LeishMANIAdb
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Xanthine phosphoribosyltransferase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Xanthine phosphoribosyltransferase
Gene product:
xanthine phosphoribosyltransferase
Species:
Leishmania infantum
UniProt:
E9AGU7_LEIIN
TriTrypDb:
LINF_210015000
Length:
241

Annotations

Annotations by Jardim et al.

Purine metabolism, Xanthine phosphoribosyltransferase XRPT

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 13
NetGPI no yes: 0, no: 13
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 4
GO:0005777 peroxisome 6 1
GO:0005829 cytosol 2 1
GO:0020015 glycosome 7 1
GO:0020022 acidocalcisome 5 1
GO:0031974 membrane-enclosed lumen 2 1
GO:0031981 nuclear lumen 5 1
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 1
GO:0042579 microbody 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0043233 organelle lumen 3 1
GO:0070013 intracellular organelle lumen 4 1
GO:0097014 ciliary plasm 5 1
GO:0099568 cytoplasmic region 3 1
GO:0110165 cellular anatomical entity 1 4

Expansion

Sequence features

E9AGU7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AGU7

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 4
GO:0006144 purine nucleobase metabolic process 5 1
GO:0006163 purine nucleotide metabolic process 5 4
GO:0006164 purine nucleotide biosynthetic process 6 4
GO:0006177 GMP biosynthetic process 8 1
GO:0006178 guanine salvage 6 1
GO:0006188 IMP biosynthetic process 8 4
GO:0006725 cellular aromatic compound metabolic process 3 4
GO:0006753 nucleoside phosphate metabolic process 4 4
GO:0006793 phosphorus metabolic process 3 4
GO:0006796 phosphate-containing compound metabolic process 4 4
GO:0006807 nitrogen compound metabolic process 2 4
GO:0008152 metabolic process 1 4
GO:0009058 biosynthetic process 2 4
GO:0009112 nucleobase metabolic process 4 1
GO:0009113 purine nucleobase biosynthetic process 6 1
GO:0009117 nucleotide metabolic process 5 4
GO:0009123 nucleoside monophosphate metabolic process 5 4
GO:0009124 nucleoside monophosphate biosynthetic process 6 4
GO:0009126 purine nucleoside monophosphate metabolic process 6 4
GO:0009127 purine nucleoside monophosphate biosynthetic process 7 4
GO:0009150 purine ribonucleotide metabolic process 6 4
GO:0009152 purine ribonucleotide biosynthetic process 7 4
GO:0009156 ribonucleoside monophosphate biosynthetic process 7 4
GO:0009161 ribonucleoside monophosphate metabolic process 6 4
GO:0009165 nucleotide biosynthetic process 6 4
GO:0009167 purine ribonucleoside monophosphate metabolic process 7 4
GO:0009168 purine ribonucleoside monophosphate biosynthetic process 8 4
GO:0009259 ribonucleotide metabolic process 5 4
GO:0009260 ribonucleotide biosynthetic process 6 4
GO:0009987 cellular process 1 4
GO:0018130 heterocycle biosynthetic process 4 4
GO:0019438 aromatic compound biosynthetic process 4 4
GO:0019637 organophosphate metabolic process 3 4
GO:0019693 ribose phosphate metabolic process 4 4
GO:0032261 purine nucleotide salvage 5 4
GO:0032263 GMP salvage 7 1
GO:0032264 IMP salvage 7 4
GO:0034641 cellular nitrogen compound metabolic process 3 4
GO:0034654 nucleobase-containing compound biosynthetic process 4 4
GO:0043094 cellular metabolic compound salvage 3 4
GO:0043096 purine nucleobase salvage 5 1
GO:0043101 purine-containing compound salvage 4 4
GO:0043173 nucleotide salvage 4 4
GO:0044237 cellular metabolic process 2 4
GO:0044238 primary metabolic process 2 4
GO:0044249 cellular biosynthetic process 3 4
GO:0044271 cellular nitrogen compound biosynthetic process 4 4
GO:0044281 small molecule metabolic process 2 4
GO:0046037 GMP metabolic process 7 1
GO:0046040 IMP metabolic process 7 4
GO:0046098 guanine metabolic process 6 1
GO:0046099 guanine biosynthetic process 7 1
GO:0046100 hypoxanthine metabolic process 6 1
GO:0046112 nucleobase biosynthetic process 5 1
GO:0046390 ribose phosphate biosynthetic process 5 4
GO:0046483 heterocycle metabolic process 3 4
GO:0055086 nucleobase-containing small molecule metabolic process 3 4
GO:0071704 organic substance metabolic process 2 4
GO:0072521 purine-containing compound metabolic process 4 4
GO:0072522 purine-containing compound biosynthetic process 5 4
GO:0090407 organophosphate biosynthetic process 4 4
GO:0106380 purine ribonucleotide salvage 6 4
GO:1901135 carbohydrate derivative metabolic process 3 4
GO:1901137 carbohydrate derivative biosynthetic process 4 4
GO:1901293 nucleoside phosphate biosynthetic process 5 4
GO:1901360 organic cyclic compound metabolic process 3 4
GO:1901362 organic cyclic compound biosynthetic process 4 4
GO:1901564 organonitrogen compound metabolic process 3 4
GO:1901566 organonitrogen compound biosynthetic process 4 4
GO:1901576 organic substance biosynthetic process 3 4
GO:0006166 purine ribonucleoside salvage 5 3
GO:0009116 nucleoside metabolic process 4 3
GO:0009119 ribonucleoside metabolic process 5 3
GO:0009163 nucleoside biosynthetic process 5 3
GO:0034404 nucleobase-containing small molecule biosynthetic process 4 3
GO:0042278 purine nucleoside metabolic process 5 3
GO:0042451 purine nucleoside biosynthetic process 6 3
GO:0042455 ribonucleoside biosynthetic process 6 3
GO:0043174 nucleoside salvage 4 3
GO:0044283 small molecule biosynthetic process 3 3
GO:0046128 purine ribonucleoside metabolic process 6 3
GO:0046129 purine ribonucleoside biosynthetic process 7 3
GO:1901657 glycosyl compound metabolic process 4 3
GO:1901659 glycosyl compound biosynthetic process 5 3
Molecular functions
Term Name Level Count
GO:0000310 xanthine phosphoribosyltransferase activity 6 4
GO:0003824 catalytic activity 1 14
GO:0004422 hypoxanthine phosphoribosyltransferase activity 6 8
GO:0016740 transferase activity 2 14
GO:0016757 glycosyltransferase activity 3 14
GO:0016763 pentosyltransferase activity 4 8
GO:0052657 guanine phosphoribosyltransferase activity 6 8
GO:0106130 purine phosphoribosyltransferase activity 5 8
GO:0000287 magnesium ion binding 5 1
GO:0005488 binding 1 4
GO:0043167 ion binding 2 4
GO:0043169 cation binding 3 4
GO:0046872 metal ion binding 4 4
GO:0000166 nucleotide binding 3 3
GO:0036094 small molecule binding 2 3
GO:0097159 organic cyclic compound binding 2 3
GO:1901265 nucleoside phosphate binding 3 3
GO:1901363 heterocyclic compound binding 2 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 56 60 PF00656 0.310
CLV_NRD_NRD_1 190 192 PF00675 0.259
CLV_PCSK_SKI1_1 147 151 PF00082 0.237
CLV_PCSK_SKI1_1 176 180 PF00082 0.346
CLV_PCSK_SKI1_1 224 228 PF00082 0.371
DOC_ANK_TNKS_1 15 22 PF00023 0.513
DOC_MAPK_gen_1 145 152 PF00069 0.451
DOC_MAPK_gen_1 176 184 PF00069 0.521
DOC_MAPK_gen_1 219 228 PF00069 0.394
DOC_PP1_RVXF_1 158 165 PF00149 0.526
DOC_PP1_RVXF_1 189 196 PF00149 0.495
DOC_PP2B_PxIxI_1 84 90 PF00149 0.467
DOC_USP7_MATH_1 25 29 PF00917 0.430
DOC_USP7_MATH_1 3 7 PF00917 0.506
DOC_USP7_UBL2_3 172 176 PF12436 0.534
DOC_WW_Pin1_4 60 65 PF00397 0.605
LIG_14-3-3_CanoR_1 119 124 PF00244 0.446
LIG_BIR_III_4 12 16 PF00653 0.517
LIG_BRCT_BRCA1_1 94 98 PF00533 0.436
LIG_DLG_GKlike_1 119 127 PF00625 0.524
LIG_FHA_1 128 134 PF00498 0.497
LIG_FHA_1 31 37 PF00498 0.364
LIG_LIR_Apic_2 81 85 PF02991 0.546
LIG_LIR_Gen_1 116 123 PF02991 0.457
LIG_LIR_Nem_3 116 120 PF02991 0.341
LIG_LIR_Nem_3 196 202 PF02991 0.471
LIG_LIR_Nem_3 218 223 PF02991 0.340
LIG_LIR_Nem_3 51 55 PF02991 0.457
LIG_LIR_Nem_3 99 105 PF02991 0.541
LIG_Pex14_2 98 102 PF04695 0.550
LIG_SH2_CRK 52 56 PF00017 0.437
LIG_SH2_CRK 82 86 PF00017 0.546
LIG_SH2_GRB2like 82 85 PF00017 0.546
LIG_SH2_SRC 82 85 PF00017 0.546
LIG_SH2_STAT5 105 108 PF00017 0.467
LIG_SH2_STAT5 168 171 PF00017 0.481
LIG_SH2_STAT5 199 202 PF00017 0.451
LIG_SH2_STAT5 208 211 PF00017 0.423
LIG_SH2_STAT5 96 99 PF00017 0.467
LIG_SUMO_SIM_par_1 148 154 PF11976 0.457
LIG_SUMO_SIM_par_1 225 231 PF11976 0.354
LIG_SUMO_SIM_par_1 83 90 PF11976 0.444
LIG_UBA3_1 86 93 PF00899 0.441
MOD_CK1_1 122 128 PF00069 0.488
MOD_CK1_1 158 164 PF00069 0.467
MOD_CK1_1 177 183 PF00069 0.480
MOD_CK1_1 63 69 PF00069 0.618
MOD_CK2_1 62 68 PF00069 0.603
MOD_GlcNHglycan 124 127 PF01048 0.262
MOD_GlcNHglycan 157 160 PF01048 0.267
MOD_GlcNHglycan 27 30 PF01048 0.490
MOD_GSK3_1 122 129 PF00069 0.451
MOD_GSK3_1 62 69 PF00069 0.542
MOD_GSK3_1 92 99 PF00069 0.432
MOD_NEK2_1 44 49 PF00069 0.458
MOD_NEK2_1 92 97 PF00069 0.433
MOD_NEK2_2 3 8 PF00069 0.503
MOD_Plk_1 232 238 PF00069 0.477
MOD_Plk_4 177 183 PF00069 0.469
MOD_Plk_4 92 98 PF00069 0.433
MOD_ProDKin_1 60 66 PF00069 0.609
TRG_DiLeu_BaLyEn_6 82 87 PF01217 0.467
TRG_ENDOCYTIC_2 199 202 PF00928 0.518
TRG_ENDOCYTIC_2 220 223 PF00928 0.345
TRG_ENDOCYTIC_2 52 55 PF00928 0.416
TRG_Pf-PMV_PEXEL_1 104 108 PF00026 0.239
TRG_Pf-PMV_PEXEL_1 163 167 PF00026 0.235
TRG_PTS1 238 241 PF00515 0.472

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IHW3 Leptomonas seymouri 66% 100%
A0A0N1PCR6 Leptomonas seymouri 32% 100%
A0A1X0NZ20 Trypanosomatidae 34% 100%
A0A1X0NZ92 Trypanosomatidae 57% 100%
A0A422N3N7 Trypanosoma rangeli 55% 100%
A0A422N3S1 Trypanosoma rangeli 37% 100%
A4HBT6 Leishmania braziliensis 34% 100%
A4HBT7 Leishmania braziliensis 80% 100%
A4II60 Xenopus tropicalis 32% 100%
D0A1D6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 55% 100%
D0A1D7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 38% 100%
D0A1E6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 38% 100%
E9AGU6 Leishmania infantum 34% 94%
E9AV58 Leishmania mexicana (strain MHOM/GT/2001/U1103) 34% 100%
E9AV59 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 99%
O66821 Aquifex aeolicus (strain VF5) 33% 100%
O69537 Mycobacterium leprae (strain TN) 31% 100%
P07833 Plasmodium falciparum (isolate K1 / Thailand) 29% 100%
P09383 Schistosoma mansoni 30% 85%
P0A5T1 Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) 31% 100%
P0DD40 Streptococcus pyogenes serotype M3 (strain ATCC BAA-595 / MGAS315) 34% 100%
P0DD41 Streptococcus pyogenes serotype M3 (strain SSI-1) 34% 100%
P20035 Plasmodium falciparum (isolate FCR-3 / Gambia) 29% 100%
P37171 Rhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003) 32% 100%
P43152 Leishmania donovani 34% 100%
P45078 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) 29% 100%
P51900 Tritrichomonas foetus 36% 100%
P96794 Mycobacterium avium 34% 100%
P9WHQ8 Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) 31% 100%
P9WHQ9 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 31% 100%
Q07010 Trypanosoma brucei brucei 39% 100%
Q26997 Toxoplasma gondii 31% 100%
Q27541 Crithidia fasciculata 33% 100%
Q4QCC2 Leishmania major 94% 99%
Q4QCC3 Leishmania major 33% 94%
Q54NJ8 Dictyostelium discoideum 28% 100%
Q5HRP4 Staphylococcus epidermidis (strain ATCC 35984 / RP62A) 28% 100%
Q5M216 Streptococcus thermophilus (strain CNRZ 1066) 32% 100%
Q5M6K8 Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311) 32% 100%
Q5XEL6 Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394) 34% 100%
Q6DCP3 Xenopus laevis 32% 100%
Q7CNQ9 Streptococcus pyogenes serotype M18 (strain MGAS8232) 34% 100%
Q7KLF3 Leishmania donovani 34% 100%
Q839B2 Enterococcus faecalis (strain ATCC 700802 / V583) 33% 100%
Q8CQV4 Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200) 28% 100%
Q8DRP8 Streptococcus pneumoniae (strain ATCC BAA-255 / R6) 34% 100%
Q8E2H3 Streptococcus agalactiae serotype V (strain ATCC BAA-611 / 2603 V/R) 35% 100%
Q8E7Y1 Streptococcus agalactiae serotype III (strain NEM316) 35% 100%
Q8K9U8 Buchnera aphidicola subsp. Schizaphis graminum (strain Sg) 31% 100%
Q97TC4 Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) 34% 100%
Q9U6Y2 Leishmania donovani 100% 100%
V5DEL0 Trypanosoma cruzi 55% 78%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS