Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

E9AGU4_LEIIN

TriTrypDb:

LINF_210005400

Length:

254

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AGU4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AGU4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	163	165	PF00675	0.573
CLV_PCSK_KEX2_1	163	165	PF00082	0.573
CLV_Separin_Metazoa	212	216	PF03568	0.490
DEG_APCC_DBOX_1	113	121	PF00400	0.540
DOC_MAPK_gen_1	236	245	PF00069	0.511
DOC_MAPK_MEF2A_6	101	109	PF00069	0.489
DOC_USP7_MATH_1	22	26	PF00917	0.699
DOC_WW_Pin1_4	164	169	PF00397	0.618
DOC_WW_Pin1_4	194	199	PF00397	0.503
LIG_14-3-3_CanoR_1	244	250	PF00244	0.524
LIG_14-3-3_CanoR_1	43	48	PF00244	0.507
LIG_14-3-3_CanoR_1	5	11	PF00244	0.688
LIG_APCC_ABBA_1	45	50	PF00400	0.533
LIG_BRCT_BRCA1_1	190	194	PF00533	0.449
LIG_FHA_1	104	110	PF00498	0.484
LIG_FHA_1	35	41	PF00498	0.515
LIG_FHA_1	60	66	PF00498	0.476
LIG_FHA_2	129	135	PF00498	0.523
LIG_LIR_Gen_1	240	250	PF02991	0.479
LIG_LIR_Gen_1	42	52	PF02991	0.514
LIG_LIR_Nem_3	240	245	PF02991	0.463
LIG_LIR_Nem_3	42	48	PF02991	0.412
LIG_MYND_3	250	254	PF01753	0.620
LIG_NRBOX	154	160	PF00104	0.434
LIG_SH2_CRK	145	149	PF00017	0.439
LIG_SH2_STAT5	226	229	PF00017	0.460
LIG_SH3_3	162	168	PF00018	0.541
LIG_SUMO_SIM_par_1	103	108	PF11976	0.466
LIG_SUMO_SIM_par_1	61	66	PF11976	0.388
MOD_CK1_1	188	194	PF00069	0.498
MOD_CK2_1	128	134	PF00069	0.571
MOD_DYRK1A_RPxSP_1	164	168	PF00069	0.482
MOD_GlcNHglycan	180	183	PF01048	0.508
MOD_GlcNHglycan	187	190	PF01048	0.385
MOD_GlcNHglycan	84	87	PF01048	0.593
MOD_GSK3_1	105	112	PF00069	0.432
MOD_GSK3_1	185	192	PF00069	0.497
MOD_GSK3_1	194	201	PF00069	0.454
MOD_GSK3_1	39	46	PF00069	0.432
MOD_N-GLC_1	150	155	PF02516	0.565
MOD_N-GLC_1	52	57	PF02516	0.525
MOD_N-GLC_2	98	100	PF02516	0.561
MOD_NEK2_1	105	110	PF00069	0.452
MOD_NEK2_1	150	155	PF00069	0.503
MOD_NEK2_1	23	28	PF00069	0.637
MOD_NEK2_1	34	39	PF00069	0.430
MOD_NEK2_1	4	9	PF00069	0.598
MOD_NEK2_1	65	70	PF00069	0.681
MOD_NEK2_2	198	203	PF00069	0.538
MOD_OFUCOSY	12	18	PF10250	0.631
MOD_PIKK_1	138	144	PF00454	0.537
MOD_PKA_2	243	249	PF00069	0.535
MOD_PKA_2	4	10	PF00069	0.700
MOD_Plk_1	150	156	PF00069	0.572
MOD_Plk_4	128	134	PF00069	0.525
MOD_Plk_4	189	195	PF00069	0.562
MOD_Plk_4	245	251	PF00069	0.503
MOD_ProDKin_1	164	170	PF00069	0.619
MOD_ProDKin_1	194	200	PF00069	0.504
MOD_SUMO_for_1	202	205	PF00179	0.580
MOD_SUMO_rev_2	225	231	PF00179	0.539
TRG_ER_diArg_1	163	165	PF00400	0.573
TRG_NES_CRM1_1	208	221	PF08389	0.409

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4IYT2	Bodo saltans	26%	79%
A0A1X0NXA5	Trypanosomatidae	31%	93%
A0A3Q8IB00	Leishmania donovani	99%	100%
A0A3R7N8W3	Trypanosoma rangeli	35%	97%
A4HBJ8	Leishmania braziliensis	63%	100%
D0A1J5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	85%
E9AUW7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QCL5	Leishmania major	91%	100%