LeishMANIAdb
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tRNA_edit domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
tRNA_edit domain-containing protein
Gene product:
Aminoacyl-tRNA editing domain containing protein - putative
Species:
Leishmania infantum
UniProt:
E9AGV9_LEIIN
TriTrypDb:
LINF_210016600 *
Length:
380

Annotations

Annotations by Jardim et al.

tRNA synthetase, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

E9AGV9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AGV9

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0002161 aminoacyl-tRNA editing activity 5 10
GO:0003824 catalytic activity 1 10
GO:0016787 hydrolase activity 2 10
GO:0016788 hydrolase activity, acting on ester bonds 3 10
GO:0052689 carboxylic ester hydrolase activity 4 10
GO:0140098 catalytic activity, acting on RNA 3 10
GO:0140101 catalytic activity, acting on a tRNA 4 10
GO:0140640 catalytic activity, acting on a nucleic acid 2 10
GO:0004812 aminoacyl-tRNA ligase activity 4 1
GO:0016874 ligase activity 2 1
GO:0016875 ligase activity, forming carbon-oxygen bonds 3 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 195 197 PF00675 0.453
CLV_NRD_NRD_1 223 225 PF00675 0.371
CLV_NRD_NRD_1 58 60 PF00675 0.482
CLV_NRD_NRD_1 68 70 PF00675 0.427
CLV_PCSK_FUR_1 193 197 PF00082 0.393
CLV_PCSK_FUR_1 56 60 PF00082 0.441
CLV_PCSK_KEX2_1 195 197 PF00082 0.533
CLV_PCSK_KEX2_1 223 225 PF00082 0.371
CLV_PCSK_KEX2_1 58 60 PF00082 0.482
CLV_PCSK_KEX2_1 68 70 PF00082 0.427
CLV_PCSK_SKI1_1 224 228 PF00082 0.391
CLV_PCSK_SKI1_1 237 241 PF00082 0.226
CLV_PCSK_SKI1_1 58 62 PF00082 0.441
CLV_PCSK_SKI1_1 68 72 PF00082 0.406
DEG_APCC_DBOX_1 67 75 PF00400 0.425
DEG_SCF_TRCP1_1 200 206 PF00400 0.377
DOC_ANK_TNKS_1 146 153 PF00023 0.531
DOC_CYCLIN_yCln2_LP_2 17 23 PF00134 0.402
DOC_CYCLIN_yCln2_LP_2 295 301 PF00134 0.511
DOC_MAPK_DCC_7 68 76 PF00069 0.427
DOC_MAPK_DCC_7 90 99 PF00069 0.476
DOC_MAPK_FxFP_2 75 78 PF00069 0.431
DOC_MAPK_gen_1 68 76 PF00069 0.463
DOC_MAPK_MEF2A_6 37 45 PF00069 0.358
DOC_MAPK_MEF2A_6 68 76 PF00069 0.427
DOC_MAPK_NFAT4_5 68 76 PF00069 0.427
DOC_PP2B_LxvP_1 17 20 PF13499 0.408
DOC_PP2B_LxvP_1 209 212 PF13499 0.525
DOC_PP2B_LxvP_1 21 24 PF13499 0.386
DOC_PP2B_LxvP_1 227 230 PF13499 0.319
DOC_PP2B_LxvP_1 332 335 PF13499 0.465
DOC_PP2B_LxvP_1 99 102 PF13499 0.455
DOC_PP4_FxxP_1 75 78 PF00568 0.431
DOC_SPAK_OSR1_1 131 135 PF12202 0.434
DOC_USP7_MATH_1 116 120 PF00917 0.561
DOC_USP7_MATH_1 158 162 PF00917 0.671
DOC_WW_Pin1_4 101 106 PF00397 0.445
DOC_WW_Pin1_4 89 94 PF00397 0.510
LIG_14-3-3_CanoR_1 167 175 PF00244 0.542
LIG_14-3-3_CanoR_1 7 17 PF00244 0.436
LIG_Actin_WH2_2 132 149 PF00022 0.497
LIG_BRCT_BRCA1_1 204 208 PF00533 0.338
LIG_CSL_BTD_1 209 212 PF09270 0.435
LIG_EVH1_1 106 110 PF00568 0.435
LIG_EVH1_1 23 27 PF00568 0.384
LIG_FHA_1 204 210 PF00498 0.497
LIG_FHA_1 334 340 PF00498 0.531
LIG_FHA_1 65 71 PF00498 0.424
LIG_FHA_2 245 251 PF00498 0.483
LIG_FHA_2 369 375 PF00498 0.441
LIG_LIR_Gen_1 205 216 PF02991 0.468
LIG_LIR_Gen_1 257 267 PF02991 0.447
LIG_LIR_Gen_1 354 363 PF02991 0.508
LIG_LIR_Nem_3 205 211 PF02991 0.345
LIG_LIR_Nem_3 257 263 PF02991 0.447
LIG_LIR_Nem_3 354 358 PF02991 0.474
LIG_MYND_1 179 183 PF01753 0.454
LIG_SH2_SRC 264 267 PF00017 0.474
LIG_SH2_STAT5 260 263 PF00017 0.447
LIG_SH2_STAT5 266 269 PF00017 0.447
LIG_SH2_STAT5 338 341 PF00017 0.530
LIG_SH3_1 90 96 PF00018 0.479
LIG_SH3_2 32 37 PF14604 0.375
LIG_SH3_3 106 112 PF00018 0.437
LIG_SH3_3 182 188 PF00018 0.460
LIG_SH3_3 21 27 PF00018 0.442
LIG_SH3_3 29 35 PF00018 0.439
LIG_SH3_3 90 96 PF00018 0.506
LIG_SH3_3 99 105 PF00018 0.463
LIG_SUMO_SIM_par_1 321 326 PF11976 0.455
LIG_TRAF2_1 278 281 PF00917 0.467
LIG_TRAF2_1 371 374 PF00917 0.396
LIG_TYR_ITIM 262 267 PF00017 0.530
MOD_CK1_1 161 167 PF00069 0.711
MOD_CK1_1 64 70 PF00069 0.422
MOD_CK1_1 9 15 PF00069 0.428
MOD_CK2_1 116 122 PF00069 0.422
MOD_CK2_1 368 374 PF00069 0.420
MOD_Cter_Amidation 286 289 PF01082 0.247
MOD_GlcNHglycan 11 14 PF01048 0.470
MOD_GlcNHglycan 136 139 PF01048 0.440
MOD_GlcNHglycan 200 203 PF01048 0.419
MOD_GlcNHglycan 308 311 PF01048 0.349
MOD_GSK3_1 157 164 PF00069 0.696
MOD_GSK3_1 198 205 PF00069 0.317
MOD_GSK3_1 302 309 PF00069 0.517
MOD_GSK3_1 323 330 PF00069 0.490
MOD_GSK3_1 364 371 PF00069 0.404
MOD_GSK3_1 60 67 PF00069 0.506
MOD_GSK3_1 79 86 PF00069 0.425
MOD_N-GLC_1 254 259 PF02516 0.340
MOD_NEK2_1 1 6 PF00069 0.436
MOD_NEK2_1 235 240 PF00069 0.448
MOD_NEK2_1 241 246 PF00069 0.450
MOD_NEK2_1 47 52 PF00069 0.389
MOD_PKA_2 166 172 PF00069 0.565
MOD_PKA_2 356 362 PF00069 0.568
MOD_PKA_2 6 12 PF00069 0.435
MOD_Plk_1 161 167 PF00069 0.674
MOD_Plk_1 254 260 PF00069 0.449
MOD_Plk_4 235 241 PF00069 0.453
MOD_Plk_4 333 339 PF00069 0.450
MOD_ProDKin_1 101 107 PF00069 0.442
MOD_ProDKin_1 89 95 PF00069 0.509
TRG_DiLeu_BaLyEn_6 66 71 PF01217 0.424
TRG_ENDOCYTIC_2 259 262 PF00928 0.448
TRG_ENDOCYTIC_2 264 267 PF00928 0.446
TRG_ER_diArg_1 193 196 PF00400 0.510
TRG_ER_diArg_1 222 224 PF00400 0.363
TRG_ER_diArg_1 56 59 PF00400 0.475
TRG_ER_diArg_1 68 70 PF00400 0.420
TRG_NES_CRM1_1 123 136 PF08389 0.435
TRG_Pf-PMV_PEXEL_1 277 281 PF00026 0.295

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I030 Leptomonas seymouri 73% 100%
A0A1X0NXR2 Trypanosomatidae 48% 100%
A0A3Q8IDY4 Leishmania donovani 97% 100%
A4HK97 Leishmania braziliensis 79% 100%
D0A1C2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 51% 100%
E9AV75 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 100%
Q4QCA6 Leishmania major 91% 100%
V5B6I0 Trypanosoma cruzi 49% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS