Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

E9AGU9_LEIIN

TriTrypDb:

LINF_210015600

Length:

855

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AGU9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AGU9

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	5
GO:0006793	phosphorus metabolic process	3	5
GO:0006796	phosphate-containing compound metabolic process	4	5
GO:0006807	nitrogen compound metabolic process	2	5
GO:0008152	metabolic process	1	5
GO:0009987	cellular process	1	5
GO:0016310	phosphorylation	5	5
GO:0019538	protein metabolic process	3	5
GO:0036211	protein modification process	4	5
GO:0043170	macromolecule metabolic process	3	5
GO:0043412	macromolecule modification	4	5
GO:0044237	cellular metabolic process	2	5
GO:0044238	primary metabolic process	2	5
GO:0071704	organic substance metabolic process	2	5
GO:1901564	organonitrogen compound metabolic process	3	5

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	5
GO:0003824	catalytic activity	1	5
GO:0004672	protein kinase activity	3	5
GO:0005488	binding	1	5
GO:0005524	ATP binding	5	5
GO:0016301	kinase activity	4	5
GO:0016740	transferase activity	2	5
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	5
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	5
GO:0017076	purine nucleotide binding	4	5
GO:0030554	adenyl nucleotide binding	5	5
GO:0032553	ribonucleotide binding	3	5
GO:0032555	purine ribonucleotide binding	4	5
GO:0032559	adenyl ribonucleotide binding	5	5
GO:0035639	purine ribonucleoside triphosphate binding	4	5
GO:0036094	small molecule binding	2	5
GO:0043167	ion binding	2	5
GO:0043168	anion binding	3	5
GO:0097159	organic cyclic compound binding	2	5
GO:0097367	carbohydrate derivative binding	2	5
GO:0140096	catalytic activity, acting on a protein	2	5
GO:1901265	nucleoside phosphate binding	3	5
GO:1901363	heterocyclic compound binding	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	127	129	PF00675	0.425
CLV_NRD_NRD_1	207	209	PF00675	0.378
CLV_NRD_NRD_1	301	303	PF00675	0.461
CLV_NRD_NRD_1	84	86	PF00675	0.453
CLV_NRD_NRD_1	844	846	PF00675	0.589
CLV_PCSK_KEX2_1	127	129	PF00082	0.476
CLV_PCSK_KEX2_1	207	209	PF00082	0.378
CLV_PCSK_KEX2_1	84	86	PF00082	0.343
CLV_PCSK_KEX2_1	844	846	PF00082	0.703
CLV_PCSK_PC7_1	80	86	PF00082	0.303
CLV_PCSK_SKI1_1	118	122	PF00082	0.375
CLV_PCSK_SKI1_1	428	432	PF00082	0.316
CLV_PCSK_SKI1_1	533	537	PF00082	0.381
CLV_PCSK_SKI1_1	84	88	PF00082	0.358
CLV_Separin_Metazoa	367	371	PF03568	0.341
DEG_APCC_DBOX_1	354	362	PF00400	0.427
DEG_SCF_FBW7_1	683	690	PF00400	0.632
DEG_SIAH_1	686	694	PF03145	0.591
DEG_SPOP_SBC_1	626	630	PF00917	0.699
DEG_SPOP_SBC_1	674	678	PF00917	0.584
DOC_CKS1_1	18	23	PF01111	0.462
DOC_CKS1_1	294	299	PF01111	0.384
DOC_CKS1_1	409	414	PF01111	0.399
DOC_CKS1_1	692	697	PF01111	0.638
DOC_CYCLIN_RxL_1	3	13	PF00134	0.505
DOC_CYCLIN_RxL_1	425	435	PF00134	0.324
DOC_MAPK_gen_1	207	213	PF00069	0.411
DOC_MAPK_gen_1	426	433	PF00069	0.427
DOC_MAPK_gen_1	84	91	PF00069	0.341
DOC_MAPK_MEF2A_6	426	433	PF00069	0.410
DOC_MAPK_MEF2A_6	504	513	PF00069	0.301
DOC_MAPK_NFAT4_5	426	434	PF00069	0.324
DOC_MAPK_RevD_3	113	128	PF00069	0.341
DOC_PP2B_LxvP_1	796	799	PF13499	0.602
DOC_PP2B_LxvP_1	89	92	PF13499	0.354
DOC_PP4_FxxP_1	360	363	PF00568	0.371
DOC_USP7_MATH_1	155	159	PF00917	0.392
DOC_USP7_MATH_1	373	377	PF00917	0.485
DOC_USP7_MATH_1	477	481	PF00917	0.494
DOC_USP7_MATH_1	547	551	PF00917	0.309
DOC_USP7_MATH_1	620	624	PF00917	0.624
DOC_USP7_MATH_1	66	70	PF00917	0.526
DOC_USP7_MATH_1	674	678	PF00917	0.641
DOC_USP7_MATH_1	699	703	PF00917	0.679
DOC_USP7_MATH_1	717	721	PF00917	0.614
DOC_USP7_MATH_1	776	780	PF00917	0.646
DOC_USP7_MATH_1	799	803	PF00917	0.697
DOC_USP7_MATH_2	218	224	PF00917	0.464
DOC_USP7_UBL2_3	842	846	PF12436	0.567
DOC_WW_Pin1_4	17	22	PF00397	0.443
DOC_WW_Pin1_4	195	200	PF00397	0.527
DOC_WW_Pin1_4	293	298	PF00397	0.389
DOC_WW_Pin1_4	30	35	PF00397	0.409
DOC_WW_Pin1_4	408	413	PF00397	0.417
DOC_WW_Pin1_4	516	521	PF00397	0.478
DOC_WW_Pin1_4	569	574	PF00397	0.446
DOC_WW_Pin1_4	628	633	PF00397	0.602
DOC_WW_Pin1_4	678	683	PF00397	0.654
DOC_WW_Pin1_4	691	696	PF00397	0.675
DOC_WW_Pin1_4	765	770	PF00397	0.745
DOC_WW_Pin1_4	786	791	PF00397	0.753
LIG_14-3-3_CanoR_1	262	267	PF00244	0.441
LIG_14-3-3_CanoR_1	28	34	PF00244	0.547
LIG_14-3-3_CanoR_1	280	284	PF00244	0.242
LIG_14-3-3_CanoR_1	35	41	PF00244	0.477
LIG_14-3-3_CanoR_1	80	84	PF00244	0.368
LIG_14-3-3_CanoR_1	85	90	PF00244	0.346
LIG_Actin_WH2_2	263	278	PF00022	0.480
LIG_Actin_WH2_2	379	397	PF00022	0.477
LIG_Actin_WH2_2	522	539	PF00022	0.409
LIG_BIR_II_1	1	5	PF00653	0.446
LIG_BIR_III_4	239	243	PF00653	0.356
LIG_BRCT_BRCA1_1	733	737	PF00533	0.624
LIG_BRCT_BRCA1_2	733	739	PF00533	0.623
LIG_Clathr_ClatBox_1	182	186	PF01394	0.274
LIG_Clathr_ClatBox_1	330	334	PF01394	0.419
LIG_Clathr_ClatBox_1	430	434	PF01394	0.330
LIG_CtBP_PxDLS_1	218	222	PF00389	0.483
LIG_eIF4E_1	409	415	PF01652	0.342
LIG_eIF4E_1	467	473	PF01652	0.353
LIG_FHA_1	104	110	PF00498	0.331
LIG_FHA_1	248	254	PF00498	0.411
LIG_FHA_1	409	415	PF00498	0.416
LIG_FHA_1	506	512	PF00498	0.311
LIG_FHA_1	55	61	PF00498	0.411
LIG_FHA_1	583	589	PF00498	0.533
LIG_FHA_1	778	784	PF00498	0.676
LIG_FHA_1	827	833	PF00498	0.736
LIG_FHA_2	252	258	PF00498	0.449
LIG_FHA_2	42	48	PF00498	0.453
LIG_FHA_2	577	583	PF00498	0.503
LIG_Integrin_isoDGR_2	260	262	PF01839	0.446
LIG_IRF3_LxIS_1	392	397	PF10401	0.330
LIG_LIR_Apic_2	29	34	PF02991	0.525
LIG_LIR_Apic_2	407	412	PF02991	0.366
LIG_LIR_Apic_2	643	649	PF02991	0.443
LIG_LIR_Nem_3	177	183	PF02991	0.283
LIG_LIR_Nem_3	318	323	PF02991	0.432
LIG_LIR_Nem_3	404	409	PF02991	0.350
LIG_NRBOX	326	332	PF00104	0.402
LIG_Pex14_2	179	183	PF04695	0.358
LIG_PTAP_UEV_1	744	749	PF05743	0.571
LIG_PTB_Apo_2	308	315	PF02174	0.386
LIG_REV1ctd_RIR_1	1	10	PF16727	0.509
LIG_SH2_CRK	215	219	PF00017	0.345
LIG_SH2_CRK	31	35	PF00017	0.457
LIG_SH2_CRK	427	431	PF00017	0.319
LIG_SH2_CRK	459	463	PF00017	0.472
LIG_SH2_CRK	531	535	PF00017	0.402
LIG_SH2_NCK_1	248	252	PF00017	0.390
LIG_SH2_PTP2	409	412	PF00017	0.315
LIG_SH2_STAP1	138	142	PF00017	0.437
LIG_SH2_STAP1	467	471	PF00017	0.351
LIG_SH2_STAT5	108	111	PF00017	0.287
LIG_SH2_STAT5	130	133	PF00017	0.530
LIG_SH2_STAT5	31	34	PF00017	0.498
LIG_SH2_STAT5	409	412	PF00017	0.315
LIG_SH2_STAT5	531	534	PF00017	0.408
LIG_SH3_2	837	842	PF14604	0.514
LIG_SH3_3	12	18	PF00018	0.410
LIG_SH3_3	607	613	PF00018	0.594
LIG_SH3_3	668	674	PF00018	0.626
LIG_SH3_3	679	685	PF00018	0.637
LIG_SH3_3	742	748	PF00018	0.710
LIG_SH3_3	788	794	PF00018	0.752
LIG_SH3_3	834	840	PF00018	0.589
LIG_Sin3_3	469	476	PF02671	0.389
LIG_SUMO_SIM_anti_2	328	334	PF11976	0.422
LIG_SUMO_SIM_par_1	233	239	PF11976	0.374
LIG_SUMO_SIM_par_1	572	577	PF11976	0.387
LIG_SUMO_SIM_par_1	794	800	PF11976	0.512
LIG_SUMO_SIM_par_1	821	826	PF11976	0.502
LIG_TRAF2_1	254	257	PF00917	0.474
LIG_TYR_ITIM	246	251	PF00017	0.270
LIG_TYR_ITIM	425	430	PF00017	0.361
MOD_CDC14_SPxK_1	681	684	PF00782	0.602
MOD_CDK_SPK_2	30	35	PF00069	0.396
MOD_CDK_SPxK_1	678	684	PF00069	0.565
MOD_CDK_SPxxK_3	293	300	PF00069	0.353
MOD_CK1_1	174	180	PF00069	0.362
MOD_CK1_1	376	382	PF00069	0.521
MOD_CK1_1	397	403	PF00069	0.372
MOD_CK1_1	54	60	PF00069	0.436
MOD_CK1_1	572	578	PF00069	0.478
MOD_CK1_1	580	586	PF00069	0.434
MOD_CK1_1	61	67	PF00069	0.562
MOD_CK1_1	627	633	PF00069	0.690
MOD_CK1_1	656	662	PF00069	0.644
MOD_CK1_1	677	683	PF00069	0.598
MOD_CK1_1	708	714	PF00069	0.701
MOD_CK1_1	746	752	PF00069	0.581
MOD_CK1_1	758	764	PF00069	0.628
MOD_CK1_1	779	785	PF00069	0.707
MOD_CK1_1	789	795	PF00069	0.745
MOD_CK1_1	802	808	PF00069	0.596
MOD_CK1_1	826	832	PF00069	0.689
MOD_CK1_1	835	841	PF00069	0.643
MOD_CK2_1	251	257	PF00069	0.452
MOD_CK2_1	268	274	PF00069	0.492
MOD_CK2_1	341	347	PF00069	0.526
MOD_CK2_1	576	582	PF00069	0.465
MOD_GlcNHglycan	173	176	PF01048	0.369
MOD_GlcNHglycan	188	191	PF01048	0.329
MOD_GlcNHglycan	230	233	PF01048	0.489
MOD_GlcNHglycan	270	273	PF01048	0.454
MOD_GlcNHglycan	327	330	PF01048	0.463
MOD_GlcNHglycan	375	378	PF01048	0.528
MOD_GlcNHglycan	419	422	PF01048	0.495
MOD_GlcNHglycan	459	462	PF01048	0.383
MOD_GlcNHglycan	466	470	PF01048	0.376
MOD_GlcNHglycan	558	561	PF01048	0.358
MOD_GlcNHglycan	579	582	PF01048	0.526
MOD_GlcNHglycan	60	63	PF01048	0.495
MOD_GlcNHglycan	605	608	PF01048	0.453
MOD_GlcNHglycan	613	616	PF01048	0.631
MOD_GlcNHglycan	655	658	PF01048	0.614
MOD_GlcNHglycan	671	674	PF01048	0.667
MOD_GlcNHglycan	677	680	PF01048	0.673
MOD_GlcNHglycan	68	71	PF01048	0.511
MOD_GlcNHglycan	707	710	PF01048	0.690
MOD_GlcNHglycan	739	742	PF01048	0.678
MOD_GlcNHglycan	745	748	PF01048	0.599
MOD_GlcNHglycan	757	760	PF01048	0.599
MOD_GlcNHglycan	825	828	PF01048	0.676
MOD_GlcNHglycan	834	837	PF01048	0.610
MOD_GSK3_1	167	174	PF00069	0.421
MOD_GSK3_1	247	254	PF00069	0.396
MOD_GSK3_1	26	33	PF00069	0.411
MOD_GSK3_1	279	286	PF00069	0.372
MOD_GSK3_1	341	348	PF00069	0.419
MOD_GSK3_1	512	519	PF00069	0.435
MOD_GSK3_1	54	61	PF00069	0.417
MOD_GSK3_1	547	554	PF00069	0.368
MOD_GSK3_1	572	579	PF00069	0.527
MOD_GSK3_1	582	589	PF00069	0.508
MOD_GSK3_1	616	623	PF00069	0.613
MOD_GSK3_1	62	69	PF00069	0.517
MOD_GSK3_1	624	631	PF00069	0.689
MOD_GSK3_1	652	659	PF00069	0.601
MOD_GSK3_1	669	676	PF00069	0.637
MOD_GSK3_1	683	690	PF00069	0.662
MOD_GSK3_1	761	768	PF00069	0.732
MOD_GSK3_1	777	784	PF00069	0.774
MOD_GSK3_1	785	792	PF00069	0.714
MOD_GSK3_1	826	833	PF00069	0.727
MOD_LATS_1	601	607	PF00433	0.462
MOD_N-GLC_1	268	273	PF02516	0.475
MOD_N-GLC_1	505	510	PF02516	0.289
MOD_N-GLC_1	591	596	PF02516	0.301
MOD_N-GLC_1	620	625	PF02516	0.655
MOD_N-GLC_2	277	279	PF02516	0.442
MOD_NEK2_1	10	15	PF00069	0.430
MOD_NEK2_1	221	226	PF00069	0.443
MOD_NEK2_1	247	252	PF00069	0.366
MOD_NEK2_1	301	306	PF00069	0.407
MOD_NEK2_1	333	338	PF00069	0.460
MOD_NEK2_1	341	346	PF00069	0.451
MOD_NEK2_1	36	41	PF00069	0.382
MOD_NEK2_1	368	373	PF00069	0.372
MOD_NEK2_1	440	445	PF00069	0.436
MOD_NEK2_1	457	462	PF00069	0.304
MOD_NEK2_1	479	484	PF00069	0.422
MOD_NEK2_1	56	61	PF00069	0.464
MOD_NEK2_1	563	568	PF00069	0.408
MOD_NEK2_1	591	596	PF00069	0.534
MOD_NEK2_1	652	657	PF00069	0.700
MOD_NEK2_1	731	736	PF00069	0.660
MOD_NEK2_1	737	742	PF00069	0.619
MOD_NEK2_1	753	758	PF00069	0.488
MOD_NEK2_2	26	31	PF00069	0.411
MOD_NEK2_2	547	552	PF00069	0.359
MOD_NEK2_2	79	84	PF00069	0.459
MOD_PIKK_1	333	339	PF00454	0.402
MOD_PIKK_1	41	47	PF00454	0.500
MOD_PIKK_1	519	525	PF00454	0.471
MOD_PIKK_1	732	738	PF00454	0.694
MOD_PIKK_1	789	795	PF00454	0.618
MOD_PK_1	262	268	PF00069	0.468
MOD_PKA_1	316	322	PF00069	0.285
MOD_PKA_2	279	285	PF00069	0.430
MOD_PKA_2	301	307	PF00069	0.389
MOD_PKA_2	51	57	PF00069	0.410
MOD_PKA_2	731	737	PF00069	0.703
MOD_PKA_2	79	85	PF00069	0.439
MOD_PKA_2	802	808	PF00069	0.584
MOD_PKB_1	463	471	PF00069	0.252
MOD_Plk_1	505	511	PF00069	0.301
MOD_Plk_1	591	597	PF00069	0.378
MOD_Plk_1	732	738	PF00069	0.643
MOD_Plk_4	103	109	PF00069	0.325
MOD_Plk_4	167	173	PF00069	0.273
MOD_Plk_4	316	322	PF00069	0.348
MOD_Plk_4	405	411	PF00069	0.336
MOD_Plk_4	479	485	PF00069	0.463
MOD_Plk_4	51	57	PF00069	0.329
MOD_Plk_4	563	569	PF00069	0.371
MOD_Plk_4	586	592	PF00069	0.433
MOD_Plk_4	687	693	PF00069	0.708
MOD_Plk_4	809	815	PF00069	0.731
MOD_Plk_4	85	91	PF00069	0.337
MOD_ProDKin_1	17	23	PF00069	0.455
MOD_ProDKin_1	195	201	PF00069	0.515
MOD_ProDKin_1	293	299	PF00069	0.387
MOD_ProDKin_1	30	36	PF00069	0.404
MOD_ProDKin_1	408	414	PF00069	0.412
MOD_ProDKin_1	516	522	PF00069	0.481
MOD_ProDKin_1	569	575	PF00069	0.446
MOD_ProDKin_1	628	634	PF00069	0.603
MOD_ProDKin_1	678	684	PF00069	0.657
MOD_ProDKin_1	691	697	PF00069	0.672
MOD_ProDKin_1	765	771	PF00069	0.746
MOD_ProDKin_1	786	792	PF00069	0.751
MOD_SUMO_for_1	596	599	PF00179	0.359
TRG_DiLeu_BaEn_2	309	315	PF01217	0.399
TRG_ENDOCYTIC_2	248	251	PF00928	0.260
TRG_ENDOCYTIC_2	427	430	PF00928	0.315
TRG_ER_diArg_1	126	128	PF00400	0.413
TRG_ER_diArg_1	299	302	PF00400	0.566
TRG_ER_diArg_1	462	465	PF00400	0.264
TRG_ER_diArg_1	83	85	PF00400	0.454
TRG_ER_diArg_1	843	845	PF00400	0.590
TRG_NES_CRM1_1	322	334	PF08389	0.399
TRG_Pf-PMV_PEXEL_1	561	565	PF00026	0.457
TRG_Pf-PMV_PEXEL_1	72	77	PF00026	0.406

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PER2	Leptomonas seymouri	54%	96%
A0A0S4KHN7	Bodo saltans	34%	100%
A0A1X0NY37	Trypanosomatidae	38%	100%
A0A3S5IS35	Trypanosoma rangeli	37%	100%
A0A3S7WWH4	Leishmania donovani	100%	100%
A4HBU3	Leishmania braziliensis	78%	99%
D0A1C9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9AV65	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	99%
O13733	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	22%	100%
Q4QCB6	Leishmania major	93%	100%
Q55GS2	Dictyostelium discoideum	25%	100%
Q96KG9	Homo sapiens	27%	100%
Q9EQC5	Mus musculus	26%	100%