	0.483
CLV_NRD_NRD_1	422	424	PF00675	0.426
CLV_NRD_NRD_1	453	455	PF00675	0.432
CLV_PCSK_FUR_1	209	213	PF00082	0.549

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3E7	Leptomonas seymouri	79%	90%
A0A1X0NTR4	Trypanosomatidae	58%	89%
A0A3R7KQW5	Trypanosoma rangeli	58%	90%
A0A3S7WX98	Leishmania donovani	100%	90%
A4HCH3	Leishmania braziliensis	92%	100%
C9ZSP9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	90%
E9AVW9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
Q4QBL0	Leishmania major	98%	100%
Q6RCE1	Chlamydomonas reinhardtii	23%	84%
Q8BKE9	Mus musculus	25%	89%

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