LeishMANIAdb
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Separase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Separase
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
E9AGZ8_LEIIN
TriTrypDb:
LINF_220018900
Length:
390

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AGZ8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AGZ8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 273 277 PF00656 0.643
CLV_PCSK_KEX2_1 64 66 PF00082 0.537
CLV_PCSK_PC1ET2_1 64 66 PF00082 0.643
CLV_PCSK_SKI1_1 11 15 PF00082 0.601
CLV_PCSK_SKI1_1 160 164 PF00082 0.430
CLV_PCSK_SKI1_1 210 214 PF00082 0.642
CLV_PCSK_SKI1_1 344 348 PF00082 0.656
CLV_PCSK_SKI1_1 92 96 PF00082 0.706
CLV_PCSK_SKI1_1 99 103 PF00082 0.549
DEG_COP1_1 150 158 PF00400 0.661
DEG_Nend_UBRbox_2 1 3 PF02207 0.782
DOC_CKS1_1 246 251 PF01111 0.660
DOC_CKS1_1 259 264 PF01111 0.608
DOC_CYCLIN_RxL_1 207 217 PF00134 0.643
DOC_CYCLIN_RxL_1 8 16 PF00134 0.610
DOC_CYCLIN_yCln2_LP_2 259 265 PF00134 0.562
DOC_CYCLIN_yCln2_LP_2 284 290 PF00134 0.650
DOC_CYCLIN_yCln2_LP_2 349 355 PF00134 0.621
DOC_MAPK_gen_1 343 351 PF00069 0.642
DOC_PP2B_LxvP_1 133 136 PF13499 0.832
DOC_PP2B_LxvP_1 349 352 PF13499 0.615
DOC_PP2B_PxIxI_1 109 115 PF00149 0.558
DOC_PP4_FxxP_1 50 53 PF00568 0.696
DOC_USP7_MATH_1 128 132 PF00917 0.686
DOC_USP7_MATH_1 170 174 PF00917 0.555
DOC_USP7_MATH_1 244 248 PF00917 0.805
DOC_USP7_MATH_1 252 256 PF00917 0.786
DOC_USP7_MATH_1 301 305 PF00917 0.771
DOC_USP7_MATH_1 377 381 PF00917 0.642
DOC_USP7_UBL2_3 98 102 PF12436 0.717
DOC_WW_Pin1_4 245 250 PF00397 0.602
DOC_WW_Pin1_4 258 263 PF00397 0.600
DOC_WW_Pin1_4 283 288 PF00397 0.498
DOC_WW_Pin1_4 361 366 PF00397 0.723
LIG_14-3-3_CanoR_1 160 168 PF00244 0.405
LIG_14-3-3_CanoR_1 46 54 PF00244 0.680
LIG_APCC_ABBA_1 31 36 PF00400 0.585
LIG_BIR_III_4 41 45 PF00653 0.698
LIG_EH1_1 7 15 PF00400 0.687
LIG_eIF4E_1 73 79 PF01652 0.730
LIG_FHA_1 259 265 PF00498 0.678
LIG_FHA_1 5 11 PF00498 0.630
LIG_FHA_2 271 277 PF00498 0.652
LIG_FHA_2 298 304 PF00498 0.645
LIG_GBD_Chelix_1 381 389 PF00786 0.654
LIG_LIR_Apic_2 48 53 PF02991 0.696
LIG_LIR_Nem_3 268 272 PF02991 0.485
LIG_MYND_1 137 141 PF01753 0.766
LIG_NRP_CendR_1 387 390 PF00754 0.623
LIG_Pex14_2 17 21 PF04695 0.623
LIG_SH2_NCK_1 253 257 PF00017 0.707
LIG_SH2_NCK_1 272 276 PF00017 0.411
LIG_SH2_PTP2 111 114 PF00017 0.530
LIG_SH2_SRC 71 74 PF00017 0.713
LIG_SH2_STAP1 253 257 PF00017 0.704
LIG_SH2_STAP1 71 75 PF00017 0.711
LIG_SH2_STAT5 111 114 PF00017 0.530
LIG_SH2_STAT5 272 275 PF00017 0.649
LIG_SUMO_SIM_anti_2 261 268 PF11976 0.583
LIG_SUMO_SIM_anti_2 318 323 PF11976 0.515
LIG_SUMO_SIM_par_1 111 117 PF11976 0.627
LIG_SUMO_SIM_par_1 261 268 PF11976 0.583
LIG_SUMO_SIM_par_1 286 292 PF11976 0.639
LIG_TRAF2_1 300 303 PF00917 0.744
MOD_CK1_1 129 135 PF00069 0.826
MOD_CK1_1 150 156 PF00069 0.687
MOD_CK1_1 310 316 PF00069 0.642
MOD_CK2_1 244 250 PF00069 0.689
MOD_CK2_1 291 297 PF00069 0.599
MOD_CK2_1 377 383 PF00069 0.646
MOD_Cter_Amidation 96 99 PF01082 0.659
MOD_GlcNHglycan 106 109 PF01048 0.545
MOD_GlcNHglycan 127 131 PF01048 0.780
MOD_GlcNHglycan 156 159 PF01048 0.688
MOD_GlcNHglycan 163 166 PF01048 0.458
MOD_GlcNHglycan 254 257 PF01048 0.758
MOD_GlcNHglycan 27 30 PF01048 0.658
MOD_GlcNHglycan 302 307 PF01048 0.811
MOD_GlcNHglycan 41 45 PF01048 0.601
MOD_GlcNHglycan 54 57 PF01048 0.549
MOD_GSK3_1 147 154 PF00069 0.680
MOD_GSK3_1 240 247 PF00069 0.600
MOD_GSK3_1 297 304 PF00069 0.776
MOD_GSK3_1 307 314 PF00069 0.680
MOD_GSK3_1 323 330 PF00069 0.490
MOD_GSK3_1 347 354 PF00069 0.460
MOD_GSK3_1 80 87 PF00069 0.660
MOD_N-GLC_1 307 312 PF02516 0.687
MOD_N-GLC_2 309 311 PF02516 0.645
MOD_NEK2_1 104 109 PF00069 0.565
MOD_NEK2_1 151 156 PF00069 0.774
MOD_NEK2_1 181 186 PF00069 0.661
MOD_NEK2_1 228 233 PF00069 0.605
MOD_NEK2_1 291 296 PF00069 0.429
MOD_NEK2_1 79 84 PF00069 0.708
MOD_PKA_1 344 350 PF00069 0.643
MOD_PKA_2 45 51 PF00069 0.698
MOD_Plk_1 147 153 PF00069 0.728
MOD_Plk_1 79 85 PF00069 0.532
MOD_Plk_4 317 323 PF00069 0.671
MOD_ProDKin_1 245 251 PF00069 0.597
MOD_ProDKin_1 258 264 PF00069 0.590
MOD_ProDKin_1 283 289 PF00069 0.496
MOD_ProDKin_1 361 367 PF00069 0.728
MOD_SUMO_rev_2 32 40 PF00179 0.595
TRG_ENDOCYTIC_2 111 114 PF00928 0.530
TRG_ENDOCYTIC_2 59 62 PF00928 0.719
TRG_Pf-PMV_PEXEL_1 11 15 PF00026 0.678
TRG_Pf-PMV_PEXEL_1 202 206 PF00026 0.687

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3Q8ICA2 Leishmania donovani 100% 100%
A4HCG5 Leishmania braziliensis 68% 100%
E9AVW0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 83% 99%
Q4QBL9 Leishmania major 87% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS