ERCC4 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

E9AGY7_LEIIN

TriTrypDb:

LINF_220005700

Length:

396

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	5
GO:0043226	organelle	2	5
GO:0043227	membrane-bounded organelle	3	5
GO:0043229	intracellular organelle	3	5
GO:0043231	intracellular membrane-bounded organelle	4	5
GO:0110165	cellular anatomical entity	1	5
GO:0000109	nucleotide-excision repair complex	3	1
GO:0000110	nucleotide-excision repair factor 1 complex	4	1
GO:0032991	protein-containing complex	1	1
GO:0070522	ERCC4-ERCC1 complex	4	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

E9AGY7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AGY7

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	6
GO:0006259	DNA metabolic process	4	6
GO:0006281	DNA repair	5	6
GO:0006725	cellular aromatic compound metabolic process	3	6
GO:0006807	nitrogen compound metabolic process	2	6
GO:0006950	response to stress	2	6
GO:0006974	DNA damage response	4	6
GO:0008152	metabolic process	1	6
GO:0009987	cellular process	1	6
GO:0033554	cellular response to stress	3	6
GO:0034641	cellular nitrogen compound metabolic process	3	6
GO:0043170	macromolecule metabolic process	3	6
GO:0044237	cellular metabolic process	2	6
GO:0044238	primary metabolic process	2	6
GO:0044260	obsolete cellular macromolecule metabolic process	3	6
GO:0046483	heterocycle metabolic process	3	6
GO:0050896	response to stimulus	1	6
GO:0051716	cellular response to stimulus	2	6
GO:0071704	organic substance metabolic process	2	6
GO:0090304	nucleic acid metabolic process	4	6
GO:1901360	organic cyclic compound metabolic process	3	6
GO:0000710	meiotic mismatch repair	4	1
GO:0006296	obsolete nucleotide-excision repair, DNA incision, 5'-to lesion	7	1
GO:0006298	mismatch repair	6	1
GO:0006310	DNA recombination	5	1
GO:0006312	mitotic recombination	6	1
GO:0009314	response to radiation	3	1
GO:0009411	response to UV	5	1
GO:0009416	response to light stimulus	4	1
GO:0009628	response to abiotic stimulus	2	1
GO:0022402	cell cycle process	2	1
GO:0022414	reproductive process	1	1
GO:0033683	obsolete nucleotide-excision repair, DNA incision	6	1
GO:0034644	cellular response to UV	6	1
GO:0061982	meiosis I cell cycle process	3	1
GO:0070914	UV-damage excision repair	6	1
GO:0071214	cellular response to abiotic stimulus	3	1
GO:0071478	cellular response to radiation	4	1
GO:0071482	cellular response to light stimulus	5	1
GO:0090305	nucleic acid phosphodiester bond hydrolysis	5	1
GO:0104004	cellular response to environmental stimulus	3	1
GO:1903046	meiotic cell cycle process	2	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	6
GO:0003677	DNA binding	4	6
GO:0003684	damaged DNA binding	5	6
GO:0005488	binding	1	6
GO:0097159	organic cyclic compound binding	2	6
GO:1901363	heterocyclic compound binding	2	6
GO:0003697	single-stranded DNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	286	290	PF00656	0.568
CLV_NRD_NRD_1	105	107	PF00675	0.499
CLV_NRD_NRD_1	131	133	PF00675	0.499
CLV_NRD_NRD_1	282	284	PF00675	0.644
CLV_NRD_NRD_1	377	379	PF00675	0.731
CLV_NRD_NRD_1	385	387	PF00675	0.644
CLV_PCSK_FUR_1	129	133	PF00082	0.657
CLV_PCSK_KEX2_1	105	107	PF00082	0.499
CLV_PCSK_KEX2_1	131	133	PF00082	0.659
CLV_PCSK_KEX2_1	376	378	PF00082	0.615
CLV_PCSK_KEX2_1	385	387	PF00082	0.530
CLV_PCSK_SKI1_1	4	8	PF00082	0.508
DEG_APCC_DBOX_1	3	11	PF00400	0.510
DEG_APCC_DBOX_1	95	103	PF00400	0.480
DEG_SCF_FBW7_1	315	322	PF00400	0.689
DEG_SCF_TRCP1_1	194	200	PF00400	0.474
DOC_CKS1_1	316	321	PF01111	0.684
DOC_CYCLIN_yCln2_LP_2	5	11	PF00134	0.513
DOC_MAPK_gen_1	129	138	PF00069	0.639
DOC_MAPK_HePTP_8	189	201	PF00069	0.442
DOC_MAPK_MEF2A_6	129	138	PF00069	0.639
DOC_MAPK_MEF2A_6	166	175	PF00069	0.628
DOC_MAPK_MEF2A_6	181	190	PF00069	0.299
DOC_MAPK_MEF2A_6	192	201	PF00069	0.464
DOC_PP1_RVXF_1	201	207	PF00149	0.531
DOC_PP2B_LxvP_1	10	13	PF13499	0.503
DOC_PP2B_LxvP_1	5	8	PF13499	0.507
DOC_PP4_FxxP_1	316	319	PF00568	0.663
DOC_PP4_FxxP_1	9	12	PF00568	0.516
DOC_USP7_MATH_1	17	21	PF00917	0.518
DOC_USP7_MATH_1	236	240	PF00917	0.489
DOC_USP7_MATH_1	290	294	PF00917	0.559
DOC_USP7_MATH_1	345	349	PF00917	0.663
DOC_USP7_MATH_1	72	76	PF00917	0.486
DOC_WW_Pin1_4	13	18	PF00397	0.501
DOC_WW_Pin1_4	265	270	PF00397	0.664
DOC_WW_Pin1_4	315	320	PF00397	0.672
DOC_WW_Pin1_4	47	52	PF00397	0.510
DOC_WW_Pin1_4	54	59	PF00397	0.501
LIG_14-3-3_CanoR_1	203	207	PF00244	0.425
LIG_14-3-3_CanoR_1	283	291	PF00244	0.643
LIG_14-3-3_CanoR_1	360	367	PF00244	0.749
LIG_14-3-3_CanoR_1	377	387	PF00244	0.585
LIG_Actin_WH2_2	81	98	PF00022	0.460
LIG_BRCT_BRCA1_1	241	245	PF00533	0.774
LIG_Clathr_ClatBox_1	85	89	PF01394	0.458
LIG_EVH1_1	11	15	PF00568	0.504
LIG_FHA_1	123	129	PF00498	0.407
LIG_FHA_1	182	188	PF00498	0.546
LIG_FHA_1	266	272	PF00498	0.655
LIG_FHA_1	316	322	PF00498	0.694
LIG_FHA_1	33	39	PF00498	0.515
LIG_FHA_1	360	366	PF00498	0.821
LIG_FHA_2	239	245	PF00498	0.758
LIG_FHA_2	271	277	PF00498	0.637
LIG_GSK3_LRP6_1	13	19	PF00069	0.504
LIG_LIR_Gen_1	205	214	PF02991	0.600
LIG_LIR_Nem_3	205	209	PF02991	0.595
LIG_LIR_Nem_3	296	301	PF02991	0.626
LIG_MYND_1	8	12	PF01753	0.515
LIG_PCNA_yPIPBox_3	317	331	PF02747	0.656
LIG_Pex14_2	316	320	PF04695	0.675
LIG_Pex14_2	83	87	PF04695	0.443
LIG_SH2_STAT5	156	159	PF00017	0.583
LIG_SH2_STAT5	231	234	PF00017	0.578
LIG_SH3_3	75	81	PF00018	0.491
LIG_SH3_3	9	15	PF00018	0.508
LIG_SUMO_SIM_par_1	111	117	PF11976	0.587
LIG_SUMO_SIM_par_1	218	224	PF11976	0.589
LIG_TRFH_1	9	13	PF08558	0.513
LIG_WRC_WIRS_1	327	332	PF05994	0.764
MOD_CDK_SPxK_1	47	53	PF00069	0.514
MOD_CK1_1	114	120	PF00069	0.516
MOD_CK1_1	149	155	PF00069	0.501
MOD_CK1_1	16	22	PF00069	0.518
MOD_CK1_1	238	244	PF00069	0.636
MOD_CK1_1	293	299	PF00069	0.620
MOD_CK1_1	334	340	PF00069	0.760
MOD_CK1_1	366	372	PF00069	0.708
MOD_CK1_1	76	82	PF00069	0.475
MOD_CK2_1	192	198	PF00069	0.650
MOD_CK2_1	238	244	PF00069	0.739
MOD_CK2_1	293	299	PF00069	0.551
MOD_Cter_Amidation	374	377	PF01082	0.735
MOD_GlcNHglycan	148	151	PF01048	0.495
MOD_GlcNHglycan	160	163	PF01048	0.575
MOD_GlcNHglycan	194	197	PF01048	0.484
MOD_GlcNHglycan	25	28	PF01048	0.506
MOD_GlcNHglycan	333	336	PF01048	0.568
MOD_GlcNHglycan	380	383	PF01048	0.641
MOD_GlcNHglycan	75	78	PF01048	0.478
MOD_GlcNHglycan	89	93	PF01048	0.456
MOD_GSK3_1	13	20	PF00069	0.554
MOD_GSK3_1	146	153	PF00069	0.498
MOD_GSK3_1	231	238	PF00069	0.416
MOD_GSK3_1	239	246	PF00069	0.663
MOD_GSK3_1	315	322	PF00069	0.689
MOD_GSK3_1	331	338	PF00069	0.528
MOD_GSK3_1	359	366	PF00069	0.700
MOD_GSK3_1	43	50	PF00069	0.489
MOD_GSK3_1	72	79	PF00069	0.482
MOD_NEK2_1	235	240	PF00069	0.463
MOD_NEK2_1	243	248	PF00069	0.694
MOD_NEK2_1	25	30	PF00069	0.509
MOD_NEK2_1	320	325	PF00069	0.748
MOD_NEK2_1	67	72	PF00069	0.490
MOD_NEK2_1	88	93	PF00069	0.454
MOD_NEK2_1	95	100	PF00069	0.456
MOD_PIKK_1	122	128	PF00454	0.471
MOD_PIKK_1	181	187	PF00454	0.587
MOD_PIKK_1	263	269	PF00454	0.660
MOD_PIKK_1	320	326	PF00454	0.669
MOD_PIKK_1	38	44	PF00454	0.471
MOD_PK_1	283	289	PF00069	0.580
MOD_PKA_1	283	289	PF00069	0.580
MOD_PKA_2	202	208	PF00069	0.436
MOD_PKA_2	282	288	PF00069	0.666
MOD_PKA_2	359	365	PF00069	0.738
MOD_PKA_2	52	58	PF00069	0.520
MOD_PKA_2	67	73	PF00069	0.456
MOD_PKA_2	95	101	PF00069	0.476
MOD_PKB_1	179	187	PF00069	0.587
MOD_PKB_1	376	384	PF00069	0.647
MOD_Plk_1	197	203	PF00069	0.561
MOD_Plk_1	335	341	PF00069	0.705
MOD_Plk_1	367	373	PF00069	0.554
MOD_Plk_2-3	363	369	PF00069	0.722
MOD_Plk_4	150	156	PF00069	0.582
MOD_Plk_4	167	173	PF00069	0.347
MOD_Plk_4	202	208	PF00069	0.578
MOD_Plk_4	326	332	PF00069	0.765
MOD_Plk_4	90	96	PF00069	0.454
MOD_ProDKin_1	13	19	PF00069	0.504
MOD_ProDKin_1	265	271	PF00069	0.657
MOD_ProDKin_1	315	321	PF00069	0.680
MOD_ProDKin_1	47	53	PF00069	0.514
MOD_ProDKin_1	54	60	PF00069	0.501
TRG_ER_diArg_1	105	107	PF00400	0.499
TRG_ER_diArg_1	128	131	PF00400	0.628
TRG_ER_diArg_1	376	378	PF00400	0.733
TRG_ER_diArg_1	385	387	PF00400	0.534
TRG_ER_diArg_1	65	68	PF00400	0.546
TRG_NES_CRM1_1	356	368	PF08389	0.592
TRG_Pf-PMV_PEXEL_1	385	390	PF00026	0.554

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IC77	Leishmania donovani	99%	100%
A4HC59	Leishmania braziliensis	77%	100%
E9AVJ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QBY7	Leishmania major	93%	100%