LeishMANIAdb
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3'a2rel-related protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
3'a2rel-related protein
Gene product:
3'a2rel-related protein
Species:
Leishmania infantum
UniProt:
E9AGZ2_LEIIN
TriTrypDb:
LINF_220012300 *
Length:
615

Annotations

LeishMANIAdb annotations

A very special family of kinetoplastid proteins, carrying multiply amyloid-like segments on their disordered extracellular domain, alongside with RGD motifs. Duplicated in Leishmaniids

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 4, no: 5
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0016020 membrane 2 7
GO:0110165 cellular anatomical entity 1 7

Expansion

Sequence features

E9AGZ2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AGZ2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 383 387 PF00656 0.681
CLV_NRD_NRD_1 175 177 PF00675 0.715
CLV_NRD_NRD_1 215 217 PF00675 0.707
CLV_NRD_NRD_1 246 248 PF00675 0.498
CLV_NRD_NRD_1 251 253 PF00675 0.521
CLV_NRD_NRD_1 331 333 PF00675 0.512
CLV_NRD_NRD_1 336 338 PF00675 0.474
CLV_PCSK_FUR_1 249 253 PF00082 0.452
CLV_PCSK_FUR_1 334 338 PF00082 0.515
CLV_PCSK_KEX2_1 175 177 PF00082 0.715
CLV_PCSK_KEX2_1 215 217 PF00082 0.707
CLV_PCSK_KEX2_1 246 248 PF00082 0.501
CLV_PCSK_KEX2_1 251 253 PF00082 0.518
CLV_PCSK_KEX2_1 333 335 PF00082 0.512
CLV_PCSK_KEX2_1 336 338 PF00082 0.492
CLV_PCSK_PC1ET2_1 251 253 PF00082 0.463
CLV_PCSK_PC1ET2_1 333 335 PF00082 0.512
CLV_PCSK_PC7_1 247 253 PF00082 0.441
CLV_PCSK_PC7_1 332 338 PF00082 0.514
CLV_PCSK_SKI1_1 146 150 PF00082 0.626
CLV_PCSK_SKI1_1 221 225 PF00082 0.572
CLV_PCSK_SKI1_1 25 29 PF00082 0.626
CLV_PCSK_SKI1_1 252 256 PF00082 0.482
CLV_PCSK_SKI1_1 461 465 PF00082 0.525
CLV_PCSK_SKI1_1 513 517 PF00082 0.481
DEG_APCC_DBOX_1 220 228 PF00400 0.372
DEG_Nend_UBRbox_4 1 3 PF02207 0.710
DEG_SCF_FBW7_1 151 157 PF00400 0.463
DEG_SPOP_SBC_1 128 132 PF00917 0.518
DEG_SPOP_SBC_1 154 158 PF00917 0.510
DEG_SPOP_SBC_1 201 205 PF00917 0.539
DEG_SPOP_SBC_1 437 441 PF00917 0.727
DOC_CKS1_1 151 156 PF01111 0.463
DOC_CKS1_1 43 48 PF01111 0.588
DOC_CYCLIN_RxL_1 249 262 PF00134 0.726
DOC_CYCLIN_RxL_1 458 468 PF00134 0.631
DOC_CYCLIN_yCln2_LP_2 230 236 PF00134 0.441
DOC_CYCLIN_yCln2_LP_2 80 86 PF00134 0.552
DOC_MAPK_gen_1 215 222 PF00069 0.437
DOC_MAPK_gen_1 249 259 PF00069 0.771
DOC_MAPK_gen_1 330 340 PF00069 0.694
DOC_MAPK_gen_1 69 78 PF00069 0.507
DOC_MAPK_MEF2A_6 215 224 PF00069 0.449
DOC_MAPK_MEF2A_6 25 32 PF00069 0.519
DOC_MAPK_MEF2A_6 69 78 PF00069 0.550
DOC_PP2B_LxvP_1 160 163 PF13499 0.428
DOC_PP2B_LxvP_1 230 233 PF13499 0.441
DOC_PP2B_LxvP_1 555 558 PF13499 0.779
DOC_PP2B_LxvP_1 71 74 PF13499 0.524
DOC_PP2B_LxvP_1 76 79 PF13499 0.494
DOC_SPAK_OSR1_1 301 305 PF12202 0.718
DOC_USP7_MATH_1 124 128 PF00917 0.559
DOC_USP7_MATH_1 129 133 PF00917 0.529
DOC_USP7_MATH_1 15 19 PF00917 0.624
DOC_USP7_MATH_1 154 158 PF00917 0.499
DOC_USP7_MATH_1 165 169 PF00917 0.499
DOC_USP7_MATH_1 170 174 PF00917 0.490
DOC_USP7_MATH_1 202 206 PF00917 0.544
DOC_USP7_MATH_1 402 406 PF00917 0.788
DOC_USP7_MATH_1 410 414 PF00917 0.726
DOC_USP7_MATH_1 423 427 PF00917 0.713
DOC_USP7_MATH_1 437 441 PF00917 0.666
DOC_USP7_MATH_1 490 494 PF00917 0.769
DOC_USP7_MATH_1 507 511 PF00917 0.651
DOC_USP7_UBL2_3 251 255 PF12436 0.672
DOC_WW_Pin1_4 11 16 PF00397 0.676
DOC_WW_Pin1_4 134 139 PF00397 0.538
DOC_WW_Pin1_4 150 155 PF00397 0.436
DOC_WW_Pin1_4 286 291 PF00397 0.667
DOC_WW_Pin1_4 360 365 PF00397 0.762
DOC_WW_Pin1_4 42 47 PF00397 0.665
LIG_14-3-3_CanoR_1 16 23 PF00244 0.532
LIG_14-3-3_CanoR_1 166 174 PF00244 0.567
LIG_14-3-3_CanoR_1 175 180 PF00244 0.519
LIG_14-3-3_CanoR_1 568 575 PF00244 0.757
LIG_EVH1_2 208 212 PF00568 0.524
LIG_FHA_1 38 44 PF00498 0.546
LIG_FHA_1 409 415 PF00498 0.794
LIG_FHA_1 437 443 PF00498 0.725
LIG_FHA_1 457 463 PF00498 0.610
LIG_FHA_1 52 58 PF00498 0.415
LIG_FHA_1 75 81 PF00498 0.530
LIG_FHA_2 568 574 PF00498 0.756
LIG_Integrin_isoDGR_2 141 143 PF01839 0.709
LIG_Integrin_RGD_1 47 49 PF01839 0.648
LIG_Integrin_RGD_1 536 538 PF01839 0.572
LIG_LIR_Gen_1 281 290 PF02991 0.748
LIG_LIR_Gen_1 35 43 PF02991 0.534
LIG_LIR_Gen_1 514 524 PF02991 0.710
LIG_LIR_Nem_3 281 285 PF02991 0.742
LIG_LIR_Nem_3 316 322 PF02991 0.670
LIG_LIR_Nem_3 514 519 PF02991 0.707
LIG_MYND_1 79 83 PF01753 0.467
LIG_NRBOX 28 34 PF00104 0.532
LIG_SH2_GRB2like 455 458 PF00017 0.738
LIG_SH2_SRC 611 614 PF00017 0.699
LIG_SH2_STAP1 541 545 PF00017 0.619
LIG_SH2_STAT5 455 458 PF00017 0.738
LIG_SH2_STAT5 467 470 PF00017 0.651
LIG_SH2_STAT5 611 614 PF00017 0.717
LIG_SH3_3 148 154 PF00018 0.468
LIG_SH3_3 159 165 PF00018 0.430
LIG_SH3_3 40 46 PF00018 0.579
LIG_SH3_3 473 479 PF00018 0.750
LIG_SH3_3 506 512 PF00018 0.733
LIG_SH3_3 607 613 PF00018 0.667
LIG_SH3_3 81 87 PF00018 0.543
LIG_SUMO_SIM_anti_2 185 191 PF11976 0.560
LIG_SUMO_SIM_par_1 187 193 PF11976 0.558
LIG_TRAF2_1 119 122 PF00917 0.531
LIG_TRAF2_1 379 382 PF00917 0.788
LIG_WRC_WIRS_1 108 113 PF05994 0.500
LIG_WRC_WIRS_1 33 38 PF05994 0.503
LIG_WRC_WIRS_1 519 524 PF05994 0.679
MOD_CDK_SPK_2 11 16 PF00069 0.595
MOD_CDK_SPK_2 42 47 PF00069 0.511
MOD_CDK_SPxK_1 286 292 PF00069 0.670
MOD_CK1_1 127 133 PF00069 0.574
MOD_CK1_1 134 140 PF00069 0.514
MOD_CK1_1 156 162 PF00069 0.589
MOD_CK1_1 169 175 PF00069 0.499
MOD_CK1_1 363 369 PF00069 0.731
MOD_CK1_1 37 43 PF00069 0.523
MOD_CK1_1 441 447 PF00069 0.776
MOD_CK2_1 375 381 PF00069 0.796
MOD_CK2_1 495 501 PF00069 0.757
MOD_CK2_1 511 517 PF00069 0.626
MOD_CK2_1 567 573 PF00069 0.759
MOD_GlcNHglycan 121 125 PF01048 0.759
MOD_GlcNHglycan 133 136 PF01048 0.677
MOD_GlcNHglycan 168 171 PF01048 0.734
MOD_GlcNHglycan 181 184 PF01048 0.660
MOD_GlcNHglycan 204 207 PF01048 0.741
MOD_GlcNHglycan 365 368 PF01048 0.555
MOD_GlcNHglycan 394 397 PF01048 0.567
MOD_GlcNHglycan 404 407 PF01048 0.494
MOD_GlcNHglycan 426 429 PF01048 0.566
MOD_GlcNHglycan 470 473 PF01048 0.568
MOD_GlcNHglycan 480 483 PF01048 0.513
MOD_GlcNHglycan 497 500 PF01048 0.459
MOD_GlcNHglycan 503 506 PF01048 0.534
MOD_GlcNHglycan 547 550 PF01048 0.538
MOD_GlcNHglycan 57 60 PF01048 0.730
MOD_GlcNHglycan 606 609 PF01048 0.509
MOD_GlcNHglycan 91 94 PF01048 0.728
MOD_GSK3_1 11 18 PF00069 0.658
MOD_GSK3_1 120 127 PF00069 0.530
MOD_GSK3_1 130 137 PF00069 0.494
MOD_GSK3_1 150 157 PF00069 0.463
MOD_GSK3_1 165 172 PF00069 0.470
MOD_GSK3_1 175 182 PF00069 0.470
MOD_GSK3_1 286 293 PF00069 0.677
MOD_GSK3_1 37 44 PF00069 0.564
MOD_GSK3_1 382 389 PF00069 0.730
MOD_GSK3_1 437 444 PF00069 0.782
MOD_GSK3_1 507 514 PF00069 0.678
MOD_GSK3_1 51 58 PF00069 0.424
MOD_GSK3_1 600 607 PF00069 0.674
MOD_N-GLC_1 11 16 PF02516 0.712
MOD_N-GLC_1 259 264 PF02516 0.556
MOD_N-GLC_1 456 461 PF02516 0.527
MOD_NEK2_1 120 125 PF00069 0.555
MOD_NEK2_1 174 179 PF00069 0.532
MOD_NEK2_1 259 264 PF00069 0.812
MOD_NEK2_1 32 37 PF00069 0.539
MOD_NEK2_1 456 461 PF00069 0.711
MOD_NEK2_1 55 60 PF00069 0.497
MOD_NEK2_2 170 175 PF00069 0.511
MOD_NEK2_2 490 495 PF00069 0.726
MOD_PIKK_1 109 115 PF00454 0.498
MOD_PIKK_1 600 606 PF00454 0.661
MOD_PK_1 511 517 PF00069 0.624
MOD_PKA_1 175 181 PF00069 0.455
MOD_PKA_2 142 148 PF00069 0.501
MOD_PKA_2 15 21 PF00069 0.527
MOD_PKA_2 165 171 PF00069 0.550
MOD_PKA_2 174 180 PF00069 0.479
MOD_PKA_2 245 251 PF00069 0.709
MOD_PKA_2 300 306 PF00069 0.717
MOD_PKA_2 465 471 PF00069 0.660
MOD_PKA_2 539 545 PF00069 0.671
MOD_PKA_2 567 573 PF00069 0.759
MOD_PKA_2 604 610 PF00069 0.670
MOD_Plk_1 315 321 PF00069 0.691
MOD_Plk_1 457 463 PF00069 0.645
MOD_Plk_1 490 496 PF00069 0.660
MOD_Plk_2-3 567 573 PF00069 0.759
MOD_Plk_4 175 181 PF00069 0.455
MOD_Plk_4 410 416 PF00069 0.792
MOD_Plk_4 438 444 PF00069 0.722
MOD_Plk_4 511 517 PF00069 0.636
MOD_ProDKin_1 11 17 PF00069 0.667
MOD_ProDKin_1 134 140 PF00069 0.537
MOD_ProDKin_1 150 156 PF00069 0.437
MOD_ProDKin_1 286 292 PF00069 0.670
MOD_ProDKin_1 360 366 PF00069 0.761
MOD_ProDKin_1 42 48 PF00069 0.670
TRG_DiLeu_BaLyEn_6 76 81 PF01217 0.465
TRG_ER_diArg_1 174 176 PF00400 0.520
TRG_ER_diArg_1 246 249 PF00400 0.707
TRG_ER_diArg_1 334 337 PF00400 0.717
TRG_ER_diArg_1 560 563 PF00400 0.689
TRG_NLS_MonoExtC_3 250 255 PF00514 0.666
TRG_NLS_MonoExtC_3 331 336 PF00514 0.714
TRG_NLS_MonoExtN_4 249 256 PF00514 0.666
TRG_NLS_MonoExtN_4 330 337 PF00514 0.714

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3Q8ILH2 Leishmania donovani 98% 100%
A0A3S7WX43 Leishmania donovani 98% 100%
A4HCB1 Leishmania braziliensis 62% 100%
A4HDA2 Leishmania braziliensis 58% 100%
E9AGZ3 Leishmania infantum 99% 100%
E9AVQ1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 82% 100%
Q4QBR2 Leishmania major 89% 100%
Q4QBS8 Leishmania major 89% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS