Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

E9AGV7_LEIIN

TriTrypDb:

LINF_210016400

Length:

425

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AGV7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AGV7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	83	87	PF00656	0.485
CLV_NRD_NRD_1	13	15	PF00675	0.588
CLV_NRD_NRD_1	332	334	PF00675	0.448
CLV_NRD_NRD_1	399	401	PF00675	0.615
CLV_NRD_NRD_1	54	56	PF00675	0.718
CLV_PCSK_KEX2_1	13	15	PF00082	0.594
CLV_PCSK_KEX2_1	216	218	PF00082	0.680
CLV_PCSK_KEX2_1	331	333	PF00082	0.471
CLV_PCSK_KEX2_1	399	401	PF00082	0.615
CLV_PCSK_KEX2_1	54	56	PF00082	0.718
CLV_PCSK_PC1ET2_1	216	218	PF00082	0.680
CLV_PCSK_PC7_1	212	218	PF00082	0.651
CLV_PCSK_SKI1_1	108	112	PF00082	0.460
CLV_PCSK_SKI1_1	262	266	PF00082	0.605
CLV_PCSK_SKI1_1	326	330	PF00082	0.442
CLV_PCSK_SKI1_1	400	404	PF00082	0.601
DEG_APCC_DBOX_1	103	111	PF00400	0.616
DEG_APCC_DBOX_1	242	250	PF00400	0.612
DEG_Nend_Nbox_1	1	3	PF02207	0.621
DEG_SPOP_SBC_1	61	65	PF00917	0.623
DOC_CDC14_PxL_1	350	358	PF14671	0.585
DOC_CYCLIN_RxL_1	163	171	PF00134	0.567
DOC_MAPK_gen_1	358	367	PF00069	0.406
DOC_MAPK_MEF2A_6	360	369	PF00069	0.457
DOC_PP1_RVXF_1	164	171	PF00149	0.500
DOC_PP2B_LxvP_1	115	118	PF13499	0.482
DOC_PP2B_LxvP_1	289	292	PF13499	0.633
DOC_USP7_MATH_1	141	145	PF00917	0.727
DOC_USP7_MATH_1	149	153	PF00917	0.572
DOC_USP7_MATH_1	188	192	PF00917	0.619
DOC_USP7_MATH_1	200	204	PF00917	0.557
DOC_USP7_MATH_1	24	28	PF00917	0.573
DOC_USP7_MATH_1	257	261	PF00917	0.581
DOC_USP7_MATH_1	292	296	PF00917	0.631
DOC_USP7_MATH_1	349	353	PF00917	0.753
DOC_USP7_MATH_1	61	65	PF00917	0.645
DOC_USP7_MATH_1	69	73	PF00917	0.542
DOC_USP7_MATH_1	84	88	PF00917	0.423
DOC_WW_Pin1_4	158	163	PF00397	0.475
DOC_WW_Pin1_4	186	191	PF00397	0.611
DOC_WW_Pin1_4	20	25	PF00397	0.557
DOC_WW_Pin1_4	247	252	PF00397	0.571
DOC_WW_Pin1_4	274	279	PF00397	0.618
DOC_WW_Pin1_4	290	295	PF00397	0.561
LIG_14-3-3_CanoR_1	14	24	PF00244	0.579
LIG_14-3-3_CanoR_1	201	208	PF00244	0.577
LIG_14-3-3_CanoR_1	262	272	PF00244	0.667
LIG_14-3-3_CanoR_1	399	408	PF00244	0.577
LIG_BRCT_BRCA1_1	272	276	PF00533	0.628
LIG_FHA_1	119	125	PF00498	0.596
LIG_FHA_1	149	155	PF00498	0.561
LIG_FHA_1	248	254	PF00498	0.436
LIG_FHA_1	75	81	PF00498	0.466
LIG_FHA_2	137	143	PF00498	0.717
LIG_FHA_2	229	235	PF00498	0.618
LIG_FHA_2	278	284	PF00498	0.587
LIG_FHA_2	302	308	PF00498	0.563
LIG_LIR_Gen_1	206	215	PF02991	0.652
LIG_LIR_Gen_1	317	325	PF02991	0.517
LIG_LIR_Gen_1	374	384	PF02991	0.542
LIG_LIR_Gen_1	421	425	PF02991	0.485
LIG_LIR_Nem_3	181	185	PF02991	0.570
LIG_LIR_Nem_3	206	211	PF02991	0.681
LIG_LIR_Nem_3	260	264	PF02991	0.586
LIG_LIR_Nem_3	3	7	PF02991	0.514
LIG_LIR_Nem_3	317	321	PF02991	0.520
LIG_LIR_Nem_3	374	380	PF02991	0.440
LIG_LIR_Nem_3	421	425	PF02991	0.485
LIG_MYND_1	294	298	PF01753	0.647
LIG_NRBOX	106	112	PF00104	0.456
LIG_PCNA_PIPBox_1	100	109	PF02747	0.525
LIG_PCNA_yPIPBox_3	322	333	PF02747	0.437
LIG_Pex3_1	116	127	PF04882	0.482
LIG_SH2_PTP2	318	321	PF00017	0.485
LIG_SH2_SRC	208	211	PF00017	0.655
LIG_SH2_SRC	314	317	PF00017	0.530
LIG_SH2_STAP1	338	342	PF00017	0.594
LIG_SH2_STAP1	377	381	PF00017	0.453
LIG_SH2_STAT5	167	170	PF00017	0.570
LIG_SH2_STAT5	314	317	PF00017	0.463
LIG_SH2_STAT5	318	321	PF00017	0.419
LIG_SH2_STAT5	338	341	PF00017	0.567
LIG_SH2_STAT5	94	97	PF00017	0.498
LIG_SH3_3	291	297	PF00018	0.621
LIG_SH3_3	351	357	PF00018	0.582
LIG_SH3_3	364	370	PF00018	0.454
LIG_SH3_3	87	93	PF00018	0.561
LIG_SH3_5	334	338	PF00018	0.560
MOD_CDK_SPxxK_3	274	281	PF00069	0.631
MOD_CK1_1	133	139	PF00069	0.675
MOD_CK1_1	189	195	PF00069	0.659
MOD_CK1_1	277	283	PF00069	0.717
MOD_CK1_1	290	296	PF00069	0.541
MOD_CK1_1	63	69	PF00069	0.643
MOD_CK1_1	71	77	PF00069	0.514
MOD_CK2_1	200	206	PF00069	0.580
MOD_CK2_1	277	283	PF00069	0.588
MOD_CK2_1	301	307	PF00069	0.502
MOD_GlcNHglycan	142	146	PF01048	0.741
MOD_GlcNHglycan	151	154	PF01048	0.562
MOD_GlcNHglycan	162	165	PF01048	0.396
MOD_GlcNHglycan	196	199	PF01048	0.687
MOD_GlcNHglycan	26	29	PF01048	0.756
MOD_GlcNHglycan	272	275	PF01048	0.654
MOD_GlcNHglycan	289	292	PF01048	0.644
MOD_GlcNHglycan	351	354	PF01048	0.651
MOD_GlcNHglycan	387	390	PF01048	0.512
MOD_GlcNHglycan	7	10	PF01048	0.545
MOD_GlcNHglycan	86	89	PF01048	0.559
MOD_GSK3_1	130	137	PF00069	0.642
MOD_GSK3_1	154	161	PF00069	0.654
MOD_GSK3_1	20	27	PF00069	0.609
MOD_GSK3_1	270	277	PF00069	0.713
MOD_GSK3_1	292	299	PF00069	0.644
MOD_GSK3_1	310	317	PF00069	0.482
MOD_GSK3_1	332	339	PF00069	0.675
MOD_GSK3_1	35	42	PF00069	0.700
MOD_GSK3_1	371	378	PF00069	0.475
MOD_GSK3_1	59	66	PF00069	0.648
MOD_GSK3_1	84	91	PF00069	0.689
MOD_NEK2_1	120	125	PF00069	0.708
MOD_NEK2_1	168	173	PF00069	0.592
MOD_NEK2_1	39	44	PF00069	0.634
MOD_NEK2_1	412	417	PF00069	0.538
MOD_NEK2_1	60	65	PF00069	0.653
MOD_NEK2_2	257	262	PF00069	0.585
MOD_PIKK_1	156	162	PF00454	0.586
MOD_PKA_1	332	338	PF00069	0.480
MOD_PKA_2	15	21	PF00069	0.536
MOD_PKA_2	200	206	PF00069	0.580
MOD_PKA_2	332	338	PF00069	0.480
MOD_PKA_2	385	391	PF00069	0.429
MOD_PKA_2	5	11	PF00069	0.564
MOD_Plk_1	35	41	PF00069	0.469
MOD_Plk_4	228	234	PF00069	0.654
MOD_Plk_4	301	307	PF00069	0.508
MOD_Plk_4	310	316	PF00069	0.500
MOD_ProDKin_1	158	164	PF00069	0.470
MOD_ProDKin_1	186	192	PF00069	0.611
MOD_ProDKin_1	20	26	PF00069	0.556
MOD_ProDKin_1	247	253	PF00069	0.572
MOD_ProDKin_1	274	280	PF00069	0.617
MOD_ProDKin_1	290	296	PF00069	0.559
MOD_SUMO_rev_2	210	218	PF00179	0.652
TRG_DiLeu_BaLyEn_6	111	116	PF01217	0.541
TRG_DiLeu_LyEn_5	248	253	PF01217	0.600
TRG_ENDOCYTIC_2	167	170	PF00928	0.570
TRG_ENDOCYTIC_2	208	211	PF00928	0.684
TRG_ENDOCYTIC_2	318	321	PF00928	0.485
TRG_ENDOCYTIC_2	377	380	PF00928	0.429
TRG_ENDOCYTIC_2	422	425	PF00928	0.485
TRG_ER_diArg_1	13	16	PF00400	0.603
TRG_ER_diArg_1	330	333	PF00400	0.481
TRG_ER_diArg_1	357	360	PF00400	0.470
TRG_Pf-PMV_PEXEL_1	108	113	PF00026	0.467

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDR9	Leptomonas seymouri	35%	96%
A0A3Q8IAW3	Leishmania donovani	99%	100%
E9AV73	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	97%
Q4QCA8	Leishmania major	88%	100%