LeishMANIAdb
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MFS domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
MFS domain-containing protein
Gene product:
Major Facilitator Superfamily - putative
Species:
Leishmania infantum
UniProt:
E9AGU5_LEIIN
TriTrypDb:
LINF_210006100
Length:
457

Annotations

Annotations by Jardim et al.

Transporters, Major facilitator transporter

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 1, no: 11
NetGPI no yes: 0, no: 12
Cellular components
Term Name Level Count
GO:0016020 membrane 2 13
GO:0110165 cellular anatomical entity 1 13

Expansion

Sequence features

E9AGU5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AGU5

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 13
GO:0022857 transmembrane transporter activity 2 13

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 226 230 PF00656 0.531
CLV_PCSK_SKI1_1 317 321 PF00082 0.260
CLV_PCSK_SKI1_1 412 416 PF00082 0.610
CLV_PCSK_SKI1_1 73 77 PF00082 0.260
DOC_CDC14_PxL_1 165 173 PF14671 0.397
DOC_CYCLIN_RxL_1 170 181 PF00134 0.341
DOC_CYCLIN_RxL_1 46 58 PF00134 0.356
DOC_MAPK_gen_1 317 325 PF00069 0.460
DOC_MAPK_gen_1 9 19 PF00069 0.462
DOC_MAPK_MEF2A_6 12 21 PF00069 0.455
DOC_MAPK_MEF2A_6 77 85 PF00069 0.516
DOC_PP1_RVXF_1 171 178 PF00149 0.341
DOC_PP1_RVXF_1 318 325 PF00149 0.471
DOC_USP7_MATH_1 105 109 PF00917 0.322
DOC_USP7_MATH_1 223 227 PF00917 0.472
DOC_WW_Pin1_4 123 128 PF00397 0.313
DOC_WW_Pin1_4 338 343 PF00397 0.403
LIG_14-3-3_CanoR_1 146 156 PF00244 0.471
LIG_14-3-3_CanoR_1 440 446 PF00244 0.541
LIG_Actin_WH2_2 67 84 PF00022 0.343
LIG_APCC_ABBA_1 273 278 PF00400 0.397
LIG_BRCT_BRCA1_1 152 156 PF00533 0.440
LIG_BRCT_BRCA1_1 265 269 PF00533 0.366
LIG_BRCT_BRCA1_1 284 288 PF00533 0.299
LIG_BRCT_BRCA1_1 410 414 PF00533 0.400
LIG_FHA_1 107 113 PF00498 0.312
LIG_FHA_1 128 134 PF00498 0.318
LIG_FHA_1 170 176 PF00498 0.318
LIG_FHA_1 426 432 PF00498 0.333
LIG_FHA_2 137 143 PF00498 0.429
LIG_FHA_2 179 185 PF00498 0.349
LIG_FHA_2 339 345 PF00498 0.429
LIG_FHA_2 74 80 PF00498 0.499
LIG_FHA_2 87 93 PF00498 0.371
LIG_LIR_Apic_2 137 143 PF02991 0.350
LIG_LIR_Apic_2 248 253 PF02991 0.541
LIG_LIR_Gen_1 153 163 PF02991 0.384
LIG_LIR_Gen_1 176 185 PF02991 0.227
LIG_LIR_Gen_1 193 203 PF02991 0.220
LIG_LIR_Gen_1 270 280 PF02991 0.302
LIG_LIR_Gen_1 355 363 PF02991 0.448
LIG_LIR_Gen_1 4 14 PF02991 0.619
LIG_LIR_Nem_3 108 113 PF02991 0.266
LIG_LIR_Nem_3 11 17 PF02991 0.501
LIG_LIR_Nem_3 153 159 PF02991 0.398
LIG_LIR_Nem_3 162 168 PF02991 0.330
LIG_LIR_Nem_3 176 180 PF02991 0.170
LIG_LIR_Nem_3 181 186 PF02991 0.293
LIG_LIR_Nem_3 270 275 PF02991 0.313
LIG_LIR_Nem_3 278 283 PF02991 0.248
LIG_LIR_Nem_3 285 291 PF02991 0.245
LIG_LIR_Nem_3 293 298 PF02991 0.359
LIG_LIR_Nem_3 355 359 PF02991 0.403
LIG_LIR_Nem_3 4 10 PF02991 0.607
LIG_LIR_Nem_3 444 448 PF02991 0.544
LIG_LIR_Nem_3 57 62 PF02991 0.305
LIG_LIR_Nem_3 67 71 PF02991 0.281
LIG_LIR_Nem_3 76 81 PF02991 0.397
LIG_MLH1_MIPbox_1 410 414 PF16413 0.400
LIG_PDZ_Class_3 452 457 PF00595 0.601
LIG_Pex14_1 272 276 PF04695 0.330
LIG_Pex14_2 64 68 PF04695 0.349
LIG_PTB_Apo_2 331 338 PF02174 0.349
LIG_REV1ctd_RIR_1 4 13 PF16727 0.500
LIG_SH2_CRK 14 18 PF00017 0.285
LIG_SH2_CRK 407 411 PF00017 0.331
LIG_SH2_CRK 78 82 PF00017 0.536
LIG_SH2_NCK_1 376 380 PF00017 0.471
LIG_SH2_PTP2 165 168 PF00017 0.371
LIG_SH2_STAP1 183 187 PF00017 0.331
LIG_SH2_STAP1 280 284 PF00017 0.303
LIG_SH2_STAP1 376 380 PF00017 0.471
LIG_SH2_STAT3 448 451 PF00017 0.617
LIG_SH2_STAT5 165 168 PF00017 0.331
LIG_SH2_STAT5 300 303 PF00017 0.325
LIG_SH2_STAT5 309 312 PF00017 0.299
LIG_SH2_STAT5 314 317 PF00017 0.429
LIG_SH2_STAT5 321 324 PF00017 0.294
LIG_SH2_STAT5 448 451 PF00017 0.560
LIG_SH3_3 121 127 PF00018 0.331
LIG_SH3_3 194 200 PF00018 0.397
LIG_SUMO_SIM_anti_2 238 244 PF11976 0.542
LIG_SxIP_EBH_1 62 73 PF03271 0.334
LIG_TRAF2_1 385 388 PF00917 0.584
LIG_TYR_ITIM 163 168 PF00017 0.331
LIG_TYR_ITIM 260 265 PF00017 0.460
LIG_TYR_ITIM 374 379 PF00017 0.331
LIG_TYR_ITIM 405 410 PF00017 0.371
LIG_WRC_WIRS_1 291 296 PF05994 0.349
LIG_WRC_WIRS_1 65 70 PF05994 0.334
MOD_CDK_SPxxK_3 338 345 PF00069 0.403
MOD_CK1_1 134 140 PF00069 0.323
MOD_CK1_1 178 184 PF00069 0.412
MOD_CK1_1 221 227 PF00069 0.373
MOD_CK1_1 241 247 PF00069 0.377
MOD_CK1_1 248 254 PF00069 0.288
MOD_CK2_1 136 142 PF00069 0.401
MOD_CK2_1 178 184 PF00069 0.331
MOD_CK2_1 393 399 PF00069 0.331
MOD_CK2_1 86 92 PF00069 0.402
MOD_GlcNHglycan 121 124 PF01048 0.328
MOD_GlcNHglycan 133 136 PF01048 0.290
MOD_GlcNHglycan 177 180 PF01048 0.403
MOD_GlcNHglycan 204 207 PF01048 0.410
MOD_GlcNHglycan 220 223 PF01048 0.457
MOD_GlcNHglycan 265 268 PF01048 0.370
MOD_GlcNHglycan 269 272 PF01048 0.331
MOD_GlcNHglycan 390 393 PF01048 0.331
MOD_GSK3_1 119 126 PF00069 0.327
MOD_GSK3_1 127 134 PF00069 0.331
MOD_GSK3_1 155 162 PF00069 0.340
MOD_GSK3_1 169 176 PF00069 0.304
MOD_GSK3_1 209 216 PF00069 0.341
MOD_GSK3_1 241 248 PF00069 0.394
MOD_GSK3_1 263 270 PF00069 0.327
MOD_GSK3_1 278 285 PF00069 0.414
MOD_GSK3_1 408 415 PF00069 0.438
MOD_GSK3_1 417 424 PF00069 0.333
MOD_N-GLC_1 441 446 PF02516 0.408
MOD_NEK2_1 136 141 PF00069 0.387
MOD_NEK2_1 155 160 PF00069 0.159
MOD_NEK2_1 175 180 PF00069 0.120
MOD_NEK2_1 218 223 PF00069 0.439
MOD_NEK2_1 276 281 PF00069 0.344
MOD_NEK2_1 313 318 PF00069 0.351
MOD_NEK2_1 325 330 PF00069 0.282
MOD_NEK2_1 352 357 PF00069 0.421
MOD_NEK2_1 425 430 PF00069 0.347
MOD_NEK2_1 55 60 PF00069 0.362
MOD_NEK2_1 64 69 PF00069 0.328
MOD_NEK2_2 271 276 PF00069 0.321
MOD_NEK2_2 290 295 PF00069 0.120
MOD_PIKK_1 241 247 PF00454 0.429
MOD_PKA_1 173 179 PF00069 0.451
MOD_PKA_2 147 153 PF00069 0.331
MOD_Plk_1 213 219 PF00069 0.435
MOD_Plk_1 343 349 PF00069 0.401
MOD_Plk_1 380 386 PF00069 0.356
MOD_Plk_1 441 447 PF00069 0.412
MOD_Plk_4 136 142 PF00069 0.429
MOD_Plk_4 150 156 PF00069 0.429
MOD_Plk_4 178 184 PF00069 0.350
MOD_Plk_4 290 296 PF00069 0.400
MOD_Plk_4 305 311 PF00069 0.244
MOD_Plk_4 345 351 PF00069 0.347
MOD_Plk_4 352 358 PF00069 0.336
MOD_Plk_4 64 70 PF00069 0.406
MOD_ProDKin_1 123 129 PF00069 0.313
MOD_ProDKin_1 338 344 PF00069 0.403
TRG_DiLeu_BaEn_1 238 243 PF01217 0.397
TRG_DiLeu_BaEn_3 286 292 PF01217 0.451
TRG_ENDOCYTIC_2 14 17 PF00928 0.285
TRG_ENDOCYTIC_2 165 168 PF00928 0.331
TRG_ENDOCYTIC_2 183 186 PF00928 0.324
TRG_ENDOCYTIC_2 262 265 PF00928 0.398
TRG_ENDOCYTIC_2 280 283 PF00928 0.349
TRG_ENDOCYTIC_2 321 324 PF00928 0.335
TRG_ENDOCYTIC_2 376 379 PF00928 0.331
TRG_ENDOCYTIC_2 407 410 PF00928 0.331
TRG_ENDOCYTIC_2 78 81 PF00928 0.422

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IJH4 Leptomonas seymouri 81% 99%
A0A0S4J692 Bodo saltans 23% 76%
A0A0S4J989 Bodo saltans 49% 92%
A0A1X0NWR8 Trypanosomatidae 24% 95%
A0A1X0NXK8 Trypanosomatidae 65% 100%
A0A3R7NE20 Trypanosoma rangeli 61% 100%
A0A3S7WUW1 Leishmania donovani 23% 89%
A0A3S7WW86 Leishmania donovani 100% 100%
A4H9A1 Leishmania braziliensis 23% 100%
A4HBK5 Leishmania braziliensis 91% 100%
A4HXM1 Leishmania infantum 23% 100%
B2RXV4 Mus musculus 23% 82%
E9ARB7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 23% 100%
E9AUX4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 98% 100%
O01735 Caenorhabditis elegans 23% 78%
P60815 Rattus norvegicus 21% 84%
Q4QCK8 Leishmania major 96% 100%
Q4QE46 Leishmania major 23% 100%
Q6GNV7 Xenopus laevis 21% 100%
Q91X85 Mus musculus 21% 83%
Q9ES43 Mus terricolor 23% 82%
Q9N1F2 Felis catus 23% 82%
Q9UPI3 Homo sapiens 21% 87%
Q9Y5Y0 Homo sapiens 23% 82%
V5BQV3 Trypanosoma cruzi 25% 83%
V5DGX2 Trypanosoma cruzi 60% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS