DUF4220 domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

E9AGV2_LEIIN

TriTrypDb:

LINF_210015900

Length:

108

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AGV2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AGV2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	45	47	PF00675	0.551
CLV_PCSK_KEX2_1	47	49	PF00082	0.511
CLV_PCSK_PC1ET2_1	47	49	PF00082	0.511
LIG_14-3-3_CanoR_1	18	27	PF00244	0.707
LIG_BIR_II_1	1	5	PF00653	0.755
LIG_BIR_III_4	71	75	PF00653	0.676
LIG_FHA_1	20	26	PF00498	0.668
LIG_SH2_NCK_1	37	41	PF00017	0.769
MOD_CK1_1	2	8	PF00069	0.744
MOD_CK2_1	39	45	PF00069	0.694
MOD_GlcNHglycan	1	4	PF01048	0.559
MOD_GlcNHglycan	94	97	PF01048	0.761
MOD_NEK2_1	50	55	PF00069	0.546
MOD_PIKK_1	39	45	PF00454	0.614
MOD_Plk_1	50	56	PF00069	0.546
MOD_Plk_4	50	56	PF00069	0.546
MOD_Plk_4	61	67	PF00069	0.411

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IA12	Leptomonas seymouri	61%	100%
A0A3S7WWH6	Leishmania donovani	100%	100%
A4HBU6	Leishmania braziliensis	84%	100%
E9AV68	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QCB3	Leishmania major	94%	100%