Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ABC transporter - putative

Species:

Leishmania infantum

UniProt:

E9AGV1_LEIIN

TriTrypDb:

LINF_210015800

Length:

951

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

E9AGV1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AGV1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0005215	transporter activity	1	5
GO:0005488	binding	1	7
GO:0005524	ATP binding	5	7
GO:0015399	primary active transmembrane transporter activity	4	5
GO:0017076	purine nucleotide binding	4	7
GO:0022804	active transmembrane transporter activity	3	5
GO:0022857	transmembrane transporter activity	2	5
GO:0030554	adenyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032559	adenyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0042626	ATPase-coupled transmembrane transporter activity	2	5
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:0140359	ABC-type transporter activity	3	5
GO:0140657	ATP-dependent activity	1	5
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	20	24	PF00656	0.711
CLV_C14_Caspase3-7	295	299	PF00656	0.584
CLV_C14_Caspase3-7	480	484	PF00656	0.676
CLV_C14_Caspase3-7	539	543	PF00656	0.699
CLV_C14_Caspase3-7	563	567	PF00656	0.646
CLV_NRD_NRD_1	252	254	PF00675	0.275
CLV_NRD_NRD_1	302	304	PF00675	0.355
CLV_NRD_NRD_1	467	469	PF00675	0.482
CLV_NRD_NRD_1	687	689	PF00675	0.256
CLV_NRD_NRD_1	74	76	PF00675	0.487
CLV_NRD_NRD_1	915	917	PF00675	0.533
CLV_NRD_NRD_1	945	947	PF00675	0.419
CLV_PCSK_FUR_1	71	75	PF00082	0.489
CLV_PCSK_FUR_1	942	946	PF00082	0.419
CLV_PCSK_KEX2_1	251	253	PF00082	0.275
CLV_PCSK_KEX2_1	302	304	PF00082	0.355
CLV_PCSK_KEX2_1	467	469	PF00082	0.482
CLV_PCSK_KEX2_1	687	689	PF00082	0.256
CLV_PCSK_KEX2_1	73	75	PF00082	0.491
CLV_PCSK_KEX2_1	915	917	PF00082	0.533
CLV_PCSK_KEX2_1	944	946	PF00082	0.429
CLV_PCSK_PC7_1	69	75	PF00082	0.488
CLV_PCSK_SKI1_1	253	257	PF00082	0.275
CLV_PCSK_SKI1_1	258	262	PF00082	0.275
CLV_PCSK_SKI1_1	396	400	PF00082	0.335
CLV_PCSK_SKI1_1	413	417	PF00082	0.325
CLV_PCSK_SKI1_1	468	472	PF00082	0.421
CLV_PCSK_SKI1_1	744	748	PF00082	0.503
CLV_PCSK_SKI1_1	885	889	PF00082	0.691
CLV_PCSK_SKI1_1	945	949	PF00082	0.418
DEG_SCF_FBW7_1	340	347	PF00400	0.652
DEG_SCF_FBW7_1	363	370	PF00400	0.652
DEG_SPOP_SBC_1	461	465	PF00917	0.646
DEG_SPOP_SBC_1	852	856	PF00917	0.406
DOC_AGCK_PIF_1	693	698	PF00069	0.452
DOC_AGCK_PIF_1	779	784	PF00069	0.291
DOC_CKS1_1	341	346	PF01111	0.670
DOC_CKS1_1	357	362	PF01111	0.660
DOC_CKS1_1	364	369	PF01111	0.632
DOC_CKS1_1	506	511	PF01111	0.613
DOC_CYCLIN_RxL_1	252	265	PF00134	0.475
DOC_MAPK_gen_1	242	250	PF00069	0.529
DOC_MAPK_gen_1	915	922	PF00069	0.326
DOC_MAPK_MEF2A_6	744	753	PF00069	0.275
DOC_MAPK_MEF2A_6	915	924	PF00069	0.268
DOC_PP1_RVXF_1	776	783	PF00149	0.529
DOC_PP2B_LxvP_1	291	294	PF13499	0.535
DOC_PP2B_PxIxI_1	532	538	PF00149	0.659
DOC_PP4_FxxP_1	375	378	PF00568	0.691
DOC_PP4_FxxP_1	606	609	PF00568	0.615
DOC_PP4_FxxP_1	736	739	PF00568	0.275
DOC_SPAK_OSR1_1	778	782	PF12202	0.475
DOC_USP7_MATH_1	170	174	PF00917	0.482
DOC_USP7_MATH_1	292	296	PF00917	0.557
DOC_USP7_MATH_1	344	348	PF00917	0.682
DOC_USP7_MATH_1	355	359	PF00917	0.717
DOC_USP7_MATH_1	439	443	PF00917	0.653
DOC_USP7_MATH_1	461	465	PF00917	0.784
DOC_USP7_MATH_1	524	528	PF00917	0.753
DOC_USP7_MATH_1	553	557	PF00917	0.723
DOC_USP7_MATH_1	754	758	PF00917	0.490
DOC_USP7_MATH_1	78	82	PF00917	0.749
DOC_USP7_MATH_1	817	821	PF00917	0.275
DOC_USP7_MATH_1	846	850	PF00917	0.474
DOC_USP7_MATH_1	853	857	PF00917	0.428
DOC_USP7_MATH_1	877	881	PF00917	0.448
DOC_WW_Pin1_4	340	345	PF00397	0.735
DOC_WW_Pin1_4	353	358	PF00397	0.707
DOC_WW_Pin1_4	363	368	PF00397	0.699
DOC_WW_Pin1_4	462	467	PF00397	0.685
DOC_WW_Pin1_4	505	510	PF00397	0.597
DOC_WW_Pin1_4	555	560	PF00397	0.653
DOC_WW_Pin1_4	568	573	PF00397	0.671
DOC_WW_Pin1_4	909	914	PF00397	0.437
LIG_14-3-3_CanoR_1	216	226	PF00244	0.482
LIG_14-3-3_CanoR_1	501	507	PF00244	0.561
LIG_14-3-3_CanoR_1	547	552	PF00244	0.736
LIG_14-3-3_CanoR_1	847	851	PF00244	0.511
LIG_14-3-3_CanoR_1	878	883	PF00244	0.482
LIG_14-3-3_CanoR_1	90	99	PF00244	0.613
LIG_14-3-3_CterR_2	946	951	PF00244	0.628
LIG_Actin_WH2_2	202	218	PF00022	0.475
LIG_Actin_WH2_2	933	950	PF00022	0.438
LIG_BIR_II_1	1	5	PF00653	0.692
LIG_BRCT_BRCA1_1	117	121	PF00533	0.561
LIG_BRCT_BRCA1_1	553	557	PF00533	0.669
LIG_BRCT_BRCA1_1	879	883	PF00533	0.385
LIG_CSL_BTD_1	769	772	PF09270	0.475
LIG_deltaCOP1_diTrp_1	738	747	PF00928	0.275
LIG_FHA_1	125	131	PF00498	0.505
LIG_FHA_1	449	455	PF00498	0.714
LIG_FHA_1	7	13	PF00498	0.723
LIG_FHA_1	704	710	PF00498	0.492
LIG_FHA_1	712	718	PF00498	0.379
LIG_FHA_1	784	790	PF00498	0.388
LIG_FHA_1	80	86	PF00498	0.704
LIG_FHA_1	822	828	PF00498	0.312
LIG_FHA_1	92	98	PF00498	0.614
LIG_FHA_2	202	208	PF00498	0.494
LIG_FHA_2	357	363	PF00498	0.661
LIG_FHA_2	372	378	PF00498	0.684
LIG_FHA_2	40	46	PF00498	0.724
LIG_FHA_2	561	567	PF00498	0.662
LIG_FHA_2	798	804	PF00498	0.454
LIG_FHA_2	899	905	PF00498	0.363
LIG_LIR_Apic_2	374	378	PF02991	0.686
LIG_LIR_Apic_2	604	609	PF02991	0.618
LIG_LIR_Apic_2	734	739	PF02991	0.275
LIG_LIR_Gen_1	137	146	PF02991	0.529
LIG_LIR_Gen_1	281	292	PF02991	0.583
LIG_LIR_Gen_1	477	486	PF02991	0.623
LIG_LIR_Gen_1	634	644	PF02991	0.340
LIG_LIR_Gen_1	689	698	PF02991	0.475
LIG_LIR_Gen_1	706	715	PF02991	0.475
LIG_LIR_Gen_1	724	733	PF02991	0.496
LIG_LIR_Gen_1	809	818	PF02991	0.303
LIG_LIR_Gen_1	903	913	PF02991	0.394
LIG_LIR_Gen_1	914	924	PF02991	0.329
LIG_LIR_Gen_1	93	104	PF02991	0.559
LIG_LIR_Gen_1	934	943	PF02991	0.183
LIG_LIR_Nem_3	137	142	PF02991	0.559
LIG_LIR_Nem_3	2	7	PF02991	0.704
LIG_LIR_Nem_3	281	287	PF02991	0.582
LIG_LIR_Nem_3	477	482	PF02991	0.636
LIG_LIR_Nem_3	528	534	PF02991	0.739
LIG_LIR_Nem_3	554	560	PF02991	0.663
LIG_LIR_Nem_3	634	639	PF02991	0.340
LIG_LIR_Nem_3	689	693	PF02991	0.501
LIG_LIR_Nem_3	697	701	PF02991	0.507
LIG_LIR_Nem_3	706	710	PF02991	0.517
LIG_LIR_Nem_3	724	728	PF02991	0.496
LIG_LIR_Nem_3	738	743	PF02991	0.277
LIG_LIR_Nem_3	783	787	PF02991	0.291
LIG_LIR_Nem_3	809	813	PF02991	0.303
LIG_LIR_Nem_3	844	848	PF02991	0.472
LIG_LIR_Nem_3	903	908	PF02991	0.346
LIG_LIR_Nem_3	914	920	PF02991	0.353
LIG_LIR_Nem_3	93	99	PF02991	0.580
LIG_NRBOX	229	235	PF00104	0.475
LIG_PCNA_yPIPBox_3	467	476	PF02747	0.612
LIG_Pex14_2	620	624	PF04695	0.522
LIG_Pex14_2	736	740	PF04695	0.275
LIG_Pex14_2	758	762	PF04695	0.381
LIG_Pex14_2	766	770	PF04695	0.237
LIG_PTB_Apo_2	894	901	PF02174	0.349
LIG_PTB_Phospho_1	894	900	PF10480	0.358
LIG_SH2_CRK	4	8	PF00017	0.644
LIG_SH2_CRK	743	747	PF00017	0.275
LIG_SH2_GRB2like	895	898	PF00017	0.368
LIG_SH2_NCK_1	479	483	PF00017	0.624
LIG_SH2_STAP1	211	215	PF00017	0.475
LIG_SH2_STAP1	785	789	PF00017	0.312
LIG_SH2_STAP1	818	822	PF00017	0.275
LIG_SH2_STAP1	905	909	PF00017	0.394
LIG_SH2_STAT3	168	171	PF00017	0.475
LIG_SH2_STAT3	652	655	PF00017	0.275
LIG_SH2_STAT5	249	252	PF00017	0.475
LIG_SH2_STAT5	284	287	PF00017	0.576
LIG_SH2_STAT5	342	345	PF00017	0.671
LIG_SH2_STAT5	560	563	PF00017	0.609
LIG_SH2_STAT5	707	710	PF00017	0.531
LIG_SH2_STAT5	785	788	PF00017	0.312
LIG_SH2_STAT5	895	898	PF00017	0.435
LIG_SH2_STAT5	900	903	PF00017	0.354
LIG_SH2_STAT5	96	99	PF00017	0.543
LIG_SH3_3	354	360	PF00018	0.688
LIG_SH3_3	423	429	PF00018	0.576
LIG_SH3_3	597	603	PF00018	0.636
LIG_SH3_3	847	853	PF00018	0.461
LIG_Sin3_3	138	145	PF02671	0.486
LIG_SUMO_SIM_anti_2	265	271	PF11976	0.475
LIG_SUMO_SIM_anti_2	405	410	PF11976	0.512
LIG_SUMO_SIM_anti_2	748	753	PF11976	0.388
LIG_SUMO_SIM_par_1	265	271	PF11976	0.475
LIG_SUMO_SIM_par_1	386	391	PF11976	0.515
LIG_SUMO_SIM_par_1	405	410	PF11976	0.626
LIG_SUMO_SIM_par_1	679	685	PF11976	0.312
LIG_SUMO_SIM_par_1	750	757	PF11976	0.316
LIG_SUMO_SIM_par_1	8	13	PF11976	0.779
LIG_SxIP_EBH_1	847	857	PF03271	0.449
LIG_WRC_WIRS_1	537	542	PF05994	0.569
LIG_WRC_WIRS_1	722	727	PF05994	0.388
LIG_WRC_WIRS_1	755	760	PF05994	0.388
LIG_WRC_WIRS_1	781	786	PF05994	0.291
MOD_CDC14_SPxK_1	912	915	PF00782	0.441
MOD_CDK_SPK_2	340	345	PF00069	0.586
MOD_CDK_SPK_2	462	467	PF00069	0.606
MOD_CDK_SPxK_1	462	468	PF00069	0.667
MOD_CDK_SPxK_1	909	915	PF00069	0.430
MOD_CDK_SPxxK_3	909	916	PF00069	0.426
MOD_CK1_1	13	19	PF00069	0.697
MOD_CK1_1	164	170	PF00069	0.322
MOD_CK1_1	190	196	PF00069	0.329
MOD_CK1_1	323	329	PF00069	0.525
MOD_CK1_1	356	362	PF00069	0.553
MOD_CK1_1	38	44	PF00069	0.650
MOD_CK1_1	505	511	PF00069	0.633
MOD_CK1_1	546	552	PF00069	0.776
MOD_CK1_1	558	564	PF00069	0.519
MOD_CK1_1	682	688	PF00069	0.289
MOD_CK1_1	757	763	PF00069	0.466
MOD_CK1_1	809	815	PF00069	0.312
MOD_CK2_1	170	176	PF00069	0.412
MOD_CK2_1	201	207	PF00069	0.336
MOD_CK2_1	222	228	PF00069	0.312
MOD_CK2_1	377	383	PF00069	0.568
MOD_CK2_1	39	45	PF00069	0.696
MOD_CK2_1	524	530	PF00069	0.597
MOD_CK2_1	797	803	PF00069	0.406
MOD_CK2_1	898	904	PF00069	0.487
MOD_GlcNHglycan	136	139	PF01048	0.363
MOD_GlcNHglycan	163	166	PF01048	0.312
MOD_GlcNHglycan	185	190	PF01048	0.380
MOD_GlcNHglycan	195	198	PF01048	0.460
MOD_GlcNHglycan	212	215	PF01048	0.237
MOD_GlcNHglycan	219	222	PF01048	0.317
MOD_GlcNHglycan	294	297	PF01048	0.449
MOD_GlcNHglycan	322	325	PF01048	0.521
MOD_GlcNHglycan	350	353	PF01048	0.650
MOD_GlcNHglycan	439	442	PF01048	0.609
MOD_GlcNHglycan	517	520	PF01048	0.767
MOD_GlcNHglycan	553	556	PF01048	0.669
MOD_GlcNHglycan	58	61	PF01048	0.614
MOD_GlcNHglycan	64	67	PF01048	0.601
MOD_GlcNHglycan	855	858	PF01048	0.717
MOD_GlcNHglycan	926	929	PF01048	0.343
MOD_GSK3_1	149	156	PF00069	0.340
MOD_GSK3_1	340	347	PF00069	0.734
MOD_GSK3_1	35	42	PF00069	0.737
MOD_GSK3_1	363	370	PF00069	0.726
MOD_GSK3_1	448	455	PF00069	0.585
MOD_GSK3_1	543	550	PF00069	0.748
MOD_GSK3_1	551	558	PF00069	0.672
MOD_GSK3_1	58	65	PF00069	0.607
MOD_GSK3_1	6	13	PF00069	0.663
MOD_GSK3_1	753	760	PF00069	0.399
MOD_GSK3_1	797	804	PF00069	0.340
MOD_GSK3_1	817	824	PF00069	0.312
MOD_GSK3_1	91	98	PF00069	0.588
MOD_GSK3_1	911	918	PF00069	0.486
MOD_LATS_1	346	352	PF00433	0.568
MOD_LATS_1	876	882	PF00433	0.496
MOD_N-GLC_1	244	249	PF02516	0.326
MOD_N-GLC_1	835	840	PF02516	0.562
MOD_N-GLC_1	841	846	PF02516	0.581
MOD_N-GLC_2	131	133	PF02516	0.388
MOD_N-GLC_2	412	414	PF02516	0.435
MOD_N-GLC_2	897	899	PF02516	0.488
MOD_NEK2_1	416	421	PF00069	0.423
MOD_NEK2_1	437	442	PF00069	0.656
MOD_NEK2_1	502	507	PF00069	0.499
MOD_NEK2_1	670	675	PF00069	0.388
MOD_NEK2_1	731	736	PF00069	0.321
MOD_NEK2_1	747	752	PF00069	0.427
MOD_NEK2_1	753	758	PF00069	0.411
MOD_NEK2_1	931	936	PF00069	0.472
MOD_NEK2_2	201	206	PF00069	0.291
MOD_NEK2_2	492	497	PF00069	0.390
MOD_NEK2_2	895	900	PF00069	0.418
MOD_PIKK_1	278	284	PF00454	0.479
MOD_PIKK_1	571	577	PF00454	0.425
MOD_PIKK_1	821	827	PF00454	0.388
MOD_PK_1	547	553	PF00069	0.604
MOD_PKA_1	915	921	PF00069	0.457
MOD_PKA_2	124	130	PF00069	0.354
MOD_PKA_2	190	196	PF00069	0.338
MOD_PKA_2	344	350	PF00069	0.592
MOD_PKA_2	35	41	PF00069	0.630
MOD_PKA_2	546	552	PF00069	0.700
MOD_PKA_2	846	852	PF00069	0.636
MOD_PKA_2	877	883	PF00069	0.603
MOD_PKA_2	915	921	PF00069	0.457
MOD_Plk_1	115	121	PF00069	0.396
MOD_Plk_1	201	207	PF00069	0.312
MOD_Plk_1	244	250	PF00069	0.341
MOD_Plk_1	482	488	PF00069	0.594
MOD_Plk_1	492	498	PF00069	0.417
MOD_Plk_1	747	753	PF00069	0.388
MOD_Plk_4	153	159	PF00069	0.448
MOD_Plk_4	170	176	PF00069	0.242
MOD_Plk_4	244	250	PF00069	0.341
MOD_Plk_4	262	268	PF00069	0.320
MOD_Plk_4	283	289	PF00069	0.394
MOD_Plk_4	388	394	PF00069	0.390
MOD_Plk_4	6	12	PF00069	0.648
MOD_Plk_4	609	615	PF00069	0.486
MOD_Plk_4	703	709	PF00069	0.392
MOD_Plk_4	721	727	PF00069	0.388
MOD_Plk_4	747	753	PF00069	0.388
MOD_Plk_4	809	815	PF00069	0.312
MOD_Plk_4	846	852	PF00069	0.576
MOD_Plk_4	878	884	PF00069	0.494
MOD_Plk_4	92	98	PF00069	0.485
MOD_Plk_4	931	937	PF00069	0.312
MOD_ProDKin_1	340	346	PF00069	0.676
MOD_ProDKin_1	353	359	PF00069	0.635
MOD_ProDKin_1	363	369	PF00069	0.625
MOD_ProDKin_1	462	468	PF00069	0.606
MOD_ProDKin_1	505	511	PF00069	0.494
MOD_ProDKin_1	555	561	PF00069	0.556
MOD_ProDKin_1	568	574	PF00069	0.585
MOD_ProDKin_1	909	915	PF00069	0.539
TRG_DiLeu_BaEn_2	903	909	PF01217	0.481
TRG_ENDOCYTIC_2	284	287	PF00928	0.454
TRG_ENDOCYTIC_2	4	7	PF00928	0.584
TRG_ENDOCYTIC_2	479	482	PF00928	0.536
TRG_ENDOCYTIC_2	690	693	PF00928	0.312
TRG_ENDOCYTIC_2	707	710	PF00928	0.225
TRG_ENDOCYTIC_2	743	746	PF00928	0.312
TRG_ENDOCYTIC_2	905	908	PF00928	0.419
TRG_ENDOCYTIC_2	96	99	PF00928	0.408
TRG_ER_diArg_1	250	253	PF00400	0.312
TRG_ER_diArg_1	302	304	PF00400	0.424
TRG_ER_diArg_1	466	468	PF00400	0.598
TRG_ER_diArg_1	68	71	PF00400	0.627
TRG_ER_diArg_1	686	688	PF00400	0.327
TRG_ER_diArg_1	73	75	PF00400	0.621
TRG_ER_diArg_1	915	917	PF00400	0.393
TRG_ER_diArg_1	941	944	PF00400	0.490
TRG_ER_diArg_1	945	947	PF00400	0.515
TRG_NES_CRM1_1	806	819	PF08389	0.340

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8B6	Leptomonas seymouri	55%	99%
A0A3Q8IBV9	Leishmania donovani	100%	100%
A4HBU5	Leishmania braziliensis	72%	100%
E9AV67	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	99%
Q4QCB4	Leishmania major	92%	100%