Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA polymerase III transcription factor (TF)IIIC subunit - putative

Species:

Leishmania infantum

UniProt:

E9AGX8_LEIIN

TriTrypDb:

LINF_210019000

Length:

698

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0000127	transcription factor TFIIIC complex	4	10
GO:0005667	transcription regulator complex	2	10
GO:0032991	protein-containing complex	1	10
GO:0090576	RNA polymerase III transcription regulator complex	3	10

Expansion

Sequence features

E9AGX8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AGX8

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	10
GO:0006352	DNA-templated transcription initiation	6	10
GO:0006384	transcription initiation at RNA polymerase III promoter	7	10
GO:0006725	cellular aromatic compound metabolic process	3	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0009058	biosynthetic process	2	10
GO:0009059	macromolecule biosynthetic process	4	10
GO:0009987	cellular process	1	10
GO:0016070	RNA metabolic process	5	10
GO:0018130	heterocycle biosynthetic process	4	10
GO:0019438	aromatic compound biosynthetic process	4	10
GO:0032774	RNA biosynthetic process	5	10
GO:0034641	cellular nitrogen compound metabolic process	3	10
GO:0034654	nucleobase-containing compound biosynthetic process	4	10
GO:0043170	macromolecule metabolic process	3	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0044249	cellular biosynthetic process	3	10
GO:0044271	cellular nitrogen compound biosynthetic process	4	10
GO:0046483	heterocycle metabolic process	3	10
GO:0071704	organic substance metabolic process	2	10
GO:0090304	nucleic acid metabolic process	4	10
GO:1901360	organic cyclic compound metabolic process	3	10
GO:1901362	organic cyclic compound biosynthetic process	4	10
GO:1901576	organic substance biosynthetic process	3	10

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	114	118	PF00656	0.796
CLV_C14_Caspase3-7	261	265	PF00656	0.593
CLV_C14_Caspase3-7	418	422	PF00656	0.444
CLV_C14_Caspase3-7	448	452	PF00656	0.344
CLV_C14_Caspase3-7	85	89	PF00656	0.716
CLV_NRD_NRD_1	215	217	PF00675	0.625
CLV_NRD_NRD_1	243	245	PF00675	0.562
CLV_NRD_NRD_1	247	249	PF00675	0.523
CLV_NRD_NRD_1	510	512	PF00675	0.476
CLV_NRD_NRD_1	541	543	PF00675	0.547
CLV_NRD_NRD_1	553	555	PF00675	0.552
CLV_NRD_NRD_1	566	568	PF00675	0.553
CLV_NRD_NRD_1	59	61	PF00675	0.656
CLV_NRD_NRD_1	603	605	PF00675	0.568
CLV_NRD_NRD_1	607	609	PF00675	0.557
CLV_NRD_NRD_1	639	641	PF00675	0.529
CLV_PCSK_FUR_1	213	217	PF00082	0.690
CLV_PCSK_FUR_1	241	245	PF00082	0.561
CLV_PCSK_FUR_1	539	543	PF00082	0.535
CLV_PCSK_KEX2_1	132	134	PF00082	0.798
CLV_PCSK_KEX2_1	212	214	PF00082	0.606
CLV_PCSK_KEX2_1	215	217	PF00082	0.625
CLV_PCSK_KEX2_1	243	245	PF00082	0.546
CLV_PCSK_KEX2_1	247	249	PF00082	0.499
CLV_PCSK_KEX2_1	510	512	PF00082	0.476
CLV_PCSK_KEX2_1	541	543	PF00082	0.485
CLV_PCSK_KEX2_1	553	555	PF00082	0.524
CLV_PCSK_KEX2_1	566	568	PF00082	0.553
CLV_PCSK_KEX2_1	59	61	PF00082	0.624
CLV_PCSK_KEX2_1	603	605	PF00082	0.520
CLV_PCSK_KEX2_1	607	609	PF00082	0.518
CLV_PCSK_PC1ET2_1	132	134	PF00082	0.798
CLV_PCSK_PC1ET2_1	212	214	PF00082	0.635
CLV_PCSK_PC7_1	239	245	PF00082	0.650
CLV_PCSK_PC7_1	537	543	PF00082	0.554
CLV_PCSK_PC7_1	603	609	PF00082	0.609
CLV_PCSK_SKI1_1	146	150	PF00082	0.663
CLV_PCSK_SKI1_1	216	220	PF00082	0.765
CLV_PCSK_SKI1_1	532	536	PF00082	0.523
DEG_APCC_DBOX_1	145	153	PF00400	0.767
DEG_APCC_DBOX_1	553	561	PF00400	0.529
DEG_SCF_FBW7_1	33	38	PF00400	0.736
DEG_SPOP_SBC_1	109	113	PF00917	0.713
DEG_SPOP_SBC_1	37	41	PF00917	0.711
DEG_SPOP_SBC_1	659	663	PF00917	0.708
DOC_CDC14_PxL_1	319	327	PF14671	0.664
DOC_CKS1_1	313	318	PF01111	0.648
DOC_CYCLIN_RxL_1	526	538	PF00134	0.525
DOC_CYCLIN_yCln2_LP_2	303	309	PF00134	0.585
DOC_CYCLIN_yCln2_LP_2	570	576	PF00134	0.513
DOC_MAPK_gen_1	143	151	PF00069	0.596
DOC_MAPK_gen_1	154	164	PF00069	0.525
DOC_MAPK_gen_1	507	516	PF00069	0.511
DOC_MAPK_gen_1	563	572	PF00069	0.493
DOC_MAPK_MEF2A_6	22	31	PF00069	0.558
DOC_MAPK_MEF2A_6	233	240	PF00069	0.520
DOC_MAPK_MEF2A_6	510	518	PF00069	0.553
DOC_MAPK_MEF2A_6	566	574	PF00069	0.488
DOC_MAPK_NFAT4_5	233	241	PF00069	0.641
DOC_PP2B_LxvP_1	570	573	PF13499	0.529
DOC_PP2B_PxIxI_1	389	395	PF00149	0.485
DOC_PP4_FxxP_1	70	73	PF00568	0.547
DOC_USP7_MATH_1	10	14	PF00917	0.775
DOC_USP7_MATH_1	110	114	PF00917	0.716
DOC_USP7_MATH_1	20	24	PF00917	0.680
DOC_USP7_MATH_1	284	288	PF00917	0.742
DOC_USP7_MATH_1	321	325	PF00917	0.614
DOC_USP7_MATH_1	358	362	PF00917	0.457
DOC_USP7_MATH_1	396	400	PF00917	0.498
DOC_USP7_MATH_1	408	412	PF00917	0.487
DOC_USP7_MATH_1	492	496	PF00917	0.355
DOC_USP7_MATH_1	50	54	PF00917	0.744
DOC_USP7_MATH_1	658	662	PF00917	0.666
DOC_USP7_MATH_1	92	96	PF00917	0.632
DOC_WW_Pin1_4	31	36	PF00397	0.641
DOC_WW_Pin1_4	312	317	PF00397	0.623
DOC_WW_Pin1_4	4	9	PF00397	0.760
DOC_WW_Pin1_4	521	526	PF00397	0.538
DOC_WW_Pin1_4	76	81	PF00397	0.656
LIG_14-3-3_CanoR_1	143	152	PF00244	0.583
LIG_14-3-3_CanoR_1	157	163	PF00244	0.505
LIG_14-3-3_CanoR_1	22	28	PF00244	0.582
LIG_14-3-3_CanoR_1	285	293	PF00244	0.559
LIG_14-3-3_CanoR_1	503	507	PF00244	0.374
LIG_14-3-3_CanoR_1	510	518	PF00244	0.426
LIG_14-3-3_CanoR_1	553	558	PF00244	0.509
LIG_14-3-3_CanoR_1	608	616	PF00244	0.479
LIG_Actin_WH2_2	497	512	PF00022	0.485
LIG_BIR_III_4	279	283	PF00653	0.661
LIG_BIR_III_4	374	378	PF00653	0.408
LIG_BRCT_BRCA1_1	122	126	PF00533	0.762
LIG_BRCT_BRCA1_1	679	683	PF00533	0.751
LIG_CtBP_PxDLS_1	598	602	PF00389	0.623
LIG_eIF4E_1	231	237	PF01652	0.540
LIG_EVH1_2	332	336	PF00568	0.369
LIG_FHA_1	159	165	PF00498	0.602
LIG_FHA_1	252	258	PF00498	0.573
LIG_FHA_1	284	290	PF00498	0.686
LIG_FHA_1	308	314	PF00498	0.734
LIG_FHA_1	32	38	PF00498	0.734
LIG_FHA_1	389	395	PF00498	0.401
LIG_FHA_1	471	477	PF00498	0.344
LIG_FHA_1	503	509	PF00498	0.412
LIG_FHA_2	554	560	PF00498	0.471
LIG_FHA_2	651	657	PF00498	0.738
LIG_GBD_Chelix_1	445	453	PF00786	0.444
LIG_Integrin_RGD_1	86	88	PF01839	0.743
LIG_LIR_Apic_2	69	73	PF02991	0.557
LIG_LIR_Gen_1	23	32	PF02991	0.654
LIG_LIR_Gen_1	308	319	PF02991	0.662
LIG_LIR_Gen_1	385	394	PF02991	0.435
LIG_LIR_Gen_1	498	509	PF02991	0.485
LIG_LIR_Nem_3	23	27	PF02991	0.615
LIG_LIR_Nem_3	308	314	PF02991	0.577
LIG_LIR_Nem_3	385	389	PF02991	0.380
LIG_LIR_Nem_3	498	504	PF02991	0.485
LIG_NRBOX	530	536	PF00104	0.505
LIG_NRBOX	626	632	PF00104	0.526
LIG_PCNA_PIPBox_1	225	234	PF02747	0.571
LIG_PCNA_yPIPBox_3	225	239	PF02747	0.543
LIG_PTB_Apo_2	226	233	PF02174	0.675
LIG_PTB_Apo_2	475	482	PF02174	0.369
LIG_PTB_Phospho_1	226	232	PF10480	0.679
LIG_SH2_CRK	159	163	PF00017	0.720
LIG_SH2_CRK	545	549	PF00017	0.630
LIG_SH2_NCK_1	493	497	PF00017	0.416
LIG_SH2_NCK_1	501	505	PF00017	0.379
LIG_SH2_PTP2	24	27	PF00017	0.633
LIG_SH2_SRC	347	350	PF00017	0.444
LIG_SH2_STAP1	616	620	PF00017	0.546
LIG_SH2_STAP1	623	627	PF00017	0.481
LIG_SH2_STAT5	159	162	PF00017	0.576
LIG_SH2_STAT5	24	27	PF00017	0.633
LIG_SH2_STAT5	474	477	PF00017	0.344
LIG_SH2_STAT5	571	574	PF00017	0.477
LIG_SH3_3	13	19	PF00018	0.696
LIG_SH3_3	24	30	PF00018	0.574
LIG_SH3_3	327	333	PF00018	0.485
LIG_SUMO_SIM_par_1	390	395	PF11976	0.485
LIG_TRAF2_1	177	180	PF00917	0.754
LIG_TRAF2_1	265	268	PF00917	0.672
LIG_TRAF2_1	395	398	PF00917	0.484
LIG_TRAF2_1	95	98	PF00917	0.727
LIG_TRAF2_2	573	578	PF00917	0.502
LIG_TYR_ITIM	499	504	PF00017	0.408
LIG_TYR_ITIM	543	548	PF00017	0.541
MOD_CK1_1	111	117	PF00069	0.758
MOD_CK1_1	118	124	PF00069	0.744
MOD_CK1_1	23	29	PF00069	0.628
MOD_CK1_1	287	293	PF00069	0.666
MOD_CK1_1	415	421	PF00069	0.485
MOD_CK1_1	495	501	PF00069	0.444
MOD_CK1_1	661	667	PF00069	0.692
MOD_CK2_1	174	180	PF00069	0.700
MOD_CK2_1	262	268	PF00069	0.684
MOD_CK2_1	392	398	PF00069	0.481
MOD_CK2_1	553	559	PF00069	0.492
MOD_CK2_1	663	669	PF00069	0.719
MOD_CK2_1	92	98	PF00069	0.742
MOD_GlcNHglycan	113	116	PF01048	0.714
MOD_GlcNHglycan	119	123	PF01048	0.700
MOD_GlcNHglycan	165	168	PF01048	0.588
MOD_GlcNHglycan	174	177	PF01048	0.645
MOD_GlcNHglycan	186	189	PF01048	0.774
MOD_GlcNHglycan	264	267	PF01048	0.727
MOD_GlcNHglycan	272	275	PF01048	0.813
MOD_GlcNHglycan	288	292	PF01048	0.659
MOD_GlcNHglycan	337	340	PF01048	0.393
MOD_GlcNHglycan	360	363	PF01048	0.429
MOD_GlcNHglycan	378	381	PF01048	0.438
MOD_GlcNHglycan	394	397	PF01048	0.459
MOD_GlcNHglycan	398	401	PF01048	0.248
MOD_GlcNHglycan	40	43	PF01048	0.736
MOD_GlcNHglycan	455	458	PF01048	0.369
MOD_GlcNHglycan	494	497	PF01048	0.444
MOD_GlcNHglycan	52	55	PF01048	0.657
MOD_GlcNHglycan	676	682	PF01048	0.687
MOD_GlcNHglycan	685	688	PF01048	0.650
MOD_GlcNHglycan	94	97	PF01048	0.783
MOD_GSK3_1	111	118	PF00069	0.778
MOD_GSK3_1	131	138	PF00069	0.701
MOD_GSK3_1	163	170	PF00069	0.645
MOD_GSK3_1	280	287	PF00069	0.752
MOD_GSK3_1	31	38	PF00069	0.607
MOD_GSK3_1	352	359	PF00069	0.432
MOD_GSK3_1	388	395	PF00069	0.485
MOD_GSK3_1	408	415	PF00069	0.155
MOD_GSK3_1	658	665	PF00069	0.653
MOD_GSK3_1	677	684	PF00069	0.713
MOD_GSK3_1	76	83	PF00069	0.680
MOD_LATS_1	551	557	PF00433	0.544
MOD_N-GLC_1	650	655	PF02516	0.737
MOD_NEK2_1	412	417	PF00069	0.485
MOD_NEK2_1	453	458	PF00069	0.444
MOD_NEK2_1	683	688	PF00069	0.704
MOD_PKA_1	553	559	PF00069	0.485
MOD_PKA_2	168	174	PF00069	0.719
MOD_PKA_2	184	190	PF00069	0.751
MOD_PKA_2	280	286	PF00069	0.784
MOD_PKA_2	440	446	PF00069	0.485
MOD_PKA_2	502	508	PF00069	0.374
MOD_PKA_2	509	515	PF00069	0.433
MOD_PKA_2	553	559	PF00069	0.459
MOD_PKB_1	517	525	PF00069	0.543
MOD_Plk_1	307	313	PF00069	0.678
MOD_Plk_1	396	402	PF00069	0.485
MOD_Plk_1	677	683	PF00069	0.727
MOD_Plk_4	408	414	PF00069	0.483
MOD_Plk_4	440	446	PF00069	0.463
MOD_Plk_4	495	501	PF00069	0.487
MOD_Plk_4	526	532	PF00069	0.488
MOD_Plk_4	553	559	PF00069	0.446
MOD_Plk_4	66	72	PF00069	0.530
MOD_ProDKin_1	31	37	PF00069	0.649
MOD_ProDKin_1	312	318	PF00069	0.619
MOD_ProDKin_1	4	10	PF00069	0.762
MOD_ProDKin_1	521	527	PF00069	0.531
MOD_ProDKin_1	76	82	PF00069	0.662
TRG_DiLeu_BaEn_1	223	228	PF01217	0.700
TRG_DiLeu_BaEn_2	60	66	PF01217	0.660
TRG_DiLeu_BaEn_4	397	403	PF01217	0.444
TRG_DiLeu_BaLyEn_6	147	152	PF01217	0.692
TRG_DiLeu_BaLyEn_6	433	438	PF01217	0.444
TRG_DiLeu_BaLyEn_6	504	509	PF01217	0.485
TRG_DiLeu_BaLyEn_6	529	534	PF01217	0.513
TRG_ENDOCYTIC_2	159	162	PF00928	0.717
TRG_ENDOCYTIC_2	24	27	PF00928	0.567
TRG_ENDOCYTIC_2	501	504	PF00928	0.444
TRG_ENDOCYTIC_2	545	548	PF00928	0.618
TRG_ENDOCYTIC_2	571	574	PF00928	0.450
TRG_ER_diArg_1	213	216	PF00400	0.646
TRG_ER_diArg_1	238	241	PF00400	0.542
TRG_ER_diArg_1	246	248	PF00400	0.513
TRG_ER_diArg_1	483	486	PF00400	0.344
TRG_ER_diArg_1	509	511	PF00400	0.555
TRG_ER_diArg_1	516	519	PF00400	0.483
TRG_ER_diArg_1	539	542	PF00400	0.541
TRG_ER_diArg_1	565	567	PF00400	0.560
TRG_ER_diArg_1	637	640	PF00400	0.565
TRG_NLS_MonoCore_2	211	216	PF00514	0.675
TRG_NLS_MonoExtC_3	211	216	PF00514	0.675
TRG_Pf-PMV_PEXEL_1	436	440	PF00026	0.342
TRG_Pf-PMV_PEXEL_1	532	536	PF00026	0.565
TRG_Pf-PMV_PEXEL_1	640	645	PF00026	0.676

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2I9	Leptomonas seymouri	51%	94%
A0A1X0NZE8	Trypanosomatidae	33%	100%
A0A3S7WWK4	Leishmania donovani	100%	100%
A0A422NAG1	Trypanosoma rangeli	34%	100%
A4HIW4	Leishmania braziliensis	84%	99%
D0A185	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AV94	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	99%
Q4QC86	Leishmania major	92%	100%