LeishMANIAdb
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3'a2rel-related protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
3'a2rel-related protein
Gene product:
3'a2rel-related protein
Species:
Leishmania infantum
UniProt:
E9AGZ3_LEIIN
TriTrypDb:
LINF_220012300
Length:
615

Annotations

LeishMANIAdb annotations

A very special family of kinetoplastid proteins, carrying multiply amyloid-like segments on their disordered extracellular domain, alongside with RGD motifs. Duplicated in Leishmaniids

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 4, no: 5
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0016020 membrane 2 7
GO:0110165 cellular anatomical entity 1 7

Expansion

Sequence features

E9AGZ3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AGZ3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 383 387 PF00656 0.701
CLV_C14_Caspase3-7 538 542 PF00656 0.829
CLV_NRD_NRD_1 175 177 PF00675 0.758
CLV_NRD_NRD_1 215 217 PF00675 0.747
CLV_NRD_NRD_1 246 248 PF00675 0.516
CLV_NRD_NRD_1 251 253 PF00675 0.502
CLV_NRD_NRD_1 331 333 PF00675 0.573
CLV_NRD_NRD_1 336 338 PF00675 0.518
CLV_PCSK_FUR_1 249 253 PF00082 0.494
CLV_PCSK_FUR_1 334 338 PF00082 0.575
CLV_PCSK_KEX2_1 175 177 PF00082 0.758
CLV_PCSK_KEX2_1 215 217 PF00082 0.747
CLV_PCSK_KEX2_1 246 248 PF00082 0.516
CLV_PCSK_KEX2_1 251 253 PF00082 0.502
CLV_PCSK_KEX2_1 333 335 PF00082 0.571
CLV_PCSK_KEX2_1 336 338 PF00082 0.542
CLV_PCSK_PC1ET2_1 251 253 PF00082 0.504
CLV_PCSK_PC1ET2_1 333 335 PF00082 0.571
CLV_PCSK_PC7_1 247 253 PF00082 0.484
CLV_PCSK_PC7_1 332 338 PF00082 0.574
CLV_PCSK_SKI1_1 221 225 PF00082 0.633
CLV_PCSK_SKI1_1 25 29 PF00082 0.678
CLV_PCSK_SKI1_1 252 256 PF00082 0.523
CLV_PCSK_SKI1_1 461 465 PF00082 0.593
CLV_PCSK_SKI1_1 513 517 PF00082 0.540
DEG_APCC_DBOX_1 220 228 PF00400 0.433
DEG_Nend_UBRbox_4 1 3 PF02207 0.717
DEG_SCF_FBW7_1 150 157 PF00400 0.482
DEG_SPOP_SBC_1 128 132 PF00917 0.559
DEG_SPOP_SBC_1 154 158 PF00917 0.543
DEG_SPOP_SBC_1 201 205 PF00917 0.575
DEG_SPOP_SBC_1 437 441 PF00917 0.768
DOC_CKS1_1 151 156 PF01111 0.484
DOC_CKS1_1 43 48 PF01111 0.652
DOC_CYCLIN_RxL_1 249 262 PF00134 0.786
DOC_CYCLIN_RxL_1 458 468 PF00134 0.662
DOC_CYCLIN_yCln2_LP_2 230 236 PF00134 0.527
DOC_CYCLIN_yCln2_LP_2 80 86 PF00134 0.606
DOC_MAPK_gen_1 215 222 PF00069 0.476
DOC_MAPK_gen_1 249 259 PF00069 0.770
DOC_MAPK_gen_1 330 340 PF00069 0.748
DOC_MAPK_gen_1 69 78 PF00069 0.549
DOC_MAPK_MEF2A_6 215 224 PF00069 0.487
DOC_MAPK_MEF2A_6 25 32 PF00069 0.596
DOC_MAPK_MEF2A_6 69 78 PF00069 0.608
DOC_PP2B_LxvP_1 160 163 PF13499 0.434
DOC_PP2B_LxvP_1 230 233 PF13499 0.527
DOC_PP2B_LxvP_1 555 558 PF13499 0.837
DOC_PP2B_LxvP_1 71 74 PF13499 0.573
DOC_PP2B_LxvP_1 76 79 PF13499 0.531
DOC_SPAK_OSR1_1 301 305 PF12202 0.767
DOC_USP7_MATH_1 124 128 PF00917 0.614
DOC_USP7_MATH_1 129 133 PF00917 0.574
DOC_USP7_MATH_1 15 19 PF00917 0.645
DOC_USP7_MATH_1 154 158 PF00917 0.519
DOC_USP7_MATH_1 165 169 PF00917 0.501
DOC_USP7_MATH_1 170 174 PF00917 0.488
DOC_USP7_MATH_1 202 206 PF00917 0.582
DOC_USP7_MATH_1 402 406 PF00917 0.850
DOC_USP7_MATH_1 410 414 PF00917 0.762
DOC_USP7_MATH_1 423 427 PF00917 0.744
DOC_USP7_MATH_1 437 441 PF00917 0.686
DOC_USP7_MATH_1 490 494 PF00917 0.835
DOC_USP7_MATH_1 507 511 PF00917 0.673
DOC_USP7_UBL2_3 251 255 PF12436 0.712
DOC_WW_Pin1_4 11 16 PF00397 0.727
DOC_WW_Pin1_4 134 139 PF00397 0.582
DOC_WW_Pin1_4 150 155 PF00397 0.447
DOC_WW_Pin1_4 286 291 PF00397 0.695
DOC_WW_Pin1_4 360 365 PF00397 0.812
DOC_WW_Pin1_4 42 47 PF00397 0.699
LIG_14-3-3_CanoR_1 16 23 PF00244 0.588
LIG_14-3-3_CanoR_1 166 174 PF00244 0.546
LIG_14-3-3_CanoR_1 175 180 PF00244 0.523
LIG_14-3-3_CanoR_1 568 575 PF00244 0.802
LIG_EVH1_2 208 212 PF00568 0.564
LIG_FHA_1 38 44 PF00498 0.596
LIG_FHA_1 409 415 PF00498 0.856
LIG_FHA_1 437 443 PF00498 0.766
LIG_FHA_1 457 463 PF00498 0.637
LIG_FHA_1 52 58 PF00498 0.437
LIG_FHA_1 75 81 PF00498 0.578
LIG_FHA_2 568 574 PF00498 0.803
LIG_Integrin_isoDGR_2 141 143 PF01839 0.728
LIG_Integrin_RGD_1 47 49 PF01839 0.676
LIG_Integrin_RGD_1 536 538 PF01839 0.646
LIG_LIR_Gen_1 281 290 PF02991 0.809
LIG_LIR_Gen_1 35 43 PF02991 0.609
LIG_LIR_Gen_1 514 524 PF02991 0.782
LIG_LIR_Nem_3 281 285 PF02991 0.804
LIG_LIR_Nem_3 316 322 PF02991 0.718
LIG_LIR_Nem_3 514 519 PF02991 0.778
LIG_MYND_1 79 83 PF01753 0.493
LIG_NRBOX 28 34 PF00104 0.615
LIG_SH2_GRB2like 455 458 PF00017 0.802
LIG_SH2_SRC 611 614 PF00017 0.746
LIG_SH2_STAT5 455 458 PF00017 0.802
LIG_SH2_STAT5 467 470 PF00017 0.683
LIG_SH2_STAT5 611 614 PF00017 0.746
LIG_SH3_3 148 154 PF00018 0.488
LIG_SH3_3 159 165 PF00018 0.440
LIG_SH3_3 40 46 PF00018 0.653
LIG_SH3_3 473 479 PF00018 0.800
LIG_SH3_3 506 512 PF00018 0.788
LIG_SH3_3 607 613 PF00018 0.695
LIG_SH3_3 81 87 PF00018 0.598
LIG_SUMO_SIM_anti_2 185 191 PF11976 0.613
LIG_SUMO_SIM_par_1 187 193 PF11976 0.612
LIG_TRAF2_1 119 122 PF00917 0.575
LIG_TRAF2_1 379 382 PF00917 0.853
LIG_WRC_WIRS_1 108 113 PF05994 0.544
LIG_WRC_WIRS_1 33 38 PF05994 0.577
LIG_WRC_WIRS_1 519 524 PF05994 0.739
MOD_CDK_SPK_2 11 16 PF00069 0.637
MOD_CDK_SPK_2 42 47 PF00069 0.552
MOD_CDK_SPxK_1 286 292 PF00069 0.698
MOD_CK1_1 127 133 PF00069 0.620
MOD_CK1_1 134 140 PF00069 0.548
MOD_CK1_1 156 162 PF00069 0.620
MOD_CK1_1 169 175 PF00069 0.473
MOD_CK1_1 363 369 PF00069 0.774
MOD_CK1_1 37 43 PF00069 0.585
MOD_CK1_1 441 447 PF00069 0.839
MOD_CK2_1 375 381 PF00069 0.859
MOD_CK2_1 495 501 PF00069 0.813
MOD_CK2_1 511 517 PF00069 0.665
MOD_CK2_1 567 573 PF00069 0.806
MOD_GlcNHglycan 121 125 PF01048 0.814
MOD_GlcNHglycan 133 136 PF01048 0.702
MOD_GlcNHglycan 168 171 PF01048 0.787
MOD_GlcNHglycan 181 184 PF01048 0.689
MOD_GlcNHglycan 204 207 PF01048 0.780
MOD_GlcNHglycan 365 368 PF01048 0.610
MOD_GlcNHglycan 394 397 PF01048 0.627
MOD_GlcNHglycan 404 407 PF01048 0.523
MOD_GlcNHglycan 426 429 PF01048 0.617
MOD_GlcNHglycan 470 473 PF01048 0.632
MOD_GlcNHglycan 480 483 PF01048 0.557
MOD_GlcNHglycan 497 500 PF01048 0.480
MOD_GlcNHglycan 503 506 PF01048 0.574
MOD_GlcNHglycan 547 550 PF01048 0.599
MOD_GlcNHglycan 57 60 PF01048 0.792
MOD_GlcNHglycan 606 609 PF01048 0.550
MOD_GlcNHglycan 91 94 PF01048 0.779
MOD_GSK3_1 11 18 PF00069 0.710
MOD_GSK3_1 120 127 PF00069 0.565
MOD_GSK3_1 130 137 PF00069 0.525
MOD_GSK3_1 150 157 PF00069 0.462
MOD_GSK3_1 165 172 PF00069 0.443
MOD_GSK3_1 175 182 PF00069 0.478
MOD_GSK3_1 286 293 PF00069 0.710
MOD_GSK3_1 37 44 PF00069 0.646
MOD_GSK3_1 382 389 PF00069 0.770
MOD_GSK3_1 437 444 PF00069 0.846
MOD_GSK3_1 507 514 PF00069 0.718
MOD_GSK3_1 51 58 PF00069 0.449
MOD_GSK3_1 600 607 PF00069 0.690
MOD_N-GLC_1 11 16 PF02516 0.752
MOD_N-GLC_1 259 264 PF02516 0.622
MOD_N-GLC_1 456 461 PF02516 0.593
MOD_NEK2_1 120 125 PF00069 0.551
MOD_NEK2_1 174 179 PF00069 0.584
MOD_NEK2_1 259 264 PF00069 0.822
MOD_NEK2_1 32 37 PF00069 0.627
MOD_NEK2_1 456 461 PF00069 0.770
MOD_NEK2_1 55 60 PF00069 0.547
MOD_NEK2_2 170 175 PF00069 0.550
MOD_NEK2_2 490 495 PF00069 0.775
MOD_PIKK_1 109 115 PF00454 0.541
MOD_PIKK_1 600 606 PF00454 0.690
MOD_PK_1 511 517 PF00069 0.661
MOD_PKA_1 175 181 PF00069 0.483
MOD_PKA_2 142 148 PF00069 0.523
MOD_PKA_2 15 21 PF00069 0.571
MOD_PKA_2 165 171 PF00069 0.575
MOD_PKA_2 174 180 PF00069 0.496
MOD_PKA_2 245 251 PF00069 0.724
MOD_PKA_2 300 306 PF00069 0.765
MOD_PKA_2 465 471 PF00069 0.696
MOD_PKA_2 539 545 PF00069 0.704
MOD_PKA_2 567 573 PF00069 0.806
MOD_PKA_2 604 610 PF00069 0.694
MOD_Plk_1 315 321 PF00069 0.746
MOD_Plk_1 457 463 PF00069 0.684
MOD_Plk_1 490 496 PF00069 0.687
MOD_Plk_2-3 567 573 PF00069 0.806
MOD_Plk_4 175 181 PF00069 0.483
MOD_Plk_4 410 416 PF00069 0.852
MOD_Plk_4 438 444 PF00069 0.764
MOD_Plk_4 511 517 PF00069 0.677
MOD_ProDKin_1 11 17 PF00069 0.721
MOD_ProDKin_1 134 140 PF00069 0.580
MOD_ProDKin_1 150 156 PF00069 0.448
MOD_ProDKin_1 286 292 PF00069 0.698
MOD_ProDKin_1 360 366 PF00069 0.813
MOD_ProDKin_1 42 48 PF00069 0.703
TRG_DiLeu_BaLyEn_6 76 81 PF01217 0.490
TRG_ER_diArg_1 174 176 PF00400 0.562
TRG_ER_diArg_1 246 249 PF00400 0.721
TRG_ER_diArg_1 334 337 PF00400 0.776
TRG_ER_diArg_1 560 563 PF00400 0.718
TRG_NLS_MonoExtC_3 250 255 PF00514 0.706
TRG_NLS_MonoExtC_3 331 336 PF00514 0.774
TRG_NLS_MonoExtN_4 249 256 PF00514 0.708
TRG_NLS_MonoExtN_4 330 337 PF00514 0.775

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3Q8ILH2 Leishmania donovani 98% 100%
A0A3S7WX43 Leishmania donovani 98% 100%
A4HCB1 Leishmania braziliensis 63% 100%
A4HDA2 Leishmania braziliensis 58% 100%
E9AGZ2 Leishmania infantum 99% 100%
E9AVQ1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 82% 100%
Q4QBR2 Leishmania major 89% 100%
Q4QBS8 Leishmania major 89% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS