LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
E9AGV8_LEIIN
TriTrypDb:
LINF_210016500 *
Length:
448

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AGV8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AGV8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 386 390 PF00656 0.495
CLV_C14_Caspase3-7 406 410 PF00656 0.487
CLV_NRD_NRD_1 133 135 PF00675 0.563
CLV_NRD_NRD_1 200 202 PF00675 0.647
CLV_NRD_NRD_1 251 253 PF00675 0.503
CLV_NRD_NRD_1 275 277 PF00675 0.585
CLV_NRD_NRD_1 340 342 PF00675 0.600
CLV_NRD_NRD_1 344 346 PF00675 0.558
CLV_NRD_NRD_1 368 370 PF00675 0.512
CLV_PCSK_KEX2_1 133 135 PF00082 0.563
CLV_PCSK_KEX2_1 199 201 PF00082 0.770
CLV_PCSK_KEX2_1 251 253 PF00082 0.503
CLV_PCSK_KEX2_1 275 277 PF00082 0.583
CLV_PCSK_KEX2_1 340 342 PF00082 0.587
CLV_PCSK_SKI1_1 11 15 PF00082 0.513
CLV_PCSK_SKI1_1 306 310 PF00082 0.603
DEG_SCF_FBW7_1 100 105 PF00400 0.583
DEG_SPOP_SBC_1 102 106 PF00917 0.545
DEG_SPOP_SBC_1 318 322 PF00917 0.633
DOC_ANK_TNKS_1 199 206 PF00023 0.532
DOC_MAPK_gen_1 251 257 PF00069 0.435
DOC_MAPK_gen_1 275 282 PF00069 0.533
DOC_MAPK_MEF2A_6 110 118 PF00069 0.435
DOC_MAPK_MEF2A_6 275 284 PF00069 0.528
DOC_PP1_RVXF_1 9 16 PF00149 0.439
DOC_PP2B_LxvP_1 36 39 PF13499 0.547
DOC_USP7_MATH_1 103 107 PF00917 0.569
DOC_USP7_MATH_1 167 171 PF00917 0.741
DOC_USP7_MATH_1 274 278 PF00917 0.558
DOC_USP7_MATH_1 317 321 PF00917 0.715
DOC_USP7_MATH_1 325 329 PF00917 0.688
DOC_WW_Pin1_4 98 103 PF00397 0.606
LIG_14-3-3_CanoR_1 11 16 PF00244 0.589
LIG_14-3-3_CanoR_1 110 114 PF00244 0.474
LIG_14-3-3_CanoR_1 275 282 PF00244 0.533
LIG_14-3-3_CanoR_1 369 373 PF00244 0.521
LIG_14-3-3_CanoR_1 4 8 PF00244 0.569
LIG_Actin_WH2_2 72 88 PF00022 0.503
LIG_BRCT_BRCA1_1 28 32 PF00533 0.393
LIG_FHA_1 103 109 PF00498 0.635
LIG_FHA_1 110 116 PF00498 0.425
LIG_FHA_1 17 23 PF00498 0.398
LIG_FHA_1 217 223 PF00498 0.581
LIG_FHA_1 295 301 PF00498 0.496
LIG_FHA_1 355 361 PF00498 0.465
LIG_FHA_1 80 86 PF00498 0.403
LIG_FHA_2 175 181 PF00498 0.704
LIG_FHA_2 231 237 PF00498 0.439
LIG_FHA_2 442 448 PF00498 0.597
LIG_LIR_Gen_1 112 120 PF02991 0.385
LIG_LIR_Gen_1 29 39 PF02991 0.421
LIG_LIR_Gen_1 350 360 PF02991 0.513
LIG_LIR_Gen_1 430 439 PF02991 0.546
LIG_LIR_Gen_1 59 66 PF02991 0.497
LIG_LIR_Nem_3 112 116 PF02991 0.382
LIG_LIR_Nem_3 29 35 PF02991 0.420
LIG_LIR_Nem_3 350 355 PF02991 0.530
LIG_LIR_Nem_3 430 434 PF02991 0.571
LIG_LIR_Nem_3 59 64 PF02991 0.497
LIG_SH2_PTP2 113 116 PF00017 0.422
LIG_SH2_SRC 148 151 PF00017 0.388
LIG_SH2_SRC 387 390 PF00017 0.500
LIG_SH2_STAP1 356 360 PF00017 0.496
LIG_SH2_STAP1 421 425 PF00017 0.604
LIG_SH2_STAT5 113 116 PF00017 0.542
LIG_SH2_STAT5 148 151 PF00017 0.388
LIG_SH2_STAT5 356 359 PF00017 0.460
LIG_SH2_STAT5 387 390 PF00017 0.500
LIG_SH3_3 10 16 PF00018 0.494
LIG_SH3_3 257 263 PF00018 0.636
LIG_SH3_3 411 417 PF00018 0.613
LIG_SUMO_SIM_anti_2 112 119 PF11976 0.427
LIG_SUMO_SIM_anti_2 211 216 PF11976 0.362
LIG_SUMO_SIM_par_1 112 119 PF11976 0.383
LIG_SUMO_SIM_par_1 280 285 PF11976 0.446
LIG_UBA3_1 299 306 PF00899 0.475
LIG_WRC_WIRS_1 363 368 PF05994 0.568
LIG_WW_3 64 68 PF00397 0.433
MOD_CK1_1 169 175 PF00069 0.659
MOD_CK1_1 358 364 PF00069 0.473
MOD_CK1_1 403 409 PF00069 0.564
MOD_CK2_1 230 236 PF00069 0.456
MOD_CK2_1 255 261 PF00069 0.495
MOD_CK2_1 362 368 PF00069 0.492
MOD_CK2_1 441 447 PF00069 0.591
MOD_GlcNHglycan 105 108 PF01048 0.602
MOD_GlcNHglycan 127 130 PF01048 0.547
MOD_GlcNHglycan 139 142 PF01048 0.377
MOD_GlcNHglycan 169 172 PF01048 0.758
MOD_GlcNHglycan 173 176 PF01048 0.699
MOD_GlcNHglycan 222 225 PF01048 0.638
MOD_GlcNHglycan 241 244 PF01048 0.340
MOD_GlcNHglycan 247 250 PF01048 0.432
MOD_GlcNHglycan 270 273 PF01048 0.611
MOD_GlcNHglycan 313 316 PF01048 0.687
MOD_GlcNHglycan 327 330 PF01048 0.598
MOD_GlcNHglycan 393 396 PF01048 0.732
MOD_GlcNHglycan 403 406 PF01048 0.595
MOD_GlcNHglycan 435 438 PF01048 0.540
MOD_GlcNHglycan 5 8 PF01048 0.587
MOD_GlcNHglycan 88 91 PF01048 0.492
MOD_GSK3_1 167 174 PF00069 0.762
MOD_GSK3_1 188 195 PF00069 0.591
MOD_GSK3_1 216 223 PF00069 0.600
MOD_GSK3_1 319 326 PF00069 0.612
MOD_GSK3_1 354 361 PF00069 0.500
MOD_GSK3_1 364 371 PF00069 0.521
MOD_GSK3_1 373 380 PF00069 0.461
MOD_GSK3_1 387 394 PF00069 0.496
MOD_GSK3_1 399 406 PF00069 0.585
MOD_GSK3_1 47 54 PF00069 0.666
MOD_GSK3_1 98 105 PF00069 0.654
MOD_N-GLC_1 181 186 PF02516 0.640
MOD_N-GLC_1 216 221 PF02516 0.510
MOD_N-GLC_1 225 230 PF02516 0.548
MOD_N-GLC_2 268 270 PF02516 0.583
MOD_NEK2_1 225 230 PF00069 0.548
MOD_NEK2_1 286 291 PF00069 0.412
MOD_NEK2_1 3 8 PF00069 0.597
MOD_NEK2_1 355 360 PF00069 0.463
MOD_NEK2_2 16 21 PF00069 0.401
MOD_NEK2_2 319 324 PF00069 0.613
MOD_NEK2_2 56 61 PF00069 0.532
MOD_PIKK_1 294 300 PF00454 0.416
MOD_PIKK_1 340 346 PF00454 0.576
MOD_PIKK_1 65 71 PF00454 0.424
MOD_PIKK_1 77 83 PF00454 0.483
MOD_PKA_1 340 346 PF00069 0.580
MOD_PKA_2 109 115 PF00069 0.477
MOD_PKA_2 274 280 PF00069 0.556
MOD_PKA_2 3 9 PF00069 0.557
MOD_PKA_2 340 346 PF00069 0.580
MOD_PKA_2 368 374 PF00069 0.485
MOD_Plk_1 26 32 PF00069 0.388
MOD_Plk_1 361 367 PF00069 0.466
MOD_Plk_2-3 362 368 PF00069 0.492
MOD_Plk_4 109 115 PF00069 0.453
MOD_Plk_4 208 214 PF00069 0.404
MOD_Plk_4 319 325 PF00069 0.637
MOD_Plk_4 355 361 PF00069 0.465
MOD_Plk_4 56 62 PF00069 0.537
MOD_Plk_4 79 85 PF00069 0.397
MOD_ProDKin_1 98 104 PF00069 0.600
MOD_SUMO_rev_2 362 372 PF00179 0.493
TRG_ENDOCYTIC_2 113 116 PF00928 0.370
TRG_ENDOCYTIC_2 356 359 PF00928 0.499
TRG_ER_diArg_1 199 201 PF00400 0.683
TRG_ER_diArg_1 339 341 PF00400 0.625
TRG_Pf-PMV_PEXEL_1 252 256 PF00026 0.461

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1ILY1 Leptomonas seymouri 48% 100%
A0A3S7WWI8 Leishmania donovani 100% 100%
A4HK96 Leishmania braziliensis 69% 99%
E9AV74 Leishmania mexicana (strain MHOM/GT/2001/U1103) 84% 98%
Q4QCA7 Leishmania major 91% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS