Uncharacterized protein

Quick info Annotations Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

E9AGW2_LEIIN

TriTrypDb:

LINF_210017000

Length:

334

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0016020	membrane	2	10
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	10

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

E9AGW2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AGW2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	208	212	PF00656	0.249
CLV_C14_Caspase3-7	299	303	PF00656	0.419
CLV_NRD_NRD_1	122	124	PF00675	0.554
CLV_NRD_NRD_1	148	150	PF00675	0.449
CLV_PCSK_SKI1_1	10	14	PF00082	0.375
CLV_PCSK_SKI1_1	150	154	PF00082	0.481
CLV_PCSK_SKI1_1	210	214	PF00082	0.534
CLV_PCSK_SKI1_1	36	40	PF00082	0.320
DEG_APCC_DBOX_1	63	71	PF00400	0.504
DOC_CYCLIN_RxL_1	182	194	PF00134	0.478
DOC_CYCLIN_RxL_1	7	17	PF00134	0.506
DOC_MAPK_gen_1	149	155	PF00069	0.273
DOC_MAPK_gen_1	182	191	PF00069	0.479
DOC_PP4_FxxP_1	311	314	PF00568	0.295
DOC_USP7_MATH_1	173	177	PF00917	0.324
DOC_WW_Pin1_4	276	281	PF00397	0.558
DOC_WW_Pin1_4	4	9	PF00397	0.566
DOC_WW_Pin1_4	42	47	PF00397	0.563
LIG_Actin_WH2_2	196	212	PF00022	0.438
LIG_Actin_WH2_2	89	107	PF00022	0.441
LIG_BIR_II_1	1	5	PF00653	0.581
LIG_BIR_III_2	211	215	PF00653	0.354
LIG_BIR_III_2	302	306	PF00653	0.321
LIG_BIR_III_4	129	133	PF00653	0.368
LIG_EH_1	303	307	PF12763	0.356
LIG_FHA_1	142	148	PF00498	0.375
LIG_FHA_1	85	91	PF00498	0.278
LIG_FHA_1	93	99	PF00498	0.269
LIG_FHA_2	206	212	PF00498	0.347
LIG_FHA_2	297	303	PF00498	0.515
LIG_FHA_2	314	320	PF00498	0.152
LIG_GBD_Chelix_1	232	240	PF00786	0.359
LIG_LIR_Gen_1	107	115	PF02991	0.301
LIG_LIR_Gen_1	319	326	PF02991	0.348
LIG_LIR_Gen_1	53	62	PF02991	0.553
LIG_LIR_Gen_1	85	93	PF02991	0.334
LIG_LIR_Nem_3	107	111	PF02991	0.292
LIG_LIR_Nem_3	11	16	PF02991	0.497
LIG_LIR_Nem_3	17	23	PF02991	0.508
LIG_LIR_Nem_3	319	323	PF02991	0.348
LIG_LIR_Nem_3	53	57	PF02991	0.556
LIG_LIR_Nem_3	85	89	PF02991	0.368
LIG_Pex14_2	311	315	PF04695	0.311
LIG_Rb_LxCxE_1	94	107	PF01857	0.343
LIG_SH2_CRK	54	58	PF00017	0.578
LIG_SH2_CRK	86	90	PF00017	0.326
LIG_SH2_GRB2like	112	115	PF00017	0.312
LIG_SH2_NCK_1	115	119	PF00017	0.374
LIG_SH2_NCK_1	54	58	PF00017	0.581
LIG_SH2_PTP2	202	205	PF00017	0.458
LIG_SH2_STAP1	115	119	PF00017	0.346
LIG_SH2_STAP1	54	58	PF00017	0.564
LIG_SH2_STAP1	86	90	PF00017	0.315
LIG_SH2_STAT5	202	205	PF00017	0.417
LIG_SH2_STAT5	320	323	PF00017	0.256
LIG_SH2_STAT5	47	50	PF00017	0.558
LIG_SH2_STAT5	86	89	PF00017	0.327
LIG_SUMO_SIM_par_1	87	95	PF11976	0.276
MOD_CDC14_SPxK_1	7	10	PF00782	0.563
MOD_CDK_SPK_2	276	281	PF00069	0.558
MOD_CDK_SPxK_1	4	10	PF00069	0.583
MOD_CDK_SPxxK_3	276	283	PF00069	0.542
MOD_CK1_1	194	200	PF00069	0.332
MOD_CK1_1	4	10	PF00069	0.596
MOD_CK1_1	53	59	PF00069	0.574
MOD_CK2_1	313	319	PF00069	0.254
MOD_GlcNHglycan	220	223	PF01048	0.518
MOD_GSK3_1	141	148	PF00069	0.310
MOD_GSK3_1	4	11	PF00069	0.558
MOD_NEK2_1	104	109	PF00069	0.313
MOD_NEK2_1	185	190	PF00069	0.503
MOD_NEK2_1	191	196	PF00069	0.294
MOD_NEK2_1	205	210	PF00069	0.152
MOD_NEK2_1	288	293	PF00069	0.377
MOD_NEK2_1	82	87	PF00069	0.326
MOD_NEK2_2	8	13	PF00069	0.562
MOD_PKA_1	218	224	PF00069	0.347
MOD_Plk_1	205	211	PF00069	0.301
MOD_Plk_1	273	279	PF00069	0.554
MOD_Plk_4	173	179	PF00069	0.337
MOD_Plk_4	235	241	PF00069	0.278
MOD_Plk_4	84	90	PF00069	0.292
MOD_ProDKin_1	276	282	PF00069	0.550
MOD_ProDKin_1	4	10	PF00069	0.567
MOD_ProDKin_1	42	48	PF00069	0.565
MOD_SUMO_rev_2	102	107	PF00179	0.344
TRG_DiLeu_BaEn_1	94	99	PF01217	0.345
TRG_ENDOCYTIC_2	202	205	PF00928	0.413
TRG_ENDOCYTIC_2	320	323	PF00928	0.348
TRG_ENDOCYTIC_2	54	57	PF00928	0.547
TRG_ENDOCYTIC_2	86	89	PF00928	0.326

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1II52	Leptomonas seymouri	59%	98%
A0A0S4JMI1	Bodo saltans	31%	100%
A0A1X0NXQ9	Trypanosomatidae	33%	98%
A0A3S5H798	Leishmania donovani	100%	100%
A0A422NWG5	Trypanosoma rangeli	34%	100%
A4HBV4	Leishmania braziliensis	73%	100%
D0A1C0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	98%
E9AV78	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4QCA2	Leishmania major	92%	100%
V5BFJ0	Trypanosoma cruzi	32%	99%