Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

E9AGW5_LEIIN

TriTrypDb:

LINF_210017300

Length:

762

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AGW5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AGW5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	180	184	PF00656	0.625
CLV_C14_Caspase3-7	338	342	PF00656	0.669
CLV_C14_Caspase3-7	401	405	PF00656	0.494
CLV_C14_Caspase3-7	434	438	PF00656	0.619
CLV_C14_Caspase3-7	529	533	PF00656	0.469
CLV_C14_Caspase3-7	586	590	PF00656	0.657
CLV_C14_Caspase3-7	748	752	PF00656	0.725
CLV_NRD_NRD_1	214	216	PF00675	0.464
CLV_NRD_NRD_1	357	359	PF00675	0.726
CLV_NRD_NRD_1	564	566	PF00675	0.535
CLV_NRD_NRD_1	569	571	PF00675	0.603
CLV_NRD_NRD_1	627	629	PF00675	0.600
CLV_NRD_NRD_1	640	642	PF00675	0.449
CLV_NRD_NRD_1	65	67	PF00675	0.516
CLV_NRD_NRD_1	655	657	PF00675	0.421
CLV_NRD_NRD_1	695	697	PF00675	0.428
CLV_NRD_NRD_1	78	80	PF00675	0.537
CLV_NRD_NRD_1	84	86	PF00675	0.530
CLV_NRD_NRD_1	94	96	PF00675	0.475
CLV_PCSK_FUR_1	567	571	PF00082	0.598
CLV_PCSK_KEX2_1	214	216	PF00082	0.464
CLV_PCSK_KEX2_1	566	568	PF00082	0.582
CLV_PCSK_KEX2_1	569	571	PF00082	0.603
CLV_PCSK_KEX2_1	642	644	PF00082	0.490
CLV_PCSK_KEX2_1	65	67	PF00082	0.516
CLV_PCSK_KEX2_1	655	657	PF00082	0.376
CLV_PCSK_KEX2_1	695	697	PF00082	0.465
CLV_PCSK_KEX2_1	78	80	PF00082	0.537
CLV_PCSK_KEX2_1	84	86	PF00082	0.530
CLV_PCSK_KEX2_1	94	96	PF00082	0.475
CLV_PCSK_PC1ET2_1	566	568	PF00082	0.585
CLV_PCSK_PC1ET2_1	642	644	PF00082	0.515
CLV_PCSK_PC7_1	565	571	PF00082	0.634
CLV_PCSK_SKI1_1	142	146	PF00082	0.466
CLV_PCSK_SKI1_1	148	152	PF00082	0.441
CLV_PCSK_SKI1_1	214	218	PF00082	0.431
CLV_PCSK_SKI1_1	220	224	PF00082	0.421
CLV_PCSK_SKI1_1	265	269	PF00082	0.581
CLV_PCSK_SKI1_1	275	279	PF00082	0.540
CLV_PCSK_SKI1_1	428	432	PF00082	0.587
CLV_PCSK_SKI1_1	444	448	PF00082	0.551
CLV_PCSK_SKI1_1	521	525	PF00082	0.505
CLV_PCSK_SKI1_1	580	584	PF00082	0.606
CLV_PCSK_SKI1_1	632	636	PF00082	0.468
CLV_PCSK_SKI1_1	642	646	PF00082	0.452
CLV_PCSK_SKI1_1	695	699	PF00082	0.478
CLV_PCSK_SKI1_1	703	707	PF00082	0.531
DEG_APCC_DBOX_1	695	703	PF00400	0.417
DEG_Nend_UBRbox_4	1	3	PF02207	0.434
DEG_SPOP_SBC_1	111	115	PF00917	0.638
DEG_SPOP_SBC_1	166	170	PF00917	0.597
DEG_SPOP_SBC_1	185	189	PF00917	0.542
DEG_SPOP_SBC_1	276	280	PF00917	0.622
DEG_SPOP_SBC_1	611	615	PF00917	0.725
DOC_CKS1_1	387	392	PF01111	0.470
DOC_CYCLIN_RxL_1	515	525	PF00134	0.518
DOC_CYCLIN_RxL_1	692	701	PF00134	0.383
DOC_MAPK_DCC_7	551	559	PF00069	0.549
DOC_MAPK_gen_1	148	158	PF00069	0.426
DOC_MAPK_gen_1	423	431	PF00069	0.520
DOC_MAPK_gen_1	479	488	PF00069	0.504
DOC_MAPK_gen_1	84	92	PF00069	0.537
DOC_MAPK_MEF2A_6	479	488	PF00069	0.492
DOC_MAPK_MEF2A_6	521	530	PF00069	0.526
DOC_MAPK_MEF2A_6	551	560	PF00069	0.490
DOC_PP1_RVXF_1	519	525	PF00149	0.574
DOC_PP2B_LxvP_1	239	242	PF13499	0.486
DOC_PP2B_LxvP_1	382	385	PF13499	0.732
DOC_USP7_MATH_1	112	116	PF00917	0.713
DOC_USP7_MATH_1	175	179	PF00917	0.795
DOC_USP7_MATH_1	185	189	PF00917	0.682
DOC_USP7_MATH_1	191	195	PF00917	0.676
DOC_USP7_MATH_1	207	211	PF00917	0.413
DOC_USP7_MATH_1	276	280	PF00917	0.672
DOC_USP7_MATH_1	288	292	PF00917	0.684
DOC_USP7_MATH_1	30	34	PF00917	0.453
DOC_USP7_MATH_1	352	356	PF00917	0.556
DOC_USP7_MATH_1	438	442	PF00917	0.568
DOC_USP7_MATH_1	611	615	PF00917	0.734
DOC_USP7_MATH_1	742	746	PF00917	0.629
DOC_USP7_UBL2_3	148	152	PF12436	0.488
DOC_WW_Pin1_4	105	110	PF00397	0.721
DOC_WW_Pin1_4	20	25	PF00397	0.433
DOC_WW_Pin1_4	279	284	PF00397	0.651
DOC_WW_Pin1_4	325	330	PF00397	0.657
DOC_WW_Pin1_4	359	364	PF00397	0.634
DOC_WW_Pin1_4	380	385	PF00397	0.760
DOC_WW_Pin1_4	386	391	PF00397	0.673
DOC_WW_Pin1_4	52	57	PF00397	0.649
LIG_14-3-3_CanoR_1	186	193	PF00244	0.540
LIG_14-3-3_CanoR_1	208	214	PF00244	0.449
LIG_14-3-3_CanoR_1	220	229	PF00244	0.393
LIG_14-3-3_CanoR_1	289	296	PF00244	0.650
LIG_14-3-3_CanoR_1	521	527	PF00244	0.455
LIG_14-3-3_CanoR_1	593	603	PF00244	0.603
LIG_14-3-3_CanoR_1	641	650	PF00244	0.442
LIG_14-3-3_CanoR_1	655	663	PF00244	0.356
LIG_14-3-3_CanoR_1	94	98	PF00244	0.646
LIG_BIR_III_4	671	675	PF00653	0.490
LIG_CtBP_PxDLS_1	384	388	PF00389	0.542
LIG_deltaCOP1_diTrp_1	516	524	PF00928	0.514
LIG_EVH1_1	408	412	PF00568	0.515
LIG_FHA_1	145	151	PF00498	0.435
LIG_FHA_1	187	193	PF00498	0.623
LIG_FHA_1	483	489	PF00498	0.551
LIG_FHA_1	490	496	PF00498	0.518
LIG_FHA_1	517	523	PF00498	0.559
LIG_FHA_1	618	624	PF00498	0.625
LIG_FHA_2	230	236	PF00498	0.435
LIG_FHA_2	290	296	PF00498	0.627
LIG_FHA_2	365	371	PF00498	0.581
LIG_FHA_2	467	473	PF00498	0.479
LIG_FHA_2	746	752	PF00498	0.773
LIG_IRF3_LxIS_1	524	531	PF10401	0.367
LIG_LIR_Gen_1	225	235	PF02991	0.557
LIG_LIR_Gen_1	472	482	PF02991	0.544
LIG_LIR_Nem_3	225	231	PF02991	0.475
LIG_LIR_Nem_3	234	240	PF02991	0.486
LIG_LIR_Nem_3	472	478	PF02991	0.561
LIG_LIR_Nem_3	553	558	PF02991	0.552
LIG_MYND_2	390	394	PF01753	0.413
LIG_NRBOX	522	528	PF00104	0.514
LIG_NRBOX	663	669	PF00104	0.420
LIG_PDZ_Class_2	757	762	PF00595	0.510
LIG_PTB_Apo_2	199	206	PF02174	0.577
LIG_PTB_Apo_2	415	422	PF02174	0.522
LIG_PTB_Phospho_1	415	421	PF10480	0.529
LIG_Rb_pABgroove_1	539	547	PF01858	0.519
LIG_SH2_CRK	636	640	PF00017	0.528
LIG_SH2_NCK_1	468	472	PF00017	0.522
LIG_SH2_NCK_1	636	640	PF00017	0.469
LIG_SH2_SRC	228	231	PF00017	0.514
LIG_SH2_STAT5	228	231	PF00017	0.455
LIG_SH2_STAT5	238	241	PF00017	0.490
LIG_SH2_STAT5	266	269	PF00017	0.561
LIG_SH2_STAT5	468	471	PF00017	0.401
LIG_SH3_1	106	112	PF00018	0.520
LIG_SH3_1	42	48	PF00018	0.460
LIG_SH3_3	106	112	PF00018	0.520
LIG_SH3_3	179	185	PF00018	0.595
LIG_SH3_3	244	250	PF00018	0.601
LIG_SH3_3	346	352	PF00018	0.729
LIG_SH3_3	403	409	PF00018	0.527
LIG_SH3_3	42	48	PF00018	0.529
LIG_SH3_4	148	155	PF00018	0.460
LIG_SUMO_SIM_anti_2	55	61	PF11976	0.575
LIG_SUMO_SIM_par_1	525	532	PF11976	0.548
LIG_TRAF2_1	318	321	PF00917	0.624
LIG_TRAF2_1	463	466	PF00917	0.482
LIG_TRAF2_1	505	508	PF00917	0.603
LIG_TRFH_1	380	384	PF08558	0.695
LIG_TYR_ITIM	634	639	PF00017	0.506
LIG_UBA3_1	474	481	PF00899	0.489
MOD_CDK_SPxxK_3	279	286	PF00069	0.607
MOD_CK1_1	105	111	PF00069	0.714
MOD_CK1_1	113	119	PF00069	0.593
MOD_CK1_1	187	193	PF00069	0.640
MOD_CK1_1	279	285	PF00069	0.618
MOD_CK1_1	291	297	PF00069	0.594
MOD_CK1_1	357	363	PF00069	0.775
MOD_CK1_1	52	58	PF00069	0.491
MOD_CK1_1	584	590	PF00069	0.666
MOD_CK1_1	610	616	PF00069	0.645
MOD_CK1_1	71	77	PF00069	0.496
MOD_CK1_1	745	751	PF00069	0.637
MOD_CK1_1	96	102	PF00069	0.674
MOD_CK2_1	174	180	PF00069	0.693
MOD_CK2_1	289	295	PF00069	0.646
MOD_CK2_1	364	370	PF00069	0.721
MOD_CK2_1	380	386	PF00069	0.609
MOD_CK2_1	460	466	PF00069	0.493
MOD_CK2_1	528	534	PF00069	0.492
MOD_CK2_1	654	660	PF00069	0.480
MOD_GlcNHglycan	163	166	PF01048	0.625
MOD_GlcNHglycan	176	180	PF01048	0.635
MOD_GlcNHglycan	189	192	PF01048	0.624
MOD_GlcNHglycan	225	228	PF01048	0.585
MOD_GlcNHglycan	243	246	PF01048	0.478
MOD_GlcNHglycan	370	374	PF01048	0.667
MOD_GlcNHglycan	377	380	PF01048	0.729
MOD_GlcNHglycan	51	54	PF01048	0.579
MOD_GlcNHglycan	585	589	PF01048	0.723
MOD_GlcNHglycan	609	612	PF01048	0.789
MOD_GlcNHglycan	70	73	PF01048	0.526
MOD_GlcNHglycan	707	710	PF01048	0.636
MOD_GlcNHglycan	725	728	PF01048	0.675
MOD_GlcNHglycan	744	747	PF01048	0.535
MOD_GSK3_1	110	117	PF00069	0.713
MOD_GSK3_1	161	168	PF00069	0.627
MOD_GSK3_1	171	178	PF00069	0.714
MOD_GSK3_1	187	194	PF00069	0.770
MOD_GSK3_1	20	27	PF00069	0.541
MOD_GSK3_1	275	282	PF00069	0.621
MOD_GSK3_1	321	328	PF00069	0.569
MOD_GSK3_1	357	364	PF00069	0.625
MOD_GSK3_1	489	496	PF00069	0.480
MOD_GSK3_1	522	529	PF00069	0.492
MOD_GSK3_1	607	614	PF00069	0.636
MOD_GSK3_1	705	712	PF00069	0.600
MOD_GSK3_1	741	748	PF00069	0.778
MOD_N-GLC_1	482	487	PF02516	0.552
MOD_NEK2_1	102	107	PF00069	0.707
MOD_NEK2_1	118	123	PF00069	0.711
MOD_NEK2_1	222	227	PF00069	0.538
MOD_NEK2_1	431	436	PF00069	0.635
MOD_NEK2_1	447	452	PF00069	0.474
MOD_NEK2_1	522	527	PF00069	0.418
MOD_NEK2_1	635	640	PF00069	0.516
MOD_NEK2_1	698	703	PF00069	0.447
MOD_NEK2_1	705	710	PF00069	0.605
MOD_NEK2_2	14	19	PF00069	0.419
MOD_NEK2_2	30	35	PF00069	0.432
MOD_PIKK_1	191	197	PF00454	0.622
MOD_PIKK_1	595	601	PF00454	0.619
MOD_PIKK_1	623	629	PF00454	0.646
MOD_PKA_1	642	648	PF00069	0.457
MOD_PKA_2	185	191	PF00069	0.540
MOD_PKA_2	207	213	PF00069	0.484
MOD_PKA_2	288	294	PF00069	0.700
MOD_PKA_2	352	358	PF00069	0.538
MOD_PKA_2	642	648	PF00069	0.502
MOD_PKA_2	654	660	PF00069	0.323
MOD_PKA_2	93	99	PF00069	0.611
MOD_Plk_1	482	488	PF00069	0.540
MOD_Plk_2-3	307	313	PF00069	0.514
MOD_Plk_4	114	120	PF00069	0.724
MOD_Plk_4	493	499	PF00069	0.437
MOD_Plk_4	55	61	PF00069	0.577
MOD_Plk_4	71	77	PF00069	0.469
MOD_ProDKin_1	105	111	PF00069	0.720
MOD_ProDKin_1	20	26	PF00069	0.434
MOD_ProDKin_1	279	285	PF00069	0.655
MOD_ProDKin_1	325	331	PF00069	0.659
MOD_ProDKin_1	359	365	PF00069	0.633
MOD_ProDKin_1	380	386	PF00069	0.759
MOD_ProDKin_1	52	58	PF00069	0.648
MOD_SUMO_for_1	582	585	PF00179	0.608
TRG_DiLeu_BaLyEn_6	389	394	PF01217	0.558
TRG_DiLeu_BaLyEn_6	518	523	PF01217	0.430
TRG_DiLeu_BaLyEn_6	663	668	PF01217	0.445
TRG_DiLeu_LyEn_5	553	558	PF01217	0.510
TRG_ENDOCYTIC_2	228	231	PF00928	0.489
TRG_ENDOCYTIC_2	636	639	PF00928	0.522
TRG_ER_diArg_1	213	215	PF00400	0.461
TRG_ER_diArg_1	426	429	PF00400	0.579
TRG_ER_diArg_1	565	568	PF00400	0.647
TRG_ER_diArg_1	65	67	PF00400	0.513
TRG_ER_diArg_1	654	656	PF00400	0.408
TRG_ER_diArg_1	694	696	PF00400	0.456
TRG_ER_diArg_1	77	79	PF00400	0.495
TRG_NLS_Bipartite_1	628	645	PF00514	0.414
TRG_NLS_MonoCore_2	565	570	PF00514	0.576
TRG_NLS_MonoExtC_3	564	569	PF00514	0.543
TRG_NLS_MonoExtC_3	640	646	PF00514	0.463
TRG_NLS_MonoExtN_4	565	570	PF00514	0.552
TRG_Pf-PMV_PEXEL_1	539	543	PF00026	0.569
TRG_Pf-PMV_PEXEL_1	666	671	PF00026	0.468
TRG_Pf-PMV_PEXEL_1	78	83	PF00026	0.560

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0P8	Leptomonas seymouri	48%	100%
A0A1X0NXZ3	Trypanosomatidae	36%	100%
A0A3S7WWN7	Leishmania donovani	100%	100%
A4HBV7	Leishmania braziliensis	72%	98%
E9AV81	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	99%
Q4QC99	Leishmania major	90%	99%
V5BFI7	Trypanosoma cruzi	38%	100%