Cytochrome b5 heme-binding domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Cytochrome b5-like Heme/Steroid binding domain containing protein - putative

Species:

Leishmania infantum

UniProt:

E9AGY1_LEIIN

TriTrypDb:

LINF_060019100

Length:

123

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 22
NetGPI	no	yes: 0, no: 22

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9
GO:0043226	organelle	2	4
GO:0043227	membrane-bounded organelle	3	4
GO:0043229	intracellular organelle	3	4
GO:0043231	intracellular membrane-bounded organelle	4	4

Expansion

Sequence features

E9AGY1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AGY1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	4
GO:0020037	heme binding	4	4
GO:0046906	tetrapyrrole binding	3	4
GO:0097159	organic cyclic compound binding	2	4
GO:1901363	heterocyclic compound binding	2	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	100	102	PF00082	0.430
CLV_PCSK_PC1ET2_1	100	102	PF00082	0.415
DEG_Nend_UBRbox_3	1	3	PF02207	0.609
DOC_MAPK_gen_1	15	25	PF00069	0.447
DOC_MAPK_gen_1	98	107	PF00069	0.624
DOC_MAPK_MEF2A_6	100	109	PF00069	0.454
DOC_MAPK_MEF2A_6	18	25	PF00069	0.480
DOC_PP4_FxxP_1	114	117	PF00568	0.201
DOC_USP7_MATH_1	31	35	PF00917	0.460
DOC_USP7_MATH_1	5	9	PF00917	0.572
DOC_USP7_UBL2_3	47	51	PF12436	0.447
DOC_USP7_UBL2_3	94	98	PF12436	0.633
LIG_deltaCOP1_diTrp_1	64	72	PF00928	0.552
LIG_LIR_Gen_1	46	56	PF02991	0.463
LIG_LIR_Gen_1	99	109	PF02991	0.446
LIG_LIR_Nem_3	99	105	PF02991	0.630
LIG_SH2_CRK	19	23	PF00017	0.513
LIG_SH2_STAT5	3	6	PF00017	0.655
LIG_SH3_3	1	7	PF00018	0.570
MOD_CK1_1	78	84	PF00069	0.644
MOD_CK1_1	96	102	PF00069	0.620
MOD_GlcNHglycan	77	80	PF01048	0.457
MOD_N-GLC_1	52	57	PF02516	0.286
MOD_PKA_1	93	99	PF00069	0.656
MOD_Plk_1	52	58	PF00069	0.528
MOD_Plk_4	32	38	PF00069	0.494
MOD_SUMO_for_1	120	123	PF00179	0.371
TRG_NES_CRM1_1	50	64	PF08389	0.437

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3U0	Leptomonas seymouri	30%	92%
A0A0N1IH82	Leptomonas seymouri	37%	100%
A0A3Q8ICI2	Leishmania donovani	38%	100%
A0A3Q8ILC3	Leishmania donovani	100%	100%
A0A3S7WPP2	Leishmania donovani	98%	100%
A0A3S7X4C9	Leishmania donovani	31%	100%
A4H4U1	Leishmania braziliensis	78%	100%
A4HJ97	Leishmania braziliensis	33%	100%
A4HJ98	Leishmania braziliensis	33%	97%
A4HJA1	Leishmania braziliensis	28%	100%
A4HT20	Leishmania infantum	99%	100%
A4I6P2	Leishmania infantum	31%	100%
A4I6P3	Leishmania infantum	35%	98%
A4I6P6	Leishmania infantum	31%	100%
E9ACS1	Leishmania major	88%	100%
E9AL09	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
E9AVI6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
E9B1R5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	99%
Q4Q6E5	Leishmania major	31%	76%
Q4Q6E6	Leishmania major	35%	99%
Q4QIU6	Leishmania major	87%	100%