LeishMANIAdb
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Tyrosine-protein phosphatase domain-containing protein

Quick info Annotations Function or PPIs Localization Phosphorylation Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Tyrosine-protein phosphatase domain-containing protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
E9AGT8_LEIIN
TriTrypDb:
LINF_200005800
Length:
575

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Phosphorylation

Amastigote: 289
Promastigote/Amastigote: 278, 280, 287

Expansion

Sequence features

E9AGT8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AGT8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 367 371 PF00656 0.457
CLV_NRD_NRD_1 157 159 PF00675 0.546
CLV_NRD_NRD_1 20 22 PF00675 0.546
CLV_NRD_NRD_1 405 407 PF00675 0.424
CLV_NRD_NRD_1 484 486 PF00675 0.550
CLV_NRD_NRD_1 85 87 PF00675 0.415
CLV_PCSK_KEX2_1 157 159 PF00082 0.546
CLV_PCSK_KEX2_1 405 407 PF00082 0.439
CLV_PCSK_KEX2_1 484 486 PF00082 0.489
CLV_PCSK_PC7_1 401 407 PF00082 0.416
CLV_PCSK_SKI1_1 125 129 PF00082 0.602
CLV_PCSK_SKI1_1 157 161 PF00082 0.551
CLV_PCSK_SKI1_1 269 273 PF00082 0.625
CLV_PCSK_SKI1_1 34 38 PF00082 0.550
CLV_PCSK_SKI1_1 401 405 PF00082 0.411
CLV_PCSK_SKI1_1 477 481 PF00082 0.635
CLV_PCSK_SKI1_1 501 505 PF00082 0.398
DEG_Nend_UBRbox_3 1 3 PF02207 0.677
DEG_SCF_FBW7_1 303 309 PF00400 0.627
DOC_CKS1_1 218 223 PF01111 0.554
DOC_CKS1_1 285 290 PF01111 0.792
DOC_CKS1_1 303 308 PF01111 0.458
DOC_CKS1_1 437 442 PF01111 0.680
DOC_CKS1_1 497 502 PF01111 0.422
DOC_CYCLIN_yCln2_LP_2 292 298 PF00134 0.727
DOC_CYCLIN_yCln2_LP_2 377 383 PF00134 0.503
DOC_MAPK_gen_1 157 165 PF00069 0.533
DOC_MAPK_gen_1 409 417 PF00069 0.556
DOC_MAPK_HePTP_8 134 146 PF00069 0.471
DOC_MAPK_MEF2A_6 129 138 PF00069 0.394
DOC_MAPK_MEF2A_6 167 176 PF00069 0.532
DOC_MAPK_MEF2A_6 504 513 PF00069 0.546
DOC_PP1_RVXF_1 155 162 PF00149 0.550
DOC_PP1_RVXF_1 373 380 PF00149 0.421
DOC_USP7_MATH_1 153 157 PF00917 0.583
DOC_USP7_MATH_1 24 28 PF00917 0.605
DOC_USP7_MATH_1 371 375 PF00917 0.469
DOC_USP7_MATH_1 442 446 PF00917 0.657
DOC_USP7_UBL2_3 121 125 PF12436 0.669
DOC_USP7_UBL2_3 457 461 PF12436 0.715
DOC_USP7_UBL2_3 515 519 PF12436 0.517
DOC_USP7_UBL2_3 529 533 PF12436 0.592
DOC_WW_Pin1_4 217 222 PF00397 0.618
DOC_WW_Pin1_4 225 230 PF00397 0.545
DOC_WW_Pin1_4 275 280 PF00397 0.647
DOC_WW_Pin1_4 284 289 PF00397 0.633
DOC_WW_Pin1_4 302 307 PF00397 0.476
DOC_WW_Pin1_4 436 441 PF00397 0.644
DOC_WW_Pin1_4 496 501 PF00397 0.445
DOC_WW_Pin1_4 505 510 PF00397 0.397
DOC_WW_Pin1_4 69 74 PF00397 0.441
LIG_14-3-3_CanoR_1 157 162 PF00244 0.544
LIG_14-3-3_CanoR_1 199 207 PF00244 0.490
LIG_14-3-3_CanoR_1 247 255 PF00244 0.449
LIG_14-3-3_CanoR_1 269 279 PF00244 0.759
LIG_14-3-3_CanoR_1 325 334 PF00244 0.486
LIG_14-3-3_CanoR_1 78 83 PF00244 0.515
LIG_BRCT_BRCA1_1 27 31 PF00533 0.606
LIG_BRCT_BRCA1_1 358 362 PF00533 0.413
LIG_BRCT_BRCA1_1 418 422 PF00533 0.539
LIG_CaM_IQ_9 317 333 PF13499 0.670
LIG_Clathr_ClatBox_1 548 552 PF01394 0.418
LIG_eIF4E_1 248 254 PF01652 0.544
LIG_eIF4E_1 543 549 PF01652 0.358
LIG_FHA_1 102 108 PF00498 0.456
LIG_FHA_1 221 227 PF00498 0.494
LIG_FHA_1 249 255 PF00498 0.449
LIG_FHA_1 260 266 PF00498 0.634
LIG_FHA_1 315 321 PF00498 0.674
LIG_FHA_1 448 454 PF00498 0.545
LIG_FHA_1 46 52 PF00498 0.584
LIG_FHA_1 506 512 PF00498 0.398
LIG_FHA_1 533 539 PF00498 0.549
LIG_FHA_1 62 68 PF00498 0.446
LIG_FHA_2 497 503 PF00498 0.421
LIG_LIR_Apic_2 215 221 PF02991 0.608
LIG_LIR_Gen_1 201 212 PF02991 0.552
LIG_LIR_Gen_1 228 238 PF02991 0.516
LIG_LIR_Gen_1 382 391 PF02991 0.382
LIG_LIR_Gen_1 470 479 PF02991 0.608
LIG_LIR_Gen_1 544 551 PF02991 0.355
LIG_LIR_Gen_1 81 90 PF02991 0.570
LIG_LIR_LC3C_4 250 255 PF02991 0.488
LIG_LIR_LC3C_4 56 59 PF02991 0.505
LIG_LIR_Nem_3 189 195 PF02991 0.577
LIG_LIR_Nem_3 201 207 PF02991 0.549
LIG_LIR_Nem_3 228 234 PF02991 0.514
LIG_LIR_Nem_3 382 386 PF02991 0.373
LIG_LIR_Nem_3 470 475 PF02991 0.607
LIG_LIR_Nem_3 544 548 PF02991 0.345
LIG_LIR_Nem_3 81 85 PF02991 0.510
LIG_NBox_RRM_1 428 438 PF00076 0.636
LIG_PCNA_PIPBox_1 355 364 PF02747 0.495
LIG_PCNA_TLS_4 466 473 PF02747 0.654
LIG_Pex14_1 379 383 PF04695 0.372
LIG_PTB_Apo_2 533 540 PF02174 0.444
LIG_PTB_Phospho_1 533 539 PF10480 0.443
LIG_SH2_CRK 231 235 PF00017 0.529
LIG_SH2_CRK 539 543 PF00017 0.430
LIG_SH2_CRK 545 549 PF00017 0.322
LIG_SH2_CRK 82 86 PF00017 0.544
LIG_SH2_GRB2like 524 527 PF00017 0.527
LIG_SH2_NCK_1 231 235 PF00017 0.522
LIG_SH2_SRC 524 527 PF00017 0.527
LIG_SH2_SRC 539 542 PF00017 0.421
LIG_SH2_SRC 543 546 PF00017 0.351
LIG_SH2_STAP1 231 235 PF00017 0.529
LIG_SH2_STAP1 543 547 PF00017 0.367
LIG_SH2_STAT5 11 14 PF00017 0.455
LIG_SH2_STAT5 248 251 PF00017 0.534
LIG_SH2_STAT5 407 410 PF00017 0.538
LIG_SH2_STAT5 524 527 PF00017 0.527
LIG_SH3_3 136 142 PF00018 0.524
LIG_SH3_3 276 282 PF00018 0.729
LIG_SH3_3 285 291 PF00018 0.695
LIG_SH3_3 300 306 PF00018 0.622
LIG_SH3_3 434 440 PF00018 0.668
LIG_SH3_5 537 541 PF00018 0.521
LIG_SUMO_SIM_anti_2 101 109 PF11976 0.403
LIG_SUMO_SIM_anti_2 145 150 PF11976 0.465
LIG_SUMO_SIM_anti_2 173 179 PF11976 0.386
MOD_CDK_SPK_2 225 230 PF00069 0.473
MOD_CDK_SPK_2 496 501 PF00069 0.440
MOD_CK1_1 179 185 PF00069 0.480
MOD_CK1_1 216 222 PF00069 0.577
MOD_CK1_1 270 276 PF00069 0.610
MOD_CK1_1 299 305 PF00069 0.727
MOD_CK1_1 314 320 PF00069 0.595
MOD_CK1_1 336 342 PF00069 0.527
MOD_CK1_1 451 457 PF00069 0.634
MOD_CK1_1 532 538 PF00069 0.548
MOD_CK1_1 61 67 PF00069 0.403
MOD_CK1_1 72 78 PF00069 0.431
MOD_CK2_1 233 239 PF00069 0.499
MOD_CK2_1 312 318 PF00069 0.715
MOD_CK2_1 347 353 PF00069 0.492
MOD_CK2_1 464 470 PF00069 0.606
MOD_CK2_1 496 502 PF00069 0.429
MOD_CK2_1 92 98 PF00069 0.530
MOD_CMANNOS 222 225 PF00535 0.377
MOD_GlcNHglycan 22 25 PF01048 0.488
MOD_GlcNHglycan 235 238 PF01048 0.466
MOD_GlcNHglycan 269 272 PF01048 0.596
MOD_GlcNHglycan 27 30 PF01048 0.486
MOD_GlcNHglycan 279 282 PF01048 0.643
MOD_GlcNHglycan 298 301 PF01048 0.613
MOD_GlcNHglycan 314 317 PF01048 0.606
MOD_GlcNHglycan 444 447 PF01048 0.727
MOD_GlcNHglycan 60 63 PF01048 0.525
MOD_GSK3_1 140 147 PF00069 0.479
MOD_GSK3_1 153 160 PF00069 0.571
MOD_GSK3_1 16 23 PF00069 0.478
MOD_GSK3_1 212 219 PF00069 0.588
MOD_GSK3_1 225 232 PF00069 0.464
MOD_GSK3_1 302 309 PF00069 0.659
MOD_GSK3_1 344 351 PF00069 0.536
MOD_GSK3_1 371 378 PF00069 0.583
MOD_GSK3_1 447 454 PF00069 0.730
MOD_GSK3_1 460 467 PF00069 0.589
MOD_GSK3_1 487 494 PF00069 0.528
MOD_GSK3_1 57 64 PF00069 0.570
MOD_GSK3_1 74 81 PF00069 0.477
MOD_LATS_1 527 533 PF00433 0.581
MOD_N-GLC_1 179 184 PF02516 0.526
MOD_N-GLC_1 216 221 PF02516 0.629
MOD_N-GLC_1 259 264 PF02516 0.706
MOD_N-GLC_1 312 317 PF02516 0.703
MOD_N-GLC_1 34 39 PF02516 0.547
MOD_N-GLC_1 410 415 PF02516 0.519
MOD_N-GLC_1 505 510 PF02516 0.392
MOD_N-GLC_1 69 74 PF02516 0.438
MOD_NEK2_1 144 149 PF00069 0.441
MOD_NEK2_1 212 217 PF00069 0.676
MOD_NEK2_1 249 254 PF00069 0.523
MOD_NEK2_1 422 427 PF00069 0.522
MOD_NEK2_1 479 484 PF00069 0.652
MOD_NEK2_1 57 62 PF00069 0.418
MOD_NEK2_1 92 97 PF00069 0.462
MOD_NEK2_2 491 496 PF00069 0.549
MOD_PIKK_1 286 292 PF00454 0.774
MOD_PIKK_1 327 333 PF00454 0.669
MOD_PIKK_1 416 422 PF00454 0.463
MOD_PKA_1 157 163 PF00069 0.539
MOD_PKA_2 157 163 PF00069 0.539
MOD_PKA_2 198 204 PF00069 0.537
MOD_PKA_2 20 26 PF00069 0.454
MOD_PKA_2 213 219 PF00069 0.662
MOD_Plk_1 100 106 PF00069 0.526
MOD_Plk_1 259 265 PF00069 0.707
MOD_Plk_1 34 40 PF00069 0.534
MOD_Plk_4 229 235 PF00069 0.539
MOD_Plk_4 249 255 PF00069 0.494
MOD_Plk_4 336 342 PF00069 0.559
MOD_Plk_4 386 392 PF00069 0.399
MOD_Plk_4 448 454 PF00069 0.572
MOD_Plk_4 491 497 PF00069 0.433
MOD_ProDKin_1 217 223 PF00069 0.608
MOD_ProDKin_1 225 231 PF00069 0.542
MOD_ProDKin_1 275 281 PF00069 0.647
MOD_ProDKin_1 284 290 PF00069 0.631
MOD_ProDKin_1 302 308 PF00069 0.472
MOD_ProDKin_1 436 442 PF00069 0.645
MOD_ProDKin_1 496 502 PF00069 0.434
MOD_ProDKin_1 505 511 PF00069 0.394
MOD_ProDKin_1 69 75 PF00069 0.440
MOD_SUMO_rev_2 118 127 PF00179 0.643
MOD_SUMO_rev_2 14 24 PF00179 0.570
MOD_SUMO_rev_2 345 350 PF00179 0.593
TRG_DiLeu_BaEn_2 467 473 PF01217 0.620
TRG_ENDOCYTIC_2 192 195 PF00928 0.559
TRG_ENDOCYTIC_2 231 234 PF00928 0.521
TRG_ENDOCYTIC_2 545 548 PF00928 0.336
TRG_ENDOCYTIC_2 556 559 PF00928 0.353
TRG_ENDOCYTIC_2 82 85 PF00928 0.515
TRG_ENDOCYTIC_2 89 92 PF00928 0.493
TRG_ER_diArg_1 157 159 PF00400 0.546
TRG_ER_diArg_1 404 406 PF00400 0.414
TRG_ER_diArg_1 483 485 PF00400 0.464
TRG_Pf-PMV_PEXEL_1 129 133 PF00026 0.531
TRG_Pf-PMV_PEXEL_1 477 481 PF00026 0.635

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I3N5 Leptomonas seymouri 83% 99%
A0A1X0NX92 Trypanosomatidae 34% 90%
A0A3Q8IEP3 Leishmania donovani 100% 100%
A0A422N7W1 Trypanosoma rangeli 34% 91%
A4HBH7 Leishmania braziliensis 93% 100%
C9ZHU6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 35% 94%
E9AUE8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 97% 100%
Q4QD36 Leishmania major 98% 100%
V5C0D6 Trypanosoma cruzi 34% 92%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS