Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain - G-beta repeat - putative

Species:

Leishmania infantum

UniProt:

E9AGZ5_LEIIN

TriTrypDb:

LINF_220018600

Length:

452

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	7
GO:0032991	protein-containing complex	1	7
GO:0043226	organelle	2	7
GO:0043228	non-membrane-bounded organelle	3	7
GO:0043229	intracellular organelle	3	7
GO:0043232	intracellular non-membrane-bounded organelle	4	7
GO:0110165	cellular anatomical entity	1	7
GO:1990904	ribonucleoprotein complex	2	7

Expansion

Sequence features

E9AGZ5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AGZ5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	282	286	PF00656	0.651
CLV_NRD_NRD_1	325	327	PF00675	0.683
CLV_NRD_NRD_1	94	96	PF00675	0.427
CLV_PCSK_KEX2_1	325	327	PF00082	0.683
CLV_PCSK_KEX2_1	94	96	PF00082	0.427
CLV_PCSK_SKI1_1	325	329	PF00082	0.623
CLV_PCSK_SKI1_1	384	388	PF00082	0.447
CLV_PCSK_SKI1_1	406	410	PF00082	0.390
CLV_PCSK_SKI1_1	424	428	PF00082	0.396
DEG_Nend_Nbox_1	1	3	PF02207	0.462
DEG_SPOP_SBC_1	181	185	PF00917	0.383
DOC_ANK_TNKS_1	258	265	PF00023	0.568
DOC_CYCLIN_RxL_1	109	120	PF00134	0.398
DOC_CYCLIN_RxL_1	370	382	PF00134	0.392
DOC_PP1_RVXF_1	373	380	PF00149	0.373
DOC_PP2B_LxvP_1	114	117	PF13499	0.398
DOC_PP2B_LxvP_1	252	255	PF13499	0.558
DOC_PP4_FxxP_1	238	241	PF00568	0.411
DOC_USP7_MATH_1	117	121	PF00917	0.574
DOC_USP7_MATH_1	207	211	PF00917	0.362
DOC_USP7_MATH_1	255	259	PF00917	0.660
DOC_USP7_MATH_1	287	291	PF00917	0.712
DOC_USP7_MATH_1	342	346	PF00917	0.356
DOC_USP7_MATH_1	49	53	PF00917	0.612
DOC_WW_Pin1_4	16	21	PF00397	0.391
DOC_WW_Pin1_4	418	423	PF00397	0.390
LIG_14-3-3_CanoR_1	180	190	PF00244	0.409
LIG_14-3-3_CanoR_1	209	214	PF00244	0.404
LIG_14-3-3_CanoR_1	230	236	PF00244	0.490
LIG_BRCT_BRCA1_1	14	18	PF00533	0.380
LIG_BRCT_BRCA1_1	289	293	PF00533	0.549
LIG_CSL_BTD_1	114	117	PF09270	0.404
LIG_DLG_GKlike_1	209	217	PF00625	0.481
LIG_FHA_1	164	170	PF00498	0.445
LIG_FHA_1	181	187	PF00498	0.412
LIG_FHA_1	37	43	PF00498	0.380
LIG_FHA_1	400	406	PF00498	0.443
LIG_FHA_1	443	449	PF00498	0.535
LIG_FHA_1	8	14	PF00498	0.401
LIG_FHA_2	160	166	PF00498	0.508
LIG_FHA_2	183	189	PF00498	0.361
LIG_FHA_2	199	205	PF00498	0.351
LIG_FHA_2	22	28	PF00498	0.495
LIG_FHA_2	232	238	PF00498	0.491
LIG_FHA_2	32	38	PF00498	0.375
LIG_FHA_2	385	391	PF00498	0.362
LIG_FHA_2	427	433	PF00498	0.373
LIG_FHA_2	79	85	PF00498	0.493
LIG_LIR_Apic_2	236	241	PF02991	0.422
LIG_LIR_Gen_1	74	82	PF02991	0.482
LIG_LIR_Nem_3	74	80	PF02991	0.482
LIG_Pex14_1	439	443	PF04695	0.403
LIG_Pex14_2	349	353	PF04695	0.351
LIG_SH2_CRK	297	301	PF00017	0.531
LIG_SH2_CRK	77	81	PF00017	0.490
LIG_SH2_SRC	147	150	PF00017	0.364
LIG_SH2_STAT5	147	150	PF00017	0.364
LIG_SH2_STAT5	373	376	PF00017	0.374
LIG_SH2_STAT5	77	80	PF00017	0.490
LIG_SH3_3	14	20	PF00018	0.399
LIG_SH3_3	187	193	PF00018	0.402
LIG_SH3_3	243	249	PF00018	0.399
LIG_SUMO_SIM_anti_2	195	201	PF11976	0.320
LIG_SUMO_SIM_par_1	244	250	PF11976	0.447
LIG_SUMO_SIM_par_1	384	393	PF11976	0.367
MOD_CDC14_SPxK_1	421	424	PF00782	0.499
MOD_CDK_SPxK_1	418	424	PF00069	0.477
MOD_CK1_1	182	188	PF00069	0.382
MOD_CK1_1	267	273	PF00069	0.714
MOD_CK1_1	288	294	PF00069	0.490
MOD_CK1_1	389	395	PF00069	0.399
MOD_CK1_1	418	424	PF00069	0.396
MOD_CK2_1	153	159	PF00069	0.600
MOD_CK2_1	198	204	PF00069	0.350
MOD_CK2_1	21	27	PF00069	0.493
MOD_CK2_1	231	237	PF00069	0.495
MOD_CK2_1	390	396	PF00069	0.369
MOD_GlcNHglycan	103	106	PF01048	0.379
MOD_GlcNHglycan	130	133	PF01048	0.559
MOD_GlcNHglycan	138	141	PF01048	0.391
MOD_GlcNHglycan	155	158	PF01048	0.559
MOD_GlcNHglycan	249	252	PF01048	0.580
MOD_GlcNHglycan	266	269	PF01048	0.747
MOD_GlcNHglycan	287	290	PF01048	0.627
MOD_GlcNHglycan	317	320	PF01048	0.702
MOD_GlcNHglycan	34	37	PF01048	0.439
MOD_GlcNHglycan	417	420	PF01048	0.364
MOD_GSK3_1	12	19	PF00069	0.387
MOD_GSK3_1	123	130	PF00069	0.594
MOD_GSK3_1	149	156	PF00069	0.478
MOD_GSK3_1	159	166	PF00069	0.615
MOD_GSK3_1	194	201	PF00069	0.401
MOD_GSK3_1	3	10	PF00069	0.462
MOD_GSK3_1	310	317	PF00069	0.729
MOD_GSK3_1	32	39	PF00069	0.375
MOD_GSK3_1	386	393	PF00069	0.450
MOD_GSK3_1	414	421	PF00069	0.372
MOD_GSK3_1	71	78	PF00069	0.530
MOD_GSK3_1	80	87	PF00069	0.471
MOD_N-GLC_1	220	225	PF02516	0.549
MOD_NEK2_1	151	156	PF00069	0.458
MOD_NEK2_1	179	184	PF00069	0.389
MOD_NEK2_1	219	224	PF00069	0.581
MOD_NEK2_1	30	35	PF00069	0.373
MOD_NEK2_1	414	419	PF00069	0.371
MOD_NEK2_1	426	431	PF00069	0.365
MOD_PIKK_1	49	55	PF00454	0.498
MOD_PKA_1	325	331	PF00069	0.607
MOD_PKA_2	123	129	PF00069	0.594
MOD_PKA_2	179	185	PF00069	0.404
MOD_PKA_2	325	331	PF00069	0.607
MOD_Plk_1	220	226	PF00069	0.549
MOD_Plk_1	37	43	PF00069	0.411
MOD_Plk_1	390	396	PF00069	0.369
MOD_Plk_1	84	90	PF00069	0.477
MOD_Plk_2-3	159	165	PF00069	0.514
MOD_Plk_4	12	18	PF00069	0.406
MOD_Plk_4	75	81	PF00069	0.603
MOD_ProDKin_1	16	22	PF00069	0.393
MOD_ProDKin_1	418	424	PF00069	0.398
MOD_SUMO_rev_2	378	386	PF00179	0.479
TRG_DiLeu_BaLyEn_6	227	232	PF01217	0.503
TRG_ENDOCYTIC_2	297	300	PF00928	0.532
TRG_ENDOCYTIC_2	77	80	PF00928	0.490
TRG_ER_diArg_1	324	326	PF00400	0.698
TRG_ER_diArg_1	93	95	PF00400	0.422

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM43	Leptomonas seymouri	68%	100%
A0A3S7WX82	Leishmania donovani	100%	100%
A4HCG2	Leishmania braziliensis	83%	100%
E9AVV7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QBM2	Leishmania major	94%	100%