Transcription factor-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

transcription factor-like protein

Species:

Leishmania infantum

UniProt:

E9AGY6_LEIIN

TriTrypDb:

LINF_220005600

Length:

772

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	18
GO:0043226	organelle	2	18
GO:0043227	membrane-bounded organelle	3	18
GO:0043229	intracellular organelle	3	18
GO:0043231	intracellular membrane-bounded organelle	4	18
GO:0110165	cellular anatomical entity	1	18

Expansion

Sequence features

E9AGY6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AGY6

Function

Biological processes
Term	Name	Level	Count
GO:0006355	regulation of DNA-templated transcription	6	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0080090	regulation of primary metabolic process	4	1
GO:1903506	regulation of nucleic acid-templated transcription	7	1
GO:2001141	regulation of RNA biosynthetic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003700	DNA-binding transcription factor activity	2	18
GO:0005488	binding	1	18
GO:0008270	zinc ion binding	6	18
GO:0043167	ion binding	2	18
GO:0043169	cation binding	3	18
GO:0046872	metal ion binding	4	18
GO:0046914	transition metal ion binding	5	18
GO:0097159	organic cyclic compound binding	2	12
GO:0140110	transcription regulator activity	1	18
GO:1901363	heterocyclic compound binding	2	12
GO:0000976	transcription cis-regulatory region binding	5	1
GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	6	1
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	3	1
GO:0001067	transcription regulatory region nucleic acid binding	4	1
GO:0003677	DNA binding	4	1
GO:0003690	double-stranded DNA binding	5	1
GO:0043565	sequence-specific DNA binding	5	1
GO:1990837	sequence-specific double-stranded DNA binding	6	1
GO:0003824	catalytic activity	1	1
GO:0016874	ligase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	647	651	PF00656	0.439
CLV_NRD_NRD_1	163	165	PF00675	0.531
CLV_NRD_NRD_1	19	21	PF00675	0.410
CLV_NRD_NRD_1	307	309	PF00675	0.473
CLV_NRD_NRD_1	310	312	PF00675	0.474
CLV_NRD_NRD_1	446	448	PF00675	0.495
CLV_NRD_NRD_1	54	56	PF00675	0.460
CLV_NRD_NRD_1	548	550	PF00675	0.615
CLV_NRD_NRD_1	571	573	PF00675	0.517
CLV_PCSK_KEX2_1	163	165	PF00082	0.496
CLV_PCSK_KEX2_1	19	21	PF00082	0.470
CLV_PCSK_KEX2_1	200	202	PF00082	0.392
CLV_PCSK_KEX2_1	312	314	PF00082	0.446
CLV_PCSK_KEX2_1	415	417	PF00082	0.448
CLV_PCSK_KEX2_1	445	447	PF00082	0.456
CLV_PCSK_KEX2_1	54	56	PF00082	0.427
CLV_PCSK_KEX2_1	548	550	PF00082	0.608
CLV_PCSK_KEX2_1	571	573	PF00082	0.500
CLV_PCSK_KEX2_1	747	749	PF00082	0.443
CLV_PCSK_PC1ET2_1	200	202	PF00082	0.450
CLV_PCSK_PC1ET2_1	312	314	PF00082	0.465
CLV_PCSK_PC1ET2_1	415	417	PF00082	0.505
CLV_PCSK_PC1ET2_1	445	447	PF00082	0.436
CLV_PCSK_PC1ET2_1	548	550	PF00082	0.623
CLV_PCSK_PC1ET2_1	747	749	PF00082	0.443
CLV_PCSK_PC7_1	308	314	PF00082	0.496
CLV_PCSK_SKI1_1	510	514	PF00082	0.335
CLV_PCSK_SKI1_1	763	767	PF00082	0.534
CLV_PCSK_SKI1_1	77	81	PF00082	0.469
CLV_Separin_Metazoa	399	403	PF03568	0.358
DOC_CKS1_1	96	101	PF01111	0.456
DOC_MAPK_gen_1	445	457	PF00069	0.358
DOC_MAPK_gen_1	583	593	PF00069	0.510
DOC_MAPK_gen_1	606	614	PF00069	0.530
DOC_MAPK_gen_1	696	703	PF00069	0.493
DOC_MAPK_MEF2A_6	696	703	PF00069	0.493
DOC_MAPK_NFAT4_5	696	704	PF00069	0.404
DOC_MAPK_RevD_3	557	572	PF00069	0.441
DOC_PP2B_LxvP_1	401	404	PF13499	0.393
DOC_PP4_FxxP_1	66	69	PF00568	0.291
DOC_SPAK_OSR1_1	723	727	PF12202	0.472
DOC_USP7_MATH_1	2	6	PF00917	0.494
DOC_USP7_MATH_1	211	215	PF00917	0.517
DOC_USP7_MATH_1	626	630	PF00917	0.464
DOC_USP7_MATH_1	653	657	PF00917	0.484
DOC_USP7_MATH_1	691	695	PF00917	0.542
DOC_USP7_UBL2_3	692	696	PF12436	0.532
DOC_WW_Pin1_4	516	521	PF00397	0.458
DOC_WW_Pin1_4	95	100	PF00397	0.361
LIG_14-3-3_CanoR_1	110	118	PF00244	0.507
LIG_14-3-3_CanoR_1	260	266	PF00244	0.323
LIG_14-3-3_CanoR_1	347	356	PF00244	0.521
LIG_14-3-3_CanoR_1	450	455	PF00244	0.434
LIG_14-3-3_CanoR_1	529	537	PF00244	0.500
LIG_14-3-3_CanoR_1	763	768	PF00244	0.538
LIG_14-3-3_CterR_2	769	772	PF00244	0.481
LIG_APCC_ABBA_1	642	647	PF00400	0.458
LIG_BIR_II_1	1	5	PF00653	0.627
LIG_BIR_III_3	1	5	PF00653	0.566
LIG_BRCT_BRCA1_1	318	322	PF00533	0.388
LIG_FHA_1	170	176	PF00498	0.515
LIG_FHA_1	187	193	PF00498	0.325
LIG_FHA_1	224	230	PF00498	0.522
LIG_FHA_1	262	268	PF00498	0.399
LIG_FHA_1	387	393	PF00498	0.500
LIG_FHA_1	536	542	PF00498	0.516
LIG_FHA_1	568	574	PF00498	0.573
LIG_FHA_1	629	635	PF00498	0.531
LIG_FHA_1	762	768	PF00498	0.541
LIG_FHA_2	580	586	PF00498	0.602
LIG_LIR_Apic_2	143	148	PF02991	0.480
LIG_LIR_Apic_2	21	26	PF02991	0.427
LIG_LIR_Apic_2	63	69	PF02991	0.325
LIG_LIR_Gen_1	619	626	PF02991	0.320
LIG_LIR_Nem_3	43	48	PF02991	0.289
LIG_LIR_Nem_3	619	624	PF02991	0.320
LIG_NRBOX	712	718	PF00104	0.369
LIG_Pex14_2	739	743	PF04695	0.474
LIG_Rb_LxCxE_1	462	481	PF01857	0.360
LIG_SH2_CRK	145	149	PF00017	0.481
LIG_SH2_CRK	93	97	PF00017	0.408
LIG_SH2_NCK_1	23	27	PF00017	0.349
LIG_SH2_STAP1	589	593	PF00017	0.391
LIG_SH2_STAT3	194	197	PF00017	0.380
LIG_SH2_STAT5	145	148	PF00017	0.382
LIG_SH2_STAT5	194	197	PF00017	0.407
LIG_SH2_STAT5	395	398	PF00017	0.414
LIG_SH2_STAT5	527	530	PF00017	0.414
LIG_SH2_STAT5	641	644	PF00017	0.499
LIG_SH3_3	178	184	PF00018	0.480
LIG_SH3_3	234	240	PF00018	0.441
LIG_SH3_3	397	403	PF00018	0.349
LIG_SH3_3	433	439	PF00018	0.495
LIG_SH3_3	517	523	PF00018	0.522
LIG_SH3_3	556	562	PF00018	0.462
LIG_SH3_3	619	625	PF00018	0.507
LIG_SH3_3	722	728	PF00018	0.480
LIG_SH3_3	85	91	PF00018	0.331
LIG_SH3_4	692	699	PF00018	0.528
LIG_SH3_CIN85_PxpxPR_1	123	128	PF14604	0.522
LIG_SUMO_SIM_par_1	668	674	PF11976	0.503
LIG_TRAF2_1	465	468	PF00917	0.413
MOD_CK1_1	176	182	PF00069	0.475
MOD_CK1_1	186	192	PF00069	0.350
MOD_CK1_1	245	251	PF00069	0.480
MOD_CK1_1	620	626	PF00069	0.510
MOD_CK1_1	715	721	PF00069	0.511
MOD_CK2_1	24	30	PF00069	0.449
MOD_CK2_1	312	318	PF00069	0.460
MOD_CK2_1	37	43	PF00069	0.342
MOD_CK2_1	579	585	PF00069	0.613
MOD_CK2_1	691	697	PF00069	0.527
MOD_Cter_Amidation	546	549	PF01082	0.612
MOD_GlcNHglycan	232	235	PF01048	0.266
MOD_GlcNHglycan	485	488	PF01048	0.318
MOD_GlcNHglycan	628	631	PF01048	0.228
MOD_GSK3_1	169	176	PF00069	0.500
MOD_GSK3_1	183	190	PF00069	0.503
MOD_GSK3_1	202	209	PF00069	0.258
MOD_GSK3_1	251	258	PF00069	0.369
MOD_GSK3_1	312	319	PF00069	0.435
MOD_GSK3_1	347	354	PF00069	0.530
MOD_GSK3_1	376	383	PF00069	0.514
MOD_GSK3_1	386	393	PF00069	0.501
MOD_GSK3_1	575	582	PF00069	0.553
MOD_GSK3_1	60	67	PF00069	0.411
MOD_GSK3_1	620	627	PF00069	0.487
MOD_GSK3_1	653	660	PF00069	0.454
MOD_N-GLC_1	320	325	PF02516	0.518
MOD_N-GLC_1	347	352	PF02516	0.553
MOD_N-GLC_1	653	658	PF02516	0.253
MOD_N-GLC_2	565	567	PF02516	0.375
MOD_NEK2_1	528	533	PF00069	0.415
MOD_NEK2_1	579	584	PF00069	0.609
MOD_NEK2_1	587	592	PF00069	0.472
MOD_NEK2_1	659	664	PF00069	0.572
MOD_NEK2_1	701	706	PF00069	0.465
MOD_NEK2_1	712	717	PF00069	0.461
MOD_NEK2_1	756	761	PF00069	0.528
MOD_NEK2_2	216	221	PF00069	0.463
MOD_NEK2_2	37	42	PF00069	0.440
MOD_OFUCOSY	168	173	PF10250	0.281
MOD_OFUCOSY	222	227	PF10250	0.270
MOD_OFUCOSY	274	280	PF10250	0.402
MOD_OFUCOSY	328	334	PF10250	0.307
MOD_OGLYCOS	484	489	PF02709	0.318
MOD_PIKK_1	316	322	PF00454	0.403
MOD_PIKK_1	347	353	PF00454	0.433
MOD_PIKK_1	376	382	PF00454	0.403
MOD_PIKK_1	406	412	PF00454	0.498
MOD_PIKK_1	758	764	PF00454	0.548
MOD_PKA_1	312	318	PF00069	0.395
MOD_PKA_2	312	318	PF00069	0.468
MOD_PKA_2	528	534	PF00069	0.474
MOD_PKA_2	535	541	PF00069	0.408
MOD_PKA_2	60	66	PF00069	0.482
MOD_Plk_1	186	192	PF00069	0.458
MOD_Plk_1	2	8	PF00069	0.621
MOD_Plk_1	206	212	PF00069	0.332
MOD_Plk_1	653	659	PF00069	0.449
MOD_Plk_4	187	193	PF00069	0.435
MOD_Plk_4	225	231	PF00069	0.503
MOD_Plk_4	450	456	PF00069	0.407
MOD_Plk_4	522	528	PF00069	0.524
MOD_Plk_4	587	593	PF00069	0.390
MOD_Plk_4	60	66	PF00069	0.437
MOD_Plk_4	617	623	PF00069	0.490
MOD_Plk_4	712	718	PF00069	0.484
MOD_Plk_4	735	741	PF00069	0.488
MOD_ProDKin_1	516	522	PF00069	0.458
MOD_ProDKin_1	95	101	PF00069	0.355
TRG_DiLeu_BaEn_1	187	192	PF01217	0.495
TRG_DiLeu_BaEn_1	697	702	PF01217	0.489
TRG_ENDOCYTIC_2	589	592	PF00928	0.419
TRG_ENDOCYTIC_2	641	644	PF00928	0.451
TRG_ENDOCYTIC_2	93	96	PF00928	0.433
TRG_ER_diArg_1	163	165	PF00400	0.396
TRG_ER_diArg_1	18	20	PF00400	0.498
TRG_ER_diArg_1	310	313	PF00400	0.479
TRG_ER_diArg_1	53	55	PF00400	0.448
TRG_ER_diArg_1	571	573	PF00400	0.517
TRG_NLS_MonoExtC_3	307	312	PF00514	0.493
TRG_NLS_MonoExtC_3	444	449	PF00514	0.357
TRG_NLS_MonoExtN_4	306	312	PF00514	0.495

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTT0	Leptomonas seymouri	68%	100%
A0A0N1I9N1	Leptomonas seymouri	36%	100%
A0A0S4INQ1	Bodo saltans	38%	100%
A0A0S4JJN5	Bodo saltans	42%	84%
A0A1X0NUI9	Trypanosomatidae	43%	96%
A0A1X0NZM6	Trypanosomatidae	37%	100%
A0A3R7M581	Trypanosoma rangeli	37%	100%
A0A3R7MD54	Trypanosoma rangeli	45%	94%
A0A3S5H7A4	Leishmania donovani	100%	100%
A0A3S7X2B6	Leishmania donovani	35%	100%
A0JMY5	Xenopus laevis	32%	84%
A4HC58	Leishmania braziliensis	87%	100%
A4HH68	Leishmania braziliensis	36%	100%
A4I4B2	Leishmania infantum	35%	100%
A6QLA0	Bos taurus	34%	69%
B1AY10	Mus musculus	34%	69%
C9ZKS5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
C9ZSC0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	96%
E9ADR2	Leishmania major	35%	100%
E9AM18	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
E9AVJ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
O74853	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	34%	72%
P40798	Drosophila melanogaster	36%	70%
P53971	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	80%
Q12986	Homo sapiens	34%	69%
Q18034	Caenorhabditis elegans	35%	69%
Q4QBY8	Leishmania major	97%	100%
Q6ZNB6	Homo sapiens	33%	85%
Q9FFK8	Arabidopsis thaliana	33%	87%
V5BFS7	Trypanosoma cruzi	44%	94%
V5BUH3	Trypanosoma cruzi	37%	100%