Phosphoglycerate kinase

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphoglycerate kinase C - glycosomal

Species:

Leishmania infantum

UniProt:

E9AGT9_LEIIN

TriTrypDb:

LINF_200006000

Length:

479

Annotations

Annotations by Jardim et al.

Glycolysis Proteins, Phosphoglycerate kinase PGKC

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 18

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 15

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Show entries

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005777	peroxisome	6	1
GO:0005829	cytosol	2	2
GO:0016020	membrane	2	3
GO:0020015	glycosome	7	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0042579	microbody	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1

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Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

E9AGT9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AGT9

Function

Show entries

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	9
GO:0005996	monosaccharide metabolic process	3	2
GO:0006006	glucose metabolic process	5	2
GO:0006082	organic acid metabolic process	3	9
GO:0006090	pyruvate metabolic process	7	9
GO:0006091	generation of precursor metabolites and energy	3	9
GO:0006094	gluconeogenesis	6	2
GO:0006096	glycolytic process	5	9
GO:0006139	nucleobase-containing compound metabolic process	3	9
GO:0006163	purine nucleotide metabolic process	5	9

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	9
GO:0003824	catalytic activity	1	9
GO:0004618	phosphoglycerate kinase activity	5	9
GO:0005488	binding	1	9
GO:0005524	ATP binding	5	9
GO:0016301	kinase activity	4	9
GO:0016740	transferase activity	2	9
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	9
GO:0016774	phosphotransferase activity, carboxyl group as acceptor	4	9
GO:0017076	purine nucleotide binding	4	9

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Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	109	113	PF00656	0.495
CLV_C14_Caspase3-7	143	147	PF00656	0.495
CLV_C14_Caspase3-7	222	226	PF00656	0.450
CLV_C14_Caspase3-7	304	308	PF00656	0.495
CLV_NRD_NRD_1	249	251	PF00675	0.250
CLV_NRD_NRD_1	471	473	PF00675	0.433
CLV_PCSK_KEX2_1	471	473	PF00082	0.433
CLV_PCSK_SKI1_1	17	21	PF00082	0.295
CLV_PCSK_SKI1_1	266	270	PF00082	0.348
CLV_PCSK_SKI1_1	289	293	PF00082	0.302

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4S0	Leptomonas seymouri	80%	100%
A0A0N1IJY4	Leptomonas seymouri	57%	95%
A0A0N1PD32	Leptomonas seymouri	45%	91%
A0A0S4JE17	Bodo saltans	69%	93%
A0A0S4JLJ4	Bodo saltans	50%	91%
A0A1X0NCV2	Trypanosomatidae	77%	100%
A0A1X0NWU8	Trypanosomatidae	81%	95%
A0A1X0P188	Trypanosomatidae	47%	91%
A0A3Q8IAF1	Leishmania donovani	99%	100%
A0A3R7MFG6	Trypanosoma rangeli	74%	100%

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