Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Adenylate cyclase associated (CAP) C terminal - putative

Species:

Leishmania infantum

UniProt:

E9AGV5_LEIIN

TriTrypDb:

LINF_210016200

Length:

713

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AGV5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AGV5

Function

Biological processes
Term	Name	Level	Count
GO:0007015	actin filament organization	5	5
GO:0009987	cellular process	1	5
GO:0016043	cellular component organization	3	5
GO:0071840	cellular component organization or biogenesis	2	5
GO:0097435	supramolecular fiber organization	4	5
GO:0007165	signal transduction	2	1
GO:0019932	second-messenger-mediated signaling	4	1
GO:0019933	cAMP-mediated signaling	6	1
GO:0019935	cyclic-nucleotide-mediated signaling	5	1
GO:0031279	regulation of cyclase activity	4	1
GO:0035556	intracellular signal transduction	3	1
GO:0045761	regulation of adenylate cyclase activity	5	1
GO:0050789	regulation of biological process	2	1
GO:0050790	regulation of catalytic activity	3	1
GO:0050794	regulation of cellular process	3	1
GO:0051339	regulation of lyase activity	4	1
GO:0065007	biological regulation	1	1
GO:0065009	regulation of molecular function	2	1

Molecular functions
Term	Name	Level	Count
GO:0003779	actin binding	4	5
GO:0005488	binding	1	5
GO:0005515	protein binding	2	5
GO:0008092	cytoskeletal protein binding	3	5
GO:0008179	adenylate cyclase binding	4	1
GO:0019899	enzyme binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	577	581	PF00656	0.329
CLV_NRD_NRD_1	112	114	PF00675	0.358
CLV_NRD_NRD_1	247	249	PF00675	0.462
CLV_NRD_NRD_1	254	256	PF00675	0.491
CLV_NRD_NRD_1	340	342	PF00675	0.474
CLV_NRD_NRD_1	471	473	PF00675	0.682
CLV_PCSK_FUR_1	252	256	PF00082	0.497
CLV_PCSK_KEX2_1	112	114	PF00082	0.358
CLV_PCSK_KEX2_1	247	249	PF00082	0.462
CLV_PCSK_KEX2_1	254	256	PF00082	0.491
CLV_PCSK_KEX2_1	339	341	PF00082	0.479
CLV_PCSK_KEX2_1	471	473	PF00082	0.682
CLV_PCSK_SKI1_1	26	30	PF00082	0.414
CLV_PCSK_SKI1_1	287	291	PF00082	0.323
CLV_PCSK_SKI1_1	383	387	PF00082	0.344
CLV_PCSK_SKI1_1	419	423	PF00082	0.377
CLV_PCSK_SKI1_1	424	428	PF00082	0.430
CLV_PCSK_SKI1_1	56	60	PF00082	0.432
CLV_PCSK_SKI1_1	707	711	PF00082	0.462
CLV_Separin_Metazoa	49	53	PF03568	0.332
DEG_APCC_DBOX_1	312	320	PF00400	0.604
DEG_APCC_DBOX_1	418	426	PF00400	0.323
DEG_SCF_FBW7_1	536	541	PF00400	0.527
DEG_SPOP_SBC_1	129	133	PF00917	0.445
DEG_SPOP_SBC_1	487	491	PF00917	0.605
DOC_CKS1_1	4	9	PF01111	0.542
DOC_CYCLIN_yCln2_LP_2	35	41	PF00134	0.355
DOC_MAPK_gen_1	461	469	PF00069	0.609
DOC_MAPK_MEF2A_6	566	574	PF00069	0.329
DOC_MAPK_MEF2A_6	646	654	PF00069	0.285
DOC_PP1_RVXF_1	154	161	PF00149	0.459
DOC_PP2B_LxvP_1	35	38	PF13499	0.433
DOC_PP2B_LxvP_1	688	691	PF13499	0.281
DOC_PP4_FxxP_1	523	526	PF00568	0.552
DOC_PP4_MxPP_1	514	517	PF00568	0.585
DOC_USP7_MATH_1	123	127	PF00917	0.476
DOC_USP7_MATH_1	129	133	PF00917	0.333
DOC_USP7_MATH_1	200	204	PF00917	0.507
DOC_USP7_MATH_1	374	378	PF00917	0.337
DOC_USP7_MATH_1	531	535	PF00917	0.697
DOC_USP7_MATH_1	645	649	PF00917	0.342
DOC_WW_Pin1_4	196	201	PF00397	0.559
DOC_WW_Pin1_4	3	8	PF00397	0.565
DOC_WW_Pin1_4	534	539	PF00397	0.591
DOC_WW_Pin1_4	557	562	PF00397	0.259
DOC_WW_Pin1_4	657	662	PF00397	0.376
LIG_14-3-3_CanoR_1	122	128	PF00244	0.496
LIG_14-3-3_CanoR_1	190	200	PF00244	0.569
LIG_14-3-3_CanoR_1	304	310	PF00244	0.399
LIG_14-3-3_CanoR_1	449	454	PF00244	0.525
LIG_14-3-3_CanoR_1	471	481	PF00244	0.714
LIG_14-3-3_CanoR_1	56	61	PF00244	0.433
LIG_Actin_WH2_2	14	32	PF00022	0.401
LIG_Actin_WH2_2	203	221	PF00022	0.415
LIG_Actin_WH2_2	278	293	PF00022	0.394
LIG_BIR_III_4	163	167	PF00653	0.355
LIG_BRCT_BRCA1_1	156	160	PF00533	0.468
LIG_FHA_1	295	301	PF00498	0.348
LIG_FHA_1	411	417	PF00498	0.421
LIG_FHA_1	53	59	PF00498	0.520
LIG_FHA_1	546	552	PF00498	0.293
LIG_FHA_1	594	600	PF00498	0.454
LIG_FHA_1	649	655	PF00498	0.296
LIG_FHA_1	658	664	PF00498	0.345
LIG_FHA_1	671	677	PF00498	0.447
LIG_FHA_1	704	710	PF00498	0.281
LIG_FHA_1	88	94	PF00498	0.534
LIG_FHA_2	331	337	PF00498	0.365
LIG_FHA_2	361	367	PF00498	0.400
LIG_FHA_2	473	479	PF00498	0.620
LIG_FHA_2	57	63	PF00498	0.445
LIG_FHA_2	695	701	PF00498	0.281
LIG_FHA_2	73	79	PF00498	0.604
LIG_LIR_Apic_2	521	526	PF02991	0.601
LIG_LIR_Gen_1	264	274	PF02991	0.371
LIG_LIR_Gen_1	411	422	PF02991	0.346
LIG_LIR_Gen_1	593	601	PF02991	0.329
LIG_LIR_LC3C_4	568	573	PF02991	0.329
LIG_LIR_Nem_3	22	28	PF02991	0.372
LIG_LIR_Nem_3	264	270	PF02991	0.376
LIG_LIR_Nem_3	539	545	PF02991	0.473
LIG_LIR_Nem_3	589	594	PF02991	0.329
LIG_PCNA_yPIPBox_3	44	56	PF02747	0.364
LIG_REV1ctd_RIR_1	118	128	PF16727	0.430
LIG_SH2_CRK	431	435	PF00017	0.367
LIG_SH2_CRK	554	558	PF00017	0.281
LIG_SH2_PTP2	594	597	PF00017	0.281
LIG_SH2_STAP1	89	93	PF00017	0.439
LIG_SH2_STAT5	167	170	PF00017	0.581
LIG_SH2_STAT5	381	384	PF00017	0.359
LIG_SH2_STAT5	39	42	PF00017	0.378
LIG_SH2_STAT5	450	453	PF00017	0.762
LIG_SH2_STAT5	594	597	PF00017	0.281
LIG_SH2_STAT5	694	697	PF00017	0.329
LIG_SH2_STAT5	89	92	PF00017	0.436
LIG_SH3_1	234	240	PF00018	0.424
LIG_SH3_3	234	240	PF00018	0.536
LIG_SH3_3	451	457	PF00018	0.572
LIG_SH3_3	477	483	PF00018	0.603
LIG_SH3_3	495	501	PF00018	0.650
LIG_SH3_3	5	11	PF00018	0.737
LIG_SH3_3	569	575	PF00018	0.281
LIG_SH3_3	592	598	PF00018	0.296
LIG_SH3_3	673	679	PF00018	0.231
LIG_SUMO_SIM_anti_2	568	574	PF11976	0.396
LIG_SUMO_SIM_par_1	570	577	PF11976	0.329
LIG_TRAF2_1	46	49	PF00917	0.340
LIG_TRAF2_1	565	568	PF00917	0.282
LIG_WRC_WIRS_1	88	93	PF05994	0.386
LIG_WW_3	7	11	PF00397	0.721
MOD_CDK_SPxxK_3	3	10	PF00069	0.542
MOD_CK1_1	130	136	PF00069	0.420
MOD_CK1_1	176	182	PF00069	0.357
MOD_CK1_1	194	200	PF00069	0.522
MOD_CK1_1	226	232	PF00069	0.386
MOD_CK1_1	377	383	PF00069	0.347
MOD_CK1_1	442	448	PF00069	0.541
MOD_CK1_1	490	496	PF00069	0.688
MOD_CK1_1	518	524	PF00069	0.659
MOD_CK1_1	534	540	PF00069	0.588
MOD_CK1_1	560	566	PF00069	0.242
MOD_CK1_1	648	654	PF00069	0.361
MOD_CK2_1	131	137	PF00069	0.410
MOD_CK2_1	181	187	PF00069	0.464
MOD_CK2_1	360	366	PF00069	0.351
MOD_CK2_1	472	478	PF00069	0.621
MOD_CK2_1	56	62	PF00069	0.434
MOD_CK2_1	623	629	PF00069	0.281
MOD_CK2_1	694	700	PF00069	0.329
MOD_GlcNHglycan	175	178	PF01048	0.397
MOD_GlcNHglycan	183	186	PF01048	0.449
MOD_GlcNHglycan	376	379	PF01048	0.396
MOD_GlcNHglycan	562	565	PF01048	0.294
MOD_GlcNHglycan	636	640	PF01048	0.327
MOD_GlcNHglycan	647	650	PF01048	0.352
MOD_GlcNHglycan	72	75	PF01048	0.611
MOD_GSK3_1	123	130	PF00069	0.483
MOD_GSK3_1	154	161	PF00069	0.410
MOD_GSK3_1	173	180	PF00069	0.423
MOD_GSK3_1	189	196	PF00069	0.483
MOD_GSK3_1	226	233	PF00069	0.388
MOD_GSK3_1	356	363	PF00069	0.369
MOD_GSK3_1	373	380	PF00069	0.351
MOD_GSK3_1	482	489	PF00069	0.686
MOD_GSK3_1	52	59	PF00069	0.557
MOD_GSK3_1	534	541	PF00069	0.557
MOD_GSK3_1	543	550	PF00069	0.572
MOD_GSK3_1	657	664	PF00069	0.317
MOD_GSK3_1	703	710	PF00069	0.323
MOD_LATS_1	54	60	PF00433	0.425
MOD_N-GLC_1	323	328	PF02516	0.401
MOD_N-GLC_1	670	675	PF02516	0.265
MOD_N-GLC_2	398	400	PF02516	0.472
MOD_NEK2_1	127	132	PF00069	0.478
MOD_NEK2_1	146	151	PF00069	0.378
MOD_NEK2_1	154	159	PF00069	0.436
MOD_NEK2_1	193	198	PF00069	0.560
MOD_NEK2_1	323	328	PF00069	0.401
MOD_NEK2_1	616	621	PF00069	0.334
MOD_NEK2_1	634	639	PF00069	0.329
MOD_NEK2_2	672	677	PF00069	0.259
MOD_NEK2_2	694	699	PF00069	0.329
MOD_NEK2_2	87	92	PF00069	0.451
MOD_PIKK_1	294	300	PF00454	0.386
MOD_PIKK_1	470	476	PF00454	0.594
MOD_PIKK_1	502	508	PF00454	0.605
MOD_PIKK_1	543	549	PF00454	0.441
MOD_PK_1	455	461	PF00069	0.581
MOD_PKA_1	383	389	PF00069	0.340
MOD_PKA_2	189	195	PF00069	0.652
MOD_PKA_2	303	309	PF00069	0.397
MOD_PKA_2	470	476	PF00069	0.571
MOD_PKA_2	623	629	PF00069	0.319
MOD_PKB_1	255	263	PF00069	0.473
MOD_PKB_1	309	317	PF00069	0.375
MOD_Plk_1	11	17	PF00069	0.524
MOD_Plk_1	323	329	PF00069	0.411
MOD_Plk_1	52	58	PF00069	0.359
MOD_Plk_1	538	544	PF00069	0.482
MOD_Plk_1	670	676	PF00069	0.265
MOD_Plk_1	707	713	PF00069	0.479
MOD_Plk_4	102	108	PF00069	0.451
MOD_Plk_4	266	272	PF00069	0.482
MOD_Plk_4	377	383	PF00069	0.347
MOD_Plk_4	56	62	PF00069	0.511
MOD_Plk_4	590	596	PF00069	0.446
MOD_ProDKin_1	196	202	PF00069	0.556
MOD_ProDKin_1	3	9	PF00069	0.560
MOD_ProDKin_1	534	540	PF00069	0.575
MOD_ProDKin_1	557	563	PF00069	0.259
MOD_ProDKin_1	657	663	PF00069	0.376
MOD_SUMO_for_1	565	568	PF00179	0.329
TRG_DiLeu_BaEn_1	423	428	PF01217	0.382
TRG_DiLeu_BaEn_1	53	58	PF01217	0.415
TRG_DiLeu_BaEn_1	700	705	PF01217	0.329
TRG_DiLeu_LyEn_5	53	58	PF01217	0.415
TRG_ENDOCYTIC_2	594	597	PF00928	0.281
TRG_ER_diArg_1	112	115	PF00400	0.361
TRG_ER_diArg_1	252	255	PF00400	0.498
TRG_ER_diArg_1	338	341	PF00400	0.612
TRG_ER_diArg_1	470	472	PF00400	0.688
TRG_NES_CRM1_1	13	27	PF08389	0.448
TRG_Pf-PMV_PEXEL_1	26	31	PF00026	0.412
TRG_Pf-PMV_PEXEL_1	449	453	PF00026	0.522

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P826	Leptomonas seymouri	47%	100%
A0A3Q8IF57	Leishmania donovani	99%	100%
Q4QCB0	Leishmania major	92%	100%