Uncharacterized protein

Quick info Localization Phosphorylation Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF4042)/HEAT-like repeat - putative

Species:

Leishmania infantum

UniProt:

E9AGV0_LEIIN

TriTrypDb:

LINF_210015700

Length:

1279

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Phosphorylation

Promastigote: 360

Expansion

Sequence features

E9AGV0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AGV0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	370	374	PF00656	0.819
CLV_C14_Caspase3-7	463	467	PF00656	0.759
CLV_C14_Caspase3-7	962	966	PF00656	0.600
CLV_NRD_NRD_1	200	202	PF00675	0.700
CLV_NRD_NRD_1	921	923	PF00675	0.524
CLV_PCSK_FUR_1	919	923	PF00082	0.520
CLV_PCSK_KEX2_1	199	201	PF00082	0.686
CLV_PCSK_KEX2_1	921	923	PF00082	0.524
CLV_PCSK_SKI1_1	1014	1018	PF00082	0.469
CLV_PCSK_SKI1_1	1097	1101	PF00082	0.457
CLV_PCSK_SKI1_1	1138	1142	PF00082	0.483
CLV_PCSK_SKI1_1	1246	1250	PF00082	0.595
CLV_PCSK_SKI1_1	1264	1268	PF00082	0.325
CLV_PCSK_SKI1_1	61	65	PF00082	0.696
CLV_PCSK_SKI1_1	928	932	PF00082	0.451
CLV_Separin_Metazoa	62	66	PF03568	0.612
CLV_Separin_Metazoa	912	916	PF03568	0.494
DEG_APCC_DBOX_1	1096	1104	PF00400	0.408
DEG_APCC_DBOX_1	1245	1253	PF00400	0.592
DEG_APCC_DBOX_1	869	877	PF00400	0.455
DEG_SCF_FBW7_1	1	7	PF00400	0.724
DOC_CKS1_1	1	6	PF01111	0.725
DOC_CKS1_1	301	306	PF01111	0.846
DOC_CKS1_1	31	36	PF01111	0.710
DOC_CYCLIN_RxL_1	1094	1101	PF00134	0.448
DOC_CYCLIN_RxL_1	263	274	PF00134	0.412
DOC_CYCLIN_RxL_1	55	67	PF00134	0.637
DOC_CYCLIN_yCln2_LP_2	646	652	PF00134	0.649
DOC_MAPK_gen_1	338	347	PF00069	0.745
DOC_MAPK_gen_1	634	643	PF00069	0.513
DOC_MAPK_MEF2A_6	1246	1253	PF00069	0.597
DOC_MAPK_MEF2A_6	268	277	PF00069	0.475
DOC_MIT_MIM_1	392	402	PF04212	0.402
DOC_PP2B_LxvP_1	116	119	PF13499	0.724
DOC_PP2B_LxvP_1	456	459	PF13499	0.690
DOC_PP2B_LxvP_1	646	649	PF13499	0.552
DOC_USP7_MATH_1	1027	1031	PF00917	0.515
DOC_USP7_MATH_1	108	112	PF00917	0.640
DOC_USP7_MATH_1	1244	1248	PF00917	0.543
DOC_USP7_MATH_1	146	150	PF00917	0.655
DOC_USP7_MATH_1	163	167	PF00917	0.720
DOC_USP7_MATH_1	211	215	PF00917	0.704
DOC_USP7_MATH_1	26	30	PF00917	0.706
DOC_USP7_MATH_1	417	421	PF00917	0.786
DOC_USP7_MATH_1	780	784	PF00917	0.691
DOC_USP7_MATH_1	802	806	PF00917	0.771
DOC_USP7_MATH_1	813	817	PF00917	0.573
DOC_USP7_MATH_1	852	856	PF00917	0.689
DOC_USP7_MATH_1	858	862	PF00917	0.611
DOC_USP7_MATH_1	947	951	PF00917	0.644
DOC_USP7_MATH_1	95	99	PF00917	0.636
DOC_USP7_MATH_1	995	999	PF00917	0.484
DOC_USP7_UBL2_3	1271	1275	PF12436	0.444
DOC_USP7_UBL2_3	16	20	PF12436	0.746
DOC_WW_Pin1_4	1034	1039	PF00397	0.500
DOC_WW_Pin1_4	111	116	PF00397	0.690
DOC_WW_Pin1_4	1209	1214	PF00397	0.467
DOC_WW_Pin1_4	1254	1259	PF00397	0.629
DOC_WW_Pin1_4	131	136	PF00397	0.761
DOC_WW_Pin1_4	144	149	PF00397	0.736
DOC_WW_Pin1_4	30	35	PF00397	0.744
DOC_WW_Pin1_4	300	305	PF00397	0.741
DOC_WW_Pin1_4	327	332	PF00397	0.683
DOC_WW_Pin1_4	4	9	PF00397	0.774
DOC_WW_Pin1_4	423	428	PF00397	0.634
DOC_WW_Pin1_4	490	495	PF00397	0.515
DOC_WW_Pin1_4	607	612	PF00397	0.683
DOC_WW_Pin1_4	627	632	PF00397	0.453
DOC_WW_Pin1_4	798	803	PF00397	0.720
DOC_WW_Pin1_4	848	853	PF00397	0.766
LIG_14-3-3_CanoR_1	375	380	PF00244	0.826
LIG_14-3-3_CanoR_1	489	495	PF00244	0.511
LIG_14-3-3_CanoR_1	552	556	PF00244	0.419
LIG_14-3-3_CanoR_1	900	904	PF00244	0.560
LIG_14-3-3_CanoR_1	928	933	PF00244	0.423
LIG_APCC_ABBAyCdc20_2	906	912	PF00400	0.514
LIG_BIR_II_1	1	5	PF00653	0.746
LIG_BIR_III_2	239	243	PF00653	0.578
LIG_BIR_III_2	965	969	PF00653	0.624
LIG_BRCT_BRCA1_1	328	332	PF00533	0.810
LIG_EVH1_2	203	207	PF00568	0.734
LIG_FHA_1	1021	1027	PF00498	0.423
LIG_FHA_1	1174	1180	PF00498	0.458
LIG_FHA_1	1210	1216	PF00498	0.414
LIG_FHA_1	149	155	PF00498	0.703
LIG_FHA_1	229	235	PF00498	0.731
LIG_FHA_1	475	481	PF00498	0.459
LIG_FHA_1	496	502	PF00498	0.494
LIG_FHA_1	52	58	PF00498	0.566
LIG_FHA_1	543	549	PF00498	0.429
LIG_FHA_1	607	613	PF00498	0.614
LIG_FHA_1	643	649	PF00498	0.647
LIG_FHA_1	665	671	PF00498	0.606
LIG_FHA_1	755	761	PF00498	0.376
LIG_FHA_1	857	863	PF00498	0.581
LIG_FHA_1	927	933	PF00498	0.456
LIG_FHA_1	975	981	PF00498	0.549
LIG_FHA_2	1074	1080	PF00498	0.570
LIG_FHA_2	1112	1118	PF00498	0.709
LIG_FHA_2	1205	1211	PF00498	0.622
LIG_FHA_2	1225	1231	PF00498	0.315
LIG_FHA_2	281	287	PF00498	0.560
LIG_FHA_2	387	393	PF00498	0.706
LIG_FHA_2	463	469	PF00498	0.681
LIG_FHA_2	706	712	PF00498	0.659
LIG_FHA_2	727	733	PF00498	0.518
LIG_FHA_2	765	771	PF00498	0.501
LIG_FHA_2	943	949	PF00498	0.639
LIG_FHA_2	984	990	PF00498	0.581
LIG_GBD_Chelix_1	1215	1223	PF00786	0.470
LIG_Integrin_RGD_1	528	530	PF01839	0.582
LIG_LIR_Apic_2	1131	1137	PF02991	0.613
LIG_LIR_Apic_2	213	218	PF02991	0.807
LIG_LIR_Gen_1	1076	1084	PF02991	0.492
LIG_LIR_Gen_1	1093	1103	PF02991	0.452
LIG_LIR_Gen_1	622	631	PF02991	0.476
LIG_LIR_Gen_1	751	760	PF02991	0.493
LIG_LIR_Gen_1	989	999	PF02991	0.469
LIG_LIR_Nem_3	1076	1080	PF02991	0.476
LIG_LIR_Nem_3	1093	1098	PF02991	0.447
LIG_LIR_Nem_3	1229	1235	PF02991	0.572
LIG_LIR_Nem_3	498	503	PF02991	0.500
LIG_LIR_Nem_3	586	592	PF02991	0.492
LIG_LIR_Nem_3	622	626	PF02991	0.428
LIG_LIR_Nem_3	741	747	PF02991	0.553
LIG_LIR_Nem_3	751	755	PF02991	0.443
LIG_LIR_Nem_3	871	875	PF02991	0.445
LIG_LIR_Nem_3	953	958	PF02991	0.479
LIG_LIR_Nem_3	989	994	PF02991	0.471
LIG_LYPXL_S_1	743	747	PF13949	0.517
LIG_LYPXL_yS_3	744	747	PF13949	0.518
LIG_MYND_1	502	506	PF01753	0.488
LIG_MYND_1	521	525	PF01753	0.496
LIG_NRBOX	1095	1101	PF00104	0.450
LIG_NRBOX	543	549	PF00104	0.455
LIG_NRBOX	59	65	PF00104	0.593
LIG_PCNA_PIPBox_1	647	656	PF02747	0.553
LIG_PCNA_PIPBox_1	737	746	PF02747	0.504
LIG_PCNA_yPIPBox_3	644	654	PF02747	0.435
LIG_Pex14_1	981	985	PF04695	0.473
LIG_PTB_Apo_2	746	753	PF02174	0.499
LIG_SH2_CRK	1134	1138	PF00017	0.567
LIG_SH2_CRK	215	219	PF00017	0.769
LIG_SH2_CRK	623	627	PF00017	0.469
LIG_SH2_STAP1	1166	1170	PF00017	0.459
LIG_SH2_STAP1	623	627	PF00017	0.433
LIG_SH2_STAP1	99	103	PF00017	0.698
LIG_SH2_STAT3	1235	1238	PF00017	0.542
LIG_SH2_STAT5	1040	1043	PF00017	0.477
LIG_SH2_STAT5	1206	1209	PF00017	0.635
LIG_SH2_STAT5	279	282	PF00017	0.482
LIG_SH2_STAT5	878	881	PF00017	0.499
LIG_SH2_STAT5	958	961	PF00017	0.564
LIG_SH2_STAT5	985	988	PF00017	0.573
LIG_SH3_1	199	205	PF00018	0.758
LIG_SH3_2	849	854	PF14604	0.641
LIG_SH3_3	112	118	PF00018	0.783
LIG_SH3_3	124	130	PF00018	0.643
LIG_SH3_3	132	138	PF00018	0.634
LIG_SH3_3	169	175	PF00018	0.636
LIG_SH3_3	199	205	PF00018	0.716
LIG_SH3_3	224	230	PF00018	0.752
LIG_SH3_3	255	261	PF00018	0.701
LIG_SH3_3	28	34	PF00018	0.706
LIG_SH3_3	496	502	PF00018	0.494
LIG_SH3_3	827	833	PF00018	0.819
LIG_SH3_3	846	852	PF00018	0.536
LIG_SH3_3	89	95	PF00018	0.582
LIG_SUMO_SIM_anti_2	1247	1253	PF11976	0.594
LIG_SUMO_SIM_anti_2	405	411	PF11976	0.501
LIG_SUMO_SIM_par_1	173	179	PF11976	0.614
LIG_SUMO_SIM_par_1	625	630	PF11976	0.479
LIG_SUMO_SIM_par_1	666	671	PF11976	0.528
LIG_TRAF2_1	1076	1079	PF00917	0.587
LIG_TRAF2_1	1114	1117	PF00917	0.732
LIG_TRAF2_1	1155	1158	PF00917	0.517
LIG_TRAF2_1	771	774	PF00917	0.430
LIG_WRC_WIRS_1	1074	1079	PF05994	0.472
LIG_WW_1	118	121	PF00397	0.700
LIG_WW_1	832	835	PF00397	0.751
MOD_CDC14_SPxK_1	851	854	PF00782	0.637
MOD_CDK_SPK_2	4	9	PF00069	0.774
MOD_CDK_SPxK_1	848	854	PF00069	0.643
MOD_CDK_SPxxK_3	4	11	PF00069	0.757
MOD_CDK_SPxxK_3	423	430	PF00069	0.598
MOD_CDK_SPxxK_3	627	634	PF00069	0.501
MOD_CK1_1	1002	1008	PF00069	0.598
MOD_CK1_1	1020	1026	PF00069	0.357
MOD_CK1_1	111	117	PF00069	0.772
MOD_CK1_1	1124	1130	PF00069	0.715
MOD_CK1_1	120	126	PF00069	0.709
MOD_CK1_1	150	156	PF00069	0.780
MOD_CK1_1	170	176	PF00069	0.313
MOD_CK1_1	21	27	PF00069	0.825
MOD_CK1_1	29	35	PF00069	0.735
MOD_CK1_1	295	301	PF00069	0.721
MOD_CK1_1	326	332	PF00069	0.636
MOD_CK1_1	420	426	PF00069	0.723
MOD_CK1_1	67	73	PF00069	0.684
MOD_CK1_1	764	770	PF00069	0.545
MOD_CK1_1	98	104	PF00069	0.675
MOD_CK2_1	1073	1079	PF00069	0.472
MOD_CK2_1	1111	1117	PF00069	0.742
MOD_CK2_1	1152	1158	PF00069	0.588
MOD_CK2_1	1224	1230	PF00069	0.534
MOD_CK2_1	279	285	PF00069	0.611
MOD_CK2_1	468	474	PF00069	0.513
MOD_CK2_1	579	585	PF00069	0.459
MOD_CK2_1	726	732	PF00069	0.526
MOD_CK2_1	764	770	PF00069	0.499
MOD_CK2_1	947	953	PF00069	0.516
MOD_GlcNHglycan	100	103	PF01048	0.654
MOD_GlcNHglycan	105	108	PF01048	0.692
MOD_GlcNHglycan	1057	1060	PF01048	0.607
MOD_GlcNHglycan	1123	1126	PF01048	0.712
MOD_GlcNHglycan	1202	1205	PF01048	0.513
MOD_GlcNHglycan	122	125	PF01048	0.799
MOD_GlcNHglycan	1246	1249	PF01048	0.542
MOD_GlcNHglycan	165	168	PF01048	0.800
MOD_GlcNHglycan	184	187	PF01048	0.299
MOD_GlcNHglycan	20	23	PF01048	0.748
MOD_GlcNHglycan	264	267	PF01048	0.609
MOD_GlcNHglycan	298	301	PF01048	0.686
MOD_GlcNHglycan	34	37	PF01048	0.647
MOD_GlcNHglycan	341	344	PF01048	0.814
MOD_GlcNHglycan	357	360	PF01048	0.607
MOD_GlcNHglycan	361	364	PF01048	0.551
MOD_GlcNHglycan	377	380	PF01048	0.615
MOD_GlcNHglycan	443	446	PF01048	0.774
MOD_GlcNHglycan	612	615	PF01048	0.575
MOD_GlcNHglycan	66	69	PF01048	0.668
MOD_GlcNHglycan	763	766	PF01048	0.519
MOD_GlcNHglycan	784	787	PF01048	0.629
MOD_GlcNHglycan	804	807	PF01048	0.815
MOD_GlcNHglycan	815	818	PF01048	0.753
MOD_GlcNHglycan	961	964	PF01048	0.499
MOD_GlcNHglycan	997	1000	PF01048	0.577
MOD_GSK3_1	1040	1047	PF00069	0.424
MOD_GSK3_1	1117	1124	PF00069	0.702
MOD_GSK3_1	1200	1207	PF00069	0.546
MOD_GSK3_1	1211	1218	PF00069	0.343
MOD_GSK3_1	1222	1229	PF00069	0.419
MOD_GSK3_1	1252	1259	PF00069	0.460
MOD_GSK3_1	14	21	PF00069	0.786
MOD_GSK3_1	144	151	PF00069	0.724
MOD_GSK3_1	163	170	PF00069	0.663
MOD_GSK3_1	26	33	PF00069	0.597
MOD_GSK3_1	288	295	PF00069	0.706
MOD_GSK3_1	296	303	PF00069	0.704
MOD_GSK3_1	323	330	PF00069	0.661
MOD_GSK3_1	339	346	PF00069	0.816
MOD_GSK3_1	351	358	PF00069	0.651
MOD_GSK3_1	384	391	PF00069	0.712
MOD_GSK3_1	417	424	PF00069	0.718
MOD_GSK3_1	47	54	PF00069	0.611
MOD_GSK3_1	579	586	PF00069	0.485
MOD_GSK3_1	603	610	PF00069	0.765
MOD_GSK3_1	664	671	PF00069	0.512
MOD_GSK3_1	722	729	PF00069	0.626
MOD_GSK3_1	798	805	PF00069	0.803
MOD_GSK3_1	848	855	PF00069	0.709
MOD_GSK3_1	995	1002	PF00069	0.497
MOD_N-GLC_1	1020	1025	PF02516	0.415
MOD_N-GLC_1	1105	1110	PF02516	0.626
MOD_N-GLC_1	18	23	PF02516	0.713
MOD_N-GLC_1	441	446	PF02516	0.665
MOD_N-GLC_1	495	500	PF02516	0.489
MOD_N-GLC_1	532	537	PF02516	0.627
MOD_N-GLC_1	885	890	PF02516	0.743
MOD_NEK2_1	1017	1022	PF00069	0.489
MOD_NEK2_1	103	108	PF00069	0.689
MOD_NEK2_1	1044	1049	PF00069	0.417
MOD_NEK2_1	1202	1207	PF00069	0.514
MOD_NEK2_1	1252	1257	PF00069	0.479
MOD_NEK2_1	323	328	PF00069	0.659
MOD_NEK2_1	334	339	PF00069	0.644
MOD_NEK2_1	421	426	PF00069	0.776
MOD_NEK2_1	428	433	PF00069	0.641
MOD_NEK2_1	495	500	PF00069	0.489
MOD_NEK2_1	551	556	PF00069	0.544
MOD_NEK2_1	578	583	PF00069	0.476
MOD_NEK2_1	591	596	PF00069	0.539
MOD_NEK2_1	619	624	PF00069	0.480
MOD_NEK2_1	756	761	PF00069	0.493
MOD_NEK2_2	1128	1133	PF00069	0.653
MOD_NEK2_2	532	537	PF00069	0.437
MOD_PIKK_1	1185	1191	PF00454	0.465
MOD_PIKK_1	179	185	PF00454	0.608
MOD_PIKK_1	412	418	PF00454	0.693
MOD_PIKK_1	428	434	PF00454	0.516
MOD_PIKK_1	591	597	PF00454	0.594
MOD_PIKK_1	793	799	PF00454	0.731
MOD_PK_1	341	347	PF00069	0.763
MOD_PK_1	351	357	PF00069	0.688
MOD_PKA_2	191	197	PF00069	0.696
MOD_PKA_2	262	268	PF00069	0.588
MOD_PKA_2	295	301	PF00069	0.748
MOD_PKA_2	334	340	PF00069	0.611
MOD_PKA_2	374	380	PF00069	0.724
MOD_PKA_2	488	494	PF00069	0.511
MOD_PKA_2	551	557	PF00069	0.627
MOD_PKA_2	64	70	PF00069	0.609
MOD_PKA_2	899	905	PF00069	0.558
MOD_PKB_1	294	302	PF00069	0.753
MOD_PKB_1	854	862	PF00069	0.503
MOD_Plk_1	441	447	PF00069	0.739
MOD_Plk_1	495	501	PF00069	0.485
MOD_Plk_1	532	538	PF00069	0.575
MOD_Plk_1	702	708	PF00069	0.582
MOD_Plk_1	826	832	PF00069	0.662
MOD_Plk_1	947	953	PF00069	0.520
MOD_Plk_2-3	1079	1085	PF00069	0.502
MOD_Plk_2-3	1117	1123	PF00069	0.705
MOD_Plk_2-3	1237	1243	PF00069	0.503
MOD_Plk_2-3	462	468	PF00069	0.802
MOD_Plk_2-3	899	905	PF00069	0.583
MOD_Plk_4	1211	1217	PF00069	0.469
MOD_Plk_4	495	501	PF00069	0.485
MOD_Plk_4	622	628	PF00069	0.577
MOD_Plk_4	664	670	PF00069	0.490
MOD_Plk_4	715	721	PF00069	0.525
MOD_ProDKin_1	1034	1040	PF00069	0.495
MOD_ProDKin_1	111	117	PF00069	0.690
MOD_ProDKin_1	1209	1215	PF00069	0.462
MOD_ProDKin_1	1254	1260	PF00069	0.632
MOD_ProDKin_1	131	137	PF00069	0.759
MOD_ProDKin_1	144	150	PF00069	0.736
MOD_ProDKin_1	30	36	PF00069	0.744
MOD_ProDKin_1	300	306	PF00069	0.741
MOD_ProDKin_1	327	333	PF00069	0.685
MOD_ProDKin_1	4	10	PF00069	0.775
MOD_ProDKin_1	423	429	PF00069	0.631
MOD_ProDKin_1	490	496	PF00069	0.516
MOD_ProDKin_1	607	613	PF00069	0.671
MOD_ProDKin_1	627	633	PF00069	0.463
MOD_ProDKin_1	798	804	PF00069	0.719
MOD_ProDKin_1	848	854	PF00069	0.763
MOD_SUMO_rev_2	1157	1167	PF00179	0.487
MOD_SUMO_rev_2	14	21	PF00179	0.692
TRG_DiLeu_BaEn_1	751	756	PF01217	0.490
TRG_DiLeu_BaEn_2	658	664	PF01217	0.647
TRG_DiLeu_BaLyEn_6	518	523	PF01217	0.578
TRG_DiLeu_BaLyEn_6	615	620	PF01217	0.505
TRG_ENDOCYTIC_2	623	626	PF00928	0.469
TRG_ENDOCYTIC_2	744	747	PF00928	0.518
TRG_ENDOCYTIC_2	985	988	PF00928	0.471
TRG_ER_diArg_1	199	201	PF00400	0.696
TRG_ER_diArg_1	636	639	PF00400	0.521
TRG_ER_diArg_1	8	11	PF00400	0.779
TRG_ER_diArg_1	918	921	PF00400	0.518
TRG_ER_diArg_1	968	971	PF00400	0.496
TRG_NES_CRM1_1	393	405	PF08389	0.388
TRG_Pf-PMV_PEXEL_1	1097	1101	PF00026	0.457
TRG_Pf-PMV_PEXEL_1	933	937	PF00026	0.465
TRG_Pf-PMV_PEXEL_1	949	953	PF00026	0.497

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1M1	Leptomonas seymouri	50%	100%
A0A3Q8IBY1	Leishmania donovani	99%	100%
A4HBU4	Leishmania braziliensis	76%	99%
E9AV66	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	99%
Q4QCB5	Leishmania major	92%	100%