CCDC66 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Coiled-coil domain-containing protein 66 - putative

Species:

Leishmania infantum

UniProt:

E9AGX1_LEIIN

TriTrypDb:

LINF_210017900

Length:

822

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AGX1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AGX1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	676	680	PF00656	0.682
CLV_C14_Caspase3-7	736	740	PF00656	0.552
CLV_C14_Caspase3-7	803	807	PF00656	0.587
CLV_NRD_NRD_1	329	331	PF00675	0.489
CLV_NRD_NRD_1	358	360	PF00675	0.592
CLV_NRD_NRD_1	395	397	PF00675	0.549
CLV_NRD_NRD_1	403	405	PF00675	0.613
CLV_NRD_NRD_1	47	49	PF00675	0.554
CLV_NRD_NRD_1	530	532	PF00675	0.481
CLV_NRD_NRD_1	544	546	PF00675	0.555
CLV_NRD_NRD_1	7	9	PF00675	0.488
CLV_NRD_NRD_1	814	816	PF00675	0.591
CLV_PCSK_FUR_1	366	370	PF00082	0.650
CLV_PCSK_KEX2_1	358	360	PF00082	0.592
CLV_PCSK_KEX2_1	368	370	PF00082	0.660
CLV_PCSK_KEX2_1	395	397	PF00082	0.550
CLV_PCSK_KEX2_1	403	405	PF00082	0.566
CLV_PCSK_KEX2_1	47	49	PF00082	0.554
CLV_PCSK_KEX2_1	530	532	PF00082	0.481
CLV_PCSK_KEX2_1	544	546	PF00082	0.555
CLV_PCSK_KEX2_1	6	8	PF00082	0.490
CLV_PCSK_KEX2_1	814	816	PF00082	0.598
CLV_PCSK_PC1ET2_1	368	370	PF00082	0.568
CLV_PCSK_PC7_1	3	9	PF00082	0.492
CLV_PCSK_PC7_1	526	532	PF00082	0.545
CLV_PCSK_SKI1_1	322	326	PF00082	0.478
CLV_PCSK_SKI1_1	371	375	PF00082	0.510
CLV_PCSK_SKI1_1	432	436	PF00082	0.614
CLV_PCSK_SKI1_1	530	534	PF00082	0.479
DEG_APCC_DBOX_1	525	533	PF00400	0.546
DEG_Nend_Nbox_1	1	3	PF02207	0.536
DEG_SPOP_SBC_1	448	452	PF00917	0.631
DEG_SPOP_SBC_1	627	631	PF00917	0.600
DOC_CKS1_1	410	415	PF01111	0.558
DOC_CKS1_1	499	504	PF01111	0.527
DOC_CKS1_1	744	749	PF01111	0.632
DOC_CYCLIN_yCln2_LP_2	175	181	PF00134	0.553
DOC_CYCLIN_yCln2_LP_2	440	446	PF00134	0.541
DOC_CYCLIN_yCln2_LP_2	471	477	PF00134	0.637
DOC_CYCLIN_yCln2_LP_2	499	505	PF00134	0.603
DOC_MAPK_gen_1	184	191	PF00069	0.599
DOC_MAPK_gen_1	544	552	PF00069	0.535
DOC_MAPK_MEF2A_6	184	191	PF00069	0.569
DOC_PP2B_LxvP_1	175	178	PF13499	0.616
DOC_PP2B_LxvP_1	440	443	PF13499	0.554
DOC_PP2B_LxvP_1	465	468	PF13499	0.681
DOC_PP2B_LxvP_1	471	474	PF13499	0.580
DOC_PP2B_LxvP_1	615	618	PF13499	0.567
DOC_PP2B_LxvP_1	663	666	PF13499	0.622
DOC_PP4_FxxP_1	691	694	PF00568	0.591
DOC_PP4_FxxP_1	695	698	PF00568	0.592
DOC_PP4_FxxP_1	772	775	PF00568	0.625
DOC_USP7_MATH_1	150	154	PF00917	0.644
DOC_USP7_MATH_1	213	217	PF00917	0.600
DOC_USP7_MATH_1	256	260	PF00917	0.640
DOC_USP7_MATH_1	275	279	PF00917	0.763
DOC_USP7_MATH_1	434	438	PF00917	0.615
DOC_USP7_MATH_1	449	453	PF00917	0.529
DOC_USP7_MATH_1	466	470	PF00917	0.513
DOC_USP7_MATH_1	546	550	PF00917	0.575
DOC_USP7_MATH_1	560	564	PF00917	0.553
DOC_USP7_MATH_1	566	570	PF00917	0.487
DOC_USP7_MATH_1	583	587	PF00917	0.682
DOC_USP7_MATH_1	626	630	PF00917	0.700
DOC_USP7_MATH_1	651	655	PF00917	0.585
DOC_USP7_MATH_1	658	662	PF00917	0.611
DOC_USP7_MATH_1	666	670	PF00917	0.604
DOC_USP7_MATH_1	753	757	PF00917	0.625
DOC_USP7_MATH_1	760	764	PF00917	0.631
DOC_USP7_UBL2_3	327	331	PF12436	0.513
DOC_USP7_UBL2_3	432	436	PF12436	0.658
DOC_WW_Pin1_4	119	124	PF00397	0.686
DOC_WW_Pin1_4	132	137	PF00397	0.530
DOC_WW_Pin1_4	160	165	PF00397	0.583
DOC_WW_Pin1_4	204	209	PF00397	0.757
DOC_WW_Pin1_4	224	229	PF00397	0.541
DOC_WW_Pin1_4	235	240	PF00397	0.638
DOC_WW_Pin1_4	247	252	PF00397	0.669
DOC_WW_Pin1_4	271	276	PF00397	0.696
DOC_WW_Pin1_4	409	414	PF00397	0.553
DOC_WW_Pin1_4	492	497	PF00397	0.583
DOC_WW_Pin1_4	498	503	PF00397	0.593
DOC_WW_Pin1_4	562	567	PF00397	0.586
DOC_WW_Pin1_4	581	586	PF00397	0.566
DOC_WW_Pin1_4	645	650	PF00397	0.643
DOC_WW_Pin1_4	701	706	PF00397	0.620
DOC_WW_Pin1_4	743	748	PF00397	0.710
DOC_WW_Pin1_4	756	761	PF00397	0.539
DOC_WW_Pin1_4	780	785	PF00397	0.613
DOC_WW_Pin1_4	793	798	PF00397	0.642
DOC_WW_Pin1_4	816	821	PF00397	0.754
LIG_14-3-3_CanoR_1	246	251	PF00244	0.622
LIG_14-3-3_CanoR_1	276	284	PF00244	0.678
LIG_14-3-3_CanoR_1	37	46	PF00244	0.496
LIG_14-3-3_CanoR_1	600	606	PF00244	0.660
LIG_14-3-3_CanoR_1	607	616	PF00244	0.601
LIG_14-3-3_CanoR_1	696	706	PF00244	0.613
LIG_14-3-3_CanoR_1	732	738	PF00244	0.556
LIG_14-3-3_CanoR_1	771	775	PF00244	0.584
LIG_14-3-3_CanoR_1	814	821	PF00244	0.594
LIG_Actin_WH2_2	477	495	PF00022	0.602
LIG_CtBP_PxDLS_1	203	207	PF00389	0.614
LIG_EH_1	27	31	PF12763	0.553
LIG_EVH1_1	615	619	PF00568	0.578
LIG_EVH1_2	187	191	PF00568	0.572
LIG_FHA_1	161	167	PF00498	0.556
LIG_FHA_1	520	526	PF00498	0.572
LIG_FHA_1	531	537	PF00498	0.422
LIG_FHA_1	672	678	PF00498	0.639
LIG_FHA_1	721	727	PF00498	0.634
LIG_FHA_2	676	682	PF00498	0.674
LIG_FHA_2	734	740	PF00498	0.552
LIG_FHA_2	803	809	PF00498	0.670
LIG_LIR_Apic_2	501	507	PF02991	0.518
LIG_LIR_Apic_2	689	694	PF02991	0.592
LIG_LIR_Nem_3	160	165	PF02991	0.570
LIG_LIR_Nem_3	642	646	PF02991	0.524
LIG_Pex14_2	691	695	PF04695	0.658
LIG_SH2_CRK	133	137	PF00017	0.603
LIG_SH2_GRB2like	80	83	PF00017	0.543
LIG_SH2_NCK_1	112	116	PF00017	0.597
LIG_SH2_NCK_1	128	132	PF00017	0.588
LIG_SH2_NCK_1	133	137	PF00017	0.603
LIG_SH2_STAT5	21	24	PF00017	0.484
LIG_SH2_STAT5	236	239	PF00017	0.654
LIG_SH2_STAT5	482	485	PF00017	0.577
LIG_SH2_STAT5	577	580	PF00017	0.606
LIG_SH3_1	89	95	PF00018	0.634
LIG_SH3_3	161	167	PF00018	0.573
LIG_SH3_3	179	185	PF00018	0.618
LIG_SH3_3	207	213	PF00018	0.742
LIG_SH3_3	215	221	PF00018	0.640
LIG_SH3_3	250	256	PF00018	0.630
LIG_SH3_3	407	413	PF00018	0.608
LIG_SH3_3	416	422	PF00018	0.796
LIG_SH3_3	467	473	PF00018	0.623
LIG_SH3_3	475	481	PF00018	0.530
LIG_SH3_3	61	67	PF00018	0.586
LIG_SH3_3	613	619	PF00018	0.574
LIG_SH3_3	622	628	PF00018	0.593
LIG_SH3_3	699	705	PF00018	0.625
LIG_SH3_3	722	728	PF00018	0.752
LIG_SH3_3	732	738	PF00018	0.534
LIG_SH3_3	741	747	PF00018	0.562
LIG_SH3_3	89	95	PF00018	0.605
LIG_SUMO_SIM_par_1	202	207	PF11976	0.611
LIG_TRAF2_1	298	301	PF00917	0.537
LIG_TRAF2_1	31	34	PF00917	0.558
LIG_WRC_WIRS_1	159	164	PF05994	0.514
MOD_CDK_SPK_2	119	124	PF00069	0.602
MOD_CDK_SPK_2	224	229	PF00069	0.727
MOD_CDK_SPK_2	271	276	PF00069	0.696
MOD_CDK_SPxxK_3	119	126	PF00069	0.589
MOD_CDK_SPxxK_3	235	242	PF00069	0.634
MOD_CK1_1	160	166	PF00069	0.576
MOD_CK1_1	452	458	PF00069	0.642
MOD_CK1_1	524	530	PF00069	0.506
MOD_CK1_1	675	681	PF00069	0.652
MOD_CK1_1	720	726	PF00069	0.607
MOD_CK1_1	756	762	PF00069	0.609
MOD_CK2_1	110	116	PF00069	0.629
MOD_CK2_1	194	200	PF00069	0.671
MOD_CK2_1	235	241	PF00069	0.611
MOD_CK2_1	28	34	PF00069	0.547
MOD_CK2_1	294	300	PF00069	0.537
MOD_CK2_1	675	681	PF00069	0.636
MOD_CK2_1	770	776	PF00069	0.592
MOD_Cter_Amidation	124	127	PF01082	0.548
MOD_GlcNHglycan	112	115	PF01048	0.605
MOD_GlcNHglycan	192	195	PF01048	0.666
MOD_GlcNHglycan	196	199	PF01048	0.639
MOD_GlcNHglycan	264	267	PF01048	0.579
MOD_GlcNHglycan	279	282	PF01048	0.574
MOD_GlcNHglycan	296	299	PF01048	0.518
MOD_GlcNHglycan	444	447	PF01048	0.609
MOD_GlcNHglycan	489	492	PF01048	0.565
MOD_GlcNHglycan	562	565	PF01048	0.627
MOD_GlcNHglycan	601	604	PF01048	0.645
MOD_GlcNHglycan	630	633	PF01048	0.586
MOD_GlcNHglycan	653	656	PF01048	0.622
MOD_GlcNHglycan	762	765	PF01048	0.640
MOD_GlcNHglycan	96	99	PF01048	0.644
MOD_GSK3_1	190	197	PF00069	0.664
MOD_GSK3_1	220	227	PF00069	0.639
MOD_GSK3_1	245	252	PF00069	0.668
MOD_GSK3_1	271	278	PF00069	0.690
MOD_GSK3_1	448	455	PF00069	0.653
MOD_GSK3_1	562	569	PF00069	0.645
MOD_GSK3_1	573	580	PF00069	0.594
MOD_GSK3_1	607	614	PF00069	0.603
MOD_GSK3_1	671	678	PF00069	0.654
MOD_GSK3_1	682	689	PF00069	0.583
MOD_GSK3_1	697	704	PF00069	0.520
MOD_GSK3_1	748	755	PF00069	0.634
MOD_GSK3_1	756	763	PF00069	0.560
MOD_GSK3_1	776	783	PF00069	0.640
MOD_GSK3_1	793	800	PF00069	0.528
MOD_N-GLC_1	262	267	PF02516	0.573
MOD_N-GLC_1	78	83	PF02516	0.595
MOD_N-GLC_2	509	511	PF02516	0.627
MOD_NEK2_1	435	440	PF00069	0.616
MOD_NEK2_1	673	678	PF00069	0.735
MOD_PIKK_1	150	156	PF00454	0.629
MOD_PIKK_1	213	219	PF00454	0.605
MOD_PIKK_1	37	43	PF00454	0.509
MOD_PIKK_1	389	395	PF00454	0.673
MOD_PIKK_1	452	458	PF00454	0.552
MOD_PIKK_1	519	525	PF00454	0.574
MOD_PK_1	788	794	PF00069	0.537
MOD_PKA_1	530	536	PF00069	0.478
MOD_PKA_1	814	820	PF00069	0.611
MOD_PKA_2	245	251	PF00069	0.779
MOD_PKA_2	275	281	PF00069	0.679
MOD_PKA_2	389	395	PF00069	0.673
MOD_PKA_2	530	536	PF00069	0.478
MOD_PKA_2	599	605	PF00069	0.655
MOD_PKA_2	770	776	PF00069	0.585
MOD_PKA_2	814	820	PF00069	0.600
MOD_PKA_2	85	91	PF00069	0.559
MOD_Plk_4	249	255	PF00069	0.684
MOD_Plk_4	466	472	PF00069	0.627
MOD_Plk_4	573	579	PF00069	0.611
MOD_Plk_4	658	664	PF00069	0.674
MOD_Plk_4	711	717	PF00069	0.621
MOD_ProDKin_1	119	125	PF00069	0.685
MOD_ProDKin_1	132	138	PF00069	0.531
MOD_ProDKin_1	160	166	PF00069	0.582
MOD_ProDKin_1	204	210	PF00069	0.753
MOD_ProDKin_1	224	230	PF00069	0.542
MOD_ProDKin_1	235	241	PF00069	0.639
MOD_ProDKin_1	247	253	PF00069	0.670
MOD_ProDKin_1	271	277	PF00069	0.692
MOD_ProDKin_1	409	415	PF00069	0.555
MOD_ProDKin_1	492	498	PF00069	0.579
MOD_ProDKin_1	562	568	PF00069	0.585
MOD_ProDKin_1	581	587	PF00069	0.570
MOD_ProDKin_1	645	651	PF00069	0.644
MOD_ProDKin_1	701	707	PF00069	0.618
MOD_ProDKin_1	743	749	PF00069	0.710
MOD_ProDKin_1	756	762	PF00069	0.537
MOD_ProDKin_1	780	786	PF00069	0.613
MOD_ProDKin_1	793	799	PF00069	0.641
MOD_ProDKin_1	816	822	PF00069	0.760
MOD_SUMO_rev_2	367	376	PF00179	0.504
TRG_DiLeu_BaEn_2	686	692	PF01217	0.600
TRG_ENDOCYTIC_2	606	609	PF00928	0.616
TRG_ER_diArg_1	36	39	PF00400	0.614
TRG_ER_diArg_1	403	406	PF00400	0.614
TRG_ER_diArg_1	46	48	PF00400	0.573
TRG_ER_diArg_1	529	531	PF00400	0.484
TRG_ER_diArg_1	6	8	PF00400	0.495
TRG_ER_diArg_1	814	816	PF00400	0.602
TRG_Pf-PMV_PEXEL_1	322	326	PF00026	0.452
TRG_Pf-PMV_PEXEL_1	337	341	PF00026	0.503
TRG_Pf-PMV_PEXEL_1	668	672	PF00026	0.553

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1W4	Leptomonas seymouri	43%	93%
A0A3S7WWJ6	Leishmania donovani	96%	100%
A4HBW3	Leishmania braziliensis	69%	100%
E9AV87	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	99%
Q4QC93	Leishmania major	90%	99%