LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
E9AGY5_LEIIN
TriTrypDb:
LINF_220005500 *
Length:
581

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AGY5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AGY5

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 125 129 PF00656 0.740
CLV_C14_Caspase3-7 518 522 PF00656 0.778
CLV_NRD_NRD_1 372 374 PF00675 0.616
CLV_NRD_NRD_1 382 384 PF00675 0.584
CLV_NRD_NRD_1 422 424 PF00675 0.471
CLV_NRD_NRD_1 447 449 PF00675 0.603
CLV_NRD_NRD_1 531 533 PF00675 0.674
CLV_PCSK_FUR_1 529 533 PF00082 0.704
CLV_PCSK_KEX2_1 316 318 PF00082 0.495
CLV_PCSK_KEX2_1 342 344 PF00082 0.603
CLV_PCSK_KEX2_1 372 374 PF00082 0.596
CLV_PCSK_KEX2_1 422 424 PF00082 0.471
CLV_PCSK_KEX2_1 447 449 PF00082 0.603
CLV_PCSK_KEX2_1 465 467 PF00082 0.629
CLV_PCSK_KEX2_1 531 533 PF00082 0.758
CLV_PCSK_PC1ET2_1 316 318 PF00082 0.519
CLV_PCSK_PC1ET2_1 342 344 PF00082 0.617
CLV_PCSK_PC1ET2_1 465 467 PF00082 0.662
CLV_PCSK_SKI1_1 531 535 PF00082 0.794
CLV_PCSK_SKI1_1 545 549 PF00082 0.565
CLV_PCSK_SKI1_1 567 571 PF00082 0.606
CLV_Separin_Metazoa 364 368 PF03568 0.607
DEG_APCC_DBOX_1 232 240 PF00400 0.552
DEG_APCC_DBOX_1 513 521 PF00400 0.747
DEG_COP1_1 128 137 PF00400 0.658
DEG_SPOP_SBC_1 116 120 PF00917 0.777
DOC_CKS1_1 27 32 PF01111 0.601
DOC_CYCLIN_yCln2_LP_2 27 33 PF00134 0.602
DOC_MAPK_gen_1 389 396 PF00069 0.574
DOC_PP1_RVXF_1 98 104 PF00149 0.516
DOC_PP4_FxxP_1 106 109 PF00568 0.554
DOC_PP4_FxxP_1 570 573 PF00568 0.548
DOC_PP4_MxPP_1 112 115 PF00568 0.760
DOC_USP7_MATH_1 148 152 PF00917 0.558
DOC_USP7_MATH_1 154 158 PF00917 0.567
DOC_USP7_MATH_1 38 42 PF00917 0.732
DOC_USP7_MATH_1 539 543 PF00917 0.658
DOC_WW_Pin1_4 126 131 PF00397 0.756
DOC_WW_Pin1_4 18 23 PF00397 0.798
DOC_WW_Pin1_4 26 31 PF00397 0.682
DOC_WW_Pin1_4 537 542 PF00397 0.679
DOC_WW_Pin1_4 67 72 PF00397 0.790
DOC_WW_Pin1_4 79 84 PF00397 0.684
LIG_14-3-3_CanoR_1 140 145 PF00244 0.653
LIG_14-3-3_CanoR_1 184 189 PF00244 0.598
LIG_14-3-3_CanoR_1 205 211 PF00244 0.609
LIG_14-3-3_CanoR_1 233 241 PF00244 0.584
LIG_14-3-3_CanoR_1 282 286 PF00244 0.532
LIG_14-3-3_CanoR_1 51 56 PF00244 0.698
LIG_14-3-3_CanoR_1 531 538 PF00244 0.693
LIG_14-3-3_CanoR_1 567 573 PF00244 0.715
LIG_Actin_WH2_2 190 207 PF00022 0.579
LIG_Actin_WH2_2 333 350 PF00022 0.574
LIG_Actin_WH2_2 442 459 PF00022 0.593
LIG_BRCT_BRCA1_1 269 273 PF00533 0.560
LIG_BRCT_BRCA1_1 478 482 PF00533 0.586
LIG_CaM_IQ_9 185 201 PF13499 0.477
LIG_Clathr_ClatBox_1 222 226 PF01394 0.496
LIG_deltaCOP1_diTrp_1 138 144 PF00928 0.653
LIG_DLG_GKlike_1 328 336 PF00625 0.565
LIG_EH1_1 216 224 PF00400 0.604
LIG_FHA_1 129 135 PF00498 0.781
LIG_FHA_1 229 235 PF00498 0.476
LIG_FHA_1 262 268 PF00498 0.513
LIG_FHA_2 310 316 PF00498 0.557
LIG_FHA_2 413 419 PF00498 0.586
LIG_LIR_Apic_2 568 573 PF02991 0.534
LIG_LIR_Gen_1 138 148 PF02991 0.553
LIG_LIR_Gen_1 361 368 PF02991 0.538
LIG_LIR_Gen_1 390 400 PF02991 0.504
LIG_LIR_Nem_3 138 144 PF02991 0.545
LIG_LIR_Nem_3 301 306 PF02991 0.529
LIG_LIR_Nem_3 361 365 PF02991 0.534
LIG_LIR_Nem_3 390 396 PF02991 0.498
LIG_LIR_Nem_3 54 60 PF02991 0.583
LIG_SH2_NCK_1 536 540 PF00017 0.701
LIG_SH2_SRC 179 182 PF00017 0.585
LIG_SH2_STAP1 314 318 PF00017 0.558
LIG_SH2_STAP1 362 366 PF00017 0.611
LIG_SH3_3 32 38 PF00018 0.705
LIG_SH3_3 42 48 PF00018 0.624
LIG_SH3_3 53 59 PF00018 0.556
LIG_SH3_3 88 94 PF00018 0.722
LIG_SUMO_SIM_par_1 220 226 PF11976 0.550
LIG_TRAF2_1 122 125 PF00917 0.783
LIG_TRAF2_1 136 139 PF00917 0.713
LIG_TRAF2_1 178 181 PF00917 0.591
LIG_TRAF2_1 350 353 PF00917 0.620
LIG_TRAF2_1 411 414 PF00917 0.574
LIG_TRAF2_1 439 442 PF00917 0.507
MOD_CDC14_SPxK_1 82 85 PF00782 0.548
MOD_CDK_SPxK_1 79 85 PF00069 0.546
MOD_CK1_1 11 17 PF00069 0.801
MOD_CK1_1 568 574 PF00069 0.652
MOD_CK1_1 65 71 PF00069 0.699
MOD_CK2_1 120 126 PF00069 0.808
MOD_CK2_1 133 139 PF00069 0.588
MOD_CK2_1 154 160 PF00069 0.618
MOD_CK2_1 298 304 PF00069 0.585
MOD_CK2_1 347 353 PF00069 0.585
MOD_CK2_1 568 574 PF00069 0.675
MOD_GlcNHglycan 10 13 PF01048 0.753
MOD_GlcNHglycan 517 520 PF01048 0.752
MOD_GlcNHglycan 567 570 PF01048 0.676
MOD_GlcNHglycan 64 67 PF01048 0.728
MOD_GlcNHglycan 96 100 PF01048 0.581
MOD_GSK3_1 116 123 PF00069 0.759
MOD_GSK3_1 126 133 PF00069 0.675
MOD_GSK3_1 16 23 PF00069 0.783
MOD_GSK3_1 277 284 PF00069 0.526
MOD_GSK3_1 298 305 PF00069 0.596
MOD_GSK3_1 33 40 PF00069 0.800
MOD_GSK3_1 347 354 PF00069 0.523
MOD_GSK3_1 568 575 PF00069 0.648
MOD_GSK3_1 67 74 PF00069 0.626
MOD_NEK2_1 117 122 PF00069 0.772
MOD_NEK2_1 229 234 PF00069 0.553
MOD_NEK2_1 267 272 PF00069 0.540
MOD_NEK2_1 281 286 PF00069 0.439
MOD_NEK2_1 336 341 PF00069 0.537
MOD_PIKK_1 120 126 PF00454 0.744
MOD_PIKK_1 179 185 PF00454 0.574
MOD_PIKK_1 20 26 PF00454 0.743
MOD_PIKK_1 33 39 PF00454 0.690
MOD_PIKK_1 59 65 PF00454 0.583
MOD_PK_1 87 93 PF00069 0.542
MOD_PKA_1 531 537 PF00069 0.757
MOD_PKA_2 139 145 PF00069 0.657
MOD_PKA_2 204 210 PF00069 0.569
MOD_PKA_2 281 287 PF00069 0.506
MOD_PKA_2 50 56 PF00069 0.775
MOD_PKA_2 515 521 PF00069 0.754
MOD_PKA_2 531 537 PF00069 0.757
MOD_PKB_1 410 418 PF00069 0.630
MOD_PKB_1 529 537 PF00069 0.708
MOD_PKB_1 558 566 PF00069 0.644
MOD_PKB_1 85 93 PF00069 0.545
MOD_Plk_1 412 418 PF00069 0.608
MOD_Plk_1 87 93 PF00069 0.734
MOD_Plk_4 412 418 PF00069 0.614
MOD_ProDKin_1 126 132 PF00069 0.754
MOD_ProDKin_1 18 24 PF00069 0.799
MOD_ProDKin_1 26 32 PF00069 0.684
MOD_ProDKin_1 537 543 PF00069 0.672
MOD_ProDKin_1 67 73 PF00069 0.675
MOD_ProDKin_1 79 85 PF00069 0.687
MOD_SUMO_for_1 341 344 PF00179 0.604
TRG_DiLeu_BaEn_1 361 366 PF01217 0.610
TRG_DiLeu_BaEn_4 248 254 PF01217 0.601
TRG_ENDOCYTIC_2 300 303 PF00928 0.476
TRG_ENDOCYTIC_2 362 365 PF00928 0.535
TRG_ER_diArg_1 409 412 PF00400 0.587
TRG_ER_diArg_1 447 449 PF00400 0.567
TRG_Pf-PMV_PEXEL_1 184 189 PF00026 0.575
TRG_Pf-PMV_PEXEL_1 425 429 PF00026 0.472

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1P9S5 Leptomonas seymouri 61% 100%
A0A0S4JKE8 Bodo saltans 31% 72%
A0A1X0NTJ5 Trypanosomatidae 32% 96%
A0A3S7WWY1 Leishmania donovani 99% 100%
A0A422N4N0 Trypanosoma rangeli 35% 93%
A4HC57 Leishmania braziliensis 86% 100%
E9AVJ0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
Q4QBY9 Leishmania major 94% 100%
V5BK97 Trypanosoma cruzi 36% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS